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Gene Review

RPL10  -  ribosomal protein L10

Homo sapiens

Synonyms: 60S ribosomal protein L10, AUTSX5, DXS648, DXS648E, FLJ23544, ...
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Disease relevance of RPL10


High impact information on RPL10


Chemical compound and disease context of RPL10

  • Amino acid sequence of the FV region of a human monoclonal IgM (NOV) with specificity for the capsular polysaccharide of the group B meningococcus and of Escherichia coli K1, which cross-reacts with polynucleotides and with denatured DNA [7].
  • The implications of the o-quinone/QM pathway for the in vivo effects of catechol estrogens are not known; however, given the direct link between excessive exposure to endogenous estrogens and the enhanced risk of breast cancer, the potential for formation of additional reactive intermediates needs to be explored [8].
  • The optimal use of mitoxantrone (NOV) in the high-dose range requires elucidation of its maximum tolerated dose with peripheral blood progenitor cell (PBPC) support and the time interval needed between drug administration and PBPC reinfusion in order to avoid graft toxicity [9].
  • Three cohorts of ten patients with breast cancer (BC) or non-Hodgkin's lymphoma (NHL) received escalating doses of NOV, 60, 75 and 90 mg m(-2) plus melphalan (L-PAM), 140-180 mg m(-2), with PBPC rescue 96 h after NOV. Haematological toxicity was evaluated daily (WHO criteria) [9].
  • These results substantiate the conclusion that the involvement of the o-quinone/ QM pathway in catechol toxicity depends on a combination between the rate of enzymatic formation of the o-quinone, the rate of isomerization to the more electrophilic QM, and the chemical reactivity of the quinoids [10].

Biological context of RPL10

  • We have identified two missense mutations in the ribosomal protein gene RPL10 located in Xq28 in two independent families with autism [11].
  • We have obtained evidence that the amino-acid substitutions L206M and H213Q at the C-terminal end of RPL10 confer hypomorphism with respect to the regulation of the translation process while keeping the basic translation functions intact [11].
  • The QM mRNA level is modulated between the tumorigenic and nontumorigenic cell lines and therefore may be involved in the maintenance of the nontumorigenic phenotype [12].
  • The QM transcript is expressed in a wide variety of embryonic and adult tissues and demonstrates a down regulation of expression in adult kidney and heart [12].
  • A subtractive cDNA/RNA hybridization performed between the tumorigenic parent (G401) and a nontumorigenic microcell hybrid of G401 (110.1/G401.1) containing the der(11) chromosome resulted in the identification of a single novel cDNA clone, designated QM [12].

Anatomical context of RPL10


Associations of RPL10 with chemical compounds

  • Ribosomal protein L10 has 213 amino acids (the NH2-terminal methionine is removed after translation of the mRNA); the molecular weight is 24,456 [13].
  • Only one QM was observed from the o-quinone of 4-hydroxyestrone, 4-OHE-QM2 (4-hydroxy-1(2),4(5),9(10)- oestratrien-3,17-dione) which is analogous to the C ring analog (2-OHE-QM2) from the o-quinone of 2-hydroxyestrone [8].
  • The o-quinone of 2-hydroxyestrone isomerized to two QMs; a QM stabilized by one alkyl substituent in the B ring, 2-OHE-QM1 (3-hydroxy-1-(10),3(4),5(6)-oestratrien-2,17-dione) and one having two alkyl substituents on the methylene group in the C ring, 2-OHE-QM2 (2-hydroxy-1(2),4(5),9(10)-oestratrien-3,17-dione) [8].
  • The effect on Adr resistance of buthionine sulfoximine (BSO, GSH synthesis inhibitor), was studied alone or in combination with verapamil (drug-efflux inhibitor), docosahexaenoic acid (membrane lipid domain affector), ethacrynic acid (GST inhibitor), aphidicolin (DNA-polymerase-alpha inhibitor) or novobiocin (NOV, topo-II inhibitor) [14].
  • In contrast, isomerization of the o-quinones to electrophilic quinone methides (4-methylene-2,5-cyclohexadien-1-one, QM) could cause cellular damage primarily through alkylation [10].

Other interactions of RPL10

  • We show here with an exon-specific polymerase chain reaction that the genomic homolog of the QM cDNA is located in the G6PD-color vision genes region in Xq28 [15].
  • This region and the 5' -half of the transcribed region of the QM gene are enriched for C and G nucleotides with no bias against CpG dinucleotides--indicative of a CpG island [16].
  • The QM gene encodes a 24 kDa basic protein that peripherally associates with the ribosomes [17].
  • In the amino-terminal region A0 contains an arginine-rich segment which shows a low but distinct similarity to that of bacterial ribosomal protein L10 through which L10 is thought to bind to 23S rRNA [18].

