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Gene Review

Lpt1  -  liver protein 1

Mus musculus

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Disease relevance of Lpt1

  • RESULTS: Liver-specific TfR2-KO mice develop significant iron overload comparable to complete TfR2-KO mice [1].
  • In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases [2].
  • BACKGROUND/AIMS: Liver regeneration following chronic injury is associated with inflammation, the proliferation of liver progenitor (oval) cells and fibrosis [3].
  • METHODS: Liver tumors were established by direct injection of CT26, a murine adenocarcinoma, into the livers of BALB/c mice, followed by three transfections with either murine IL-12, murine granulocyte-macrophage colony-stimulating factor, or luciferase cDNA using particle-mediated gene transfer [4].
  • The mouse model (Cftr(tm1UNC)/Cftr(tm1UNC)) for cystic fibrosis (CF) shows mucus accumulation and increased Muc1 mucin mRNA levels due to altered splicing (Hinojosa-Kurtzberg AM, Johansson MEV, Madsen CS, Hansson GC, and Gendler SJ. Am J Physiol Gastrointest Liver Physiol 284: G853-G862, 2003) [5].

High impact information on Lpt1


Chemical compound and disease context of Lpt1


Biological context of Lpt1


Anatomical context of Lpt1

  • BACKGROUND/AIMS: Liver natural killer 1.1 antigen (NK1)+ T cells and IL-4 play a crucial role in concanavalin-A (Con-A)-induced hepatic injury in mice, and a T helper (Th) 2 immune response was thus suggested to be involved [21].
  • METHODS: Liver dendritic cell progenitors were enriched from normal C57BL/6 mice by culturing non-parenchymal cells with granulocyte-macrophage colony stimulating factor for 7 days [22].
  • BACKGROUND/AIMS: Liver regeneration is dependent upon coordinated proliferation of hepatocytes and endothelial cells [23].
  • METHODS: Liver fibrosis was induced in rats by bile duct resection (BDR), and by intraperitoneal injections of carbon tetrachloride (CCl4) or porcine serum, and in mice by intragastric administrations of CCl4, and BDR [24].
  • CONCLUSION: Liver and spleen pathology of AGU was corrected by bone marrow transplantation, but there was no effect on lysosomal accumulation in the CNS and in the kidneys [25].

Associations of Lpt1 with chemical compounds


Regulatory relationships of Lpt1


Other interactions of Lpt1

  • Zonal Gene Expression in Mouse Liver Resembles Expression Patterns of Ha-ras and {beta}-Catenin Mutated Hepatomas [34].
  • Hematopoietic Cells Are a Source of Nidogen-1 and Nidogen-2 during Mouse Liver Development [35].
  • (v) Liver fibrosis was induced in wild-type mice with TAA, and mice received additional leptin or a control solution [36].
  • The opposite hepatic outcomes in Liver mt PPARgamma Tg as a result of fasting and high-fat feeding may indicate distinct roles of PPARalpha and PPARgamma in 2 different types of nutritionally provoked steatosis [37].
  • CONCLUSIONS: Liver-derived IGF-I is permissive for ovx-induced trabecular bone loss [38].

