Gene Review:
PRKAA2 - protein kinase, AMP-activated, alpha 2...
Homo sapiens
Synonyms:
5'-AMP-activated protein kinase catalytic subunit alpha-2, ACACA kinase, AMPK, AMPK subunit alpha-2, AMPK2, ...
- Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. Yun, H., Lee, M., Kim, S.S., Ha, J. J. Biol. Chem. (2005)
- Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. Brusq, J.M., Ancellin, N., Grondin, P., Guillard, R., Martin, S., Saintillan, Y., Issandou, M. J. Lipid Res. (2006)
- AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma. Neurath, K.M., Keough, M.P., Mikkelsen, T., Claffey, K.P. Glia (2006)
- Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Ahmad, F., Arad, M., Musi, N., He, H., Wolf, C., Branco, D., Perez-Atayde, A.R., Stapleton, D., Bali, D., Xing, Y., Tian, R., Goodyear, L.J., Berul, C.I., Ingwall, J.S., Seidman, C.E., Seidman, J.G. Circulation (2005)
- Sequential changes in the signal transduction responses of skeletal muscle following food deprivation. de Lange, P., Farina, P., Moreno, M., Ragni, M., Lombardi, A., Silvestri, E., Burrone, L., Lanni, A., Goglia, F. FASEB J. (2006)
- Role of hypothalamic 5'-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. Kim, M.S., Lee, K.U. J. Mol. Med. (2005)
- Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. Alba, G., El Bekay, R., Alvarez-Maqueda, M., Chacón, P., Vega, A., Monteseirín, J., Santa María, C., Pintado, E., Bedoya, F.J., Bartrons, R., Sobrino, F. FEBS Lett. (2004)
- Skeletal muscle lipid metabolism in exercise and insulin resistance. Kiens, B. Physiol. Rev. (2006)
- TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth. Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., Wang, C.Y., He, X., Macdougald, O.A., You, M., Williams, B.O., Guan, K.L. Cell (2006)
- The hyperleptinemia of obesity-regulator of caloric surpluses. Unger, R.H. Cell (2004)
- TSC2 mediates cellular energy response to control cell growth and survival. Inoki, K., Zhu, T., Guan, K.L. Cell (2003)
- AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K., Herscovitz, H., Brecher, P., Ruderman, N.B., Cohen, R.A. J. Biol. Chem. (2004)
- AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. Xue, B., Kahn, B.B. J. Physiol. (Lond.) (2006)
- Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation. Jing, M., Ismail-Beigi, F. Am. J. Physiol., Cell Physiol. (2007)
- Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase. Jaswal, J.S., Gandhi, M., Finegan, B.A., Dyck, J.R., Clanachan, A.S. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Hwang, J.T., Ha, J., Park, I.J., Lee, S.K., Baik, H.W., Kim, Y.M., Park, O.J. Cancer Lett. (2007)
- Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB1 with type 2 diabetes. Sun, M.W., Lee, J.Y., de Bakker, P.I., Burtt, N.P., Almgren, P., Råstam, L., Tuomi, T., Gaudet, D., Daly, M.J., Hirschhorn, J.N., Altshuler, D., Groop, L., Florez, J.C. Diabetes (2006)
- AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. Spencer-Jones, N.J., Ge, D., Snieder, H., Perks, U., Swaminathan, R., Spector, T.D., Carter, N.D., O'Dell, S.D. J. Med. Genet. (2006)
- AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. Rencurel, F., Stenhouse, A., Hawley, S.A., Friedberg, T., Hardie, D.G., Sutherland, C., Wolf, C.R. J. Biol. Chem. (2005)
- Activation of Lipoprotein Lipase by Glucose-dependent Insulinotropic Polypeptide in Adipocytes: A ROLE FOR A PROTEIN KINASE B, LKB1, AND AMP-ACTIVATED PROTEIN KINASE CASCADE. Kim, S.J., Nian, C., McIntosh, C.H. J. Biol. Chem. (2007)
- Adenosine 5'-Monophosphate Kinase-Activated Protein Kinase (PRKA) Activators Delay Meiotic Resumption in Porcine Oocytes. Mayes, M.A., Laforest, M.F., Guillemette, C., Gilchrist, R.B., Richard, F.J. Biol. Reprod. (2007)
- Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. Carey, A.L., Steinberg, G.R., Macaulay, S.L., Thomas, W.G., Holmes, A.G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M.J., James, D.E., Kemp, B.E., Pedersen, B.K., Febbraio, M.A. Diabetes (2006)
- Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. Hallows, K.R., McCane, J.E., Kemp, B.E., Witters, L.A., Foskett, J.K. J. Biol. Chem. (2003)
- Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. Browne, G.J., Finn, S.G., Proud, C.G. J. Biol. Chem. (2004)
- Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. Steinberg, G.R., Watt, M.J., Fam, B.C., Proietto, J., Andrikopoulos, S., Allen, A.M., Febbraio, M.A., Kemp, B.E. Endocrinology (2006)
- Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36. Lang, T., Yu, L., Tu, Q., Jiang, J., Chen, Z., Xin, Y., Liu, G., Zhao, S. Genomics (2000)
- Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells. Lee, Y.M., Lee, J.O., Jung, J.H., Kim, J.H., Park, S.H., Park, J.M., Kim, E.K., Suh, P.G., Kim, H.S. J. Biol. Chem. (2008)
- Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise. Roepstorff, C., Vistisen, B., Donsmark, M., Nielsen, J.N., Galbo, H., Green, K.A., Hardie, D.G., Wojtaszewski, J.F., Richter, E.A., Kiens, B. J. Physiol. (Lond.) (2004)
- Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Wojtaszewski, J.F., Mourtzakis, M., Hillig, T., Saltin, B., Pilegaard, H. Biochem. Biophys. Res. Commun. (2002)
- Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. Watt, M.J., Steinberg, G.R., Chan, S., Garnham, A., Kemp, B.E., Febbraio, M.A. FASEB J. (2004)
- A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Shindo, S., Numazawa, S., Yoshida, T. Biochem. J. (2007)
- Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. Levine, Y.C., Li, G.K., Michel, T. J. Biol. Chem. (2007)
- AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. Kudchodkar, S.B., Del Prete, G.Q., Maguire, T.G., Alwine, J.C. J. Virol. (2007)
- Exercise increases nuclear AMPK alpha2 in human skeletal muscle. McGee, S.L., Howlett, K.F., Starkie, R.L., Cameron-Smith, D., Kemp, B.E., Hargreaves, M. Diabetes (2003)
- Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. Aguan, K., Scott, J., See, C.G., Sarkar, N.H. Gene (1994)
- The bovine 5' AMPK gene family: mapping and single nucleotide polymorphism detection. McKay, S.D., White, S.N., Kata, S.R., Loan, R., Womack, J.E. Mamm. Genome (2003)
- Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. Beri, R.K., Marley, A.E., See, C.G., Sopwith, W.F., Aguan, K., Carling, D., Scott, J., Carey, F. FEBS Lett. (1994)