The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

thymidine     1-[(2R,4S,5R)-4-hydroxy-5...

Synonyms: Thymidin, DThyd, dThd, deoxythymidine, Beta-Thymidine, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of deoxythymidine


High impact information on deoxythymidine


Chemical compound and disease context of deoxythymidine


Biological context of deoxythymidine


Anatomical context of deoxythymidine

  • We report a method to test for this proliferative stimulus in the form of a sensitive microassay based upon the tritiated-thymidine incorporation of continuous murine tumor-specific cytotoxic T cell lines (CTLL) [17].
  • Native LDL (20 to 200 micrograms/mL) caused a dose-dependent increase in (3H)thymidine incorporation and increased mesangial cell numbers over 96 h [12].
  • After MSH injections, the level of (3H)thymidine incorporation in keratinocytes increased significantly in black skin but not in white [18].
  • The autoimmune response had been assayed both by determination of the lymphocyte proliferation, using a (3H)thymidine incorporation test, as well as by determination of their specific cytostatic activity against monolayer-forming testis cells which was measured in a terminal 51Cr uptake assay [19].
  • The mitogenic activity of eluted fractions on quiescent subconfluent Swiss Albino 3T3 fibroblasts was tested employing a tritiated-thymidine-incorporation assay [20].

Associations of deoxythymidine with other chemical compounds


Gene context of deoxythymidine


Analytical, diagnostic and therapeutic context of deoxythymidine

  • The chimeric spleen cells lacked responsiveness to host-type, but not to third-party, antigens in the mixed-leukocyte reaction (MLR) as judged by (3H)thymidine incorporation and the generation of cytolytic cells [31].
  • Tritiated-thymidine autoradiographic techniques and 5-bromo-2;-deoxyuridine (BrdU) immunocytochemistry were used to identify cells synthesizing DNA [32].
  • Effect of a copper IUD on the incorporation of (3H)thymidine and (5-3H)uridine into the endometrium of the rabbit during early pregnancy [33].
  • To evaluate this hypothesis we examined the effect of IL-4 on the proportion of B cells stimulated to divide by different doses of anti-IgM using flow cytometry in combination with measurements of tritiated-thymidine incorporation [34].
  • Xenograft tumors exhibited in vivo-like three-dimensional growth on the collagen gel matrix and had increasing incorporation of tritiated (3H)thymidine for 2 weeks [35].


