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Chemical Compound Review

dm-PGE2     (Z)-7-[(1R,2S,3R)-3-hydroxy- 2-[(E,3R)-3...

Synonyms: DiPGE2, SureCN674246, CHEMBL1221529, BSPBio_001365, D0160_SIGMA, ...
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Disease relevance of 16,16-Dimethyl-pge2


High impact information on 16,16-Dimethyl-pge2


Chemical compound and disease context of 16,16-Dimethyl-pge2


Biological context of 16,16-Dimethyl-pge2


Anatomical context of 16,16-Dimethyl-pge2


Associations of 16,16-Dimethyl-pge2 with other chemical compounds


Gene context of 16,16-Dimethyl-pge2


Analytical, diagnostic and therapeutic context of 16,16-Dimethyl-pge2


  1. Prevention of sepsis-induced gastric lesions in dogs by cimetidine via inhibition of gastric secretion and by prostaglandin via cytoprotection. Odonkor, P., Mowat, C., Himal, H.S. Gastroenterology (1981) [Pubmed]
  2. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Robert, A., Schultz, J.R., Nezamis, J.E., Lancaster, C. Gastroenterology (1976) [Pubmed]
  3. Effect of oral and intravenous 16,16-dimethyl prostaglandin E2 in duodenal ulcer and Zollinger-Ellison syndrome patients. Ippoliti, A.F., Isenberg, J.I., Hagie, L. Gastroenterology (1981) [Pubmed]
  4. 16,16-dimethyl-PGE2 protection against alpha-naphthylisothiocyanate-induced experimental cholangitis in the rat. Ruwart, M.J., Rush, B.D., Friedle, N.M., Stachura, J., Tarnawski, A. Hepatology (1984) [Pubmed]
  5. Immunoregulatory activities of eicosanoids in the rainbow trout (Oncorhynchus mykiss). Knight, J., Rowley, A.F. Immunology (1995) [Pubmed]
  6. Stimulation of alkaline secretion in amphibian-isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2 alpha. A proposed explanation for some of the cytoprotective actions of prostaglandins. Garner, A., Heylings, J.R. Gastroenterology (1979) [Pubmed]
  7. Effect of E-series prostaglandins on cyclic AMP-dependent and -independent hormone-stimulated glycogenolysis in hepatocytes. Brass, E.P., Garrity, M.J. Diabetes (1985) [Pubmed]
  8. Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1. Caton, M.P., Coffee, E.C., Hambling, D.J., Hardy, C.J., Palfreyman, M.N. Prostaglandins (1984) [Pubmed]
  9. The effects of E series prostaglandins on blastogenic responses in vitro and graft vs. host responses in vivo. Duffie, G.P., Romanelli, R.R., Ellis, N.K., Young, M.R., Wepsic, H.T. Immunopharmacology and immunotoxicology. (1988) [Pubmed]
  10. Alloxan-induced hyperglycemia in rats is reduced by 16,16-dimethyl-PGE2. Ruwart, M.J., Sammons, D.W., Kolaja, G.J., Rush, B.D., Friedle, N.M., Adams, L.D. Res. Commun. Chem. Pathol. Pharmacol. (1983) [Pubmed]
  11. Modulation of the kinetics of the initial leukocyte migration into renal allografts by 16,16-dimethyl PGE2. Schreiner, G.F., Kamei, T., Lefkowith, J., Flye, M.W. Transplantation (1993) [Pubmed]
  12. Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. Tanigawa, T., Watanabe, T., Hamaguchi, M., Sasaki, E., Tominaga, K., Fujiwara, Y., Oshitani, N., Matsumoto, T., Higuchi, K., Arakawa, T. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  13. Effect of 16,16-dimethylPGE2 on gastric emptying and intestinal transit of a barium-food test meal in man. Nylander, B., Mattsson, O. Scand. J. Gastroenterol. (1975) [Pubmed]
  14. Cervical dilatation with 16,16 dimethyl PGE2 p-benzaldehyde semicarbazone ester prior to vacuum aspiration in first trimester nulliparae. Karim, S.M., Ratnam, S.S., Selvadural, V., Wun, W., Prasad, R.N. Prostaglandins (1977) [Pubmed]
  15. The action of prostanoid receptor agonists and antagonists on smooth muscle and platelets. Eglen, R.M., Whiting, R.L. Br. J. Pharmacol. (1988) [Pubmed]
  16. Prostaglandins E2 and F2 alpha are not involved in the monocytic-product (interleukin-1)-induced stimulation of hepatic fibrinogen synthesis in rats. Holtslag, J.C., Moshage, H.J., van Pelt, J.F., Kleuskens, J.A., Gribnau, F.W., Yap, S.H. Clin. Sci. (1988) [Pubmed]
  17. Cyclic nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid hormone and 16,16-dimethyl prostaglandin E2 in chicks. Shaw, A.J., Dacke, C.G. Calcif. Tissue Int. (1989) [Pubmed]
  18. Cytoprotection by 16,16-dimethylprostaglandin E2. Role of gastric juice and mucus gel layer. Taniguchi, Y., Yoshida, Y., Kimura, K., Mato, M. J. Clin. Gastroenterol. (1992) [Pubmed]
  19. Intragraft delivery of 16, 16-dimethyl PGE2 induces donor-specific tolerance in rat cardiac allograft recipients. Kamei, T., Callery, M.P., Flye, M.W. Transplantation (1991) [Pubmed]
  20. Methylated analogues of prostaglandin E2 and the gastric mucosal barrier. Kenyon, G.S., Ansell, I.F., Carter, D.C. Prostaglandins (1978) [Pubmed]
  21. Changes in thymidine uptake in the gastrointestinal tract of the rat following treatment with 16,16-dimethyl prostaglandin E2. Gilbertson, T.J., Stryd, R.P., Brunden, M.N., Christianson, C.A., Rush, B.D. Prostaglandins (1984) [Pubmed]
  22. Use of fluorescent hydrophobic dyes in establishing the presence of lipids in the gastric mucus gel layer. Lichtenberger, L.M., Ahmed, T.N., Barreto, J.C., Kao, Y.C., Dial, E.J. J. Clin. Gastroenterol. (1992) [Pubmed]
  23. Role of cyclooxygenase-2 in gastric mucosal defense. Peskar, B.M., Maricic, N., Gretzera, B., Schuligoi, R., Schmassmann, A. Life Sci. (2001) [Pubmed]
  24. TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. Riehl, T.E., Newberry, R.D., Lorenz, R.G., Stenson, W.F. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  25. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Kiriyama, M., Ushikubi, F., Kobayashi, T., Hirata, M., Sugimoto, Y., Narumiya, S. Br. J. Pharmacol. (1997) [Pubmed]
  26. The effects of 16,16-dimethyl PGE2 and phosphodiesterase inhibitors on Con A blastogenic responses and NK cytotoxic activity of mouse spleen cells. Ellis, N.K., Duffie, G.P., Young, M.R., Wepsic, H.T. J. Leukoc. Biol. (1990) [Pubmed]
  27. BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro. McKenniff, M.G., Norman, P., Cuthbert, N.J., Gardiner, P.J. Br. J. Pharmacol. (1991) [Pubmed]
  28. Prostaglandin prevents alterations in DNA, RNA, and protein in damaged gastric mucosa. Miller, T.A., Gum, E.T., Guinn, E.J., Henagan, J.M. Dig. Dis. Sci. (1982) [Pubmed]
  29. Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress. Takeuchi, K., Suzuki, K., Araki, H., Mizoguchi, H., Sugamoto, S., Umdeda, M. J. Physiol. Paris (1999) [Pubmed]
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