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Gene Review

Cnr2  -  cannabinoid receptor 2 (macrophage)

Mus musculus

Synonyms: CB-2, CB2, CB2-R, Cannabinoid receptor 2, cannabinoid receptor 2 (spleen), ...
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Disease relevance of Cnr2


Psychiatry related information on Cnr2

  • This multifocal expression of CB2 immunoreactivity in brain suggests that CB2 receptors may play broader roles in the brain than previously anticipated and may be exploited as new targets in the treatment of depression and substance abuse [6].

High impact information on Cnr2


Chemical compound and disease context of Cnr2


Biological context of Cnr2


Anatomical context of Cnr2

  • Mice with a targeted deletion of either the cannabinoid receptor type 1 (Cnr1) or type 2 (Cnr2) gene show an alteration of bone mass, and pharmacological modification of both receptors can regulate osteoclast activity and BMD [18].
  • CB2 is expressed in osteoblasts, osteocytes, and osteoclasts [14].
  • A CB2-specific agonist that does not have any psychotropic effects enhances endocortical osteoblast number and activity and restrains trabecular osteoclastogenesis, apparently by inhibiting proliferation of osteoclast precursors and receptor activator of NF-kappaB ligand expression in bone marrow-derived osteoblasts/stromal cells [14].
  • In line with this, we found that Langerhans cells (MHC class II(+)) contain a substantial amount of CB2 receptor mRNA, whereas keratinocytes (MHC class II(-)) do not [3].
  • This compound was equipotent to anandamide in competing with [3H]CP55,940 binding to plasma membranes prepared from L cells expressing the human CB1 receptor and from ATt-20 cells expressing the human CB2 receptor [19].

