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MeSH Review

Lens Plant

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Disease relevance of Lens Plant


High impact information on Lens Plant


Chemical compound and disease context of Lens Plant


Biological context of Lens Plant


Anatomical context of Lens Plant


Associations of Lens Plant with chemical compounds

  • Glycopeptides obtained by Pronase digestion of each isolated chain were passed sequentially over columns of immobilized concanavalin A, Lens culinaris lectin, and phytohemagglutinins E and L in a prescribed manner to generate a lectin affinity profile which could be used to assign a minimal oligosaccharide structure for each glycopeptide studied [24].
  • The variant glycophorin is of a smaller size, does not bind to Lens culinaris lectin agarose, and lacks residues approximately 40-60 of alpha-glycophorin and its single asparagine-linked carbohydrate; it contains approximately 2 less O-glycosidically bound units whose structures are identical to those found in alpha-glycophorins [25].
  • The lectin from Lens culinaris (lentil) has a binding specificity for glycopeptides bearing 6-O-linked fucose on the reducing terminus on complex-type N-linked oligosaccharides [26].
  • The glycan microheterogeneity of ceruloplasmin was analyzed by crossed affinoimmunoelectrophoresis with free Lens culinaris agglutinin (LCA) and wheat germ agglutinin (WGA) [27].
  • Comparable fucose contents and abilities of beta-core and hCG beta to bind to Lens culinaris indicate a similar extent of fucosylation on the internal N-acetylglucosamine in both molecules [28].

Gene context of Lens Plant

  • Also, whereas essentially all of the HLA-A and B antigens and about half of the HLA-CW2 antigen were adsorbed strongly by Lens culinaris lectin-Sepharose, the remaining HLA-CW2 antigen was bound much more weakly and did not require sugar for elution [29].
  • Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) is a recently described marker of HCC [30].
  • The dystrophic syndrome increased the liver content of the light AChE forms with Lens culinaris agglutinin (LCA) reactivity [31].
  • N-Glycosidically linked glycopeptides released by mild alkaline treatment of human factor VIII/von Willebrand factor (FVIII/vWF) were fractionated by serial affinity chromatography on columns of Sepharose linked to concanavalin A (ConA) and Lens culinaris agglutinin (LCA) [32].
  • The mannose-binding lectin obtained from Lens culinaris (LCL) was a particularly efficient inducer of trypsin-sensitive antiviral activity, which qualified as IFN-gamma because it was 90-95% destroyed by pH 2 treatment but not neutralized by anti-IFN-gamma antibodies [33].

