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Chemical Compound Review

AG-F-85595     1,3-dihydroxypropan-2-yl icosa-5,8,11,14...

Synonyms: KBioGR_000133, KBioSS_000133, CBiol_001835, AC1L1BOX, CTK8F4105, ...
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Disease relevance of C13856


Psychiatry related information on C13856


High impact information on C13856


Chemical compound and disease context of C13856


Biological context of C13856


Anatomical context of C13856


Associations of C13856 with other chemical compounds


Gene context of C13856


Analytical, diagnostic and therapeutic context of C13856


  1. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. Di Marzo, V., Hill, M.P., Bisogno, T., Crossman, A.R., Brotchie, J.M. FASEB J. (2000) [Pubmed]
  2. Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice. Oka, S., Wakui, J., Ikeda, S., Yanagimoto, S., Kishimoto, S., Gokoh, M., Nasui, M., Sugiura, T. J. Immunol. (2006) [Pubmed]
  3. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. Sancho, R., de la Vega, L., Macho, A., Appendino, G., Di Marzo, V., Muñoz, E. J. Immunol. (2005) [Pubmed]
  4. 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. Kishimoto, S., Gokoh, M., Oka, S., Muramatsu, M., Kajiwara, T., Waku, K., Sugiura, T. J. Biol. Chem. (2003) [Pubmed]
  5. CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition. Panikashvili, D., Mechoulam, R., Beni, S.M., Alexandrovich, A., Shohami, E. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  6. The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake. Valenti, M., Cottone, E., Martinez, R., De Pedro, N., Rubio, M., Viveros, M.P., Franzoni, M.F., Delgado, M.J., Di Marzo, V. J. Neurochem. (2005) [Pubmed]
  7. Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse. González, S., Valenti, M., de Miguel, R., Fezza, F., Fernández-Ruiz, J., Di Marzo, V., Ramos, J.A. Br. J. Pharmacol. (2004) [Pubmed]
  8. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Witting, A., Walter, L., Wacker, J., Möller, T., Stella, N. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Wang, L., Liu, J., Harvey-White, J., Zimmer, A., Kunos, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Maccarrone, M., Finazzi-Agró, A. Cell Death Differ. (2003) [Pubmed]
  11. Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils. Kurihara, R., Tohyama, Y., Matsusaka, S., Naruse, H., Kinoshita, E., Tsujioka, T., Katsumata, Y., Yamamura, H. J. Biol. Chem. (2006) [Pubmed]
  12. Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1). McVey, D.C., Schmid, P.C., Schmid, H.H., Vigna, S.R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  13. Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart. Bouchard, J.F., Lépicier, P., Lamontagne, D. Life Sci. (2003) [Pubmed]
  14. Elimination of 2-arachidonoylglycerol action by direct hemoperfusion through immobilized polymyxin B fibers: an experimental study in conscious Guinea pigs. Shiga, N., Nemoto, K., Shimada, Y., Nakanowatari, Y., Ninomiya, N., Yamamoto, Y. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (2006) [Pubmed]
  15. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds. Sugiura, T., Kodaka, T., Nakane, S., Miyashita, T., Kondo, S., Suhara, Y., Takayama, H., Waku, K., Seki, C., Baba, N., Ishima, Y. J. Biol. Chem. (1999) [Pubmed]
  16. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Dinh, T.P., Kathuria, S., Piomelli, D. Mol. Pharmacol. (2004) [Pubmed]
  17. Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. Sugiura, T., Yoshinaga, N., Kondo, S., Waku, K., Ishima, Y. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  18. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakane, S., Kodaka, T., Suhara, Y., Takayama, H., Waku, K. J. Biol. Chem. (2000) [Pubmed]
  19. Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status. Rayman, N., Lam, K.H., Laman, J.D., Simons, P.J., Löwenberg, B., Sonneveld, P., Delwel, R. J. Immunol. (2004) [Pubmed]
  20. Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level. Pagotto, U., Marsicano, G., Fezza, F., Theodoropoulou, M., Grübler, Y., Stalla, J., Arzberger, T., Milone, A., Losa, M., Di Marzo, V., Lutz, B., Stalla, G.K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  21. Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. Maccarrone, M., Attinà, M., Bari, M., Cartoni, A., Ledent, C., Finazzi-Agrò, A. J. Neurochem. (2001) [Pubmed]
  22. Endocannabinoids protect the rat isolated heart against ischaemia. Lépicier, P., Bouchard, J.F., Lagneux, C., Lamontagne, D. Br. J. Pharmacol. (2003) [Pubmed]
  23. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Darmani, N.A., McClanahan, B.A., Trinh, C., Petrosino, S., Valenti, M., Di Marzo, V. Neuropharmacology (2005) [Pubmed]
  24. Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: is 2-arachidonoylglycerol a possible vasomodulator? Sugiura, T., Kodaka, T., Nakane, S., Kishimoto, S., Kondo, S., Waku, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  25. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Sugiura, T., Kobayashi, Y., Oka, S., Waku, K. Prostaglandins Leukot. Essent. Fatty Acids (2002) [Pubmed]
  26. 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. Zhao, Q., He, Z., Chen, N., Cho, Y.Y., Zhu, F., Lu, C., Ma, W.Y., Bode, A.M., Dong, Z. J. Biol. Chem. (2005) [Pubmed]
  27. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, enhances the adhesion of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes. Gokoh, M., Kishimoto, S., Oka, S., Metani, Y., Sugiura, T. FEBS Lett. (2005) [Pubmed]
  28. Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. Maccarrone, M., Fride, E., Bisogno, T., Bari, M., Cascio, M.G., Battista, N., Finazzi Agrò, A., Suris, R., Mechoulam, R., Di Marzo, V. Mol. Hum. Reprod. (2005) [Pubmed]
  29. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. Maejima, T., Oka, S., Hashimotodani, Y., Ohno-Shosaku, T., Aiba, A., Wu, D., Waku, K., Sugiura, T., Kano, M. J. Neurosci. (2005) [Pubmed]
  30. An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. Savinainen, J.R., Saario, S.M., Niemi, R., Järvinen, T., Laitinen, J.T. Br. J. Pharmacol. (2003) [Pubmed]
  31. Involvement of cannabinoid CB(2) receptors in the IgE-mediated triphasic cutaneous reaction in mice. Ueda, Y., Miyagawa, N., Wakitani, K. Life Sci. (2007) [Pubmed]
  32. Endocannabinoid mechanisms of pain modulation. Hohmann, A., Suplita, R. The AAPS journal (2006) [Pubmed]
  33. Cannabimimetic effects of osteopathic manipulative treatment. McPartland, J.M., Giuffrida, A., King, J., Skinner, E., Scotter, J., Musty, R.E. The Journal of the American Osteopathic Association. (2005) [Pubmed]
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