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Gene Review

TES  -  testis derived transcript (3 LIM domains)

Homo sapiens

Synonyms: DKFZP586B2022, TESS, TESS-2, TESTIN, Testin, ...
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Disease relevance of TES


Psychiatry related information on TES

  • CONCLUSIONS: The results of this study call into question the use of the TES and the interpretation of a large body of literature purporting to study the relationship of teachers' self-efficacy beliefs to important educational outcomes [5].
  • The Toxic Exposure Surveillance System (TESS) of the American Association of Poison Control Systems offers an opportunity to evaluate the epidemiology of volatile substance abuse using a data set that captures data from a large geographic area covering a wide-ranging group of socioeconomic strata, ethnic groups, and demographics [6].

High impact information on TES


Chemical compound and disease context of TES

  • Oxidized Fe protein from Azotobacter vinelandii (Av2(0)) was reduced by dithionite (DT) in the absence and presence of nucleotides, over the temperature range 10-40 degrees C, over the pH range 7-8, and in various buffers--inorganic phosphate, TES, HEPES, and Tris [10].
  • We examined by TES-enzyme-linked immunosorbent test and immunoblot assay for toxocarosis and cysticercosis the baseline and final follow-up sera of 10 pigs, before and after (3 months) infection with Taenia solium [11].
  • With HCO3 solution, anoxic H1 efflux rate was approximately 50% of normoxia (0.333 vs. 0.645 mmol.l-1.min-1), but in TES solution, H1 efflux rate was unaffected by anoxia [12].

Biological context of TES


Anatomical context of TES


Associations of TES with chemical compounds

  • Bicine and TES buffer not only hydrogen ions but also metal ions [7].
  • Under these conditions, conductance increased from 7.0 pS at 22 degrees C to 10.9 pS at 37 degrees C. The conductance at 22 degrees C was approximately 1.0 pS higher when TES and HEPES were omitted from the solution, suggesting weak, voltage-independent block by pH buffers [16].
  • The final separation buffer consisted of 80 mM sodium cholate in 50 mM N-tris (hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES), pH 7 [17].
  • [reaction: see text] Addition of magnesium anion 4 (M = MgBr, R(1) = TES) to ketone 6 (R(2) = PMB) at -78 degrees C in THF proceeded under chelation control to provide alcohol 7, which possesses the full set of the chiral centers of fostriecin [18].
  • [reaction: see text] A triphenylmethyl (trityl) ether was reductively and instantaneously cleaved by triethylsilane in the presence of a catalytic amount of TES- (or TMS)-triflate [19].

Regulatory relationships of TES


Other interactions of TES

  • We found that CAV1, CAV2, MET and TES mRNA expression was lower in prostate tumors than in normal prostate tissues [14].
  • Accordingly, most of TES- and Poa p IX-specific T cell clones derived from cultures containing IFN-gamma or IFN-alpha displayed strong cytolytic activity [20].
  • After LPS1, TNF-alpha AUC was greater in TES than CON (P<0.05) [21].
  • Three patients also underwent transcranial bifocal electric cortical stimulation (TES) and MEPs were recorded from the APB muscle, and CMCT, MEP threshold and amplitude were measured [22].
  • DESIGN: Semen aliquots from normozoospermic donors either were subjected to conventional semen freezing (TES and Tris yolk buffer in 7.4% final glycerol) with post-thaw processing or were preprocessed and frozen in HEPES-buffered human tubal fluid with 1% human serum albumin, 4% sucrose, and 6% glycerol [23].

Analytical, diagnostic and therapeutic context of TES

  • The specificity of the recombinant Toxocara canis antigen developed for the immunodiagnosis of human toxocariasis was compared with that of the excretory-secretory antigen from T. canis second-stage larvae (TES) by enzyme-linked immunosorbent assay [24].
  • METHODS: From September 1995 to January 1998, 24 patients (11 men and 13 women; mean age, 28.2 years) underwent repeat transthoracic sympathectomy (TES) [25].
  • Patients' assessments of pain intensity and pain relief suggested better analgesia with buprenorphine TES than with placebo, although the differences did not reach statistical significance [26].
  • The repeat TES was performed with patients under general anesthesia using either a standard single-lumen endotracheal tube (12 patients) or a double-lumen endotracheal tube (12 patients) [25].
  • TES and Tris yolk buffer was most effective at protecting sperm from the negative effects of the cryopreservation process [27].


