The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FARP2  -  FERM, RhoGEF and pleckstrin domain protein 2

Homo sapiens

Synonyms: FERM domain including RhoGEF, FERM, RhoGEF and pleckstrin domain-containing protein 2, FIR, FRG, KIAA0793, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FARP2

  • Nomifensine (Merital, Alival; Hoechst, Frankfurt, FRG), an antidepressant drug, may cause immune hemolytic anemia (IHA) of the so-called immune complex type that is believed to occur by means of an innocent-bystander mechanism [1].
  • As well as the birth cohort effects, there was some evidence of a recent overall decline in mortality rates in several countries, e.g. Austria, FRG, Greece and the UK, and this may be due to an increase in survival resulting from improved management and treatment of women with breast cancer [2].
  • Regional risk factors for stomach cancer in the FRG [3].
  • This study evaluated the clinical feasibility of a 99mTc-labeled anti-CEA monoclonal antibody (BW 431/26, Behring Institute, FRG) in 11 patients for staging of primary adenocarcinoma of the lung [4].
  • A transcultural questionnaire study was made of 111 girls with Turner's syndrome aged 17 to 30 from Belgium, Canada, Denmark, France, the FRG and Hungary [5].

Psychiatry related information on FARP2

  • We have established a relationship between these two syndromes in a cohort of 42 outpatients who presented themselves to a clinic for seasonal affective disorder at the Psychiatric Department of the University of Bonn, FRG [6].
  • The data of established paediatricians and paediatric institutions in FRG show that music therapy is already accepted in the treatment of autistic children [7].
  • Life style, subsistence and mortality in the Slavonic village at Espenfeld (Kr. Arnstadt, FRG). A trace element study [8].
  • Results from neuropsychological tests, collected under double-blind-precautions, were evaluated for 115 schoolage children (mean age: 9.4 years) living in a lead smelter area (Stolberg, FRG) [9].
  • In a clinical trial of 30 patients suffering from psychovegetative disorders and anxiety neuroses, Mepiprazol (test designation: EMD 16-923; supplier: E. Merck, Darmstadt, FRG) was proven in a treatment period of 14 days to be an effective, well-tolerated medication [10].

High impact information on FARP2

  • We therefore conclude that FARP2 is a key molecule involved in the response of neuronal growth cones to class-3 semaphorins [11].
  • Poly-beta-hydroxybutyric acid (PHB) is at present the most promising PHA; and BIOPOL, its copolymer with poly-beta-hydroxy-valerate (PHV), is already industrially produced (ICI, UK), and used as packaging material (WELLA, FRG) [12].
  • In a prospective randomized trial, the immunorestorative potential of a combined therapy with the thymomimetic substance Thymopentin (TP-5; Timunox, Cilag GMBH, Sulzbach, FRG) and the cyclooxygenase inhibitor indomethacin (Indo) in 60 patients (mean age, 63 +/- 2 years) undergoing open heart surgery was studied [13].
  • The patients were from nine different populations and ranged in number from 193 to 686 per population (London, Warsaw, Berlin (FRG), New Delhi, Tokyo, Havana, Oklahoma Indians, Arizona Pima Indians, and a national sample in Switzerland) [14].
  • Fifty-five types of commercial cigarettes on the open market in the FRG and several samples of pure tobacco types were analyzed for preformed tobacco-specific nitrosamines (TSNA) and nitrate in the tobacco [15].

Chemical compound and disease context of FARP2


Biological context of FARP2

  • Ion transport across biological membranes and its control. Workshop organized by the Sonderforschungsbereich 160--Eigenschaften biologischer Membranen--September 25-27 1983, Maria Laach, FRG [20].
  • The study population consisted of male vegetarians (aged 28-50 years), who were recruited from the vegetarian cohort being followed by the Department of Epidemiology (German Cancer Research Center, Heidelberg, FRG), and the same number of age- and sex-matched controls from the personnel of the same center [21].
  • In cooperation, Storz Medical (Kreuzlingen, Switzerland) and the Department of Urology (Klinikum Mannheim, FRG), have developed a new lithotriptor designed to overcome these drawbacks [22].
  • A phase I study with recombinant human tumor necrosis factor alpha (rhuTNF-alpha; Knoll AG, Ludwigshafen, FRG) in patients with advanced malignant disease was undertaken to evaluate drug toxicity (organ specificity, time course, predictability, reversibility, maximal tolerated dose), effectiveness, antigenicity and pharmacokinetics [23].
  • In 7 of 24 patients with Decapeptyl (D-Trp6-luteinizing hormone-releasing hormone [LH-RH], Ferring, Kiel, FRG) treatment, and in 5 of 22 patients treated with Buserelin (Superfact, Hoechst A.G., Frankfurt, FRG), solitary ovarian cysts developed during the down-regulation phase [24].

