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Chemical Compound Review

Isopaque     3-acetamido-5-(ethanoyl- methyl-amino)-2,4...

Synonyms: Triosil, Metrizoate, Isopaque 440, Metrizoic acid, CHEMBL1736, ...
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Disease relevance of Metrizoate


High impact information on Metrizoate


Chemical compound and disease context of Metrizoate


Biological context of Metrizoate


Anatomical context of Metrizoate

  • Renografin 76 injection into the left coronary artery produced a higher median T wave amplitude in lead II relative to Isopaque 370 only in the abnormal group (p = 0.01) [16].
  • A procedure is described for simultaneously removing red cells and dead cells from lymphoid cell suspensions, based on the observation that when populations of lymphoid cells are centrifuged on a mixture of Isopaque/Ficoll, dead cells and red cells sediment whereas viable cells float [19].
  • Monocytes were isolated from 300 to 360 ml of heparinized human blood using a Double Density technique employing Ficoll Isopaque and 46% iso-osmotic Percoll [20].
  • Almost pure eosinophils have been isolated from chicken bursa, spleen, thymus or blood using Ficoll metrizoate and Ficoll gradient (eosinophil p.c. 71.4-87.6) [21].
  • Peripheral blood neutrophils were purified by a two-step dextran sedimentation and metrizoate sodium Ficoll (Lymphoprep., Nyegaard, Oslo, Norway) centrifugation [22].

