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Gene Review

Cel  -  carboxyl ester lipase

Rattus norvegicus

Synonyms: BAL, BSSL, Bal, Bile salt-activated lipase, Bile salt-stimulated lipase, ...
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Disease relevance of Cel


High impact information on Cel

  • Experiments performed in vivo with hypophysectomized female rats indicate that the trypsin digest of 16k fragment stimulates cholesterol ester hydrolase (cholesterol esterase; sterol-ester acylhydrolase, EC activity in the adrenal cortex but fails to activate cholesterol side-chain cleavage [6].
  • In contrast, the R63A and R423A mutant enzymes displayed 5- and 11-fold decreases in k(cat), in comparison with wild type CEL, for bile salt-dependent cholesteryl ester hydrolysis [7].
  • However, the x-ray crystal structure of CEL failed to show the involvement of arginine residues in CEL-bile salt interaction [7].
  • Although taurocholate induced similar changes in circular dichroism spectra for wild type, R63A, and R423G proteins, this bile salt was less efficient in protecting the mutant enzymes against thermal inactivation in comparison with control CEL [7].
  • Mutations of Arg(63) to Ala(63) (R63A) and Arg(423) to Gly(423) (R423G) resulted in enzymes with increased bile salt-independent hydrolytic activity against lysophosphatidylcholine, having 6.5- and 2-fold higher k(cat) values, respectively, in comparison to wild type CEL [7].

Chemical compound and disease context of Cel


Biological context of Cel


Anatomical context of Cel


Associations of Cel with chemical compounds


Regulatory relationships of Cel


Other interactions of Cel


Analytical, diagnostic and therapeutic context of Cel


  1. Hemodynamic effects on aortic enzyme activities in spontaneously hypertensive rats. Tomita, T., Shirasaki, Y., Takiguchi, Y., Ozaki, Y., Hayashi, E. Atherosclerosis (1980) [Pubmed]
  2. Chelation of cadmium from metallothionein in vivo and its excretion in rats repeatedly injected with cadmium chloride. Cherian, M.G., Rodgers, K. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  3. Characterization of amiodarone pneumonitis as related to inflammatory cells and surfactant apoprotein. Nagata, N., Suematsu, R., Yoshii, C., Miyazaki, H., Sueishi, K., Kido, M. Chest (1997) [Pubmed]
  4. Cholesterol metabolism in rat adrenal gland during reversible endotoxic shock. Abarca, S., García, R. Eur. J. Biochem. (1993) [Pubmed]
  5. Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits. Inns, R.H., Rice, P., Bright, J.E., Marrs, T.C. Human & experimental toxicology. (1990) [Pubmed]
  6. Adrenocortical response to corticotropin is potentiated by part of the amino-terminal region of pro-corticotropin/endorphin. Pedersen, R.C., Brownie, A.C. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  7. Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase. Liang, Y., Medhekar, R., Brockman, H.L., Quinn, D.M., Hui, D.Y. J. Biol. Chem. (2000) [Pubmed]
  8. Aortic cholesterol esterase and other lysosomal enzyme activities in DOCA-salt, renal and spontaneous hypertension in the rat. Tomita, T., Shirasaki, Y., Takiguchi, Y., Okada, T., Hayashi, E. Atherosclerosis (1981) [Pubmed]
  9. Development of a therapeutic procedure for bismuth intoxication with chelating agents. Slikkerveer, A., Jong, H.B., Helmich, R.B., de Wolff, F.A. J. Lab. Clin. Med. (1992) [Pubmed]
  10. Regions of the haptoglobin 5' flanking gene sequence show different binding affinities to nuclear matrix proteins during the acute phase response. Poznanovic, G., Grujic, V., Ivanovic-Matic, S., Sevaljevic, L. J. Biochem. (1994) [Pubmed]
  11. Identification of the active site serine in pancreatic cholesterol esterase by chemical modification and site-specific mutagenesis. DiPersio, L.P., Fontaine, R.N., Hui, D.Y. J. Biol. Chem. (1990) [Pubmed]
  12. Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase. DiPersio, L.P., Fontaine, R.N., Hui, D.Y. J. Biol. Chem. (1991) [Pubmed]
  13. Structure of the rat pancreatic cholesterol esterase gene. Fontaine, R.N., Carter, C.P., Hui, D.Y. Biochemistry (1991) [Pubmed]
  14. The influence of estradiol on cholesterol processing by the corpus luteum. Azhar, S., Khan, I., Gibori, G. Biol. Reprod. (1989) [Pubmed]
  15. Effects of tocopherol deficiency on lipid metabolism in the arterial wall of rats on normal and high cholesterol diets. Shirai, K., Matsuoka, N., Morisaki, N., Murano, S., Sasaki, N., Shinomiya, M., Saito, Y., Kumagai, A., Mizobuchi, M. Artery (1980) [Pubmed]
  16. Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase. Kissel, J.A., Fontaine, R.N., Turck, C.W., Brockman, H.L., Hui, D.Y. Biochim. Biophys. Acta (1989) [Pubmed]
  17. Studies on intestinal absorption by single-injection technique and continuous measurement of portal vein blood electrolyte concentration and hematocrit in the alert rat. Aziz, O., Sommer, E. Zeitschrift für Gastroenterologie. (1983) [Pubmed]
  18. Cholesterol esterase biosynthesis in rat pancreatic AR42J cells. Post-transcriptional activation by gastric hormones. Huang, Y., Hui, D.Y. J. Biol. Chem. (1991) [Pubmed]
  19. Amylin mobilizes [Ca2+]i and stimulates the release of pancreatic digestive enzymes from rat acinar AR42J cells: evidence for an exclusive receptor system of amylin. Huang, Y., Fischer, J.E., Balasubramaniam, A. Peptides (1996) [Pubmed]
  20. Linkage mapping of the carboxyl ester lipase gene (Cel) to rat chromosome 3. Pravenec, M., Kren, V., Wang, J., Bottger, A., van Zutphen, L.F., Kurtz, T.W. Mamm. Genome (1996) [Pubmed]
  21. Cholesterol absorption in rat intestine: role of cholesterol esterase and acyl coenzyme A:cholesterol acyltransferase. Gallo, L.L., Clark, S.B., Myers, S., Vahouny, G.V. J. Lipid Res. (1984) [Pubmed]
  22. Dietary regulation of cholesterol esterase mRNA level in rat pancreas. Brodt-Eppley, J., Hui, D.Y. J. Lipid Res. (1994) [Pubmed]
  23. A critical perspective of the use of (13)C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism. Des Rosiers, C., Lloyd, S., Comte, B., Chatham, J.C. Metab. Eng. (2004) [Pubmed]
  24. Increased activity of intestinal acyl-CoA: cholesterol acyltransferase in rats with streptozocin-induced diabetes and restoration by insulin supplementation. Jiao, S., Matsuzawa, Y., Matsubara, K., Kihara, S., Nakamura, T., Tokunaga, K., Kubo, M., Tarui, S. Diabetes (1988) [Pubmed]
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