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Chemical Compound Review

Nickel-59     nickel

Synonyms: AC1L3GEW, 59Ni, Nickel, isotope of mass 59
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Disease relevance of nickel

  • However, T cells which are specific for non-peptidic haptens have been described, in particular in patients with contact sensitivity reactions to metals such as nickel (Ni) [1].
  • Tissue nickel levels and nickel dermatitis. I. Nickel in hair [2].
  • BACKGROUND: Delayed-type hypersensitivity reactions to nickel (Ni2+) in humans are associated with increased production of both T helper (Th) 1- and Th2-like cytokines [3].
  • In summary, ROFA-induced in vivo acute pulmonary inflammation appears to be associated with its water-leachable V content; however, protein leakage appears to be associated with its water-leachable Ni content [4].
  • High-Level Resistance to Cobalt and Nickel but Probably No Transenvelope Efflux: Metal Resistance in the Cuban Serratia marcescens Strain C-1 [5].

Psychiatry related information on nickel

  • The predictive value of the Neonatal Neurological Examination (NNE) adapted from Prechtl (1977) and the Infant Motor Screen (IMS) from Nickel (1989) at 4 months was studied in severely jaundiced infants in Zimbabwe. Fifty infants were examined with the NNE, 41 with the IMS and 43 with the Bayley Scales of Infant Development (BSID) (Bayley 1969) [6].

High impact information on nickel

  • Previously, we isolated MHC class II-restricted Ni-specific T cell clones from patients with Ni allergy [1].
  • The effect of divalent nickel (Ni2+) on in vitro DNA replication by DNA polymerase alpha [7].
  • New target organs for Ni during the infection were the heart, pancreas and lungs in which inflammatory lesions were present [8].
  • Ni and MeHg appeared to have a direct effect on immune cells that resulted in changed natural killer cell activity and decreased mobilization of macrophages, CD4+ and CD8+ cells into the inflammatory lesions [8].
  • Hydrogenation with Raney Nickel gave 21 from which after removal of the protecting group at C-1a the trichloroacetimidate 25 was prepared [9].

Chemical compound and disease context of nickel


Biological context of nickel

  • 1) Nickel ions appear to stabilize closed channel states and, as a result, slow activation kinetics [14].
  • These compounds were transformed into malonates 8 and succinic semialdehyde derivatives 9 by Raney Nickel mediated desulfuration or decarboxylation, respectively [15].
  • In addition, a requirement for GTP hydrolysis at an early stage of COPI vesicle biogenesis has been established since cargo uptake is impaired in the presence of GTPgammaS (Nickel, W., Malsam, J., Gorgas, K., Ravazzola, M., Jenne, N., Helms, J.B. and Wieland, F.T. (1998) J. Cell Sci. 111, 3081-3090), a non-hydrolyzable analogue of GTP [16].
  • Acylation of Nickel meso-Tetraarylporphyrins: Porphyrin to Corrole Ring Contraction and Formation of seco-Porphyrins [17].
  • If, however, two edge-sharing Ni(II) ions are removed from [Ni6] (one of these lies at a vertex of the open book and the other, on the book-cover line), we obtain a 4-nuclear fragment recorded in the molecular structure of 4 [18].

Anatomical context of nickel

  • In guinea-pig ventricular myocytes, we investigated inhibition of Na/Ca exchange by external Ni under phosphorylated (cells dialysed with cAMP) and non-phosphorylated conditions [19].
  • Nickel (Ni2+) enhancement of microtubule assembly in vitro is dependent on GTP function [20].
  • BACKGROUND AND OBJECTIVE: Nickel sulphate stimulates the proliferation of lymphocytes in nickel-allergic subjects [21].
  • While the other four implant materials were progressively encapsulated with bone tissues, Ni was encapsulated with connective tissues through the 168-day experimental period, and the Ni implants showed no bone contact at any time during the experimental period [22].
  • We have investigated the actions of Nickel (Ni(2+)) on a human cardiac potassium channel (hKv1.5), the main component of human atrial ultra-rapid delayed rectifier current, stably expressed in Chinese hamster ovary cell line using the whole-cell voltage-clamp technique [23].

