Disease relevance of uric acid

• To determine whether this is a reflection of the physiological contribution of ONOO(-) to an immune response against a neurotropic pathogen, we have assessed the effects on adult rats acutely infected with Borna disease virus (BDV) of administration of uric acid (UA), an inhibitor of select chemical reactions associated with ONOO(-) [1].
• In summary, TH, AOPP, Hx, Xa, and UA production is increased in fetal blood during hypoxia [2].
• Hyperuricemia was defined as serum UA levels >or= 420 micromol/l in men and >or= 360 micromol/l in women [3].
• For the entire cohort with severe pulmonary hypertension (n = 191), there was a positive correlation between the natural logarithm of the serum UA (lnUA) and the mean right atrial pressure (RAP; r = 0.47; p < 0.001) [4].
• Addition of UA to both sera abolished the difference in cell viability, and toxicity of ACC serum reached that of CON [5].

Psychiatry related information on uric acid

• Body mass index and serum triglycerides had the strongest associations with serum UA in both genders, followed by alcohol drinking and diastolic blood pressure in men, and systolic blood pressure and total cholesterol in women [3].

High impact information on uric acid

• UA treatment inhibited the onset of clinical disease, and prevented the elevated blood-brain barrier permeability as well as CNS inflammation seen in control-treated BDV-infected rats [1].
• With the removable cannula system, only a smaller, transient increase in UA during the first 3 days after surgery was observed, with no change in DA or monoamine metabolites [6].
• Amounts of Asc and GSH in neoplastic tissue correlated closely with DNA values and percentage of epithelium, those of Cys not so closely and those of UA not at all [7].
• RESULTS: Wave speed, wave impedance, dynamic mechanical properties and microhardness of EDTA treated COM stones and tromethamine treated UA stones were found to decrease compared to untreated (synthetic urine) control groups [8].
• Higher Hx, Xa, UA, TH, and AOPP levels were found in hypoxic newborn infants than in controls [2].

Chemical compound and disease context of uric acid

• Age- and sex-adjusted relative risks for the development of hypertension by quartiles of BMI, serum UA, TG, and the sum of insulin values (sigmainsulin) during a glucose load were highest in highest quartile of the distribution [9].
• This study examined the interactions and plasma levels of xanthine oxidase (XO) and uric acid (UA), catalase (CAT) and liver function parameters GOT, GPT and bilirubin in asymptomatic (n=20), uncomplicated (n=32), and severe (n=18) falciparum malaria children aged 3-13 years [10].
• We conclude that in the right clinical setting, high free water intake and low serum urea and UA favor acute hyponatremia [11].

Biological context of uric acid

• Fasting serum uric acid (UA) and lipid profiles were determined, as well as height, weight, and blood pressure [3].
• A significant circadian rhythm in UA (p = 0.001) and NO (p = 0.048) was evident in ND but not in D (p = 0.214 and 0.065) [12].
• Unexpectedly, lipid peroxidation did not correlate to TAC, neither to sCr or UA [13].
• Our results suggest that elevated TAC in uraemia is likely to be dependent on increased UA levels and does not seem to induce an effective protection in vivo from oxidative stress [13].

Anatomical context of uric acid

• The elderly subjects had lower erythrocyte GSH-Px activity (15.7 +/- 4.8 vs 20.2 +/- 7.0 U/g Hb, p < 0.001; mean +/- SD) and plasma UA levels (192 +/- 46 vs 240 +/- 54 mmol/L, p < 0.001), but higher MDA levels (5.3 +/- 0.8 vs 4.1 +/- 0.8 mmol/L, p < 0.001) than the young subjects [14].
• We conclude that, in terms of tolerance and mobilization of CD34+ cells and leukocytes, G-CSF is superior to GM-CSF, but higher levels of UA and LDH and late decrease in platelets make monitoring of these parameters necessary [15].
• The LMWA concentrations were decreasing from urothelium to serosa except of UA [16].
• Salivary gland function was assessed by sialometric and biochemistry means, which included measuring total protein, secretory IgA (SIgA) and the antioxidants peroxidase, uric acid (UA), and total antioxidant status (TAS) in the collected saliva [17].
• A 64-year-old man with alcoholic liver cirrhosis had a progressive decrease in the serum uric acid (UA) until it became undetectable, an increase renal UA clearance, mild glycosuria with normal serum glucose and a decrease in the tubular reabsorption of phosphate in association with cholestasis secondary to a gallbladder carcinoma [18].

Associations of uric acid with other chemical compounds

• This study is a field test of methods for the analysis of 11 metabolic variables in capillary serum [glucose (GLUC), uric acid (UA), total, free and esterified cholesterol (TC, C, CE), triacylglycerols (TG), phosphatidylethanolamine (PE), phosphatidylcholine (PC); beta-, pre-beta- and alpha-lipoproteins (LPs)] [19].
• At 10 min reperfusion, local blood glutathione and UA peaked at 7.08 +/- 0.46 mumol.ml-1 and 4.67 +/- 0.26 mumol.ml-1, respectively, while the other metabolites decreased significantly toward pretourniquet levels [20].
• Some patients with PPH had serum UA measurements repeated during treatment with chronic IV prostacyclin infusion [4].
• Body mass index (BMI), blood pressure (BP), serum total cholesterol (TC), triglycerides (TG), uric acid (UA), and glucose and insulin responses at baseline, 1 h, and 2 h after a glucose load were analyzed [9].
• In fasting blood and urine samples the following quantities were estimated: s-alkaline phosphatase (AP), s-bilirubin (Bil), s-creatinine (Cre), s-uric acid (UA), haemoglobin (Hb), haematocrit (Hct), mean cell haemoglobin content (MCHC), erythrocyte sedimentation rate (ESR) and urine specific gravity (USG) [21].

Gene context of uric acid

• The SOD, CAT, GSHPx and UA levels were measured in plasma and saliva in study and control groups [22].
• CONCLUSION: One fourth of patients with SARS developed hypouricemia, which might result from a defect in renal UA handling and was associated with a high serum IL-8 level [23].
• CONCLUSION: There is a positive correlation between the RAP elevation and the serum UA levels in patients with PPH [4].
• Plasma UA and AA levels were used to assess the impact of the RTE on the peripheral antioxidant pool [24].
• In addition, serum UA was significantly correlated to serum TAS and probably accounted for much of the antioxidant activity observed [25].

Analytical, diagnostic and therapeutic context of uric acid

• CONCLUSIONS: A long-term vegetarian diet is associated with markedly higher fasting plasma AA concentrations and lower concentrations of TAG, UA, and hsCRP [26].
• We conclude that the tumor burden is the single most important prognostic factor in Burkitt's lymphoma, and that this is reflected directly by LDH and UA concentrations, and probably indirectly by anti-EA titer [27].
• The following antioxidant profile was examined both in saliva and lavage of the patients: total antioxidant status (TAS), uric acid (UA), peroxidase and super oxide dismutase (SOD) [28].

References