Gene Review:
Chrm2 - cholinergic receptor, muscarinic 2, cardiac
Mus musculus
Synonyms:
AChR M2, AChR-M2, Chrm-2, M2, Muscarinic acetylcholine receptor M2, ...
- Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Bymaster, F.P., Carter, P.A., Yamada, M., Gomeza, J., Wess, J., Hamilton, S.E., Nathanson, N.M., McKinzie, D.L., Felder, C.C. Eur. J. Neurosci. (2003)
- Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase. Minic, J., Molgó, J., Karlsson, E., Krejci, E. Eur. J. Neurosci. (2002)
- Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Bymaster, F.P., McKinzie, D.L., Felder, C.C., Wess, J. Neurochem. Res. (2003)
- Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition. McKinney, M., Miller, J.H., Gibson, V.A., Nickelson, L., Aksoy, S. Mol. Pharmacol. (1991)
- Zebrafish M2 muscarinic acetylcholine receptor: cloning, pharmacological characterization, expression patterns and roles in embryonic bradycardia. Hsieh, D.J., Liao, C.F. Br. J. Pharmacol. (2002)
- M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. Coleman, C.G., Lydic, R., Baghdoyan, H.A. Neuroscience (2004)
- In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Sánchez, C., Arnt, J., Didriksen, M., Dragsted, N., Moltzen Lenz, S., Matz, J. Psychopharmacology (Berl.) (1998)
- Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Labarca, C., Nowak, M.W., Zhang, H., Tang, L., Deshpande, P., Lester, H.A. Nature (1995)
- The location of the gate in the acetylcholine receptor channel. Wilson, G.G., Karlin, A. Neuron (1998)
- Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Akabas, M.H., Kaufmann, C., Archdeacon, P., Karlin, A. Neuron (1994)
- Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. Fisher, J.T., Vincent, S.G., Gomeza, J., Yamada, M., Wess, J. FASEB J. (2004)
- Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist. Giachetti, A., Micheletti, R., Montagna, E. Life Sci. (1986)
- Inhibition of cyclic AMP formation in N1E-115 neuroblastoma cells is mediated by a non-cardiac M2 muscarinic receptor subtype. Surichamorn, W., Amrhein, C.L., Forray, C., el-Fakahany, E.E. Brain Res. (1989)
- Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes. Matsui, M., Araki, Y., Karasawa, H., Matsubara, N., Taketo, M.M., Seldin, M.F. Genes Genet. Syst. (1999)
- Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Struckmann, N., Schwering, S., Wiegand, S., Gschnell, A., Yamada, M., Kummer, W., Wess, J., Haberberger, R.V. Mol. Pharmacol. (2003)
- Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists. Shannon, H.E., Bymaster, F.P., Hendrix, J.C., Quimby, S.J., Mitch, C.H. Psychopharmacology (Berl.) (1995)
- Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse. Tran, J.A., Matsui, M., Ehlert, F.J. J. Pharmacol. Exp. Ther. (2006)
- Specific Gq protein involvement in muscarinic M3 receptor-induced phosphatidylinositol hydrolysis and Ca2+ release in mouse duodenal myocytes. Morel, J.L., Macrez, N., Mironneau, J. Br. J. Pharmacol. (1997)
- Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum. Takeuchi, T., Fujinami, K., Goto, H., Fujita, A., Taketo, M.M., Manabe, T., Matsui, M., Hata, F. J. Neurophysiol. (2005)
- Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Jagoda, E.M., Kiesewetter, D.O., Shimoji, K., Ravasi, L., Yamada, M., Gomeza, J., Wess, J., Eckelman, W.C. Neuropharmacology (2003)
- SR 46559A: a novel and potent muscarinic compound with no cholinergic syndrome. Kan, J.P., Steinberg, R., Oury-Donat, F., Michaud, J.C., Thurneyssen, O., Terranova, J.P., Gueudet, C., Souilhac, J., Brodin, R., Boigegrain, R. Psychopharmacology (Berl.) (1993)
- Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Zhang, H.M., Chen, S.R., Matsui, M., Gautam, D., Wess, J., Pan, H.L. Mol. Pharmacol. (2006)
- Presynaptic muscarinic acetylcholine receptors suppress GABAergic synaptic transmission in the intermediate grey layer of mouse superior colliculus. Li, F., Endo, T., Isa, T. Eur. J. Neurosci. (2004)
- Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency. Ratnakumari, L., Qureshi, I.A., Butterworth, R.F. Pediatr. Res. (1996)
- Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes. Rodrigues, L., Pires de Miranda, M., Caloca, M.J., Bustelo, X.R., Simas, J.P. J. Virol. (2006)
- Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. Allen, I.C., Hartney, J.M., Coffman, T.M., Penn, R.B., Wess, J., Koller, B.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. DeLapp, N.W., McKinzie, J.H., Sawyer, B.D., Vandergriff, A., Falcone, J., McClure, D., Felder, C.C. J. Pharmacol. Exp. Ther. (1999)
- Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Tzavara, E.T., Bymaster, F.P., Felder, C.C., Wade, M., Gomeza, J., Wess, J., McKinzie, D.L., Nomikos, G.G. Mol. Psychiatry (2003)
- Postsynaptic muscarinic M1 receptors activate prefrontal cortical EEG of C57BL/6J mouse. Douglas, C.L., Baghdoyan, H.A., Lydic, R. J. Neurophysiol. (2002)
- DNA immunizations with M2 muscarinic and beta1 adrenergic receptor coding plasmids impair cardiac function in mice. Giménez, L.E., Hernández, C.C., Mattos, E.C., Brandão, I.T., Olivieri, B., Campelo, R.P., Araújo-Jorge, T., Silva, C.L., Campos de Carvalho, A.C., Kurtenbach, E. J. Mol. Cell. Cardiol. (2005)
- Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Gomeza, J., Zhang, L., Kostenis, E., Felder, C.C., Bymaster, F.P., Brodkin, J., Shannon, H., Xia, B., Duttaroy, A., Deng, C.X., Wess, J. Life Sci. (2001)