Associations of nickel with other chemical compounds

  • A detailed characterization of previous exposure by job interviews, and for current exposure with personal air sampling and biological monitoring of chromium (Cr) and nickel (Ni) in blood and urine, was done for 32 of these welders [24].
  • We compared the cytotoxicity of soluble and particulate titanium (Ti), vanadium (V) and nickel (Ni) by biochemical functional analysis and by microscopic morphology with micro-area elemental analysis in vitro using human neutrophils as probes and in vivo in animals [25].
  • In this study we use a noninvasive method, electrical impedance (IMP), to compare nickel (Ni) allergic contact reactions with an irritant contact reaction induced by sodium lauryl sulfate, which has already been carefully evaluated with this method [26].
  • After T cell priming for 7 days, wells were split and challenged for another 7 days with Ni or HEMA, and potentially cross-reactive haptens [27].
  • By taking advantage of the consecutive histidine residues present at position 11 and 12 in VEGF, a novel method of purification using Nickel affinity chromatography was developed [28].

Gene context of nickel

  • OBJECTIVE: Nickel and cobalt ions activate ICAM1 expression on endothelial cells and keratinocytes [29].
  • The E. aerogenes acrA, acrB and tolC open reading frames were individually inserted in the expression vector pET24a(+), in frame with a sequence coding a C-terminal hexahistidine tag to allow purification by INAC (Immobilized Nickel Affinity Chromatography) [30].
  • This finding confirms the exclusion of GAA from 17q25----17qter reported by Nickel et al [31].
  • RESULTS: Nickel-stimulated PBMC of nickel-allergic patients with AD proliferated significantly less and secreted significantly lower amounts of IL-2 than cells of nonatopic nickel-allergic patients [32].
  • Combined with earlier results (Weil et al. 1979; Nickel et al. 1982; Honig et al. 1984), the gene for GAA can be assigned to 17q21.2----17q23 [33].

Analytical, diagnostic and therapeutic context of nickel

  • Here we show that 1- and 2-euro coins induce positive skin-test reactions in sensitized individuals and release 240-320-fold more nickel than is allowed under the European Union Nickel Directive [34].
  • Both proteins were synthesized with an aminoterminal tag of six histidines that could be used for purification by Nickel chelate affinity chromatography [35].
  • The halo. A spinal skeletal traction fixation device. By Vernon L. Nickel, Jacquelin Perry, Alice Garrett, and Malcolm Heppenstall, 1968 [36].
  • Poly (dG-dC) induced by carcinogenic or mutagenic Nickel compounds has been studied by ultraviolet absorbance and circular dichroïsm measurements [37].
  • The decrease in APD was significantly greater for the Ni++ group (11.8 +/- 14.3 msec) than for either the control group or rapid pacing group (both p < or = 0.023) [38].