Anatomical context of FARP2

  • This gene, termed FERM domain including RhoGEF (FIR), was abundantly expressed in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons [25].
  • METHODS: Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the end point) delivered by a Hugo-Sachs stimulator (Type 221, reiburg, FRG) [26].
  • In a meeting held in Düsseldorf, FRG, the immunotoxicology of dioxin was discussed with respect to the pathomechanisms of dioxins on lymphocyte stem cells, thymus and T cells, cytokine modulation, and other components of the immune system [27].
  • We provide evidence that the principal generator of the K+-mediated potential is the Müller (glial) cell, but that the FRG b-wave cannot be explained solely by this K+-mediated potential without considering involvement of the electrical activities of neuronal cells [28].
  • The high use of thyroid drugs by Augsburg women (11%) is indicative of the high frequency of endemic goitre in the southeastern quarter of the FRG [29].

Associations of FARP2 with chemical compounds

  • Effects of single oral doses of the beta-blocking drugs propranolol (40 mg) and metipranolol (Disorat, Boehringer, Mannheim, FRG, 5 and 20 mg), in comparison with placebo, on mental performance and psychophysiological measures were investigated in a double-blind crossover study comprising 12 healthy volunteers [30].
  • Diacylglycerol and mono-, di-, and trigalactosyldiacylglycerol and phosphatidylcholine were separated on a LiChrosorb NH2 column (7-microns particles, Merck, FRG), but acidic lipids were retained [31].
  • Benefits of the short-term utilization of a gonadotropin-releasing hormone (GnRH) agonist (Buserelin, Hoechst, AG, Frankfurt am Mein, FRG) for induction of ovulation in an in vitro fertilization program (IVF) program were assessed [32].
  • He failed to improve when therapy was continued with low-molecular-weight (LMW) heparin (Fragmin, Kabi Pfrimmer, Erlangen, FRG) [33].
  • In tests to determine the susceptibility of the organisms to ciprofloxacin 16 strains (14.3%), originating from France, the FRG, Israel and Italy, were shown to be resistant to this agent [34].

Analytical, diagnostic and therapeutic context of FARP2

  • Despite an increasing acceptance rate of patients with diabetic nephropathy, the annual death rates on hemodialysis decreased or remained stable both for the total Registry and for the FRG [35].
  • Measles-mumps vaccination in the FRG: an empirical analysis after 14 years of use. I. Efficacy and analysis of vaccine failures [36].
  • Since the initiation of the clinical trial utilizing a second-generation lithotripor (Lithostar, Siemens, Erlangen, FRG), 96 patients with distal ureteral calculi (i.e. calculi below the pelvic brim) underwent local shock-wave lithotripsy [37].
  • The association between the frequency of manifest infectious diseases and cancer risk was investigated in a case-control study at Heidelberg, FRG [38].
  • LH-RH was administered in subcutaneous pulses of 4 to 16 micrograms, with a portable infusion pump (ZYKLOMAT, Ferring Corp., Kiel, FRG); treatment periods ranged from 6 to 24 months [39].


