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Chemical Compound Review

Deblaston     10-ethyl-7-oxo-3-piperazin-1- yl-2,4,10...

Synonyms: Uromidin, Pipedac, Pipemid, Pipemidic, Dolcol, ...
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Disease relevance of Deblaston


High impact information on Deblaston


Chemical compound and disease context of Deblaston


Biological context of Deblaston


Anatomical context of Deblaston


Associations of Deblaston with other chemical compounds


Gene context of Deblaston

  • The interaction of cinoxacin (CINX), nalidixic acid (NA), and pipemidic acid (PPA) with human and rat serum albumins (HSA and RSA) was studied by UV difference absorption and circular dichroism (CD) spectroscopy [28].
  • Separation of Cip and pipemidic acid (internal standard) was achieved on Nucleosil C18 (4.6 mm x 250 mm) using fluorescence detection with lambda exc 274 nm and lambda emi 418 nm [29].

Analytical, diagnostic and therapeutic context of Deblaston


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  4. In vitro activities of ciprofloxacin, norfloxacin, pipemidic acid, cinoxacin, and nalidixic acid against Chlamydia trachomatis. Heessen, F.W., Muytjens, H.L. Antimicrob. Agents Chemother. (1984) [Pubmed]
  5. New nalidixic acid resistance mutations related to deoxyribonucleic acid gyrase activity. Yamagishi, J., Furutani, Y., Inoue, S., Ohue, T., Nakamura, S., Shimizu, M. J. Bacteriol. (1981) [Pubmed]
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  7. In vitro activity and concentrations in serum, urine, prostatic secretion and adenoma tissue of ofloxacin in urological patients. Naber, K.G., Adam, D., Kees, F. Drugs (1987) [Pubmed]
  8. Single- and multiple-dose pharmacokinetics of pipemidic acid in normal human volunteers. Klinge, E., Männistö, P.T., Mäntylä, R., Mattila, J., Hänninen, U. Antimicrob. Agents Chemother. (1984) [Pubmed]
  9. Selective decontamination of the digestive tract by pipemidic acid. Muytjens, H.L., van Veldhuizen, G.L., Welling, G.W., van der Ros-van de Repe, J., Boerema, H.B., van der Waaij, D. Antimicrob. Agents Chemother. (1983) [Pubmed]
  10. In vivo activity of ciprofloxacin, ofloxacin, norfloxacin and pipemidic acid against Escherichia coli infections in mice. Obana, Y., Nishino, T. Drugs under experimental and clinical research. (1989) [Pubmed]
  11. Quinolones in vitro. Willems, F.T. Pharmaceutisch weekblad. Scientific edition. (1986) [Pubmed]
  12. Microbiological basis for the use of fosfomycin trometamol as single-dose therapy for simple cystitis. Gismondo, M.R., Romeo, M.A., Lo Bue, A.M., Chisari, G., Nicoletti, G. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1986) [Pubmed]
  13. Quantitative in vitro assessment of drug phototoxicity by a chemiluminescence method. Yan, C., Liao, K., Hu, Y., Xu, Y. Chin. Med. J. (1999) [Pubmed]
  14. Combination of pipemidic acid, colistin sodium methanesulfonate and nystatin may be less effective than nystatin alone for prevention of infection during chemotherapy-induced granulocytopenia in acute leukemia. Sampi, K., Sakurai, M., Kumai, R., Maseki, N., Kaneko, Y., Hattori, M. Medical oncology and tumor pharmacotherapy. (1989) [Pubmed]
  15. Inhibition of conjugal transfer of R plasmids by pipemidic acid and related compounds. Nakamura, S., Inoue, S., Shimizu, M., Iyobe, S., Mitsuhashi, S. Antimicrob. Agents Chemother. (1976) [Pubmed]
  16. Pharmacokinetics of pipemidic acid in chickens after single intravenous and oral dosings. Anadón, A., Martínez-Larrañaga, M.R., Díaz, M.J., Vélez, C., Bringas, P. Am. J. Vet. Res. (1990) [Pubmed]