  1. Selective interaction of Ni with an MHC-bound peptide. Romagnoli, P., Labhardt, A.M., Sinigaglia, F. EMBO J. (1991) [Pubmed]
  2. Tissue nickel levels and nickel dermatitis. I. Nickel in hair. Katz, S.A., Bowen, H.J., Comaish, J.S., Samitz, M.H. Br. J. Dermatol. (1975) [Pubmed]
  3. Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals. Masjedi, K., Ahlborg, N., Gruvberger, B., Bruze, M., Karlberg, A.T. Br. J. Dermatol. (2003) [Pubmed]
  4. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Kodavanti, U.P., Hauser, R., Christiani, D.C., Meng, Z.H., McGee, J., Ledbetter, A., Richards, J., Costa, D.L. Toxicol. Sci. (1998) [Pubmed]
  5. High-Level Resistance to Cobalt and Nickel but Probably No Transenvelope Efflux: Metal Resistance in the Cuban Serratia marcescens Strain C-1. Marrero, J., Auling, G., Coto, O., Nies, D.H. Microb. Ecol. (2007) [Pubmed]
  6. The predictive value of developmental testing of extremely jaundiced African infants. Wolf, M.J., Wolf, B., Bijleveld, C., Beunen, G., Casaer, P. Developmental medicine and child neurology. (1998) [Pubmed]
  7. The effect of divalent nickel (Ni2+) on in vitro DNA replication by DNA polymerase alpha. Chin, Y.E., Snow, E.T., Cohen, M.D., Christie, N.T. Cancer Res. (1994) [Pubmed]
  8. New aspects of murine coxsackie B3 myocarditis--focus on heavy metals. Ilbäck, N.G., Lindh, U., Fohlman, J., Friman, G. Eur. Heart J. (1995) [Pubmed]
  9. Synthesis of a novel ether-bridged GM3-lactone analogue as a target for an antibody-based cancer therapy. Tietze, L.F., Keim, H., Janssen, C.O., Tappertzhofen, C., Olschimke, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2000) [Pubmed]
  10. Efficient production of Clostridium botulinum exotoxin C3 in bacteria: a screening method to optimize production yields. Gadea, G., Boublik, Y., Delga, S., Roux, P. Protein Expr. Purif. (2005) [Pubmed]
  11. A historical prospective study of European stainless steel, mild steel, and shipyard welders. Simonato, L., Fletcher, A.C., Andersen, A., Anderson, K., Becker, N., Chang-Claude, J., Ferro, G., Gérin, M., Gray, C.N., Hansen, K.S. British journal of industrial medicine. (1991) [Pubmed]
  12. Occupational dermatoses among workers in a porcelain manufacturing factory. Gabal, M.S., Helmy, G.A., Faris, R. The Journal of the Egyptian Public Health Association (1994) [Pubmed]
  13. Effective treatment of seborrheic dermatitis using a low dose, oral homeopathic medication consisting of potassium bromide, sodium bromide, nickel sulfate, and sodium chloride in a double-blind, placebo-controlled study. Smith, S.A., Baker, A.E., Williams, J.H. Alternative medicine review : a journal of clinical therapeutic. (2002) [Pubmed]
  14. State-dependent nickel block of a high-voltage-activated neuronal calcium channel. McFarlane, M.B., Gilly, W.F. J. Neurophysiol. (1998) [Pubmed]
  15. Asymmetric synthesis of succinic semialdehyde derivatives. Lassaletta, J.M., Vázquez, J., Prieto, A., Fernández, R., Raabe, G., Enders, D. J. Org. Chem. (2003) [Pubmed]
  16. A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis. Malsam, J., Gommel, D., Wieland, F.T., Nickel, W. FEBS Lett. (1999) [Pubmed]
  17. Acylation of Nickel meso-Tetraarylporphyrins: Porphyrin to Corrole Ring Contraction and Formation of seco-Porphyrins. Jeandon, C., Ruppert, R., Callot, H.J. J. Org. Chem. (2006) [Pubmed]
  18. Synthesis, structure, and magnetic properties of (6-9)-nuclear Ni(II) trimethylacetates and their heterospin complexes with nitroxides. Ovcharenko, V., Fursova, E., Romanenko, G., Eremenko, I., Tretyakov, E., Ikorskii, V. Inorganic chemistry. (2006) [Pubmed]
  19. Inhibition of Na/Ca exchange by external Ni in guinea-pig ventricular myocytes at 37 degrees C, dialysed internally with cAMP-free and cAMP-containing solutions. Hinde, A.K., Perchenet, L., Hobai, I.A., Levi, A.J., Hancox, J.C. Cell Calcium (1999) [Pubmed]