Analytical, diagnostic and therapeutic context of Lpt1


  1. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Wallace, D.F., Summerville, L., Subramaniam, V.N. Gastroenterology (2007) [Pubmed]
  2. In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases. Bouvet, M., Tsuji, K., Yang, M., Jiang, P., Moossa, A.R., Hoffman, R.M. Cancer Res. (2006) [Pubmed]
  3. Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. Knight, B., Akhurst, B., Matthews, V.B., Ruddell, R.G., Ramm, G.A., Abraham, L.J., Olynyk, J.K., Yeoh, G.C. J. Hepatol. (2007) [Pubmed]
  4. Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors. Weber, S.M., Shi, F., Heise, C., Warner, T., Mahvi, D.M. Ann. Surg. Oncol. (1999) [Pubmed]
  5. Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression. Malmberg, E.K., Noaksson, K.A., Phillipson, M., Johansson, M.E., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S.J., Hansson, G.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  6. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Radaeva, S., Sun, R., Jaruga, B., Nguyen, V.T., Tian, Z., Gao, B. Gastroenterology (2006) [Pubmed]
  7. Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Lin, X., Jung, J., Kang, D., Xu, B., Zaret, K.S., Zoghbi, H. Gastroenterology (2002) [Pubmed]
  8. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Meyer zum Büschenfelde, K.H., Galle, P.R., Rose-John, S. Gastroenterology (2000) [Pubmed]
  9. Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver. Nakamura, K., Moore, R., Negishi, M., Sueyoshi, T. J. Biol. Chem. (2007) [Pubmed]
  10. Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1. Okamoto, Y., Ogawa, W., Nishizawa, A., Inoue, H., Teshigawara, K., Kinoshita, S., Matsuki, Y., Watanabe, E., Hiramatsu, R., Sakaue, H., Noda, T., Kasuga, M. Diabetes (2007) [Pubmed]
  11. A novel role of alkaline phosphatase in protection from immunological liver injury in mice. Xu, Q., Lu, Z., Zhang, X. Liver (2002) [Pubmed]
  12. Changes in the microvascular architecture of colorectal liver metastases following the administration of SMANCS/lipiodol. Kuruppu, D., Christophi, C., Maeda, H., O'Brien, P.E. J. Surg. Res. (2002) [Pubmed]
  13. Effects of cyproterone acetate in C57B1/10J mice. Tucker, M.J., Jones, D.V. Human & experimental toxicology. (1996) [Pubmed]
  14. Effect of thalidomide on colorectal cancer liver metastases in CBA mice. Daruwalla, J., Nikfarjam, M., Malcontenti-Wilson, C., Muralidharan, V., Christophi, C. Journal of surgical oncology. (2005) [Pubmed]
  15. Species differences in the metabolism and hepatotoxicity of coumarin. Fentem, J.H., Fry, J.R. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1993) [Pubmed]
  16. Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. Shiri-Sverdlov, R., Wouters, K., van Gorp, P.J., Gijbels, M.J., Noel, B., Buffat, L., Staels, B., Maeda, N., van Bilsen, M., Hofker, M.H. J. Hepatol. (2006) [Pubmed]
  17. Donor pretreatment with Flt-3 ligand augments antidonor cytotoxic T lymphocyte, natural killer, and lymphokine-activated killer cell activities within liver allografts and alters the pattern of intragraft apoptotic activity. Qian, S., Lu, L., Fu, F., Li, W., Pan, F., Steptoe, R.J., Chambers, F.G., Starzl, T.E., Fung, J.J., Thomson, A.W. Transplantation (1998) [Pubmed]
  18. A mutant for the yeast scERV1 gene displays a new defect in mitochondrial morphology and distribution. Becher, D., Kricke, J., Stein, G., Lisowsky, T. Yeast (1999) [Pubmed]
  19. Suppression of Apoptosis in the Liver by Systemic and Local Delivery of Small-Interfering RNAs. Zender, L., Kubicka, S. Methods Mol. Biol. (2006) [Pubmed]
  20. Circadian rhythms. Liver regeneration clocks on. Schibler, U. Science (2003) [Pubmed]
  21. Inhibition of concanavalin A-induced hepatic injury of mice by bacterial lipopolysaccharide via the induction of IL-6 and the subsequent reduction of IL-4: the cytokine milieu of concanavalin A hepatitis. Nishikage, T., Seki, S., Toyabe, S., Abo, T., Kagata, Y., Iwai, T., Hiraide, H. J. Hepatol. (1999) [Pubmed]
  22. Induction of cytokine production and proliferation of memory lymphocytes by murine liver dendritic cell progenitors: role of these progenitors as immunogenic resident antigen-presenting cells in the liver. Abe, M., Akbar, S.M., Horiike, N., Onji, M. J. Hepatol. (2001) [Pubmed]
  23. Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice. Redaelli, C.A., Semela, D., Carrick, F.E., Ledermann, M., Candinas, D., Sauter, B., Dufour, J.F. J. Hepatol. (2004) [Pubmed]
  24. Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice. Sugihara, A., Tsujimura, T., Fujita, Y., Nakata, Y., Terada, N. J. Hepatol. (1999) [Pubmed]
