The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tmem45a  -  transmembrane protein 45a

Mus musculus

Synonyms: 19.5, C630002M10Rik, Dermal papilla-derived protein 7 homolog, Derp7, M32486, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tmem45a

  • A LV rescue schedule consisting of 300 mg/kg administered at 4.5 and 19.5 hr after high-dose MTX (300 mg/kg/week for 3 weeks) prevented MTX toxicity [1].
  • Treatment with rt-PA significantly reduced infarction volume (20.7 +/- 3.3, = 0.01) at 10 mg/kg and at 20 mg/kg (19.5 +/- 8.2%, P < 0.05) [2].
  • In concert with the hemodynamic data, glomerular filtration rate (GFR), as measured by inulin clearance, was higher in the HO inhibitor compared with the vehicle controls during endotoxemia (111.5 +/- 19.5 vs. 66.0 +/- 3.5 microl/min, P < 0.05) [3].
  • In contrast to some conclusions of the lack of a threshold for carcinogenesis that have been made in the past from this study, this reanalysis showed a clear and consistent threshold for bladder neoplasms at about 10 19.5 molecules/kg/day and for liver neoplasms at about 10 19.1 molecules/kg/day [4].
  • The numbers of activated microglia in the striatum increased in response to the adenovirus in both young [contralateral 19.5 (3.7), ipsilateral 36 (3.0)] and old [contralateral 23.1 (9.6), ipsilateral 40.8 (6.9)] mice (two-way anova; P < 0.0001), but there was no significant difference between the two age groups [5].

Psychiatry related information on Tmem45a

  • NBQX (10 mg/kg) enhanced the activity of anticonvulsant drugs decreasing their ED50S against maximal electroshock from 321 to 190 mg/kg for valproate, from 19.5 to 14.5 mg/kg for carbamazepine, from 31.0 to 21.4 mg/kg for phenobarbital, from 17.8 to 9.5 mg/kg for diphenylhydantoin and from 19.5 to 10.5 mg/kg for diazepam [6].

High impact information on Tmem45a

  • The purified chimera, consisting of four identical subunits, bound one biotin and approximately seven Cd2+ ions per subunit (19.5 kDa) [7].
  • To investigate whether genetic alterations within this gene result in abnormal weight in humans, we sequenced its coding exons and splice sites in a large cohort of extremely obese [n = 379; average body mass index (BMI), 49.0 kg/m2] and lean (n = 378; average BMI, 19.5 kg/m2) individuals [8].
  • As a consequence, we studied the expression of HOX B6 and EPO gene expression from 6.5 to 19.5 days of gestation, in the neonate, and in the adult [9].
  • In fact, on replating, the blast-cell colonies cultured from the Rho-dull population give rise to many more secondary colonies and had a greater replating efficiency than those obtained from Rho-bright cells (replating efficiency: 29.0 +/- 6.3 v 19.5 +/- 3.7, respectively, P < .01) [10].
  • When DBA/2 mice syngenic for the tumor were depleted of leukocytes by cyclophosphamide administration (before and during viral administration), there was again no significant difference observed in the survival times (19.0 +/- 1.9 versus 19.5 +/- 2.7, respectively) [11].

Chemical compound and disease context of Tmem45a


Biological context of Tmem45a

  • Its four exons span 0.65 kilobases and are interrupted by three introns with an aggregate length of 19.5 kilobases [13].
  • We identified a cDNA clone for epiprofin, which is preferentially expressed in teeth, by differential hybridization using DNA microarrays from an embryonic day 19.5 mouse molar cDNA library [14].
  • RESULTS: Gliclazide blocked whole-cell beta-cell KATP currents with an IC50 of 184 +/- 30 nmol/l (n = 6-10) but was much less effective in cardiac and smooth muscle (IC50s of 19.5 +/- 5.4 micromol/l (n = 6-12) and 37.9 +/- 1.0 micromol/l (n = 5-10), respectively) [15].
  • In control pups on day 17.5 of gestation (term is 19.5 d), a multilayered SC was present and neutral lipid deposition in a membrane pattern was observed using Nile red fluorescence histochemistry [16].
  • Bs is saturable and is to a single class of high-affinity (Ka = 3.6 x 10(9) M-1) low-capacity (Bmax = 19.5 fmol/mg protein) binding sites [17].

