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Chemical Compound Review

SureCN895602     3-[(1R)-1-hydroxy-2- methylamino-ethyl]phenol

Synonyms: KST-1A6757, AC1L2GDL, SBB064156, AR-1A7872, LS-187086, ...
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Disease relevance of L-Phenylephrine


High impact information on L-Phenylephrine

  • The increase in cardiac glycogen synthase phosphorylation induced by DL-isoproterenol, glucagon, and L-phenylephrine was identical, with or without insulin pretreatment; this despite the fact that these three hormones promoted a 3- to 4-fold larger decrease in the enzyme activity ratio with the insulin-treated tissue [6].
  • In perfused hearts from normal animals, DL-isoproterenol and glucagon caused an increase in glycogen synthase phosphorylation of 85-100 pmol/unit of enzyme activity, while L-phenylephrine increased the phosphate content by only 20-35 pmol, but all three hormones caused the same degree of inactivation [6].
  • The tension responses of ET-free segments of the thoracic aorta to 5 x 10(-6) mmol/L phenylephrine, 60 mmol/L KCl, and cumulative doses of ET-1 were assessed [7].
  • Correspondingly, [Ca2+]i responses evoked by 10 micromol/l phenylephrine in hepatocyte doublets shifted from transient to sinusoidal-type [Ca2+]i oscillations and then to a sustained increase in [Ca2+]i, followed by a gradual return to baseline [8].
  • The most potent activator of phospholipase C (as measured by inositol phosphate release) was carbachol (muscarinic M1 receptor agonist), followed by L-phenylephrine (alpha 1-adrenergic receptor agonist) in normal oligodendrocytes [9].

Chemical compound and disease context of L-Phenylephrine

  • Dose-response curves of inhibitory agents (e.g. WB4101, cholera and pertussis toxins) were determined by comparing the remaining contractility after incubating with the respective drug with a control contraction that was evoked three times (10 mumol/L phenylephrine) and the mean set at 100% [10].

Biological context of L-Phenylephrine


Anatomical context of L-Phenylephrine


Associations of L-Phenylephrine with other chemical compounds


Gene context of L-Phenylephrine


Analytical, diagnostic and therapeutic context of L-Phenylephrine


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