  1. Rh blood group-specific antibodies in immune hemolytic anemia induced by nomifensine. Salama, A., Mueller-Eckhardt, C. Blood (1986) [Pubmed]
  2. Breast cancer mortality rates are levelling off or beginning to decline in many western countries: analysis of time trends, age-cohort and age-period models of breast cancer mortality in 20 countries. Hermon, C., Beral, V. Br. J. Cancer (1996) [Pubmed]
  3. Regional risk factors for stomach cancer in the FRG. Boeing, H., Frentzel-Beyme, R. Environ. Health Perspect. (1991) [Pubmed]
  4. 99mTc-anti-CEA radioimmunoscintigraphy of lung adenocarcinoma. Leitha, T., Walter, R., Schlick, W., Dudczak, R. Chest (1991) [Pubmed]
  5. Transcultural study of Turner's syndrome. Nielsen, J., Stradiot, M. Clin. Genet. (1987) [Pubmed]
  6. Recurrent brief depression and its relationship to seasonal affective disorder. Kasper, S., Ruhrmann, S., Haase, T., Möller, H.J. European archives of psychiatry and clinical neuroscience. (1992) [Pubmed]
  7. Music therapy in the treatment of autistic children. Medico-sociological data from the Federal Republic of Germany. Evers, S. Acta paedopsychiatrica. (1992) [Pubmed]
  8. Life style, subsistence and mortality in the Slavonic village at Espenfeld (Kr. Arnstadt, FRG). A trace element study. Grupe, G., Bach, H. Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur. (1993) [Pubmed]
  9. Neuropsychological studies in children with elevated tooth-lead concentrations. II. Extended study. Winneke, G., Krämer, U., Brockhaus, A., Ewers, U., Kujanek, G., Lechner, H., Janke, W. International archives of occupational and environmental health. (1983) [Pubmed]
  10. Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders. Pöldinger, W. International pharmacopsychiatry. (1975) [Pubmed]
  11. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Toyofuku, T., Yoshida, J., Sugimoto, T., Zhang, H., Kumanogoh, A., Hori, M., Kikutani, H. Nat. Neurosci. (2005) [Pubmed]
  12. Fungal degradation of polyhydroxyalkanoates and a semiquantitative assay for screening their degradation by terrestrial fungi. Matavulj, M., Molitoris, H.P. FEMS Microbiol. Rev. (1992) [Pubmed]
  13. Immunomodulatory therapy with thymopentin and indomethacin. Successful restoration of interleukin-2 synthesis in patients undergoing major surgery. Faist, E., Markewitz, A., Fuchs, D., Lang, S., Zarius, S., Schildberg, F.W., Wachter, H., Reichart, B. Ann. Surg. (1991) [Pubmed]
  14. Interrelationships of microangiopathy, plasma glucose and other risk factors in 3583 diabetic patients: a multinational study. West, K.M., Ahuja, M.M., Bennett, P.H., Grab, B., Grabauskas, V., Mateo-de-Acosta, O., Fuller, J.H., Jarrett, R.J., Keen, H., Kosaka, K., Krolewski, A.S., Miki, E., Schliack, V., Teuscher, A. Diabetologia (1982) [Pubmed]
  15. Preformed tobacco-specific nitrosamines in tobacco--role of nitrate and influence of tobacco type. Fischer, S., Spiegelhalder, B., Preussmann, R. Carcinogenesis (1989) [Pubmed]
  16. Buserelin suppression of endogenous gonadotropin secretion in infertile women with ovarian feedback disorders given human menopausal/human chorionic gonadotropin treatment. Weise, H.C., Fiedler, K., Kato, K. Fertil. Steril. (1988) [Pubmed]
  17. Prognostic risk factors in advanced Hodgkin's lymphoma. Report of the German Hodgkin Study Group. Loeffler, M., Pfreundschuh, M., Hasenclever, D., Hiller, E., Gerhartz, H., Wilmanns, W., Rohloff, R., Rühl, U., Kühn, G., Fuchs, R. Blut (1988) [Pubmed]
  18. Acute effect of urapidil on peripheral serotonin metabolism. Sebeková, K., Fedelesová, V., Blazícek, P., Dzúrik, R. Cor et vasa. (1990) [Pubmed]
  19. Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses. Róna, K., Gachályi, B., Vereczkey, L., Nádas, B., Káldor, A. International journal of clinical pharmacology, therapy, and toxicology. (1987) [Pubmed]
