The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PLIN1  -  perilipin 1

Homo sapiens

Synonyms: FPLD4, Lipid droplet-associated protein, PERI, PLIN, Perilipin-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PLIN

  • OBJECTIVE: The objective of the study was to examine the association of several polymorphisms at the perilipin (PLIN) locus with obesity and weight reduction in response to a low-energy diet in obese patients [1].
  • The current study investigated the association between PLIN polymorphisms and the combination of hypertension and obesity (HO) and the related clinical features [2].
  • In summary, our data suggest that common alleles at the PLIN locus modulate body weight and metabolic variables in humans [3].
  • CONCLUSIONS: We show the presence and induction of perilipin in atheroma [4].
  • Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction [1].

Psychiatry related information on PLIN


High impact information on PLIN

  • We found that truncated DRPLA proteins containing an expanded polyglutamine stretch form filamentous peri- and intranuclear aggregates and undergo apoptosis [9].
  • Sequence-specific catalytic DNA enzymes inhibited rat PAI-1 mRNA and protein expression in peri-infarct endothelium within 48 h of administration, and maintained down-regulation for at least 2 wk [10].
  • Bone loss was significantly associated with lower androgen concentrations in premenopausal women, and with lower estrogens and androgens in peri- and postmenopausal women [11].
  • Lymphocytes had peri- and intraganglionic location [12].
  • CONCLUSIONS: EUS-FNA accurately and safely evaluates solid peri-intestinal lesions and improves lymph node staging accuracy [13].

Chemical compound and disease context of PLIN


Biological context of PLIN

  • DESIGN: This study was a 1-yr randomized (depending on the PLIN genotype) trial with three follow-up evaluations [1].
  • No associations between PLIN haplotypes and obesity risk were found in Chinese. To simplify the haplotype analyses we used a subgroup of three SNPs (11482G>A, 13041A>G, and 14995A>T) in positive linkage disequilibrium [18].
  • Moreover, individual SNP analyses demonstrated that the PLIN 14995A>T SNP is the most informative single genetic marker for the observed haplotype association, being significantly associated with increased obesity risk in both Malays OR 2.28 (95% CI 1.45-3.57) and Indians OR 2.04 (95% CI 1.08-3.64) [18].
  • Polymorphism 1243 in the PLIN gene did not seem to be associated with HO but with TC levels in Chinese. The PLIN gene may be involved in human lipid metabolism [2].
  • Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women [3].

Anatomical context of PLIN


Associations of PLIN with chemical compounds

  • However, there was no significant relationship between perilipin expression and blood NEFA, nor was there a significant relationship between perilipin expression and insulin resistance, using the insulin sensitivity index derived from the iv glucose tolerance test with minimal modeling [20].
  • We conclude that ritonavir decreases PDE3B and perilipin protein expression and affects both basal and catecholamine-stimulated lipolysis in 3T3-L1 adipocytes primarily through actions at sites downstream of PKA [21].
  • Adipocyte content of perilipin was inversely correlated with the circulating concentrations of glycerol (r=0.62) and non-esterified fatty acids (n=0.49) [14].
  • RESULTS: Basal and noradrenaline-induced rates of lipolysis were two to fourfold increased (p<0.01) and perilipin protein content decreased 50% (p=0.005) in adipocytes of the obese women [14].
  • Testosterone caused a depot-specific 50% reduction of the protein expression of hormone-sensitive lipase and beta(2)-adrenoceptors in differentiated subcutaneous pre-adipocytes, but no change in beta(1)-adrenoceptors, protein kinase A subunits or perilipin expression [22].

Regulatory relationships of PLIN


Other interactions of PLIN

  • We have evaluated the association between several polymorphisms at the perilipin (PLIN) locus (PLIN1 : 6209T > C, PLIN4 : 11482G > A, PLIN5 : 13041A > G, and PLIN6 : 14995A > T) with obesity-related phenotypes in 1589 White subjects randomly selected from a general Spanish population [3].
  • In addition, there was no significant relationship between perilipin and adipocyte or systemic inflammatory markers, such as TNFalpha, IL-6, and adiponectin [20].
  • On differentiated human preadipocytes, ANP-mediated lipolysis, associated with an increased phosphorylation of HSL and of perilipin A, was strongly decreased by treatment with the inhibitor of the cGMP-dependent protein kinase I (cGKI), Rp-8-pCPT-cGMPS [24].
  • The present study was undertaken to reveal whether the mammalian lipid body proteins perilipin A, adipose differentiation-related protein, and tail-interacting protein of 47 kDa (TIP47), which comprise the so called PAT family proteins, and the maize (Zea mays L.) oleosin are targeted to prokaryotic TAG bodies in vivo [25].
  • RESULTS: A 48-h incubation with TNF-alpha resulted in a pronounced increase in lipolysis, which was paralleled by a decrease in the mRNA and protein expression of PLIN [23].