  17. Protein binding of quinolonecarboxylic acids. I. Cinoxacin, nalidixic acid and pipemidic acid. Izumi, T., Kitagawa, T. Chem. Pharm. Bull. (1989) [Pubmed]
  18. Determination of pipemidic acid based on flow-injection chemiluminescence due to energy transfer from peroxynitrous acid synthesized on-line. Liang, Y.D., Song, J.F., Tian, T. Analytical and bioanalytical chemistry. (2004) [Pubmed]
  19. Genotoxic evaluation of norfloxacin and pipemidic acid with the Escherichia coli Pol A-/Pol A+ and the ames test. Arriaga-Alba, M., Barrón-Moreno, F., Flores-Paz, R., García-Jiménez, E., Rivera-Sánchez, R. Arch. Med. Res. (1998) [Pubmed]
  20. Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes. Fuhr, U., Wolff, T., Harder, S., Schymanski, P., Staib, A.H. Drug Metab. Dispos. (1990) [Pubmed]
  21. The study of drug release from microspheres adhered on pig vesical mucosa. Burjak, M., Bogataj, M., Velnar, M., Grabnar, I., Mrhar, A. International journal of pharmaceutics. (2001) [Pubmed]
  22. Influence of physicochemical and biological parameters on drug release from microspheres adhered on vesical and intestinal mucosa. Bogataj, M., Mrhar, A., Korosec, L. International journal of pharmaceutics. (1999) [Pubmed]
  23. Resistance of Pseudomonas aeruginosa PAO to nalidixic acid and low levels of beta-lactam antibiotics: mapping of chromosomal genes. Rella, M., Haas, D. Antimicrob. Agents Chemother. (1982) [Pubmed]
  24. Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test. Itoh, T., Mitsumori, K., Kawaguchi, S., Sasaki, Y.F. Mutat. Res. (2006) [Pubmed]
  25. Determination of rufloxacin, a new tricyclic fluoroquinolone in biological fluids using high-performance liquid chromatography with ultraviolet detection. Carlucci, G., Mazzeo, P., Fanini, D., Palumbo, G. Therapeutic drug monitoring. (1991) [Pubmed]
  26. Complexation of antibacterial quinolonic acid and cinolonic derivatives with Zn(II) and Al(III): application to their determination in human urine. Durán Merás, I., Muñoz de la Peña, A., Salinas López, F., Rodríguez Cáceres, M.I. The Analyst. (2000) [Pubmed]
  27. Reversed-phase ion-pair high-performance liquid chromatographic determination of fluoroquinolones in human plasma. Nangia, A., Lam, F., Hung, C.T. Journal of pharmaceutical sciences. (1990) [Pubmed]
  28. Protein binding of quinolonecarboxylic acids. II. Spectral changes on the interaction of cinoxacin, nalidixic acid and pipemidic acid with human and rat albumins. Izumi, T., Nagayama, T., Kitagawa, T. Chem. Pharm. Bull. (1989) [Pubmed]
  29. An improved HPLC assay for ciprofloxacin in biological samples. Pei, Y.Y., Meng, X., Nightingale, C.H. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1994) [Pubmed]
  30. Determination of pipemidic acid in plasma by normal-phase high-pressure liquid chromatography. Ito, H., Inoue, M., Morikawa, M., Tsuboi, M., Oka, K. Antimicrob. Agents Chemother. (1985) [Pubmed]
  31. Influence of ofloxacin, norfloxacin, nalidixic acid, pyromidic acid and pipemidic acid on human gamma-interferon production and blastogenesis. De Simone, C., Baldinelli, L., Ferrazzi, M., De Santis, S., Pugnaloni, L., Sorice, F. J. Antimicrob. Chemother. (1986) [Pubmed]
  32. A general practitioner multicenter study: fosfomycin trometamol single dose versus pipemidic acid multiple dose. Jardin, A. Infection (1990) [Pubmed]
  33. Comparative in vitro activity of norfloxacin and four other chemotherapeutics against urinary gram-negative isolates. Esposito, S., Galante, D., Pennucci, C., Barba, D., Limauro, D., Scioli, C. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1984) [Pubmed]
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