  20. Ion transport across biological membranes and its control. Workshop organized by the Sonderforschungsbereich 160--Eigenschaften biologischer Membranen--September 25-27 1983, Maria Laach, FRG. Deuticke, B., Hildebrand, E., Schnakenberg, J., Stieve, H. FEBS Lett. (1984) [Pubmed]
  21. Natural killer cells, vitamins, and other blood components of vegetarian and omnivorous men. Malter, M., Schriever, G., Eilber, U. Nutrition and cancer. (1989) [Pubmed]
  22. Modulith SL 10/20--experimental introduction and first clinical experience with a new interdisciplinary lithotriptor. Rassweiler, J., Köhrmann, U., Heine, G., Back, W., Wess, O., Alken, P. Eur. Urol. (1990) [Pubmed]
  23. Phase I study of recombinant human tumor necrosis factor alpha in advanced malignant disease. Moritz, T., Niederle, N., Baumann, J., May, D., Kurschel, E., Osieka, R., Kempeni, J., Schlick, E., Schmidt, C.G. Cancer Immunol. Immunother. (1989) [Pubmed]
  24. Ovarian cyst formation: a complication of gonadotropin-releasing hormone agonist therapy. Feldberg, D., Ashkenazi, J., Dicker, D., Yeshaya, A., Goldman, G.A., Dicker, D., Goldman, J.A. Fertil. Steril. (1989) [Pubmed]
  25. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. Kubo, T., Yamashita, T., Yamaguchi, A., Sumimoto, H., Hosokawa, K., Tohyama, M. J. Neurosci. (2002) [Pubmed]
  26. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Borowicz, K.K., Gasior, M., Kleinrok, Z., Czuczwar, S.J. Epilepsia (1996) [Pubmed]
  27. Dioxins and the immune system: mechanisms of interference. A meeting report. Esser, C. Int. Arch. Allergy Immunol. (1994) [Pubmed]
  28. Local potassium concentration changes in the retina and the electroretinographic (ERG) b-wave. Yanagida, T., Tomita, T. Brain Res. (1982) [Pubmed]
  29. Drug utilization by the 30-64 year-old people in two cities in the Federal Republic of Germany in 1984. Tennis, P. Eur. J. Clin. Pharmacol. (1990) [Pubmed]
  30. Metipranolol and propranolol: no CNS effects of a single oral dose. Levander, S., Gillner, A. Psychopharmacology (Berl.) (1982) [Pubmed]
  31. Separation of chloroplast polar lipids and measurement of galactolipid metabolism by high-performance liquid chromatography. Heemskerk, J.W., Bögemann, G., Scheijen, M.A., Wintermans, J.F. Anal. Biochem. (1986) [Pubmed]
  32. Short-term utilization of a gonadotropin-releasing hormone agonist (buserelin) for induction of ovulation in an in vitro fertilization program. Loumaye, E., de Cooman, S., Anoma, M., Psalti, I., Depreester, S., Schmit, M., Thomas, K. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  33. Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins. Greinacher, A., Drost, W., Michels, I., Leitl, J., Gottsmann, M., Kohl, H.J., Glaser, M., Mueller-Eckhardt, C. Ann. Hematol. (1992) [Pubmed]
  34. Ciprofloxacin resistance in methicillin- and gentamicin-resistant Staphylococcus aureus. Maple, P., Hamilton-Miller, J., Brumfitt, W. Eur. J. Clin. Microbiol. Infect. Dis. (1989) [Pubmed]
  35. Results of renal replacement therapy in Europe, 1980 to 1987. Registration Committee of the EDTA-ERA. Brunner, F.P., Selwood, N.H. Am. J. Kidney Dis. (1990) [Pubmed]
  36. Measles-mumps vaccination in the FRG: an empirical analysis after 14 years of use. I. Efficacy and analysis of vaccine failures. Fescharek, R., Quast, U., Maass, G., Merkle, W., Schwarz, S. Vaccine (1990) [Pubmed]
  37. Local shock-wave lithotripsy of distal ureteral calculi. Voges, G.E., Wilbert, D.M., Stöckle, M., Hohenfellner, R. Eur. Urol. (1988) [Pubmed]
  38. Common infections in the history of cancer patients and controls. Abel, U., Becker, N., Angerer, R., Frentzel-Beyme, R., Kaufmann, M., Schlag, P., Wysocki, S., Wahrendorf, J., Schulz, G. J. Cancer Res. Clin. Oncol. (1991) [Pubmed]
  39. Pulsatile luteinizing hormone-releasing hormone treatment of male hypogonadotropic hypogonadism. Aulitzky, W., Frick, J., Galvan, G. Fertil. Steril. (1988) [Pubmed]
WikiGenes - Universities