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Gene Review

INPP5K  -  inositol polyphosphate-5-phosphatase K

Homo sapiens

Synonyms: Inositol polyphosphate 5-phosphatase K, PPS, SKIP, Skeletal muscle and kidney-enriched inositol phosphatase
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Disease relevance of SKIP


Psychiatry related information on SKIP

  • Medicare's PPS implementation and increase in recording of psychotic depressive disorder: some thoughts on the reasons [6].
  • The Medicare Prospective Payment System (PPS) and the financial incentives it creates are likely to influence physician practices, as well as to offer new opportunities for research into clinical decision making [7].
  • Functional ability was estimated by physical performance (PPS), physical activity during the preceding year, and impairment in activities of daily living (ADL) [8].
  • None of the MMPI controls produced PPS values associated with spectrum membership [9].
  • The aim of this study is to investigate the usefulness of a paper based instrument (the Patient Perspective Survey, or PPS) to enhance general practitioner-patient communication and patients' self reported coping skills [10].

High impact information on SKIP

  • Short-term pre-CPB and post-CPB methylprednisolone treatment may complicate PPS [11].
  • OBJECTIVE: The aim of this study was to determine the effect of prophylactic immune suppression on the incidence and severity ofpostpericardiotomy syndrome (PPS) in children after cardiac surgery with cardiopulmonary bypass (CPB) [11].
  • Clearly, a better understanding of PPS and PPMA will allow more effective management of these patients' problems and might also provide insight into other motor neuron and neuromuscular junction diseases [2].
  • 2. For internal polyamines relief from block was most pronounced for spermine, weaker for N-(4-hydroxyphenylpropanoyl)-spermine (PPS), and virtually absent for philanthotoxin 343 (PhTX 343), suggesting that permeation of polyamines varies with cross-sectional width (spermine, 0.44 nm; PPS, 0.70 nm; PhTX 343, 0.75 nm) [12].
  • The effects of four heparin derivatives [unfractionated heparin (UFH) at 5-50 IU/ml, low molecular weight heparin (LMWH) at 2-20 IU/ml, pentasaccharide (Penta) at 5 IU/ml and a synthetic heparinoid (PPS) at 10(-6)-10(-5) M] on various polymorphonuclear (PMN) leukocyte end-functions (aggregation, chemotaxis, phagocytosis and burst) were examined [13].

Chemical compound and disease context of SKIP


Biological context of SKIP

  • In contrast to a current hypothesis the antithrombin III independent effect of PPS on blood coagulation is not caused by preventing the binding of the factors IX, IXa, X, Xa, VIII, V, Va and II onto procoagulant phospholipids [16].
  • A PPS fraction of MW = 3200 Daltons represented the critical size required to affect cell proliferation induced by FGFs [17].
  • We also demonstrate that the VkappaL6 family component of the antibody response recognizes the polysaccharide antigens of Group B streptococci (GBS), thereby accounting for the previously reported cross-reaction between PPS 23F-specific antisera and Group B streptococci [18].
  • The kinetics of AA oxidation by AAPH was also characterized in PPS [19].
  • Only the KCCT was affected by low concentrations of PPS unlike heparin by which both thrombin time and KCCT were affected [20].

Anatomical context of SKIP


Associations of SKIP with chemical compounds

  • This effect is additional to the heparin-like action of PPS, i.e. potentiation of the activity of antithrombin III and/or heparin cofactor II.(ABSTRACT TRUNCATED AT 250 WORDS)[16]
  • Finally, reanalysis of the Voyager PPS 7500-angstroms phase angle data utilizing the fCH4,s value derived here confirms the Pryor et al. result of a tropospheric CH4 haze opacity of a few tenths in the 22-30 degrees S latitude region, several times that of the Equatorial Region or of the globe [24].
  • This study has, for the fist time, directly compared the differences in nuclease resistance, cellular uptake, antisense potency and sequence specificity of PS and end-capped, pyrimidine-protected (PPS) undecamer ODNs, that are complementary to the initiation codon region of human Ha-ras mRNA [25].
  • DMSO and PPS have been evaluated through early placebo-controlled trials, and these two agents are FDA approved treatments for IC [26].
  • We evaluated the interaction between ascorbic acid (AA) and (+)-catechin (CTCH) in potassium phosphate solution, pH 7.4 (PPS) and in human plasma [19].

Analytical, diagnostic and therapeutic context of SKIP

  • For both Medicare and comparison patients combined, MICU length of stay decreased 14% and patients after the PPS were less likely to be discharged to go home [27].
  • After implementation of the PPS, the mean length of hospitalization fell from 16.6 to 10.3 days, and the mean number of physical therapy sessions received decreased from 9.7 to 4 [1].
  • After the PPS, the number of intensive care unit beds decreased 31%, without changes in MICU patients' illness severity or treatment intensity [27].
  • Complicated PPS--noncomplicated PPS plus hospital readmission +/- pericardiocentesis or thoracentesis [11].
  • I examine the effects of the new PPS on the level of rehabilitation therapy provided in SNFs [28].