Anatomical context of Tmem45a

  • During differentiation induced by a 48-h treatment of postconfluent cells with methylisobutylxanthine, dexamethasone, and insulin, fatty acid synthetase activity increased to a level 19.5-fold higher than that of undifferentiated 3T3-L1 cells or nondifferentiating 3T3-C2 cells [18].
  • At 17.5 and 19.5 days p.c., expression of both receptors was observed in chondrocytes and in osteoblasts [19].
  • In whole cell studies, compounds of this class were growth inhibitory against Swiss 3T3 mouse fibroblasts with IC50 values from 0.5 to 19.5 microM, and the observed SAR was different from that of the 2,2'-dithiobis(1H-indoles) [20].
  • Nuclear-transfer oocytes with follicular epithelial cells developed into blastocysts (34%) after serial nuclear transfer, and 4 living fetuses on Day 10.5 (25%, 16 transferred) and 1 dead fetus on Day 19.5 of pregnancy (3%, 30 transferred) were obtained after transfer to recipients [21].
  • Chromatogrphic analysis of pronase digests of the thyroid glands showed that the iodothyronine content of the old and new pools were 19.5 and 7.4 per cent respectively [22].

Associations of Tmem45a with chemical compounds


Analytical, diagnostic and therapeutic context of Tmem45a

  • Although all allogeneic cardiac grafts in animals preinfused with tolerant CD4/CD8 negative 12 DN Treg clones survived over 100 days, allograft survival is unchanged following infusion of mutant clones (19.5 +/- 11.1 days) compared with untreated controls (22.8 +/- 10.5 days; p < 0.001) [28].
  • A 2/3 partial hepatectomy was performed (0 h), then the animals were treated with benzidine (0, 7.8, 19.5, 38.2 or 97.8 mg/kg, i.p.) and an agar-coated 50 mg 5-bromodeoxyuridine tablet was implanted subcutaneously (58 h) [29].
  • Tramadol also displayed antinociceptive activity in the rat air-induced abdominal constriction [ED50 = 1.7 (0.7-3.2) mg/kg p.o.] and hot-plate [51 degrees C, ED50 = 19.5 (10.3-27.5) mg/kg i.p.] tests [30].
  • Mice treated with GCV or HSV-TK alone died from 14.4 +/- 1.7 to 19.5 +/- 3.5 days after treatment as did untreated controls [31].
  • In the first experiment, cellular levels of GnRH mRNA in neurons located throughout the nose and forebrain were examined in embryonic day (E) 12.5, 14.5, 16.5 and 19.5 mice using in situ hybridization [32].


