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Gene Review

Ppr1  -  plasma protein 1

Mus musculus

Synonyms: P60, Ppr-1, protein P60
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Disease relevance of Ppr1


Psychiatry related information on Ppr1

  • Experiments were performed at different postnatal ages: postnatal day 12 (P12), before eye opening; P24, corresponding roughly to the peak of the critical period for monocular deprivation, and P60, after the end of the critical period [6].

High impact information on Ppr1


Chemical compound and disease context of Ppr1

  • RESULTS: Plasma of women with pre-eclampsia, and interestingly, plasma of non-pregnant women, significantly enhanced myogenic tone at pressures > or =70 mmHg (P < 0.001) and blunted the maximum relaxation to methacholine (P < 0.001; P < 0.005) in isolated arteries [12].

Biological context of Ppr1


Anatomical context of Ppr1


Associations of Ppr1 with chemical compounds

  • RESULTS: Plasma glucose and insulin concentrations under basal and hyperinsulinaemic conditions were similar in MTII- and placebo-treated mice [22].
  • RESULTS: Plasma corticosterone concentrations were dose dependently elevated by flesinoxan in wild type mice but not in knockout mice [23].
  • RESULTS: Plasma elimination studies in mice indicated that the drug:drug ratio before injection [4:1 doxorubicin:vincristine (wt:wt ratio)] changed to 20:1 at the 24-h time point, indicative of more rapid release of vincristine from the liposomes than doxorubicin [24].
  • EXPERIMENTAL DESIGN: Plasma from a NHL patient treated with Lym-1 was precipitated with ammonium sulfate and octanoic acid, followed by immunoadsorbant chromatography with solid phase Lym-1 monoclonal antibody to purify Ab2 [25].
  • Both Tr and Pmp22tg mice show strongly reduced expression of genes important for cholesterol synthesis at P4, a characteristic that is common to all three mutants at P60 [26].

Regulatory relationships of Ppr1

  • RESULTS: Plasma from these transgenic mice was capable of blocking PDGF-induced receptor autophosphorylation in tissue culture [27].
  • CONCLUSIONS: Plasma CETP is posttranscriptionally downregulated in the lcat(-/-) mice, presumably by its extremely low HDL [28].
  • RESULTS: Plasma total homocysteine was elevated with the high-methionine diet compared with the control diet for both Cbs+/+ (7.9+/-1.0 versus 5.0+/-0.5 micromol/L; P<0.05) and Cbs+/- (20.5+/-3.1 versus 8.2+/-0.9 micromol/L; P<0.001) mice [29].

Other interactions of Ppr1

  • RESEARCH METHODS AND PROCEDURES: Plasma resistin, adiponectin, and leptin levels were examined in mice fed ad libitum, a 75% restricted diet, or a diet supplemented with 10% sucrose [30].
  • METHODS: Plasma membranes were isolated from male wild-type (+/+) and mdr2 (-/-) mice for measurement of Na+-dependent taurocholate transport and assessment of Ntcp protein levels by Western blotting [31].
  • On day 3, the ameliorative effects of CCR2 knockout were not observed; the increase in the urinary protein/creatinine ratio was similar in nephritic CCR2 wild-type (92 +/- 11.2) and knockout mice (102 +/- 9. 2). Plasma markers of disease were evaluated on days 4 and 7 [32].
  • METHODS: Plasma corticosterone levels were determined in wild-type and p55-deficient mice that received systemic treatments with TNF-alpha and LPS, as well as exposure to auditory and restraint stressors [33].
  • BACKGROUND: Plasma activity of semicarbazide-sensitive amine oxidase (SSAO) has been reported to be significantly higher in diabetic patients compared to healthy controls [34].

Analytical, diagnostic and therapeutic context of Ppr1

  • METHODS: Plasma samples from lupus-prone (MRL/lpr and MRL/+) and control (CBA, Swiss, and BALB/c) mice were tested in enzyme-linked immunosorbent assays for the presence of nucleosomes, antinucleosome antibodies, and nucleosome-Ig complexes [35].
  • METHODS: Plasma membrane potential and ion currents were measured with microelectrodes and the patch-clamp technique [36].
  • RESULTS: Plasma ADMA and SDMA concentrations in members of the hypertensive group [0.23 +/- 0.03 and 1.37 +/- 0.06 micromol/l, respectively (means +/- SEM)] were significantly higher than those in members of the control group (ADMA 0.10 +/- 0.01 micromol/l and SDMA 1.18 +/- 0.06 micromol/l) [37].
  • Retinal ganglion cells at ages P6 and P60 were purified by immunopanning, total RNA was extracted, and mRNA levels of the above proteins were determined by semiquantitative PCR [38].
  • Embryos on embryonic day (E)10.5, E12.5, E15.5, and E18.5 and eyes from mice on postnatal day (P)0, P7, P11, P15, P30, and P60 were collected for immunofluorescence staining [39].


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  20. The p75 neurotrophin receptor appears in plasma in diabetic rats-characterisation of a potential early test for neuropathy. Chilton, L., Middlemas, A., Gardiner, N., Tomlinson, D.R. Diabetologia (2004) [Pubmed]
  21. Oscillations of membrane potential and cytosolic Ca(2+) concentration in SUR1(-/-) beta cells. Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., Drews, G. Diabetologia (2004) [Pubmed]
  22. Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Heijboer, A.C., van den Hoek, A.M., Pijl, H., Voshol, P.J., Havekes, L.M., Romijn, J.A., Corssmit, E.P. Diabetologia (2005) [Pubmed]
  23. Stress-induced hyperthermia in the 5-HT(1A) receptor knockout mouse is normal. Pattij, T., Hijzen, T.H., Groenink, L., Oosting, R.S., van der Gugten, J., Maes, R.A., Hen, R., Olivier, B. Biol. Psychiatry (2001) [Pubmed]
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  26. Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point mutation. Giambonini-Brugnoli, G., Buchstaller, J., Sommer, L., Suter, U., Mantei, N. Neurobiol. Dis. (2005) [Pubmed]
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  34. Semicarbazide-sensitive amine oxidase (SSAO) gene expression in alloxan-induced diabetes in mice. Nordquist, J.E., Göktürk, C., Oreland, L. Mol. Med. (2002) [Pubmed]
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