Associations of Metrizoate with other chemical compounds


Gene context of Metrizoate


Analytical, diagnostic and therapeutic context of Metrizoate


  1. Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog. Higgins, C.B., Schmidt, W. Circulation (1978) [Pubmed]
  2. Renal angiography with iohexol and metrizoate. Törnquist, C., Holtås, S. Radiology. (1984) [Pubmed]
  3. Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Comparison of normal humans and patients with Duchenne muscular dystrophy. Galbraith, D.A., Watts, D.C. Biochem. J. (1980) [Pubmed]
  4. Iohexol in phlebography of the leg. A comparative investigation with meglumine metrizoate. Gjølberg, T., Andrew, E., Enge, I. Investigative radiology. (1985) [Pubmed]
  5. Arrhythmogenic and cardiodepressive effects of contrast media on isolated rat atria. Refsum, H., Passwal, M. Investigative radiology. (1978) [Pubmed]
  6. Use of Ficoll-sodium metrizoate density gradient to separate human X-and Y-bearing spermatozoa. Shastry, P.R., Hegle, U.C., Rao, S.S. Nature (1977) [Pubmed]
  7. Changes in cell density induced by isopaque. Splinter, T.A., Beudeker, M., Van Beek, A. Exp. Cell Res. (1978) [Pubmed]
  8. Knee arthrography: a comparison of iohexol, ioxaglate sodium meglumine, and metrizoate. Obermann, W.R., Kieft, G.J. Radiology. (1987) [Pubmed]
  9. Postphlebographic thrombosis: a double-blind study with methylglucamine metrizoate and metrizamide. Laerum, F., Holm, H.A. Radiology. (1981) [Pubmed]
  10. Differential effects of sodium meglumine calcium metrizoate on the inotropic state of normal and ischemic myocardium. Als, A.V., Serur, J.R., LaRaia, P.J., Miner, N.C., Paulin, S. Radiology. (1978) [Pubmed]
  11. Comparative effects of three radiographic contrast agents in isolated normal and ischemic canine hearts. Serur, J.R., Als, A.V., Miner-Green, N., Paulin, S. Investigative radiology. (1980) [Pubmed]
  12. Purification of virions and nucleocapsids of herpes simplex virus by means of metrizamide and sodium metrizoate gradients. Blomberg, J., Björck, E., Olofsson, S., Berg, G., Lycke, E. Arch. Virol. (1976) [Pubmed]
  13. Cardiovascular and electrocardiographic effects of iopentol in left ventricular angiography. Comparison of the low-osmolar, non-ionic iopentol (Imagopaque 350) and the hyper-osmolar, ionic metrizoate meglumine-Na-Ca (Isopaque Coronar 370) in patients with coronary heart disease. Vik-Mo, H., Danielsen, R., Skinningsrud, K., Haider, T., Bjørkhaug, A. European radiology. (1997) [Pubmed]
  14. Coronary angiography with Iopamidol. Selin, K., Wallin, J., Björk, L. Acta radiologica: diagnosis. (1982) [Pubmed]
  15. Two new contrast media in coronary angiography. Selin, K., Björk, L. Acta radiologica: diagnosis. (1983) [Pubmed]
  16. Effects of the intracoronary and intraventricular injections of a commonly available vs. a newly available contrast medium. Baltaxe, H.A., Sos, T.A., McGrath, M.B. Investigative radiology. (1976) [Pubmed]
  17. Studies on the acute toxicity of ionic and non-ionic contrast media following rapid intravenous injection. An experimental study in mice. Aspelin, P., Almén, T. Investigative radiology. (1976) [Pubmed]
  18. Inflammatory synovial T cells in different activity subgroups of patients with rheumatoid arthritis and juvenile rheumatoid arthritis. Thoen, J., Waalen, K., Førre, O., Kvarnes, L., Natvig, J.B. Scand. J. Rheumatol. (1989) [Pubmed]
  19. A procedure for removing red cells and dead cells from lymphoid cell suspensions. Davidson, W.F., Parish, C.R. J. Immunol. Methods (1975) [Pubmed]
  20. Method for large scale isolation, culture and cryopreservation of human monocytes suitable for chemotaxis, cellular adhesion assays, macrophage and dendritic cell differentiation. Seager Danciger, J., Lutz, M., Hama, S., Cruz, D., Castrillo, A., Lazaro, J., Phillips, R., Premack, B., Berliner, J. J. Immunol. Methods (2004) [Pubmed]
  21. Isolation of chicken eosinophils and their migration response in chick embryos. Moriya, O., Ichikawa, Y. Dev. Comp. Immunol. (1982) [Pubmed]
  22. Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass. Kharazmi, A., Andersen, L.W., Baek, L., Valerius, N.H., Laub, M., Rasmussen, J.P. J. Thorac. Cardiovasc. Surg. (1989) [Pubmed]
  23. Cytostatic effects of radiographic contrast media in synchronized cell cultures. Nordby, A., Halgunset, J., Haugen, O.A. Investigative radiology. (1987) [Pubmed]
  24. Angiography with metrizamide. Animal experiments and preliminary clinical experiences. Almén, T. Acta radiologica. Supplementum. (1977) [Pubmed]
  25. In vivo fluorescence microscopy of microcirculation in the renal cortex of mice. Part II. Effects of mannitol and contrast media infusions. Högström, B., Rooth, P., Sunnegårdh, O., Hietala, S.O. Acta radiologica (Stockholm, Sweden : 1987) (1993) [Pubmed]
  26. Image quality and safety in pediatric urography using an ionic and a non-ionic iodinated contrast agent. Nybonde, T., Wahlgren, H., Brekke, O., Kristofferssen, D.T., Mortensson, W. Pediatric radiology. (1994) [Pubmed]
  27. Effects of iodixanol, iopentol, iohexol and metrizoate on femoral blood flow after injection into the femoral artery of the dog. Almén, T. Acta radiologica. Supplementum. (1987) [Pubmed]
  28. Demonstration of splenic and portal veins at routine celiac angiography. A clinical investigation of metrizoate and ioxaglate. Nilsson, P., Aspelin, P. Acta radiologica (Stockholm, Sweden : 1987) (1989) [Pubmed]
  29. Demonstration of the renal venous system at routine nephroangiography. A comparison between metrizoate, metrizamide and ioxaglate. Nilsson, P.E., Aspelin, P., Holtås, S. Acta radiologica: diagnosis. (1985) [Pubmed]
  30. Addition of local anesthetics to contrast media. I. Effects on patient discomfort and hemodynamics in aortofemoral angiography. Nilsson, P., Almén, T., Golman, K., Jonsson, K., Nyman, U. Acta radiologica (Stockholm, Sweden : 1987) (1987) [Pubmed]
  31. Alterations in T-lymphocyte subpopulations in type I diabetes. Exploration of genetic influence in identical twins. Johnston, C., Alviggi, L., Millward, B.A., Leslie, R.D., Pyke, D.A., Vergani, D. Diabetes (1988) [Pubmed]
  32. Subjective responses and albuminuria induced by ioxaglate during renal angiography in man. Nilsson, P.E., Holtås, S.L., Tejler, L.T. Radiology. (1982) [Pubmed]
  33. Detection and separation of lymphocytes with specific surface receptors, by using microparticles. Ljungsted, I., Ekman, B., Sjöholm, I. Biochem. J. (1978) [Pubmed]
  34. Pulmonary edema following high intravenous doses of ionic contrast media. Effect of the anion composition and concentration. Mare, K., Violante, M., Fischer, H.W. Investigative radiology. (1984) [Pubmed]
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