Analytical, diagnostic and therapeutic context of Lens Plant


  1. Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. Sato, Y., Nakata, K., Kato, Y., Shima, M., Ishii, N., Koji, T., Taketa, K., Endo, Y., Nagataki, S. N. Engl. J. Med. (1993) [Pubmed]
  2. Susceptibility of bovine germinal vesicle-stage oocytes from antral follicles to direct effects of heat stress in vitro. Payton, R.R., Romar, R., Coy, P., Saxton, A.M., Lawrence, J.L., Edwards, J.L. Biol. Reprod. (2004) [Pubmed]
  3. A novel method for the detection of Down syndrome with the use of four serum markers. Azuma, M., Yamamoto, R., Wakui, Y., Minobe, S., Satomura, S., Fujimoto, S. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  4. Evaluation of the natural killer cell-interferon system in patients with mid-gut carcinoid tumours treated with leucocyte interferon. Funa, K., Alm, G.V., Rönnblom, L., Oberg, K. Clin. Exp. Immunol. (1983) [Pubmed]
  5. Influence of metribuzin on the Rhizobium leguminosarum--lentil (Lens culinaris) symbiosis. Sprout, S.L., Nelson, L.M., Germida, J.J. Can. J. Microbiol. (1992) [Pubmed]
  6. Newer markers for hepatocellular carcinoma. Marrero, J.A., Lok, A.S. Gastroenterology (2004) [Pubmed]
  7. Subcellular compartmentalization of saccharide moieties in cultured normal and malignant cells. Virtanen, I., Ekblom, P., Laurila, P. J. Cell Biol. (1980) [Pubmed]
  8. Characterization of a membrane antigen from rabbit testis and sperm isolated by using monoclonal antibodies and effect of its antiserum on fertility. Naz, R.K., Rosenblum, B.B., Menge, A.C. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  9. Thrombospondin in essential thrombocythemia. Lawler, J., Cohen, A.M., Chao, F.C., Moriarty, D.J. Blood (1986) [Pubmed]
  10. The collagen binding specificity of bone and platelet osteonectin is related to differences in glycosylation. Kelm, R.J., Mann, K.G. J. Biol. Chem. (1991) [Pubmed]
  11. Cell surface biochemical and metastatic properties of Lens culinaris hemagglutinin-binding variants of a murine large cell lymphoma. Tressler, R.J., Nicolson, G.L. Invasion Metastasis (1988) [Pubmed]
  12. The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells. Chandrasekaran, E.V., Chawda, R., Rhodes, J.M., Locke, R.D., Piskorz, C.F., Matta, K.L. Carbohydr. Res. (2003) [Pubmed]
  13. Concanavalin A and Lens culinaris agglutinin binding patterns in normal and neoplastic sebaceous epithelium. Von Kuster, L., Liwnicz, B.H., Ward, D.E. J. Cutan. Pathol. (1986) [Pubmed]
  14. Interaction of DNA with cationic liposomes: ability of transfecting lentil protoplasts. Maccarrone, M., Dini, L., Di Marzio, L., Di Giulio, A., Rossi, A., Mossa, G., Finazzi-Agrò, A. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  15. Yolk sac tumor of the ovary during pregnancy: a case report. Aoki, Y., Higashino, M., Ishii, S., Tanaka, K. Gynecol. Oncol. (2005) [Pubmed]
  16. Bioavailability of phytic acid-phosphorus and magnesium from lentils (Lens culinaris m.) in growing rats: influence of thermal treatment and vitamin-mineral supplementation. Porres, J.M., López-Jurado, M., Aranda, P., Urbano, G. Nutrition (Burbank, Los Angeles County, Calif.) (2004) [Pubmed]
  17. Analysis and partial reversal of multidrug resistance to anthelmintics due to P-glycoprotein in Haemonchus contortus eggs using Lens culinaris lectin. Kerboeuf, D., Guégnard, F., Le Vern, Y. Parasitol. Res. (2002) [Pubmed]
  18. Effect of lectin-binding to fibrinogen D and E domains on coagulation and fibrinolysis. Solis, D., Albert, A., Diaz-Mauriño, T. Biochim. Biophys. Acta (1987) [Pubmed]
  19. Characterization of plasma-membrane glycoproteins from functional domains of the rat hepatocyte. Enrich, C., Gahmberg, C.G. Biochem. J. (1985) [Pubmed]
  20. Role of CD59 in experimental glomerulonephritis in rats. Matsuo, S., Nishikage, H., Yoshida, F., Nomura, A., Piddlesden, S.J., Morgan, B.P. Kidney Int. (1994) [Pubmed]
  21. Distribution of prepubertal and adult goat oocyte cortical granules during meiotic maturation and fertilisation: ultrastructural and cytochemical study. Velilla, E., Izquierdo, D., Rodríguez-González, E., López-Béjar, M., Vidal, F., Paramio, M.T. Mol. Reprod. Dev. (2004) [Pubmed]
  22. Increase of mannose residues, as Salmonella typhimurium-adhering factor, on the cecal mucosa of germ-free chickens infected with Eimeria tenella. Baba, E., Tsukamoto, Y., Fukata, T., Sasai, K., Arakawa, A. Am. J. Vet. Res. (1993) [Pubmed]
  23. Characterization of glycoconjugate expression during development of Meckel's cartilage in the rat. Zschäbitz, A., Weiser, H., Stofft, E., Krahn, V., Gabius, H.J., Khaw, A., Biesalski, H.K. Anat. Embryol. (1995) [Pubmed]
  24. Analysis of normal human tonsil class II antigen glycosylation by lectin affinity chromatography. Zacheis, M., Giacoletto, K., Schwartz, B.D. J. Biol. Chem. (1986) [Pubmed]
  25. Membrane glycophorins of Dantu blood group erythrocytes. Blumenfeld, O.O., Smith, A.J., Moulds, J.J. J. Biol. Chem. (1987) [Pubmed]
  26. Synthesis of 1-N-glycyl beta-oligosaccharide derivatives. Reactivity of Lens culinaris lectin with a fluorescent labeled streptavidin pseudoglycoprotein and immobilized neoglycolipid. Manger, I.D., Wong, S.Y., Rademacher, T.W., Dwek, R.A. Biochemistry (1992) [Pubmed]
  27. Heterogeneity in copper and glycan content of ceruloplasmin in human serum differs in health and disease. Hansen, J.E., Heegaard, P.M., Jensen, S.P., Nørgaard-Pedersen, B., Bøg-Hansen, T.C. Electrophoresis (1988) [Pubmed]
  28. Carbohydrate composition of beta-core. Blithe, D.L., Wehmann, R.E., Nisula, B.C. Endocrinology (1989) [Pubmed]
  29. Molecular structure of human histocompatibility antigens: the HLA-C series. Snary, D., Barnstable, C.J., Bodmer, W.F., Crumpton, M.J. Eur. J. Immunol. (1977) [Pubmed]
  30. Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma. Nakatsura, T., Nishimura, Y. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. (2005) [Pubmed]
  31. Muscular dystrophy alters the processing of light acetylcholinesterase but not butyrylcholinesterase forms in liver of Lama2(dy) mice. Gómez, J.L., García-Ayllón, M.S., Campoy, F.J., Vidal, C.J. J. Neurosci. Res. (2000) [Pubmed]
  32. Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor. Samor, B., Michalski, J.C., Debray, H., Mazurier, C., Goudemand, M., Van Halbeek, H., Vliegenthart, J.F., Montreuil, J. Eur. J. Biochem. (1986) [Pubmed]
  33. Lectins as inducers of interferon-gamma production in human lymphocytes: lentil lectin is highly efficient. Rönnblom, L., Funa, K., Ersson, B., Alm, G.V. Scand. J. Immunol. (1982) [Pubmed]
  34. Prognostic significance of Lens culinaris agglutinin A-reactive alpha-fetoprotein in small hepatocellular carcinomas. Yamashita, F., Tanaka, M., Satomura, S., Tanikawa, K. Gastroenterology (1996) [Pubmed]
  35. Comparative effects of four legume species on plasma lipids and faecal steroid excretion in hypercholesterolaemic pigs. Kingman, S.M., Walker, A.F., Low, A.G., Sambrook, I.E., Owen, R.W., Cole, T.J. Br. J. Nutr. (1993) [Pubmed]
  36. Nephritogenicity and immunocytochemical localization of the 70-kilodalton glycoprotein subunit (gp70) of Heymann antigen. Singh, A.K., Schwartz, M.M. Clin. Immunol. Immunopathol. (1988) [Pubmed]
  37. Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome. Yamamoto, M., Otsubo, T., Ariizumi, S., Nakano, M., Takasaki, K. International surgery. (2005) [Pubmed]
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