Gene Review:
Cdkn2a - cyclin-dependent kinase inhibitor 2A
Rattus norvegicus
Synonyms:
Arf, INK4A, MTS1, p16, p16Cdkn2a, ...
- The p16/Cdkn2a/Ink4a gene is frequently deleted in nitrosourea-induced rat glial tumors. Schlegel, J., Piontek, G., Kersting, M., Schuermann, M., Kappler, R., Scherthan, H., Weghorst, C., Buzard, G., Mennel, H. Pathobiology (1999)
- Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Swafford, D.S., Middleton, S.K., Palmisano, W.A., Nikula, K.J., Tesfaigzi, J., Baylin, S.B., Herman, J.G., Belinsky, S.A. Mol. Cell. Biol. (1997)
- Mts1 protein expression in the central nervous system after injury. Kozlova, E.N., Lukanidin, E. Glia (2002)
- Cloning of the 5' upstream region of the rat p16 gene and its role in silencing. Abe, M., Okochi, E., Kuramoto, T., Kaneda, A., Takato, T., Sugimura, T., Ushijima, T. Jpn. J. Cancer Res. (2002)
- Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis. Huber, L.A., Ullrich, O., Takai, Y., Lütcke, A., Dupree, P., Olkkonen, V., Virta, H., de Hoop, M.J., Alexandrov, K., Peter, M. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Parr, M.J., Manome, Y., Tanaka, T., Wen, P., Kufe, D.W., Kaelin, W.G., Fine, H.A. Nat. Med. (1997)
- Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Serrano, M., Gómez-Lahoz, E., DePinho, R.A., Beach, D., Bar-Sagi, D. Science (1995)
- Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing. Sugimoto, M., Kuo, M.L., Roussel, M.F., Sherr, C.J. Mol. Cell (2003)
- Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Kato, A., Shimizu, K., Shimoichi, Y., Fujii, H., Honoki, K., Tsujiuchi, T. Mol. Carcinog. (2006)
- Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats. Sasaki, Y., Tsujiuchi, T., Murata, N., Kubozoe, T., Tsutsumi, M., Konishi, Y. Cancer Lett. (2000)
- Diminished basal phosphorylation level of phospholamban in the postinfarction remodeled rat ventricle: role of beta-adrenergic pathway, G(i) protein, phosphodiesterase, and phosphatases. Huang, B., Wang, S., Qin, D., Boutjdir, M., El-Sherif, N. Circ. Res. (1999)
- Analysis of mechanisms and frequency of CDKN2A/B gene loss during progression of RAS-transformed rat embryo fibroblast clones. Zhou, J.N., Hashemi, J., Helou, K., Zhang, A., Röhme, D., Zetterberg, A., Levan, G., Linder, S. Somat. Cell Mol. Genet. (1998)
- Ink4a/Arf expression is a biomarker of aging. Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., Sharpless, N.E. J. Clin. Invest. (2004)
- Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. Tao, L., Kramer, P.M., Wang, W., Yang, S., Lubet, R.A., Steele, V.E., Pereira, M.A. Carcinogenesis (2002)
- p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine. Bai, H., Gu, L., Zhou, J., Deng, D. Mutat. Res. (2003)
- Calcineurin inhibition ameliorates structural, contractile, and electrophysiologic consequences of postinfarction remodeling. Deng, L., Huang, B., Qin, D., Ganguly, K., El-Sherif, N. J. Cardiovasc. Electrophysiol. (2001)
- Phenotypic switching in GH3 rat pituitary tumor cells: linked expression of growth hormone and another hormonally responsive protein. Ivarie, R., Morris, J. DNA (1983)
- Overexpression of cell cycle inhibitors (p16INK4 and p21Cip1) and cyclin D1 using adenovirus vectors regulates proliferation of rat mesangial cells. Terada, Y., Yamada, T., Nakashima, O., Tamamori, M., Ito, H., Sasaki, S., Marumo, F. J. Am. Soc. Nephrol. (1997)
- Assignment of the cyclin-dependent kinase inhibitor genes Cdkn2a and Cdkn2b to rat chromosome bands 5q32-->q34 and 5q31-->q33, respectively by fluorescence in situ hybridization, using small PCR-generated probes. Laes, J.F., Van Vooren, P., Szpirer, J., Szpirer, C. Cytogenet. Cell Genet. (1998)
- Cyclin D1, p16, and retinoblastoma gene regulate mitogenic signaling of endothelin in rat mesangial cells. Terada, Y., Inoshita, S., Nakashima, O., Yamada, T., Tamamori, M., Ito, H., Sasaki, S., Marumo, F. Kidney Int. (1998)
- A possible role for p16INK4 in neuronal cell death after retinal ischemia-reperfusion injury. Kuroiwa, S., Katai, N., Yoshimura, N. Invest. Ophthalmol. Vis. Sci. (1999)
- Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. Joosten, S.A., van Ham, V., Nolan, C.E., Borrias, M.C., Jardine, A.G., Shiels, P.G., van Kooten, C., Paul, L.C. Am. J. Pathol. (2003)
- Effects of dorsal root transection on morphology and chemical composition of degenerating nerve fibers and reactive astrocytes in the dorsal funiculus. Wroblewski, R., Roomans, G.M., Kozlova, E.N. Exp. Neurol. (2000)