Associations of Cnr2 with chemical compounds


Regulatory relationships of Cnr2


Other interactions of Cnr2


Analytical, diagnostic and therapeutic context of Cnr2


  1. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Teixeira-Clerc, F., Julien, B., Grenard, P., Tran Van Nhieu, J., Deveaux, V., Li, L., Serriere-Lanneau, V., Ledent, C., Mallat, A., Lotersztajn, S. Nat. Med. (2006) [Pubmed]
  2. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Julien, B., Grenard, P., Teixeira-Clerc, F., Van Nhieu, J.T., Li, L., Karsak, M., Zimmer, A., Mallat, A., Lotersztajn, S. Gastroenterology (2005) [Pubmed]
  3. Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in Oxazolone-Induced Contact Dermatitis in Mice. Oka, S., Wakui, J., Ikeda, S., Yanagimoto, S., Kishimoto, S., Gokoh, M., Nasui, M., Sugiura, T. J. Immunol. (2006) [Pubmed]
  4. The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. Shoemaker, J.L., Seely, K.A., Reed, R.L., Crow, J.P., Prather, P.L. J. Neurochem. (2007) [Pubmed]
  5. Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. Di Filippo, C., Rossi, F., Rossi, S., D'Amico, M. J. Leukoc. Biol. (2004) [Pubmed]
  6. Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain. Onaivi, E.S., Ishiguro, H., Gong, J.P., Patel, S., Perchuk, A., Meozzi, P.A., Myers, L., Mora, Z., Tagliaferro, P., Gardner, E., Brusco, A., Akinshola, B.E., Liu, Q.R., Hope, B., Iwasaki, S., Arinami, T., Teasenfitz, L., Uhl, G.R. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  7. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Idris, A.I., van 't Hof, R.J., Greig, I.R., Ridge, S.A., Baker, D., Ross, R.A., Ralston, S.H. Nat. Med. (2005) [Pubmed]
  8. Control of pain initiation by endogenous cannabinoids. Calignano, A., La Rana, G., Giuffrida, A., Piomelli, D. Nature (1998) [Pubmed]
  9. Cannabinoid receptors and their endogenous agonists. Felder, C.C., Glass, M. Annu. Rev. Pharmacol. Toxicol. (1998) [Pubmed]
  10. Antigenic and immunogenic properties of cyanogen bromide peptides from gonococcal outer membrane protein IB. Evidence for the existence of a surface-exposed conserved epitope. Teerlink, T., Versantvoort, H., Beuvery, E.C. J. Exp. Med. (1987) [Pubmed]
  11. Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. Bátkai, S., Pacher, P., Járai, Z., Wagner, J.A., Kunos, G. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  12. Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids. Sade, H., Muraki, K., Ohya, S., Hatano, N., Imaizumi, Y. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  13. Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice. Berdyshev, E., Boichot, E., Corbel, M., Germain, N., Lagente, V. Life Sci. (1998) [Pubmed]
  14. Peripheral cannabinoid receptor, CB2, regulates bone mass. Ofek, O., Karsak, M., Leclerc, N., Fogel, M., Frenkel, B., Wright, K., Tam, J., Attar-Namdar, M., Kram, V., Shohami, E., Mechoulam, R., Zimmer, A., Bab, I. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  15. Downregulation of cannabinoid receptor 2 (CB2) messenger RNA expression during in vitro stimulation of murine splenocytes with lipopolysaccharide. Lee, S.F., Newton, C., Widen, R., Friedman, H., Klein, T.W. Adv. Exp. Med. Biol. (2001) [Pubmed]
  16. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Paria, B.C., Das, S.K., Dey, S.K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  17. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. McKallip, R.J., Lombard, C., Fisher, M., Martin, B.R., Ryu, S., Grant, S., Nagarkatti, P.S., Nagarkatti, M. Blood (2002) [Pubmed]
  18. Cannabinoid receptor type 2 gene is associated with human osteoporosis. Karsak, M., Cohen-Solal, M., Freudenberg, J., Ostertag, A., Morieux, C., Kornak, U., Essig, J., Erxlebe, E., Bab, I., Kubisch, C., de Vernejoul, M.C., Zimmer, A. Hum. Mol. Genet. (2005) [Pubmed]
  19. Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors. Priller, J., Briley, E.M., Mansouri, J., Devane, W.A., Mackie, K., Felder, C.C. Mol. Pharmacol. (1995) [Pubmed]
  20. Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors. Ross, R.A., Gibson, T.M., Stevenson, L.A., Saha, B., Crocker, P., Razdan, R.K., Pertwee, R.G. Br. J. Pharmacol. (1999) [Pubmed]
  21. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Ni, X., Geller, E.B., Eppihimer, M.J., Eisenstein, T.K., Adler, M.W., Tuma, R.F. Mult. Scler. (2004) [Pubmed]
  22. Involvement of cannabinoid CB1 and CB2 receptor activity in the development of behavioural sensitization to methamphetamine effects in mice. Landa, L., Sulcova, A., Slais, K. Neuro Endocrinol. Lett. (2006) [Pubmed]
  23. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Carlisle, S.J., Marciano-Cabral, F., Staab, A., Ludwick, C., Cabral, G.A. Int. Immunopharmacol. (2002) [Pubmed]
  24. 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. Zhao, Q., He, Z., Chen, N., Cho, Y.Y., Zhu, F., Lu, C., Ma, W.Y., Bode, A.M., Dong, Z. J. Biol. Chem. (2005) [Pubmed]
  25. Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation. McCoy, K.L., Matveyeva, M., Carlisle, S.J., Cabral, G.A. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  26. Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., Winter, J. Neuroscience (2005) [Pubmed]
  27. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. Molina-Holgado, F., Pinteaux, E., Moore, J.D., Molina-Holgado, E., Guaza, C., Gibson, R.M., Rothwell, N.J. J. Neurosci. (2003) [Pubmed]
  28. Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Herring, A.C., Koh, W.S., Kaminski, N.E. Biochem. Pharmacol. (1998) [Pubmed]
  29. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. Juan-Picó, P., Fuentes, E., Javier Bermúdez-Silva, F., Javier Díaz-Molina, F., Ripoll, C., Rodríguez de Fonseca, F., Nadal, A. Cell Calcium (2006) [Pubmed]
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