Disease relevance of Metrizoate

• During systemic hypocalcemia, the calcium metrizoate compound induced increases in LVPSP and dp/dt/LBP40 [1].
• Metrizoate affected renal function, as indicated both by a transient decrease in glomerular filtration rate and by a transient albuminuria [2].
• Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Comparison of normal humans and patients with Duchenne muscular dystrophy [3].
• Comparing iohexol 240 mg I/ml, iohexol 300 mg I/ml and meglumine-Ca metrizoate 200 mg I/ml in phlebography of the leg in patients on or without anticoagulants, no sign of postphlebographic thrombosis was found using the 125I-fibrinogen uptake test and repeat phlebography [4].
• The addition of the ionic contrast media to concentrations of 28 and 84 mg I/ml induced atrial arrhythmias in the following order of potency: meglumine iothalamate greater than meglumine--Na--Ca metrizoate greater than meglumine--Na diatrizoate [5].

High impact information on Metrizoate

• Use of Ficoll-sodium metrizoate density gradient to separate human X-and Y-bearing spermatozoa [6].
• Changes in cell density induced by isopaque [7].
• The arthrographic image quality and relative morbidity resulting from use of Omnipaque 300 (iohexol), Hexabrix 320 (ioxaglate sodium meglumine), and Isopaque Coronar 370 (metrizoate) were compared in a prospective double-blind study performed with 120 patients [8].
• A double-blind, randomized study was conducted in 170 patients to compare the effects of two hypertonic contrast media in phlebography of the leg: one was ionic [methylglucamine metrizoate (Isopaque Cerebral, 280 mg I/mI)] and the other nonionic [metrizamide (Amipaque, 280 mg I/mI)] [9].
• Sodium meglumine calcium metrizoate was injected into isolated blood-perfused canine hearts to evaluate the effect of contrast agents containing calcium on normal and ischemic myocardium [10].

Chemical compound and disease context of Metrizoate

• During ischemia, however, the positive inotropic effect of sodium meglumine calcium metrizoate was followed by a decrease in contractile force to 93 +/- 5% of baseline after 2 minutes [11].
• Purification of virions and nucleocapsids of herpes simplex virus by means of metrizamide and sodium metrizoate gradients [12].
• Cardiovascular and electrocardiographic effects of iopentol in left ventricular angiography. Comparison of the low-osmolar, non-ionic iopentol (Imagopaque 350) and the hyper-osmolar, ionic metrizoate meglumine-Na-Ca (Isopaque Coronar 370) in patients with coronary heart disease [13].
• Iopamidol caused significantly less bradycardia, less ECG changes and less fall in blood pressure than Isopaque Coronar [14].
• Amipaque, ioxaglic acid and Isopaque Coronar 300 were compared in a double blind investigation of coronary angiography in patients with ischemic heart disease [15].

Biological context of Metrizoate

• The heart rate dropped more severely in the normal patients when the left coronary artery was injected with Renografin 76 than with Isopaque 370 (p = 0.05) [16].
• Amipaque had a significantly higher LD50 than Isopaque Coronar (17.3 respectively 9.8 gm I/kg) [17].
• Both contrast media induced a biphasic change in left ventricular (LV) systolic pressure, with an initial fall followed by a prolonged rise, but the alterations were statistically significantly more pronounced with metrizoate than with iopentol [13].
• Cardiac output and heart rate increased more with metrizoate, while stroke volume was equally increased by both agents [13].
• The CD4/CD8 ratio just after enzyme treatment (stage I) was significantly higher than at later stages, i.e. after removal of adherent cells (stage II, p less than 0.05) and after Isopaque Ficoll gradient centrifugation (stage III, p less than 0.01) [18].

Anatomical context of Metrizoate

• Renografin 76 injection into the left coronary artery produced a higher median T wave amplitude in lead II relative to Isopaque 370 only in the abnormal group (p = 0.01) [16].
• A procedure is described for simultaneously removing red cells and dead cells from lymphoid cell suspensions, based on the observation that when populations of lymphoid cells are centrifuged on a mixture of Isopaque/Ficoll, dead cells and red cells sediment whereas viable cells float [19].
• Monocytes were isolated from 300 to 360 ml of heparinized human blood using a Double Density technique employing Ficoll Isopaque and 46% iso-osmotic Percoll [20].
• Almost pure eosinophils have been isolated from chicken bursa, spleen, thymus or blood using Ficoll metrizoate and Ficoll gradient (eosinophil p.c. 71.4-87.6) [21].
• Peripheral blood neutrophils were purified by a two-step dextran sedimentation and metrizoate sodium Ficoll (Lymphoprep., Nyegaard, Oslo, Norway) centrifugation [22].

Associations of Metrizoate with other chemical compounds

• The cytostatic effects of conventional high osmolal ionic contrast media (meglumine-calcium metrizoate and Na-metrizoate) and new low osmolal nonionic contrast media (iohexol and iopamidol) in synchronized cell cultures were tested [23].
• The non-ionic contrast medium metrizamide (Amipaque) was compared in animal experiments with diatrizoate, iothalamate and metrizoate [24].
• While the blood flow was increased in some capillaries it was to some extent simultaneously decreased in others, significantly more after infusion of metrizoate than after infusion of mannitol 0.3 mol/l [25].
• The safety and diagnostic efficacy of the new non-ionic, monomeric contrast medium iopentol (Imagopaque) were evaluated and compared with those of the ionic medium metrizoate (Isopaque), in urography in children in a randomized, double-blind, parallel study [26].
• The femoral blood flow was measured before, during and three min after random injection of iodixanol, iopentol, iohexol and metrizoate into the femoral arteries of 12 beagle dogs [27].

Gene context of Metrizoate

• Demonstration of splenic and portal veins at routine celiac angiography. A clinical investigation of metrizoate and ioxaglate [28].
• The renal veins and the inferior vena cava were significantly better and more often demonstrated when ioxaglate was used compared with metrizoate and metrizmide [29].
• Effects of equiosmolar solutions (osmolality 1.35 mol/kg) of the ratio 1.5 contrast medium metrizoate (250 mg I/ml) containing either the local anesthetic mepivacaine or saline were evaluated on subjective discomfort, aortic blood pressure and heart rate in 17 patients referred for aortofemoral angiography due to intermittent claudication [30].

Analytical, diagnostic and therapeutic context of Metrizoate

• Subsets were assessed by monoclonal antibodies and a pure preparation of peripheral blood mononuclear cells obtained by centrifugation of heparinized whole blood with a Ficoll/Triosil gradient [31].
• The degree of pain/heat sensation following semiselective renal arteriography with metrizoate and ioxaglate was also compared using a visual analog scale in 34 patients [32].
• The cell-particle complexes could be separated from cells that had not reacted by density-gradient centrifugation in Ficoll/metrizoate [33].
• Two contrast media (Renografin 76 and Isopaque 370) were used in a double-blind study for coronary angiography and left ventriculography [16].
• In this study, meglumine salts of diatrizoate, iothalamate, and metrizoate were evaluated for their capacity to induce pulmonary edema following intravenous injections [34].

References