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Chemical Compound Review

thymidine     1-[(2R,4S,5R)-4-hydroxy-5...

Synonyms: Thymidin, DThyd, dThd, deoxythymidine, Beta-Thymidine, ...
 
 
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Disease relevance of deoxythymidine

 

High impact information on deoxythymidine

 

Chemical compound and disease context of deoxythymidine

 

Biological context of deoxythymidine

 

Anatomical context of deoxythymidine

  • We report a method to test for this proliferative stimulus in the form of a sensitive microassay based upon the tritiated-thymidine incorporation of continuous murine tumor-specific cytotoxic T cell lines (CTLL) [17].
  • Native LDL (20 to 200 micrograms/mL) caused a dose-dependent increase in (3H)thymidine incorporation and increased mesangial cell numbers over 96 h [12].
  • After MSH injections, the level of (3H)thymidine incorporation in keratinocytes increased significantly in black skin but not in white [18].
  • The autoimmune response had been assayed both by determination of the lymphocyte proliferation, using a (3H)thymidine incorporation test, as well as by determination of their specific cytostatic activity against monolayer-forming testis cells which was measured in a terminal 51Cr uptake assay [19].
  • The mitogenic activity of eluted fractions on quiescent subconfluent Swiss Albino 3T3 fibroblasts was tested employing a tritiated-thymidine-incorporation assay [20].
 

Associations of deoxythymidine with other chemical compounds

 

Gene context of deoxythymidine

 

Analytical, diagnostic and therapeutic context of deoxythymidine

  • The chimeric spleen cells lacked responsiveness to host-type, but not to third-party, antigens in the mixed-leukocyte reaction (MLR) as judged by (3H)thymidine incorporation and the generation of cytolytic cells [31].
  • Tritiated-thymidine autoradiographic techniques and 5-bromo-2;-deoxyuridine (BrdU) immunocytochemistry were used to identify cells synthesizing DNA [32].
  • Effect of a copper IUD on the incorporation of (3H)thymidine and (5-3H)uridine into the endometrium of the rabbit during early pregnancy [33].
  • To evaluate this hypothesis we examined the effect of IL-4 on the proportion of B cells stimulated to divide by different doses of anti-IgM using flow cytometry in combination with measurements of tritiated-thymidine incorporation [34].
  • Xenograft tumors exhibited in vivo-like three-dimensional growth on the collagen gel matrix and had increasing incorporation of tritiated (3H)thymidine for 2 weeks [35].

References

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  12. Oxidative modification of low-density lipoproteins by mesangial cells. Keane, W.F., O'Donnell, M.P., Kasiske, B.L., Kim, Y. J. Am. Soc. Nephrol. (1993) [Pubmed]
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  18. The effect of MSH on thymidine incorporation by keratinocytes in the epidermal melanin unit. Erickson, K.L., Hu, F., Giacometti, L. J. Invest. Dermatol. (1976) [Pubmed]
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  23. Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Sholley, M.M., Ferguson, G.P., Seibel, H.R., Montour, J.L., Wilson, J.D. Lab. Invest. (1984) [Pubmed]
  24. Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism. Garg, U.C., Hassid, A. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  25. Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. Rampazzo, C., Fabris, S., Franzolin, E., Crovatto, K., Frangini, M., Bianchi, V. J. Biol. Chem. (2007) [Pubmed]
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  28. Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit-blasted c.p. titanium endosseous implants. Cooper, L.F., Zhou, Y., Takebe, J., Guo, J., Abron, A., Holmén, A., Ellingsen, J.E. Biomaterials (2006) [Pubmed]
  29. Proteinolytic activity against IGF-binding proteins involved in the paracrine interactions between prostate adenocarcinoma cells and osteoblasts. Koutsilieris, M., Polychronakos, C. Anticancer Res. (1992) [Pubmed]
  30. Effects of TGF-beta1 on proliferation and IGFBP-3 production in a primary culture of human fetal epiphyseal chondrocytes (HFEC). Garcia-Ramirez, M., Audi, L., Andaluz, P., Carrascosa, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  31. Identification of donor-derived antigen-specific suppressor cells in murine bone marrow chimeras prepared with total-lymphoid irradiation. Okada, S., Palathumpat, V., Strober, S. Transplantation (1983) [Pubmed]
  32. Basic fibroblast growth factor inhibits cell proliferation in cultured avian inner ear sensory epithelia. Oesterle, E.C., Bhave, S.A., Coltrera, M.D. J. Comp. Neurol. (2000) [Pubmed]
  33. Effect of a copper IUD on the incorporation of (3H)thymidine and (5-3H)uridine into the endometrium of the rabbit during early pregnancy. Grundsell, H. J. Reprod. Fertil. (1975) [Pubmed]
  34. Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal. Hodgkin, P.D., Go, N.F., Cupp, J.E., Howard, M. Cell. Immunol. (1991) [Pubmed]
  35. In vitro chemosensitivity test of human brain tumors using a three-dimensional organ culture with a collagen gel matrix. Yuki, K., Uozumi, T., Kodama, Y., Kurisu, K., Mikami, T. J. Neurooncol. (1994) [Pubmed]
 
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