Analytical, diagnostic and therapeutic context of PLIN


  1. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. Corella, D., Qi, L., Sorlí, J.V., Godoy, D., Portolés, O., Coltell, O., Greenberg, A.S., Ordovas, J.M. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  2. Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Yan, W., Chen, S., Huang, J., Shen, Y., Qiang, B., Gu, D. Obes. Res. (2004) [Pubmed]
  3. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women. Qi, L., Corella, D., Sorlí, J.V., Portolés, O., Shen, H., Coltell, O., Godoy, D., Greenberg, A.S., Ordovas, J.M. Clin. Genet. (2004) [Pubmed]
  4. Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Forcheron, F., Legedz, L., Chinetti, G., Feugier, P., Letexier, D., Bricca, G., Beylot, M. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  5. Rett syndrome: case reports and management strategies. Burd, L., Gascon, G., Kerbeshian, J. Neuroscience and biobehavioral reviews. (1988) [Pubmed]
  6. Peri-sleep-onset cortisol levels in children and adolescents with affective disorders. Forbes, E.E., Williamson, D.E., Ryan, N.D., Birmaher, B., Axelson, D.A., Dahl, R.E. Biol. Psychiatry (2006) [Pubmed]
  7. Predictors of chronic post-traumatic stress disorder. A prospective study. Freedman, S.A., Brandes, D., Peri, T., Shalev, A. The British journal of psychiatry : the journal of mental science. (1999) [Pubmed]
  8. Post-partum depression and the mother-infant relationship in a South African peri-urban settlement. Cooper, P.J., Tomlinson, M., Swartz, L., Woolgar, M., Murray, L., Molteno, C. The British journal of psychiatry : the journal of mental science. (1999) [Pubmed]
  9. Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Igarashi, S., Koide, R., Shimohata, T., Yamada, M., Hayashi, Y., Takano, H., Date, H., Oyake, M., Sato, T., Sato, A., Egawa, S., Ikeuchi, T., Tanaka, H., Nakano, R., Tanaka, K., Hozumi, I., Inuzuka, T., Takahashi, H., Tsuji, S. Nat. Genet. (1998) [Pubmed]
  10. Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors. Xiang, G., Schuster, M.D., Seki, T., Kocher, A.A., Eshghi, S., Boyle, A., Itescu, S. J. Exp. Med. (2004) [Pubmed]
  11. Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women. Slemenda, C., Longcope, C., Peacock, M., Hui, S., Johnston, C.C. J. Clin. Invest. (1996) [Pubmed]
  12. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Törnblom, H., Lindberg, G., Nyberg, B., Veress, B. Gastroenterology (2002) [Pubmed]
  13. Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment. Wiersema, M.J., Vilmann, P., Giovannini, M., Chang, K.J., Wiersema, L.M. Gastroenterology (1997) [Pubmed]
  14. Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Mottagui-Tabar, S., Rydén, M., Löfgren, P., Faulds, G., Hoffstedt, J., Brookes, A.J., Andersson, I., Arner, P. Diabetologia (2003) [Pubmed]
  15. The 11482G >A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes. Kang, E.S., Cha, B.S., Kim, H.J., Kim, H.J., Kim, S.H., Hur, K.Y., Lee, H.J., Shim, W.S., Ahn, C.W., Lee, H.C. Diabetes Care (2006) [Pubmed]
  16. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Abidov, M.T., del Rio, M.J., Ramazanov, T.Z., Klimenov, A.L., Dzhamirze, S.h., Kalyuzhin, O.V. Bull. Exp. Biol. Med. (2006) [Pubmed]
  17. The dobutamine stress test with thallium-201 single-photon emission computed tomography and radionuclide angiography: postinfarction study. Coma-Canella, I., Gómez Martínez, M.V., Rodrigo, F., Castro Beiras, J.M. J. Am. Coll. Cardiol. (1993) [Pubmed]
  18. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. Qi, L., Tai, E.S., Tan, C.E., Shen, H., Chew, S.K., Greenberg, A.S., Corella, D., Ordovas, J.M. J. Mol. Med. (2005) [Pubmed]
  19. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. Moore, H.P., Silver, R.B., Mottillo, E.P., Bernlohr, D.A., Granneman, J.G. J. Biol. Chem. (2005) [Pubmed]
  20. Perilipin expression in human adipose tissue is elevated with obesity. Kern, P.A., Di Gregorio, G., Lu, T., Rassouli, N., Ranganathan, G. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  21. Effects of the human immunodeficiency virus-protease inhibitor, ritonavir, on basal and catecholamine-stimulated lipolysis. Adler-Wailes, D.C., Liu, H., Ahmad, F., Feng, N., Londos, C., Manganiello, V., Yanovski, J.A. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  22. Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots. Dicker, A., Rydén, M., Näslund, E., Muehlen, I.E., Wirén, M., Lafontan, M., Arner, P. Diabetologia (2004) [Pubmed]
  23. Targets for TNF-alpha-induced lipolysis in human adipocytes. Rydén, M., Arvidsson, E., Blomqvist, L., Perbeck, L., Dicker, A., Arner, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  24. Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. Sengenes, C., Bouloumie, A., Hauner, H., Berlan, M., Busse, R., Lafontan, M., Galitzky, J. J. Biol. Chem. (2003) [Pubmed]
  25. Eukaryotic lipid body proteins in oleogenous actinomycetes and their targeting to intracellular triacylglycerol inclusions: impact on models of lipid body biogenesis. H??nisch, J., W??ltermann, M., Robenek, H., Steinb??chel, A. Appl. Environ. Microbiol. (2006) [Pubmed]
  26. Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Nishiu, J., Tanaka, T., Nakamura, Y. Genomics (1998) [Pubmed]
  27. Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line. Sztalryd, C., Bell, M., Lu, X., Mertz, P., Hickenbottom, S., Chang, B.H., Chan, L., Kimmel, A.R., Londos, C. J. Biol. Chem. (2006) [Pubmed]
WikiGenes - Universities