  1. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Tobias, E.S., Hurlstone, A.F., MacKenzie, E., McFarlane, R., Black, D.M. Oncogene (2001) [Pubmed]
  2. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Tatarelli, C., Linnenbach, A., Mimori, K., Croce, C.M. Genomics (2000) [Pubmed]
  3. Downregulation of RUNX3 and TES by hypermethylation in glioblastoma. Mueller, W., Nutt, C.L., Ehrich, M., Riemenschneider, M.J., von Deimling, A., van den Boom, D., Louis, D.N. Oncogene (2007) [Pubmed]
  4. The relationship between maximal ventilation, breathing pattern and mechanical limitation of ventilation. Jensen, J.I., Lyager, S., Pedersen, O.F. J. Physiol. (Lond.) (1980) [Pubmed]
  5. Confirmatory factor analysis of the Teacher Efficacy Scale for prospective teachers. Denzine, G.M., Cooney, J.B., McKenzie, R. The British journal of educational psychology. (2005) [Pubmed]
  6. Epidemiology of volatile substance abuse (VSA) cases reported to US poison centers. Spiller, H.A. The American journal of drug and alcohol abuse. (2004) [Pubmed]
  7. Free-metal ion depletion by "Good's" buffers. Nakon, R., Krishnamoorthy, C.R. Science (1983) [Pubmed]
  8. Human cell-mediated cytotoxicity estimated by lymphocyte titration. Hakala, T.R., Lange, P.H., Fraley, E.E. Cancer Res. (1976) [Pubmed]
  9. Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions. Grima, J., Zhu, L., Cheng, C.Y. J. Biol. Chem. (1997) [Pubmed]
  10. Reduction of nitrogenase Fe protein from Azotobacter vinelandii by dithionite: quantitative and qualitative effects of nucleotides, temperature, pH and reaction buffer. Wilson, P.E., Bunker, J., Lowery, T.J., Watt, G.D. Biophys. Chem. (2004) [Pubmed]
  11. Evaluation of immunodiagnostics for toxocarosis in experimental porcine cysticercosis. Garc??a, H.H., Cancrini, G., Bartalesi, F., Rodriguez, S., Jimenez, J.A., Roldan, W., Mantella, A., Nicoletti, A., Bartoloni, A. Trop. Med. Int. Health (2007) [Pubmed]
  12. Mechanisms of pHi recovery from NH4Cl-induced acidosis in anoxic isolated turtle heart: a 31P-NMR study. Shi, H., Hamm, P.H., Meyers, R.S., Lawler, R.G., Jackson, D.C. Am. J. Physiol. (1997) [Pubmed]
  13. TES is a novel focal adhesion protein with a role in cell spreading. Coutts, A.S., MacKenzie, E., Griffith, E., Black, D.M. J. Cell. Sci. (2003) [Pubmed]
  14. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. Chêne, L., Giroud, C., Desgrandchamps, F., Boccon-Gibod, L., Cussenot, O., Berthon, P., Latil, A. Int. J. Cancer (2004) [Pubmed]
  15. RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisation. Griffith, E., Coutts, A.S., Black, D.M. Cell Motil. Cytoskeleton (2005) [Pubmed]
  16. Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels. Tabcharani, J.A., Linsdell, P., Hanrahan, J.W. J. Gen. Physiol. (1997) [Pubmed]
  17. Separation of naphthalene-2,3-dicarboxaldehyde-derivatized-substance P and its metabolites by micellar electrokinetic chromatography. Freed, A.L., Lunte, S.M. Electrophoresis (2000) [Pubmed]
  18. Formal total synthesis of fostriecin. Wang, Y.G., Kobayashi, Y. Org. Lett. (2002) [Pubmed]
  19. Triethyl- (or trimethyl-)silyl triflate-catalyzed reductive cleavage of triphenylmethyl (trityl) ethers with triethylsilane. Imagawa, H., Tsuchihashi, T., Singh, R.K., Yamamoto, H., Sugihara, T., Nishizawa, M. Org. Lett. (2003) [Pubmed]
  20. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. Parronchi, P., De Carli, M., Manetti, R., Simonelli, C., Sampognaro, S., Piccinni, M.P., Macchia, D., Maggi, E., Del Prete, G., Romagnani, S. J. Immunol. (1992) [Pubmed]
  21. Exogenous testosterone modulates tumor necrosis factor-alpha and acute phase protein responses to repeated endotoxin challenge in steers. Kahl, S., Elsasser, T.H. Domest. Anim. Endocrinol. (2006) [Pubmed]
  22. Excitatory and inhibitory mechanisms in Wilson's disease: investigation with magnetic motor cortex stimulation. Perretti, A., Pellecchia, M.T., Lanzillo, B., Campanella, G., Santoro, L. J. Neurol. Sci. (2001) [Pubmed]
  23. An intrauterine insemination-ready cryopreservation method compared with sperm recovery after conventional freezing and post-thaw processing. Larson, J.M., McKinney, K.A., Mixon, B.A., Burry, K.A., Wolf, D.P. Fertil. Steril. (1997) [Pubmed]
  24. Development of a highly specific recombinant Toxocara canis second-stage larva excretory-secretory antigen for immunodiagnosis of human toxocariasis. Yamasaki, H., Araki, K., Lim, P.K., Zasmy, N., Mak, J.W., Taib, R., Aoki, T. J. Clin. Microbiol. (2000) [Pubmed]
  25. Repeat transthoracic endoscopic sympathectomy for palmar and axillary hyperhidrosis. Lin, T.S., Fang, H.Y., Wu, C.Y. Surgical endoscopy. (2000) [Pubmed]
  26. Transdermal buprenorphine in the treatment of chronic pain: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. Sorge, J., Sittl, R. Clinical therapeutics. (2004) [Pubmed]
  27. Cryopreservation of human spermatozoa: comparison of two cryopreservation methods and three cryoprotectants. Nallella, K.P., Sharma, R.K., Allamaneni, S.S., Aziz, N., Agarwal, A. Fertil. Steril. (2004) [Pubmed]
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