Disease relevance of Flubenisolone

• The adrenal to body weight ratio was significantly greater (P < 0.05) in EGF-treated fetuses (0.988 +/- 0.046 x 10(-3) g/g) and significantly reduced (P < 0.05) in beta-methasone-treated fetuses (0.401 +/- 0.056 x 10(-3) g/g) compared with that in control fetuses (0.689 +/- 0.050 x 10(-3) g/g) [1].
• Mongolian gerbils were observed for the effects of beta-methasone on ischemic brain edema which developed during ischemia or after blood flow restoration [2].
• The increase in adrenal weight with EGF administration was due to hypertrophy of definitive zone cells of the adrenal cortex, whereas the reduction in adrenal weight after beta-methasone treatment was due to a decrease in the size of definitive and fetal zone cells of the adrenal cortex [1].
• Glucocorticoid pretreatment (beta-methasone, 0.4 mg x kg-1 x day-1) for 7 days produced a decrease in the ratio of activated mu-calpain in all three fractions in nearly all samples before, during, and after hypoxia, compared with untreated animals [3].
• Compared with Endo, Beta + Endo lambs had increased lung inflammation but equivalent lung volumes 15 days after treatment [4].

Psychiatry related information on Flubenisolone

• The results do not appear to be due to stressful effects of DBHI's, causing release of corticosteroids; neither corticosterone nor beta-methasone had any significant effect on L-DOPA-induced locomotor activity in reserpinised animals, although they did increase spontaneous motor activity in normal animals [5].

High impact information on Flubenisolone

• We determined the effects of epidermal growth factor (EGF) and beta-methasone on the growth and development of the adrenal gland of the fetal rhesus monkey in vivo between 121-128 days of gestation [1].
• BM concentrations in the aqueous humor, vitreous, and retina-choroid (posterior half and anterior half) were determined by high-performance liquid chromatography (HPLC) at weeks 1, 2, and 4 after implantation [6].
• Antenatal betamethasone (Beta) is widely used in women with asymptomatic chorioamnionitis at risk for preterm delivery, but its effects on fetal inflammation are unstudied [4].
• However, compared with Endo 5 days after treatment, Beta + Endo lambs had increased alveolar neutrophils, proinflammatory cytokine mRNA expression, and serum amyloid A3 (SAA3) mRNA expression [4].
• Beta-methasone (0.25 mg/kg ip) pretreatment 24 h prior to the gastric juice exposure enhanced tracheal extravasation [7].

Chemical compound and disease context of Flubenisolone

• The effect of a liposomal preparation of beta-methasone dipropionate (0.039%, BDP) has been compared to that of a commercial propylene glycol-gel containing 0.064% BDP in a double-blind, randomized, paired trial lasting 14 d in 10 patients with atopic eczema and 10 patients with psoriasis vulgaris [8].
• IM + BM inhibited both leukocytopenia and thrombocytopenia [9].

Biological context of Flubenisolone

• The maturational effect of beta-methasone on duodenal motility was most pronounced in infants whose gestational age at birth was 26 to 29 weeks [10].
• Deflazacort is a synthetic glucocorticoid with fewer adverse effects on bone and carbohydrate metabolism than prednisone or beta-methasone [11].
• Beta-methasone did inhibit the elevation (AUC, 271) [12].

Anatomical context of Flubenisolone

• The incidence of significant neonatal respiratory complications was statistically higher for beta-methasone-treated (26.6%) compared with non-treated patients (11.1%) who delivered more than 48 hours after rupture of membranes [13].
• Beta-methasone increases sweat gland formation and suppresses fibre formation in fetal sheep [14].
• Distinct delayed T-cell response to beta-methasone and penicillin-G in the same patient [15].
• In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied [16].
• IL-6, IL-8, and ICAM-1 expression from conjunctival epithelium by Ad5 was significantly inhibited by treatment with betamethasone (BM) [17].

Associations of Flubenisolone with other chemical compounds

• The oral administration of 1alpha-hydroxycholecalciferol (2 microgram/day) in combination with beta-methasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value [18].
• Fetal blood samples were obtained prior to and 48 hr after the start of the hydrocortisone infusions and prior to and 24 hr after the second dose of beta-methasone given to the pregnant ewes [19].
• In contrast, administration of vitamin C, coenzyme Q, cytochrome c, beta-methasone, mannitol or germanium-132 did not result in prolongation of survival time [20].
• Oral epinastine as well as the reference compounds beta-methasone and the LTB4-receptor antagonist 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy) propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid (ADCA) demonstrated a dose-dependent inhibition of granulocyte accumulation [21].

Gene context of Flubenisolone

• Inhibition of growth and adrenal suppression are reported following the use of intranasal beta-methasone (0.1%) in a 9-year-old boy with cystic fibrosis and nasal polyps and in a 3-year-old girl with allergic rhinitis [22].

Analytical, diagnostic and therapeutic context of Flubenisolone

• Immunosuppression by BM after latency had developed also resulted in the reappearance of cytolytic infection in the spleen but only at a very low level [23].
• That topical administration of diterpene esters results in the rapid, local induction of MEG-CSA which can be blocked by beta-methasone pretreatment suggests a mechanism for the thrombocytosis associated with some inflammatory states [24].
• Gas Chromatography combined with Negative Chemical Ionisation Mass Spectrometry (GCMS) was used to determine the absorption of topically applied beta-methasone sodium phosphate into the aqueous humour of human subjects undergoing routine intraocular surgery [25].
• In addition, preterm labor with tocolysis and/or beta-methasone was more common in women with pneumonia, and these women were more likely to deliver preterm and have low birthweight infants compared to women without pneumonia [26].

References