Gene Review:
BAG1 - BCL2-associated athanogene
Homo sapiens
Synonyms:
BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, HAP, RAP46
- Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Takayama, S., Krajewski, S., Krajewska, M., Kitada, S., Zapata, J.M., Kochel, K., Knee, D., Scudiero, D., Tudor, G., Miller, G.J., Miyashita, T., Yamada, M., Reed, J.C. Cancer Res. (1998)
- BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. Townsend, P.A., Cutress, R.I., Carroll, C.J., Lawrence, K.M., Scarabelli, T.M., Packham, G., Stephanou, A., Latchman, D.S. J. Biol. Chem. (2004)
- BAG-1 expression in normal and neoplastic endometrium. Moriyama, T., Littell, R.D., Debernardo, R., Oliva, E., Lynch, M.P., Rueda, B.R., Duska, L.R. Gynecol. Oncol. (2004)
- BAG-1 expression in hyperplastic and neoplastic prostate tissue: is there any relationship with BCL-related proteins and androgen receptor status? Bozdogan, O., Atasoy, P., Bozdogan, N., Erekul, S., Batislam, E., Yilmaz, E., Başar, M.M. Tumori. (2005)
- The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. Zhou, R., Gray, N.A., Yuan, P., Li, X., Chen, J., Chen, G., Damschroder-Williams, P., Du, J., Zhang, L., Manji, H.K. J. Neurosci. (2005)
- Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Sondermann, H., Scheufler, C., Schneider, C., Hohfeld, J., Hartl, F.U., Moarefi, I. Science (2001)
- Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Song, J., Takeda, M., Morimoto, R.I. Nat. Cell Biol. (2001)
- A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. Schneikert, J., Hübner, S., Martin, E., Cato, A.C. J. Cell Biol. (1999)
- p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. Matsuzawa, S., Takayama, S., Froesch, B.A., Zapata, J.M., Reed, J.C. EMBO J. (1998)
- BAG-1 accelerates cell motility of human gastric cancer cells. Naishiro, Y., Adachi, M., Okuda, H., Yawata, A., Mitaka, T., Takayama, S., Reed, J.C., Hinoda, Y., Imai, K. Oncogene (1999)
- Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Liman, J., Ganesan, S., Dohm, C.P., Krajewski, S., Reed, J.C., Bähr, M., Wouters, F.S., Kermer, P. Mol. Cell. Biol. (2005)
- BAG1L enhances trans-activation function of the vitamin D receptor. Guzey, M., Takayama, S., Reed, J.C. J. Biol. Chem. (2000)
- Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Takayama, S., Kochel, K., Irie, S., Inazawa, J., Abe, T., Sato, T., Druck, T., Huebner, K., Reed, J.C. Genomics (1996)
- BAG-1 modulates the chaperone activity of Hsp70/Hsc70. Takayama, S., Bimston, D.N., Matsuzawa, S., Freeman, B.C., Aime-Sempe, C., Xie, Z., Morimoto, R.I., Reed, J.C. EMBO J. (1997)
- Disruption of the Toxoplasma gondii bradyzoite-specific gene BAG1 decreases in vivo cyst formation. Zhang, Y.W., Kim, K., Ma, Y.F., Wittner, M., Tanowitz, H.B., Weiss, L.M. Mol. Microbiol. (1999)
- Accumulation of Hsp70/Hsc70 molecular chaperone regulator BAG-1 on COPI-coated structures in gastric epithelial cells. Takamura, A., Adachi, M., Wada, I., Mitaka, T., Takayama, S., Imai, K. Int. J. Oncol. (2003)
- HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. Bardelli, A., Longati, P., Albero, D., Goruppi, S., Schneider, C., Ponzetto, C., Comoglio, P.M. EMBO J. (1996)
- BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation. Lin, J., Hutchinson, L., Gaston, S.M., Raab, G., Freeman, M.R. J. Biol. Chem. (2001)
- The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1. Brive, L., Takayama, S., Briknarová, K., Homma, S., Ishida, S.K., Reed, J.C., Ely, K.R. Biochem. Biophys. Res. Commun. (2001)
- Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Pickering, B.M., Mitchell, S.A., Evans, J.R., Willis, A.E. Nucleic Acids Res. (2003)
- Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. Liu, R., Takayama, S., Zheng, Y., Froesch, B., Chen, G.Q., Zhang, X., Reed, J.C., Zhang, X.K. J. Biol. Chem. (1998)
- GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. Höhfeld, J., Jentsch, S. EMBO J. (1997)
- Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Nollen, E.A., Brunsting, J.F., Song, J., Kampinga, H.H., Morimoto, R.I. Mol. Cell. Biol. (2000)
- What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins. Doong, H., Vrailas, A., Kohn, E.C. Cancer Lett. (2002)
- Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. Yang, X., Pater, A., Tang, S.C. Oncogene (1999)