  1. Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue. Martin, D.S., Stolfi, R.L., Sawyer, R.C., Spiegelman, S., Young, C.W. Cancer Res. (1983) [Pubmed]
  2. Glycoprotein IIb/IIIa antagonist, murine 7E3 F(ab') 2, and tissue plasminogen activator in focal ischemia: evaluation of efficacy and risk of hemorrhage with combination therapy. Shuaib, A., Yang, Y., Nakada, M.T., Li, Q., Yang, T. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  3. Role of heme oxygenase-1 in endotoxemic acute renal failure. Poole, B., Wang, W., Chen, Y.C., Zolty, E., Falk, S., Mitra, A., Schrier, R. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  4. Thresholds of carcinogenicity in the ED01 study. Waddell, W.J. Toxicol. Sci. (2003) [Pubmed]
  5. The glial cell response to a viral vector in the aged brain. Davies, C.A., Gollins, H., Stevens, N., Fotheringham, A.P., Davies, I. Neuropathol. Appl. Neurobiol. (2004) [Pubmed]
  6. 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice. Zarnowski, T., Kleinrok, Z., Turski, W.A., Czuczwar, S.J. Neuropharmacology (1993) [Pubmed]
  7. A streptavidin-metallothionein chimera that allows specific labeling of biological materials with many different heavy metal ions. Sano, T., Glazer, A.N., Cantor, C.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. A PYY Q62P variant linked to human obesity. Ahituv, N., Kavaslar, N., Schackwitz, W., Ustaszewska, A., Collier, J.M., Hébert, S., Doelle, H., Dent, R., Pennacchio, L.A., McPherson, R. Hum. Mol. Genet. (2006) [Pubmed]
  9. Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations. Zimmermann, F., Rich, I.N. Blood (1997) [Pubmed]
  10. Isolation and biological characterization of two classes of blast-cell colony-forming cells from normal murine marrow. Migliaccio, G., Baiocchi, M., Adamson, J.W., Migliaccio, A.R. Blood (1996) [Pubmed]
  11. Role of the immune response during neuro-attenuated herpes simplex virus-mediated tumor destruction in a murine intracranial melanoma model. Miller, C.G., Fraser, N.W. Cancer Res. (2000) [Pubmed]
  12. Pharmacological and phytochemical evaluation of Adiantum ceneatum growing in Brazil. Bresciani, L.F., Priebe, J.P., Yunes, R.A., Dal Magro, J., Delle Monache, F., de Campos, F., de Souza, M.M., Cechinel-Filho, V. Z. Naturforsch., C, J. Biosci. (2003) [Pubmed]
  13. The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. Demmer, L.A., Birkenmeier, E.H., Sweetser, D.A., Levin, M.S., Zollman, S., Sparkes, R.S., Mohandas, T., Lusis, A.J., Gordon, J.I. J. Biol. Chem. (1987) [Pubmed]
  14. The Krüppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. Nakamura, T., Unda, F., de-Vega, S., Vilaxa, A., Fukumoto, S., Yamada, K.M., Yamada, Y. J. Biol. Chem. (2004) [Pubmed]
  15. Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Lawrence, C.L., Proks, P., Rodrigo, G.C., Jones, P., Hayabuchi, Y., Standen, N.B., Ashcroft, F.M. Diabetologia (2001) [Pubmed]
  16. Glucocorticoid deficiency delays stratum corneum maturation in the fetal mouse. Hanley, K., Feingold, K.R., Kömüves, L.G., Elias, P.M., Muglia, L.J., Majzoub, J.A., Williams, M.L. J. Invest. Dermatol. (1998) [Pubmed]
  17. Prolactin and testicular Leydig cell function: characterization of prolactin receptors in the murine MA-10 testicular Leydig cell line. Barkey, R.J., Weiss-Messer, E., Hacham, H., Herscovich, S., Ber, R., Amit, T. Proc. Soc. Exp. Biol. Med. (1994) [Pubmed]
  18. Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. Student, A.K., Hsu, R.Y., Lane, M.D. J. Biol. Chem. (1980) [Pubmed]
  19. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., Sakou, T. J. Bone Miner. Res. (1995) [Pubmed]
  20. Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. Showalter, H.D., Sercel, A.D., Leja, B.M., Wolfangel, C.D., Ambroso, L.A., Elliott, W.L., Fry, D.W., Kraker, A.J., Howard, C.T., Lu, G.H., Moore, C.W., Nelson, J.M., Roberts, B.J., Vincent, P.W., Denny, W.A., Thompson, A.M. J. Med. Chem. (1997) [Pubmed]
  21. Developmental potential of mouse follicular epithelial cells and cumulus cells after nuclear transfer. Kato, Y., Yabuuchi, A., Motosugi, N., Kato, J., Tsunoda, Y. Biol. Reprod. (1999) [Pubmed]
  22. Role of the heterogeneity of thyroglobulin in the secretion of thyroid hormone in mice. Bagchi, N., Brown, T.R., Shivers, B., Mack, R.E. J. Endocrinol. (1980) [Pubmed]
  23. Pharmacological, toxicological, and therapeutic evaluation in mice of doxorubicin entrapped in cardiolipin liposomes. Rahman, A., White, G., More, N., Schein, P.S. Cancer Res. (1985) [Pubmed]
  24. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. McBee, J.K., Van Hooser, J.P., Jang, G.F., Palczewski, K. J. Biol. Chem. (2001) [Pubmed]
  25. Interaction of angiotensin II and nitric oxide in isolated perfused afferent arterioles of mice. Patzak, A., Mrowka, R., Storch, E., Hocher, B., Persson, P.B. J. Am. Soc. Nephrol. (2001) [Pubmed]
  26. Enhanced aspartate release related to epilepsy in (EL) mice. Flavin, H.J., Seyfried, T.N. J. Neurochem. (1994) [Pubmed]
  27. Biochemical analysis and biological activities of immunoaffinity purified natural murine gamma interferon (MuIFN-gamma). Greenfield, R.S., Kiener, P.A., Chin, D.P., Curry, R.C., Spitalny, G.L. J. Leukoc. Biol. (1986) [Pubmed]
  28. Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. Lee, B.P., Mansfield, E., Hsieh, S.C., Hernandez-Boussard, T., Chen, W., Thomson, C.W., Ford, M.S., Bosinger, S.E., Der, S., Zhang, Z.X., Zhang, M., Kelvin, D.J., Sarwal, M.M., Zhang, L. J. Immunol. (2005) [Pubmed]
  29. The correlation between DNA adducts and chromosomal aberrations in the target organ of benzidine exposed, partially-hepatectomized mice. Talaska, G., Au, W.W., Ward, J.B., Randerath, K., Legator, M.S. Carcinogenesis (1987) [Pubmed]
  30. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Raffa, R.B., Friderichs, E., Reimann, W., Shank, R.P., Codd, E.E., Vaught, J.L. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  31. In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration. Tong, X.W., Block, A., Chen, S.H., Contant, C.F., Agoulnik, I., Blankenburg, K., Kaufman, R.H., Woo, S.L., Kieback, D.G. Gynecol. Oncol. (1996) [Pubmed]
  32. Regulation of gonadotropin-releasing hormone (GnRH) gene expression during GnRH neuron migration in the mouse. Simonian, S.X., Herbison, A.E. Neuroendocrinology (2001) [Pubmed]
WikiGenes - Universities