Gene Review:
Pak1 - p21 protein (Cdc42/Rac)-activated kinase 1
Mus musculus
Synonyms:
AW045634, Alpha-PAK, CDC42/RAC effector kinase PAK-A, PAK-1, Paka, ...
- P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. Wang, R.A., Mazumdar, A., Vadlamudi, R.K., Kumar, R. EMBO J. (2002)
- PAK1 hyperactivation is sufficient for mammary gland tumor formation. Wang, R.A., Zhang, H., Balasenthil, S., Medina, D., Kumar, R. Oncogene (2006)
- Outgrowth of neurites from NIE-115 neuroblastoma cells is prevented on repulsive substrates through the action of PAK. Marler, K.J., Kozma, R., Ahmed, S., Dong, J.M., Hall, C., Lim, L. Mol. Cell. Biol. (2005)
- Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, Shk1. Kim, H.W., Yang, P., Qyang, Y., Lai, H., Du, H., Henkel, J.S., Kumar, K., Bao, S., Liu, M., Marcus, S. Mol. Cell (2001)
- Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Howe, A.K., Juliano, R.L. Nat. Cell Biol. (2000)
- Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. Sussman, M.A., Welch, S., Walker, A., Klevitsky, R., Hewett, T.E., Price, R.L., Schaefer, E., Yager, K. J. Clin. Invest. (2000)
- Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands. Wang, R.A., Vadlamudi, R.K., Bagheri-Yarmand, R., Beuvink, I., Hynes, N.E., Kumar, R. J. Cell Biol. (2003)
- Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2. Makisumi, K., Takahashi, K., Takako, S., Sonoda, S. Gastroenterol. Jpn. (1990)
- Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors). Hirokawa, Y., Levitzki, A., Lessene, G., Baell, J., Xiao, Y., Zhu, H., Maruta, H. Cancer Lett. (2007)
- Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes. Burbelo, P.D., Kozak, C.A., Finegold, A.A., Hall, A., Pirone, D.M. Gene (1999)
- Opposing roles for akt1 and akt2 in rac/pak signaling and cell migration. Zhou, G.L., Tucker, D.F., Bae, S.S., Bhatheja, K., Birnbaum, M.J., Field, J. J. Biol. Chem. (2006)
- Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis. Banerjee, M., Worth, D., Prowse, D.M., Nikolic, M. Curr. Biol. (2002)
- Regulation of macropinocytosis by p21-activated kinase-1. Dharmawardhane, S., Schürmann, A., Sells, M.A., Chernoff, J., Schmid, S.L., Bokoch, G.M. Mol. Biol. Cell (2000)
- Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. Lessmann, E., Grochowy, G., Weingarten, L., Giesemann, T., Aktories, K., Leitges, M., Krystal, G., Huber, M. Exp. Hematol. (2006)
- Targeted disruption of the gene for the PAK5 kinase in mice. Li, X., Minden, A. Mol. Cell. Biol. (2003)
- Activation of Rac and Cdc42 by integrins mediates cell spreading. Price, L.S., Leng, J., Schwartz, M.A., Bokoch, G.M. Mol. Biol. Cell (1998)
- Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. Kissil, J.L., Johnson, K.C., Eckman, M.S., Jacks, T. J. Biol. Chem. (2002)
- An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies. He, H., Hirokawa, Y., Levitzki, A., Maruta, H. Cancer journal (Sudbury, Mass.) (2000)
- PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Nheu, T., He, H., Hirokawa, Y., Walker, F., Wood, J., Maruta, H. Cell Cycle (2004)
- A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. Soulet, C., Hechler, B., Gratacap, M.P., Plantavid, M., Offermanns, S., Gachet, C., Payrastre, B. J. Thromb. Haemost. (2005)
- Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Carstanjen, D., Yamauchi, A., Koornneef, A., Zang, H., Filippi, M.D., Harris, C., Towe, J., Atkinson, S., Zheng, Y., Dinauer, M.C., Williams, D.A. J. Immunol. (2005)
- Gene Targeting of Cdc42 and Cdc42GAP Affirms the Critical Involvement of Cdc42 in Filopodia Induction, Directed Migration, and Proliferation in Primary Mouse Embryonic Fibroblasts. Yang, L., Wang, L., Zheng, Y. Mol. Biol. Cell (2006)
- Characterization of Pseudomonas aeruginosa exoenzyme S as a bifunctional enzyme in J774A.1 macrophages. Rocha, C.L., Coburn, J., Rucks, E.A., Olson, J.C. Infect. Immun. (2003)
- Role of the serine-threonine kinase PAK-1 in myxoma virus replication. Johnston, J.B., Barrett, J.W., Chang, W., Chung, C.S., Zeng, W., Masters, J., Mann, M., Wang, F., Cao, J., McFadden, G. J. Virol. (2003)