  1. Changing patterns of hip fracture care before and after implementation of the prospective payment system. Fitzgerald, J.F., Fagan, L.F., Tierney, W.M., Dittus, R.S. JAMA (1987) [Pubmed]
  2. Neurological manifestations of the post-polio syndrome. Jubelt, B., Cashman, N.R. Critical reviews in neurobiology. (1987) [Pubmed]
  3. Inflammatory cytokine (interleukin 6 and tumour necrosis factor alpha) release in a human whole blood system in response to Streptococcus pneumoniae serotype 14 and its capsular polysaccharide. Jagger, M.P., Huo, Z., Riches, P.G. Clin. Exp. Immunol. (2002) [Pubmed]
  4. The epidemiology of the postpericardiotomy syndrome: a common complication of cardiac surgery. Miller, R.H., Horneffer, P.J., Gardner, T.J., Rykiel, M.F., Pearson, T.A. Am. Heart J. (1988) [Pubmed]
  5. Preoperative prediction of postoperative edema and effusion in pediatric cardiac surgery by altered antigen expression patterns on granulocytes and monocytes. Tárnok, A., Bocsi, J., Pipek, M., Osmancik, P., Valet, G., Schneider, P., Hambsch, J. Cytometry. (2001) [Pubmed]
  6. Medicare's PPS implementation and increase in recording of psychotic depressive disorder: some thoughts on the reasons. Wells, K.B. General hospital psychiatry. (1992) [Pubmed]
  7. The impact of DRG-based prospective payment on clinical decision making. Williams, S.V. Medical decision making : an international journal of the Society for Medical Decision Making. (1985) [Pubmed]
  8. Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women. Lebrun, C.E., van der Schouw, Y.T., de Jong, F.H., Pols, H.A., Grobbee, D.E., Lamberts, S.W. Maturitas. (2006) [Pubmed]
  9. A comparison of the MMPI and the Psychosis Proneness Scales in their classification of normals controls for use in schizophrenia spectrum research. Merritt, R.D., Balogh, D.W. Journal of personality assessment. (1994) [Pubmed]
  10. The patient perspective survey. Can consultations for complex health problems be enhanced? Laerum, E., Schattner, P., McCall, L., Steine, S., Murtagh, J. Australian family physician. (2001) [Pubmed]
  11. The effect of short-term prophylactic methylprednisolone on the incidence and severity of postpericardiotomy syndrome in children undergoing cardiac surgery with cardiopulmonary bypass. Mott, A.R., Fraser, C.D., Kusnoor, A.V., Giesecke, N.M., Reul, G.J., Drescher, K.L., Watrin, C.H., Smith, E.O., Feltes, T.F. J. Am. Coll. Cardiol. (2001) [Pubmed]
  12. Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines. Bähring, R., Bowie, D., Benveniste, M., Mayer, M.L. J. Physiol. (Lond.) (1997) [Pubmed]
  13. Influence of selected heparins on human neutrophil functions in vitro. Labrouche, S., Freyburger, G., Belloc, F., Boisseau, M.R. Thromb. Haemost. (1992) [Pubmed]
  14. Variability of the symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome during intermittent therapy with rectal prednisolone foam for ulcerative colitis. Talbot, M., Bates, S. International journal of STD & AIDS. (2001) [Pubmed]
  15. Effect of pentosan polysulfate therapy on intravesical potassium sensitivity. Parsons, C.L., Forrest, J., Nickel, J.C., Evans, R., Lloyd, L.K., Barkin, J., Mosbaugh, P.G., Kaufman, D.M., Hernandez-Graulau, J.M., Atkinson, L., Albrecht, D. Urology (2002) [Pubmed]
  16. Localization of the inhibitory site(s) of pentosan polysulphate in blood coagulation. Wagenvoord, R., Hendrix, H., Soria, C., Hemker, H.C. Thromb. Haemost. (1988) [Pubmed]
  17. Activity of pentosan polysulphate and derived compounds on vascular endothelial cell proliferation and migration induced by acidic and basic FGF in vitro. Herbert, J.M., Cottineau, M., Driot, F., Pereillo, J.M., Maffrand, J.P. Biochem. Pharmacol. (1988) [Pubmed]
  18. Correlation of antigenic epitope and antibody gene usage in the human immune response to Streptococcus pneumoniae type 23F capsular polysaccharide. Reason, D.C., Zhou, J. Clin. Immunol. (2004) [Pubmed]
  19. Ascorbate protects (+)-catechin from oxidation both in a pure chemical system and human plasma. Lotito, S.B., Fraga, C.G. Biol. Res. (2000) [Pubmed]
  20. Anticoagulant and antiheparin activities of a pentosan polysulphate. Scully, M.F., Weerasinghe, K.M., Ellis, V., Djazaeri, B., Kakkar, V.V. Thromb. Res. (1983) [Pubmed]
  21. Retention and resistance provided by nine self-threading pins. Burgess, J.O., Summitt, J.B. Operative dentistry. (1991) [Pubmed]
  22. Analysis of risk factors for skip lymphatic metastasis and their prognostic value in operated N2 non-small-cell lung carcinoma. Benoit, L., Anusca, A., Ortega-Deballon, P., Cheynel, N., Bernard, A., Favre, J.P. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2006) [Pubmed]
  23. Nasopharynx: clinical, pathologic, and radiologic assessment. Weber, A.L., al-Arayedh, S., Rashid, A. Neuroimaging Clin. N. Am. (2003) [Pubmed]
  24. Clouds, hazes, and the stratospheric methane abundance in Neptune. Baines, K.H., Hammel, H.B. Icarus. (1994) [Pubmed]
  25. Inhibition of Ras p21 synthesis by antisense undecamers with uniform and specifically arranged phosphorothioate linkages. Rait, A., Uhlmann, E., Peyman, A., Will, D.W., Chang, E.H. Anticancer Drugs (2000) [Pubmed]
  26. Current management of interstitial cystitis. Lukban, J.C., Whitmore, K.E., Sant, G.R. Urol. Clin. North Am. (2002) [Pubmed]
  27. The early effect of Medicare's prospective payment system on the use of medical intensive care services in three community hospitals. Mayer-Oakes, S.A., Oye, R.K., Leake, B., Brook, R.H. JAMA (1988) [Pubmed]
  28. Rehabilitation therapy in skilled nursing facilities: effects of Medicare's new prospective payment system. White, C. Health affairs (Project Hope) (2003) [Pubmed]
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