Analytical, diagnostic and therapeutic context of RPL10


  1. The QM protein associates with ribosomes in the rough endoplasmic reticulum. Loftus, T.M., Nguyen, Y.H., Stanbridge, E.J. Biochemistry (1997) [Pubmed]
  2. Ribosomal protein L10 interacts with the SH3 domain and regulates GDNF-induced neurite growth in SH-SY-5y cells. Park, S., Jeong, D.G. J. Cell. Biochem. (2006) [Pubmed]
  3. Reduction of QM protein expression correlates with tumor grade in prostatic adenocarcinoma. Altinok, G., Powell, I.J., Che, M., Hormont, K., Sarkar, F.H., Sakr, W.A., Grignon, D., Liao, D.J. Prostate Cancer Prostatic Dis. (2006) [Pubmed]
  4. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Elkon, K., Skelly, S., Parnassa, A., Moller, W., Danho, W., Weissbach, H., Brot, N. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  5. Four-step high-dose sequential chemotherapy with double hematopoietic progenitor-cell rescue for metastatic breast cancer. Patrone, F., Ballestrero, A., Ferrando, F., Brema, F., Moraglio, L., Valbonesi, M., Basta, P., Ghio, R., Gobbi, M., Sessarego, M. J. Clin. Oncol. (1995) [Pubmed]
  6. QM, a putative tumor suppressor, regulates proto-oncogene c-yes. Oh, H.S., Kwon, H., Sun, S.K., Yang, C.H. J. Biol. Chem. (2002) [Pubmed]
  7. Amino acid sequence of the FV region of a human monoclonal IgM (NOV) with specificity for the capsular polysaccharide of the group B meningococcus and of Escherichia coli K1, which cross-reacts with polynucleotides and with denatured DNA. Gawinowicz, M.A., Merlini, G., Birken, S., Osserman, E.F., Kabat, E.A. J. Immunol. (1991) [Pubmed]
  8. p-Quinone methides are the major decomposition products of catechol estrogen o-quinones. Bolton, J.L., Shen, L. Carcinogenesis (1996) [Pubmed]
  9. High-dose mitoxantrone with peripheral blood progenitor cell rescue: toxicity, pharmacokinetics and implications for dosage and schedule. Ballestrero, A., Ferrando, F., Garuti, A., Basta, P., Gonella, R., Esposito, M., Vannozzi, M.O., Sorice, G., Friedman, D., Puglisi, M., Brema, F., Mela, G.S., Sessarego, M., Patrone, F. Br. J. Cancer (1997) [Pubmed]
  10. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells. Bolton, J.L., Pisha, E., Shen, L., Krol, E.S., Iverson, S.L., Huang, Z., van Breemen, R.B., Pezzuto, J.M. Chem. Biol. Interact. (1997) [Pubmed]
  11. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. Klauck, S.M., Felder, B., Kolb-Kokocinski, A., Schuster, C., Chiocchetti, A., Schupp, I., Wellenreuther, R., Schm??tzer, G., Poustka, F., Breitenbach-Koller, L., Poustka, A. Mol. Psychiatry (2006) [Pubmed]
  12. The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. Dowdy, S.F., Lai, K.M., Weissman, B.E., Matsui, Y., Hogan, B.L., Stanbridge, E.J. Nucleic Acids Res. (1991) [Pubmed]
  13. The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor. Chan, Y.L., Diaz, J.J., Denoroy, L., Madjar, J.J., Wool, I.G. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  14. Combined in vitro modulation of adriamycin resistance. Meijer, C., Mulder, N.H., Timmer-Bosscha, H., Peters, W.H., de Vries, E.G. Int. J. Cancer (1991) [Pubmed]
  15. The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor. van den Ouweland, A.M., Verdijk, M., Mannens, M.M., van Oost, B.A. Hum. Genet. (1992) [Pubmed]
  16. Isolation and characterization of the QM promoter. Farmer, A.A., Johnsen, J.I., Loftus, T.M., Smith, K.P., Stanbridge, E.J. Nucleic Acids Res. (1996) [Pubmed]
  17. Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm. Nguyen, Y.H., Mills, A.A., Stanbridge, E.J. J. Cell. Biochem. (1998) [Pubmed]
  18. The gene and the primary structure of acidic ribosomal protein A0 from yeast Saccharomyces cerevisiae which shows partial homology to bacterial ribosomal protein L10. Mitsui, K., Nakagawa, T., Tsurugi, K. J. Biochem. (1989) [Pubmed]
  19. Molecular cloning and expression of a pearl oyster (Pinctada fucata) homologue of mammalian putative tumor suppressor QM. Zhang, Y., Huang, J., Meng, Q., Jiang, T., Xie, L., Wang, Z., Zhang, R. Mar. Biotechnol. (2004) [Pubmed]
  20. Characterisation of the QM gene of Trypanosoma brucei. Lillico, S.G., Mottram, J.C., Murphy, N.B., Welburn, S.C. FEMS Microbiol. Lett. (2002) [Pubmed]
  21. Serum bupivacaine concentrations during continuous extrapleural infusion. Dauphin, A., Gupta, R.N., Young, J.E., Morton, W.D. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1997) [Pubmed]
  22. Intraperitoneal regional chemotherapy with mitroxantrone. Link, K.H., Hepp, G., Staib, L., Butzer, U., Böhm, W., Beger, H.G. Cancer Treat. Res. (1996) [Pubmed]
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