Disease relevance of SKIP

• We tested the hypothesis that since the implementation of the prospective payment system (PPS), elderly patients hospitalized for hip fractures receive shorter, less care-intensive hospitalizations and are more frequently institutionalized [1].
• Patients with late effects of poliomyelitis, i.e., PPS, are being seen at an ever increasing frequency by general physicians, neurologists, and orthopedists [2].
• The different cytokine responses to PPS and LPS suggest that there are differences in the receptors and/or signalling pathways for Gram-negative and Gram-positive bacteria [3].
• PPS is a major cause of morbidity after cardiac surgery and may cause bypass graft closure and fatal cardiac tamponade [4].
• Postoperative edema and effusion (POEE) following cardiopulmonary bypass (CPB) surgery in children retards recovery and may aggravate postpericardiotomy (PPS), capillary leak syndrome (CLS), or multiorgan failure (MOF) [5].

Psychiatry related information on SKIP

• Medicare's PPS implementation and increase in recording of psychotic depressive disorder: some thoughts on the reasons [6].
• The Medicare Prospective Payment System (PPS) and the financial incentives it creates are likely to influence physician practices, as well as to offer new opportunities for research into clinical decision making [7].
• Functional ability was estimated by physical performance (PPS), physical activity during the preceding year, and impairment in activities of daily living (ADL) [8].
• None of the MMPI controls produced PPS values associated with spectrum membership [9].
• The aim of this study is to investigate the usefulness of a paper based instrument (the Patient Perspective Survey, or PPS) to enhance general practitioner-patient communication and patients' self reported coping skills [10].

High impact information on SKIP

• Short-term pre-CPB and post-CPB methylprednisolone treatment may complicate PPS [11].
• OBJECTIVE: The aim of this study was to determine the effect of prophylactic immune suppression on the incidence and severity ofpostpericardiotomy syndrome (PPS) in children after cardiac surgery with cardiopulmonary bypass (CPB) [11].
• Clearly, a better understanding of PPS and PPMA will allow more effective management of these patients' problems and might also provide insight into other motor neuron and neuromuscular junction diseases [2].
• 2. For internal polyamines relief from block was most pronounced for spermine, weaker for N-(4-hydroxyphenylpropanoyl)-spermine (PPS), and virtually absent for philanthotoxin 343 (PhTX 343), suggesting that permeation of polyamines varies with cross-sectional width (spermine, 0.44 nm; PPS, 0.70 nm; PhTX 343, 0.75 nm) [12].
• The effects of four heparin derivatives [unfractionated heparin (UFH) at 5-50 IU/ml, low molecular weight heparin (LMWH) at 2-20 IU/ml, pentasaccharide (Penta) at 5 IU/ml and a synthetic heparinoid (PPS) at 10(-6)-10(-5) M] on various polymorphonuclear (PMN) leukocyte end-functions (aggregation, chemotaxis, phagocytosis and burst) were examined [13].

Chemical compound and disease context of SKIP

• We describe the response of symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/PPS) in a man treated with rectal prednisolone for concomitant ulcerative colitis [14].
• OBJECTIVES: To evaluate further the intravesical potassium sensitivity test (PST) as an indicator of the epithelial leak of interstitial cystitis (IC) and determine whether successful pentosan polysulfate (PPS; Elmiron) treatment is associated with a change in PST results [15].

Biological context of SKIP

• In contrast to a current hypothesis the antithrombin III independent effect of PPS on blood coagulation is not caused by preventing the binding of the factors IX, IXa, X, Xa, VIII, V, Va and II onto procoagulant phospholipids [16].
• A PPS fraction of MW = 3200 Daltons represented the critical size required to affect cell proliferation induced by FGFs [17].
• We also demonstrate that the VkappaL6 family component of the antibody response recognizes the polysaccharide antigens of Group B streptococci (GBS), thereby accounting for the previously reported cross-reaction between PPS 23F-specific antisera and Group B streptococci [18].
• The kinetics of AA oxidation by AAPH was also characterized in PPS [19].
• Only the KCCT was affected by low concentrations of PPS unlike heparin by which both thrombin time and KCCT were affected [20].

Anatomical context of SKIP

• However, PPS had a strong inhibitory effect on the growth of bovine aortic endothelial cells (BAEC), as did heparin [17].
• Pentosan polysulphate (PPS, SP 54, HEMOCLAR), a highly sulphated semi-synthetic polysaccharide of MW 4700 Daltons is as efficient as heparin in potentiating the mitogenic activity of acidic FGF (aFGF) on human umbilical vein endothelial cells (HUVEC) [17].
• Minim and PPS pins provided significantly better retention in dentin than the other pins [21].
• CONCLUSIONS: Skip metastasis are frequent in non-small-cell lung cancer and complete dissection of hilar and mediastinal lymph nodes should remain the surgical standard procedure for this disease [22].
• The size of the NPC varies from 1 to 2 cm to large tumors that extend to the oropharynx, PPS, nasal cavities, paranasal sinuses, and orbits [23].

Associations of SKIP with chemical compounds

• This effect is additional to the heparin-like action of PPS, i.e. potentiation of the activity of antithrombin III and/or heparin cofactor II.(ABSTRACT TRUNCATED AT 250 WORDS)[16]
• Finally, reanalysis of the Voyager PPS 7500-angstroms phase angle data utilizing the fCH4,s value derived here confirms the Pryor et al. result of a tropospheric CH4 haze opacity of a few tenths in the 22-30 degrees S latitude region, several times that of the Equatorial Region or of the globe [24].
• This study has, for the fist time, directly compared the differences in nuclease resistance, cellular uptake, antisense potency and sequence specificity of PS and end-capped, pyrimidine-protected (PPS) undecamer ODNs, that are complementary to the initiation codon region of human Ha-ras mRNA [25].
• DMSO and PPS have been evaluated through early placebo-controlled trials, and these two agents are FDA approved treatments for IC [26].
• We evaluated the interaction between ascorbic acid (AA) and (+)-catechin (CTCH) in potassium phosphate solution, pH 7.4 (PPS) and in human plasma [19].

Analytical, diagnostic and therapeutic context of SKIP

• For both Medicare and comparison patients combined, MICU length of stay decreased 14% and patients after the PPS were less likely to be discharged to go home [27].
• After implementation of the PPS, the mean length of hospitalization fell from 16.6 to 10.3 days, and the mean number of physical therapy sessions received decreased from 9.7 to 4 [1].
• After the PPS, the number of intensive care unit beds decreased 31%, without changes in MICU patients' illness severity or treatment intensity [27].
• Complicated PPS--noncomplicated PPS plus hospital readmission +/- pericardiocentesis or thoracentesis [11].
• I examine the effects of the new PPS on the level of rehabilitation therapy provided in SNFs [28].

References