  25. Correction of peripheral lysosomal accumulation in mice with aspartylglucosaminuria by bone marrow transplantation. Laine, M., Richter, J., Fahlman, C., Rapola, J., Renlund, M., Peltonen, L., Karlsson, S., Jalanko, A. Exp. Hematol. (1999) [Pubmed]
  26. Acetaminophen-induced Liver Injury Is Attenuated in Male Glutamate-cysteine Ligase Transgenic Mice. Botta, D., Shi, S., White, C.C., Dabrowski, M.J., Keener, C.L., Srinouanprachanh, S.L., Farin, F.M., Ware, C.B., Ladiges, W.C., Pierce, R.H., Fausto, N., Kavanagh, T.J. J. Biol. Chem. (2006) [Pubmed]
  27. Assessment of efficiency and safety of adenovirus mediated gene transfer into normal and damaged murine livers. Nakatani, T., Kuriyama, S., Tominaga, K., Tsujimoto, T., Mitoro, A., Yamazaki, M., Tsujinoue, H., Yoshiji, H., Nagao, S., Fukui, H. Gut (2000) [Pubmed]
  28. Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice. Lee, T.H., Jawan, B., Chou, W.Y., Lu, C.N., Wu, C.L., Kuo, H.M., Concejero, A.M., Wang, C.H. The journal of gene medicine. (2006) [Pubmed]
  29. Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins. Guler, R., Olleros, M.L., Vesin, D., Parapanov, R., Vesin, C., Kantengwa, S., Rubbia-Brandt, L., Mensi, N., Angelillo-Scherrer, A., Martinez-Soria, E., Tacchini-Cottier, F., Garcia, I. J. Hepatol. (2004) [Pubmed]
  30. Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity. Badawy, A.A., Evans, M. Biochem. J. (1976) [Pubmed]
  31. Macrophage inflammatory protein-1alpha plays a crucial role in concanavalin A-induced liver injury through induction of proinflammatory cytokines in mice. Okamoto, S., Yokohama, S., Yoneda, M., Haneda, M., Nakamura, K. Hepatol. Res. (2005) [Pubmed]
  32. Liver-infiltrating T lymphocytes cause hepatocyte damage by releasing humoral factors via LFA-1/ICAM-1 interaction in immunological liver injury. Xu, Q., Cao, J.S., Zhang, X.M. Inflamm. Res. (2002) [Pubmed]
  33. Trichloroethylene: further studies of the effects on body and organ weights and plasma butyrylcholinesterase activity in mice. Kjellstrand, P., Holmquist, B., Alm, P., Kanje, M., Romare, S., Jonsson, I., Månsson, L., Bjerkemo, M. Acta pharmacologica et toxicologica. (1983) [Pubmed]
  34. Zonal Gene Expression in Mouse Liver Resembles Expression Patterns of Ha-ras and {beta}-Catenin Mutated Hepatomas. Braeuning, A., Ittrich, C., Köhle, C., Buchmann, A., Schwarz, M. Drug Metab. Dispos. (2007) [Pubmed]
  35. Hematopoietic Cells Are a Source of Nidogen-1 and Nidogen-2 during Mouse Liver Development. Tomte, L.T., Annatshah, Y., Schlüter, N.K., Miosge, N., Herken, R., Quondamatteo, F. J. Histochem. Cytochem. (2006) [Pubmed]
  36. In vitro and in vivo protection of stellate cells from apoptosis by leptin. Qamar, A., Sheikh, S.Z., Masud, A., Jhandier, M.N., Inayat, I.B., Hakim, W., Mehal, W.Z. Dig. Dis. Sci. (2006) [Pubmed]
  37. Transgenic expression of mutant peroxisome proliferator-activated receptor gamma in liver precipitates fasting-induced steatosis but protects against high-fat diet-induced steatosis in mice. Tanaka, T., Masuzaki, H., Ebihara, K., Ogawa, Y., Yasue, S., Yukioka, H., Chusho, H., Miyanaga, F., Miyazawa, T., Fujimoto, M., Kusakabe, T., Kobayashi, N., Hayashi, T., Hosoda, K., Nakao, K. Metab. Clin. Exp. (2005) [Pubmed]
  38. Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss. Lindberg, M.K., Svensson, J., Venken, K., Chavoshi, T., Andersson, N., Movérare Skrtic, S., Isaksson, O., Vanderschueren, D., Carlsten, H., Ohlsson, C. Bone (2006) [Pubmed]
  39. Pseudo-hydrodynamic Delivery of Helper-dependent Adenoviral Vectors into Non-human Primates for Liver-directed Gene Therapy. Brunetti-Pierri, N., Stapleton, G.E., Palmer, D.J., Zuo, Y., Mane, V.P., Finegold, M.J., Beaudet, A.L., Leland, M.M., Mullins, C.E., Ng, P. Mol. Ther. (2007) [Pubmed]
  40. Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice. Haga, S., Ogawa, W., Inoue, H., Terui, K., Ogino, T., Igarashi, R., Takeda, K., Akira, S., Enosawa, S., Furukawa, H., Todo, S., Ozaki, M. J. Hepatol. (2005) [Pubmed]
  41. Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation. Bilbao, G., Contreras, J.L., Gómez-Navarro, J., Eckhoff, D.E., Mikheeva, G., Krasnykh, V., Hynes, T., Thomas, F.T., Thomas, J.M., Curiel, D.T. Transplantation (1999) [Pubmed]
  42. Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. Nguyen, T.H., Mai, G., Villiger, P., Oberholzer, J., Salmon, P., Morel, P., Bühler, L., Trono, D. J. Hepatol. (2005) [Pubmed]
  43. Co-transplantation of donor-derived hepatocytes induces long-term tolerance to cardiac allografts in a rat model. Yoo-Ott, K.A., Schiller, H., Fändrich, F., Oswald, H., Richter, K., Xhu, X.F., Kampen, W.U., Krönke, M., Zavazava, N. Transplantation (2000) [Pubmed]
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