Gene Review:
ARHGAP4 - Rho GTPase activating protein 4
Homo sapiens
Synonyms:
C1, KIAA0131, RGC1, RHOGAP4, Rho GTPase-activating protein 4, ...
- Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus. Demura, M., Takeda, Y., Yoneda, T., Furukawa, K., Usukura, M., Itoh, Y., Mabuchi, H. Hum. Mutat. (2002)
- Prekallikrein activation and high-molecular-weight kininogen consumption in hereditary angioedema. Schapira, M., Silver, L.D., Scott, C.F., Schmaier, A.H., Prograis, L.J., Curd, J.G., Colman, R.W. N. Engl. J. Med. (1983)
- Virus-specific phosphoproteins in simian sarcoma virus-transformed primate cells. Born, M., von der Helm, K., Deinhardt, F. EMBO J. (1982)
- C1-inhibitor-serine proteinase complexes and the biosynthesis of C1-inhibitor by Hep G2 and U 937 cells. Patston, P.A., Medcalf, R.L., Kourteva, Y., Schapira, M. Blood (1993)
- Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia. Hubmann, R., Schwarzmeier, J.D., Shehata, M., Hilgarth, M., Duechler, M., Dettke, M., Berger, R. Blood (2002)
- Controllability of an aversive stimulus in depressed patients and health controls: a study using slow brain potentials. Bolz, J., Giedke, H. Biol. Psychiatry (1981)
- Complement C1-inhibitor expression in Alzheimer's disease. Veerhuis, R., Janssen, I., Hoozemans, J.J., De Groot, C.J., Hack, C.E., Eikelenboom, P. Acta Neuropathol. (1998)
- The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Grotewold, E., Drummond, B.J., Bowen, B., Peterson, T. Cell (1994)
- Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Carstea, E.D., Morris, J.A., Coleman, K.G., Loftus, S.K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M.A., Pavan, W.J., Krizman, D.B., Nagle, J., Polymeropoulos, M.H., Sturley, S.L., Ioannou, Y.A., Higgins, M.E., Comly, M., Cooney, A., Brown, A., Kaneski, C.R., Blanchette-Mackie, E.J., Dwyer, N.K., Neufeld, E.B., Chang, T.Y., Liscum, L., Strauss, J.F., Ohno, K., Zeigler, M., Carmi, R., Sokol, J., Markie, D., O'Neill, R.R., van Diggelen, O.P., Elleder, M., Patterson, M.C., Brady, R.O., Vanier, M.T., Pentchev, P.G., Tagle, D.A. Science (1997)
- Cholesterol in signal transduction. Incardona, J.P., Eaton, S. Curr. Opin. Cell Biol. (2000)
- Identification of functional domains in the maize transcriptional activator C1: comparison of wild-type and dominant inhibitor proteins. Goff, S.A., Cone, K.C., Fromm, M.E. Genes Dev. (1991)
- Compound deletion of the rhoGAP C1 and V2 vasopressin receptor genes in a patient with nephrogenic diabetes insipidus. Schöneberg, T., Pasel, K., von Baehr, V., Schulz, A., Volk, H.D., Gudermann, T., Filler, G. Hum. Mutat. (1999)
- A comparison of the abilities of nitrobenzylthioinosine, dilazep, and dipyridamole to protect human hematopoietic cells from 7-deazaadenosine (tubercidin). Cass, C.E., King, K.M., Montaño, J.T., Janowska-Wieczorek, A. Cancer Res. (1992)
- Feasibility of imaging pentose cycle glucose metabolism in gliomas with PET: studies in rat brain tumor models. Spence, A.M., Graham, M.M., Muzi, M., Freeman, S.D., Link, J.M., Grierson, J.R., O'Sullivan, F., Stein, D., Abbott, G.L., Krohn, K.A. J. Nucl. Med. (1997)
- QscR, a LysR-type transcriptional regulator and CbbR homolog, is involved in regulation of the serine cycle genes in Methylobacterium extorquens AM1. Kalyuzhnaya, M.G., Lidstrom, M.E. J. Bacteriol. (2003)
- Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules. Foletta, V.C., Brown, F.D., Young, W.S. Brain Res. Mol. Brain Res. (2002)
- An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. Tribioli, C., Droetto, S., Bione, S., Cesareni, G., Torrisi, M.R., Lotti, L.V., Lanfrancone, L., Toniolo, D., Pelicci, P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin. Harpel, P.C., Cooper, N.R. J. Clin. Invest. (1975)
- The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130. Lowe, M., Gonatas, N.K., Warren, G. J. Cell Biol. (2000)
- Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells. Turner, H., Gomez, M., McKenzie, E., Kirchem, A., Lennard, A., Cantrell, D.A. J. Exp. Med. (1998)
- Synthesis of C1 inhibitor in fibroblasts from patients with type I and type II hereditary angioneurotic edema. Kramer, J., Katz, Y., Rosen, F.S., Davis, A.E., Strunk, R.C. J. Clin. Invest. (1991)
- Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function. Verpy, E., Couture-Tosi, E., Eldering, E., Lopez-Trascasa, M., Späth, P., Meo, T., Tosi, M. J. Clin. Invest. (1995)
- Studies on human plasma C1 inactivator-enzyme interactions. II. Structural features of an abnormal C1 inactivator from a kindred with hereditary angioneurotic edema. Harpel, P.C., Hugli, T.E., Cooper, N.R. J. Clin. Invest. (1975)
- Evidence that Golgi structure depends on a p115 activity that is independent of the vesicle tether components giantin and GM130. Puthenveedu, M.A., Linstedt, A.D. J. Cell Biol. (2001)
- Alternatively spliced products of the maize P gene encode proteins with homology to the DNA-binding domain of myb-like transcription factors. Grotewold, E., Athma, P., Peterson, T. Proc. Natl. Acad. Sci. U.S.A. (1991)
- RNA-dependent phosphorylation of a nuclear RNA binding protein. Fung, P.A., Labrecque, R., Pederson, T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Severe combined immunodeficiency associated with nephrogenic diabetes insipidus and a deletion in the Xq28 region. Broides, A., Ault, B.H., Arthus, M.F., Bichet, D.G., Conley, M.E. Clin. Immunol. (2006)
- p115 Rho GTPase activating protein interacts with MEKK1. Christerson, L.B., Gallagher, E., Vanderbilt, C.A., Whitehurst, A.W., Wells, C., Kazempour, R., Sternweis, P.C., Cobb, M.H. J. Cell. Physiol. (2002)
- Molecular analysis of the C1-I allele from Zea mays: a dominant mutant of the regulatory C1 locus. Paz-Ares, J., Ghosal, D., Saedler, H. EMBO J. (1990)
- Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF. Koç, O.N., Gerson, S.L., Cooper, B.W., Laughlin, M., Meyerson, H., Kutteh, L., Fox, R.M., Szekely, E.M., Tainer, N., Lazarus, H.M. J. Clin. Oncol. (2000)
- Expression of functional human C1 inhibitor in COS cells. Eldering, E., Nuijens, J.H., Hack, C.E. J. Biol. Chem. (1988)
- The macromolecular structure of the first component of complement. Assimeh, S.N., Painter, R.H. J. Immunol. (1975)