  20. Nickel (Ni2+) enhancement of microtubule assembly in vitro is dependent on GTP function. Li, W., Zhao, Y., Gantz, D.L., Chou, I.N. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  21. Early DNA synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects. Falsafi-Amin, H., Lundeberg, L., Bakhiet, M., Nordlind, K. Int. Arch. Allergy Immunol. (2000) [Pubmed]
  22. Histomorphometric analysis of the response of rat tibiae to shape memory alloy (nitinol). Takeshita, F., Takata, H., Ayukawa, Y., Suetsugu, T. Biomaterials (1997) [Pubmed]
  23. External nickel blocks human Kv1.5 channels stably expressed in CHO cells. Perchenet, L., Clément-Chomienne, O. J. Membr. Biol. (2001) [Pubmed]
  24. Chromosome damage in lymphocytes of stainless steel welders related to past and current exposure to manual metal arc welding fumes. Jelmert, O., Hansteen, I.L., Langård, S. Mutat. Res. (1994) [Pubmed]
  25. Effects of Ti ions and particles on neutrophil function and morphology. Kumazawa, R., Watari, F., Takashi, N., Tanimura, Y., Uo, M., Totsuka, Y. Biomaterials (2002) [Pubmed]
  26. Electrical impedance as a potential tool to distinguish between allergic and irritant contact dermatitis. Nyrén, M., Kuzmina, N., Emtestam, L. J. Am. Acad. Dermatol. (2003) [Pubmed]
  27. Human T lymphocyte priming in vitro by haptenated autologous dendritic cells. Rustemeyer, T., De Ligter, S., Von Blomberg, B.M., Frosch, P.J., Scheper, R.J. Clin. Exp. Immunol. (1999) [Pubmed]
  28. A novel method to purify recombinant vascular endothelial growth factor (VEGF121) expressed in yeast. Mohanraj, D., Olson, T., Ramakrishnan, S. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  29. Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells. Messer, R.L., Wataha, J.C., Lewis, J.B., Lockwood, P.E., Caughman, G.B., Tseng, W.Y. Journal of long-term effects of medical implants. (2005) [Pubmed]
  30. Overexpression and purification of the three components of the Enterobacter aerogenes AcrA-AcrB-TolC multidrug efflux pump. Masi, M., Pagès, J.M., Pradel, E. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
  31. Confirmation of the regional localization of the genes for human acid alpha-glucosidase (GAA) and adenosine deaminase (ADA) by somatic cell hybridization. Honig, J., Martiniuk, F., D'Eustachio, P., Zamfirescu, C., Desnick, R., Hirschhorn, K., Hirschhorn, L.R., Hirschhorn, R. Ann. Hum. Genet. (1984) [Pubmed]
  32. Impaired responses of peripheral blood mononuclear cells to nickel in patients with nickel-allergic contact dermatitis and concomitant atopic dermatitis. Buchvald, D., Lundeberg, L. Br. J. Dermatol. (2004) [Pubmed]
  33. Further regional localization of the genes for human acid alpha glucosidase (GAA), peptidase D (PEPD), and alpha mannosidase B (MANB) by somatic cell hybridization. Martiniuk, F., Ellenbogen, A., Hirschhorn, K., Hirschhorn, R. Hum. Genet. (1985) [Pubmed]
  34. Metallurgy: high nickel release from 1- and 2-euro coins. Nestle, F.O., Speidel, H., Speidel, M.O. Nature (2002) [Pubmed]
  35. Bacterial expression and purification of hepatitis C virus capsid proteins of different size. Handschuh, G., Caselmann, W.H. J. Hepatol. (1995) [Pubmed]
  36. The halo. A spinal skeletal traction fixation device. By Vernon L. Nickel, Jacquelin Perry, Alice Garrett, and Malcolm Heppenstall, 1968. Nickel, V.L., Perry, J., Garrett, A., Heppenstall, M. Clin. Orthop. Relat. Res. (1989) [Pubmed]
  37. Spectroscopic studies of conformational transitions in double stranded DNAs in the presence of carcinogenic nickel compounds and an antitumoral drug (SOAZ). Liquier, J., Bourtayre, P., Pizzorni, L., Sournies, F., Labarre, J.F., Taillandier, E. Anticancer Res. (1984) [Pubmed]
  38. Atrial electrical remodeling by rapid pacing in the isolated rabbit heart: effects of Ca++ and K+ channel blockade. Wood, M.A., Caponi, D., Sykes, A.M., Wenger, E.J. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. (1998) [Pubmed]
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