  1. Hodgkin's disease. An immunodepleting and immunosuppressive disorder. Twomey, J.J., Laughter, A.H., Farrow, S., Douglass, C.C. J. Clin. Invest. (1975) [Pubmed]
  2. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Kavanaugh, W.M., Williams, L.T., Ives, H.E., Coughlin, S.R. Mol. Endocrinol. (1988) [Pubmed]
  3. Vaccinia virus infection of HeLa cells. I. Synthesis of vaccinia DNA in host cell nuclei. LaColla, P., Weissbach, A. J. Virol. (1975) [Pubmed]
  4. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro. Cole, B.C., Golightly-Rowland, L., Ward, J.R. Infect. Immun. (1975) [Pubmed]
  5. Adhesion and growth rate of Clostridium cellulolyticum ATCC 35319 on crystalline cellulose. Gelhaye, E., Petitdemange, H., Gay, R. J. Bacteriol. (1993) [Pubmed]
  6. Meiotic DNA synthesis during mouse spermatogenesis. Meistrich, M.L., Reid, B.O., Barcellona, W.J. J. Cell Biol. (1975) [Pubmed]
  7. Effect of recombinant granulocyte-macrophage colony-stimulating factor on murine thrombocytopoiesis in vitro and in vivo. Ishibashi, T., Kimura, H., Shikama, Y., Uchida, T., Kariyone, S., Maruyama, Y. Blood (1990) [Pubmed]
  8. Effects of low molecular weight B-cell growth factor on proliferation of leukemic cells from children with B-cell precursor-acute lymphoblastic leukemia. Findley, H.W., Zhou, M.X., Davis, R., Abdul-Rahim, Y., Hnath, R., Ragab, A.H. Blood (1990) [Pubmed]
  9. G-protein gamma 7 is down-regulated in cancers and associated with p 27kip1-induced growth arrest. Shibata, K., Tanaka, S., Shiraishi, T., Kitano, S., Mori, M. Cancer Res. (1999) [Pubmed]
  10. Cell proliferation and subcellular localization of alkaline phosphatase activity in rat liver parenchyma during azo dye carcinogenesis. Karasaki, S. Cancer Res. (1975) [Pubmed]
  11. Adaptation of thymidine utilization to changing rates of DNA synthesis in the cell cycle. Miller, G.G., Schaer, J.C., Gautschi, J.R., Schindler, R. Mol. Cell. Biochem. (1979) [Pubmed]
  12. Oxidative modification of low-density lipoproteins by mesangial cells. Keane, W.F., O'Donnell, M.P., Kasiske, B.L., Kim, Y. J. Am. Soc. Nephrol. (1993) [Pubmed]
  13. Effect of tunicamycin, an inhibitor of protein glycosylation, on division of tumour cells in vitro. Savage, K.E., Baur, P.S. J. Cell. Sci. (1983) [Pubmed]
  14. The time course of male meiosis in the red-backed salamander, Plethodon cinereus. Morgan, G.T. J. Cell. Sci. (1979) [Pubmed]
  15. A study of ocular morphogenesis in the rat using (3H)thymidine autoradiography: evidence for thymidine recycling in the developing retina. Silver, J. Dev. Biol. (1976) [Pubmed]
  16. Transforming growth factor beta 1 induces mitogenesis in fetal rat brown adipocytes. Teruel, T., Valverde, A.M., Benito, M., Lorenzo, M. J. Cell. Physiol. (1996) [Pubmed]
  17. T cell growth factor: parameters of production and a quantitative microassay for activity. Gillis, S., Ferm, M.M., Ou, W., Smith, K.A. J. Immunol. (1978) [Pubmed]
  18. The effect of MSH on thymidine incorporation by keratinocytes in the epidermal melanin unit. Erickson, K.L., Hu, F., Giacometti, L. J. Invest. Dermatol. (1976) [Pubmed]
  19. In vitro induction of experimental autoimmune orchitis: characterization of a primary T lymhocyte response against testicular self antigens. Wekerle, H., Begemann, M. Eur. J. Immunol. (1978) [Pubmed]
  20. Heparin-binding growth factor isolated from human prostatic extracts. Mydlo, J.H., Bulbul, M.A., Richon, V.M., Heston, W.D., Fair, W.R. Prostate (1988) [Pubmed]
  21. In vitro assessment of immunocompetence in patients with malignant melanoma. Golub, S.H., Rangel, D.M., Morton, D.L. Int. J. Cancer (1977) [Pubmed]
  22. The proliferative state of early erythropoietic progenitor cells (BFU-E) in human umbilical cord blood: low probability of finding BFU-E in DNA synthesis. Shekhter-Levin, S., Amato, D., Axelrad, A.A. Exp. Hematol. (1984) [Pubmed]
  23. Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Sholley, M.M., Ferguson, G.P., Seibel, H.R., Montour, J.L., Wilson, J.D. Lab. Invest. (1984) [Pubmed]
  24. Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism. Garg, U.C., Hassid, A. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  25. Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. Rampazzo, C., Fabris, S., Franzolin, E., Crovatto, K., Frangini, M., Bianchi, V. J. Biol. Chem. (2007) [Pubmed]
  26. Optimisation of the CT h4S bioassay for detection of human interleukin-4 secreted by mononuclear cells stimulated by phytohaemaglutinin or by human leukocyte antigen mismatched mixed lymphocyte culture. Petersen, S.L., Russell, C.A., Bendtzen, K., Vindeløv, L.L. Immunol. Lett. (2002) [Pubmed]
  27. Interleukin-2 and phytohaemagglutinin stimulate the proliferation of tunicate cells. Raftos, D.A., Stillman, D.L., Cooper, E.L. Immunol. Cell Biol. (1991) [Pubmed]
  28. Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit-blasted c.p. titanium endosseous implants. Cooper, L.F., Zhou, Y., Takebe, J., Guo, J., Abron, A., Holmén, A., Ellingsen, J.E. Biomaterials (2006) [Pubmed]
  29. Proteinolytic activity against IGF-binding proteins involved in the paracrine interactions between prostate adenocarcinoma cells and osteoblasts. Koutsilieris, M., Polychronakos, C. Anticancer Res. (1992) [Pubmed]
  30. Effects of TGF-beta1 on proliferation and IGFBP-3 production in a primary culture of human fetal epiphyseal chondrocytes (HFEC). Garcia-Ramirez, M., Audi, L., Andaluz, P., Carrascosa, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  31. Identification of donor-derived antigen-specific suppressor cells in murine bone marrow chimeras prepared with total-lymphoid irradiation. Okada, S., Palathumpat, V., Strober, S. Transplantation (1983) [Pubmed]
  32. Basic fibroblast growth factor inhibits cell proliferation in cultured avian inner ear sensory epithelia. Oesterle, E.C., Bhave, S.A., Coltrera, M.D. J. Comp. Neurol. (2000) [Pubmed]
  33. Effect of a copper IUD on the incorporation of (3H)thymidine and (5-3H)uridine into the endometrium of the rabbit during early pregnancy. Grundsell, H. J. Reprod. Fertil. (1975) [Pubmed]
  34. Interleukin-4 enhances anti-IgM stimulation of B cells by improving cell viability and by increasing the sensitivity of B cells to the anti-IgM signal. Hodgkin, P.D., Go, N.F., Cupp, J.E., Howard, M. Cell. Immunol. (1991) [Pubmed]
  35. In vitro chemosensitivity test of human brain tumors using a three-dimensional organ culture with a collagen gel matrix. Yuki, K., Uozumi, T., Kodama, Y., Kurisu, K., Mikami, T. J. Neurooncol. (1994) [Pubmed]
WikiGenes - Universities