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Gene Review

Stc1  -  stanniocalcin 1

Mus musculus

Synonyms: STC-1, Stanniocalcin-1, Stc
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Disease relevance of Stc1

  • STC has also been linked to cancer, pregnancy, lactation, angiogenesis, organogenesis, cerebral ischemia, and hypertonic stress [1].
  • Neoplastic adipocytes in well-differentiated liposarcomas also stained for STC-1, while the frequency of STC-1-positive cells was lower in high-grade liposarcomas [2].
  • Interestingly, STC1 and STC2 are expressed in many tumor cell lines, and the expression of STC2 is enhanced by estradiol in breast cancer cells [3].
  • STC did not increase cAMP in ROS 17/2.8 or UMR-108 osteosarcoma cells, OK kidney cells, fetal rat limb bones, or neonatal mouse calvariae, and similarly failed to increase urinary cAMP in rats [4].
  • After pertussis toxin treatment (200 ng/ml; 5 h), the peptone- and cephalexin-induced CCK secretion was significantly reduced, suggesting the involvement of pertussis toxin-sensitive heterotrimeric G protein(s) in the secretory activity of STC-1 cells [5].

Psychiatry related information on Stc1


High impact information on Stc1


Chemical compound and disease context of Stc1


Biological context of Stc1

  • Since then, STC homologs have been identified in various genomes including human, mouse, rat, Xenopus and zebrafish [10].
  • Upregulated expression of stanniocalcin-1 during adipogenesis [2].
  • Untreated 3T3-L1 cells displayed negligible amounts of STC-1, whereas 3T3-L1 cells, treated with an adipogenic cocktail, upregulated the expression of STC-1 concomitantly with acquisition of the adipocytic phenotype [2].
  • We have also shown that expression of STC-1 confers increased resistance to hypoxic and oxidative stress in neurons [2].
  • The kinetics of STC-1 expression during adipogenesis was investigated in 3T3-LI cells, which can be induced to adipocyte differentiation [2].

Anatomical context of Stc1

  • In this report we have characterized the STC receptor and the functional targeting of ligand and receptor to mitochondria [1].
  • Given this, our findings suggest that STC-1, also in terminally differentiated adipocytes, may function as a "survival factor", which contributes to the maintenance of the integrity of mature adipose tissue [2].
  • We have previously reported a high expression of STC-1 in postmitotically differentiated neurons and megakaryocytes [2].
  • Our results indicate that STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis through effects on osteoblasts, osteoclasts, myoblasts/myocytes, and endothelial cells [11].
  • Consequently, STC may act as a signaling molecule between the thecal-interstitial cell compartment and the corpus luteum and oocyte, thereby regulating the activity of these structures in some way [12].

Associations of Stc1 with chemical compounds


Physical interactions of Stc1

  • Electromobility shift assays using STC-1 nuclear extracts demonstrated the specific binding of PDX-1 protein to a specific regulatory region in the GIP promoter [14].

Regulatory relationships of Stc1


Other interactions of Stc1


Analytical, diagnostic and therapeutic context of Stc1


  1. Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. McCudden, C.R., James, K.A., Hasilo, C., Wagner, G.F. J. Biol. Chem. (2002) [Pubmed]
  2. Upregulated expression of stanniocalcin-1 during adipogenesis. Serlachius, M., Andersson, L.C. Exp. Cell Res. (2004) [Pubmed]
  3. Prospect of a stanniocalcin endocrine/paracrine system in mammals. Ishibashi, K., Imai, M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  4. Salmon stanniocalcin and bovine parathyroid hormone have dissimilar actions on mammalian bone. Stern, P.H., Shankar, G., Fargher, R.C., Copp, D.H., Milliken, C.E., Sato, K.J., Goltzman, D., Herrmann-Erlee, M.P. J. Bone Miner. Res. (1991) [Pubmed]
  5. Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells. Némoz-Gaillard, E., Bernard, C., Abello, J., Cordier-Bussat, M., Chayvialle, J.A., Cuber, J.C. Endocrinology (1998) [Pubmed]
  6. Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth. Zaidi, D., James, K.A., Wagner, G.F. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  7. The murine stanniocalcin 1 gene is not essential for growth and development. Chang, A.C., Cha, J., Koentgen, F., Reddel, R.R. Mol. Cell. Biol. (2005) [Pubmed]
  8. Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion. Palazzo, M., Balsari, A., Rossini, A., Selleri, S., Calcaterra, C., Gariboldi, S., Zanobbio, L., Arnaboldi, F., Shirai, Y.F., Serrao, G., Rumio, C. J. Immunol. (2007) [Pubmed]
  9. Effects of dibutyryl cAMP on stanniocalcin and stanniocalcin-related protein mRNA expression in neuroblastoma cells. Wong, C.K., Yeung, H.Y., Mak, N.K., DiMattia, G.E., Chan, D.K., Wagner, G.F. J. Endocrinol. (2002) [Pubmed]
  10. Avian stanniocalcin-2 is expressed in developing striated muscle and joints. Mittapalli, V.R., Pr??ls, F., Huang, R., Christ, B., Scaal, M. Anat. Embryol. (2006) [Pubmed]
  11. Stanniocalcin 1 alters muscle and bone structure and function in transgenic mice. Filvaroff, E.H., Guillet, S., Zlot, C., Bao, M., Ingle, G., Steinmetz, H., Hoeffel, J., Bunting, S., Ross, J., Carano, R.A., Powell-Braxton, L., Wagner, G.F., Eckert, R., Gerritsen, M.E., French, D.M. Endocrinology (2002) [Pubmed]
  12. Comparative analysis of mammalian stanniocalcin genes. Varghese, R., Wong, C.K., Deol, H., Wagner, G.F., DiMattia, G.E. Endocrinology (1998) [Pubmed]
  13. Identification of signal transduction pathways that modulate dibutyryl cyclic adenosine monophosphate activation of stanniocalcin gene expression in neuroblastoma cells. Yeung, H.Y., Chan, D.K., Mak, N.K., Wagner, G.F., Wong, C.K. Endocrinology (2003) [Pubmed]
  14. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Jepeal, L.I., Fujitani, Y., Boylan, M.O., Wilson, C.N., Wright, C.V., Wolfe, M.M. Endocrinology (2005) [Pubmed]
  15. Insulin-like growth factor I receptors are expressed by the enteroendocrine cell line STC-1: relationship with proliferation and cholecystokinin expression. Ye, F., Chevrier, A.M., Langlois, D., Cuber, J.C., Saez, J.M., Chayvialle, J.A., Abello, J. Horm. Res. (1998) [Pubmed]
  16. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Katsuma, S., Hirasawa, A., Tsujimoto, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. Stanniocalcin gene expression during mouse urogenital development: a possible role in mesenchymal-epithelial signalling. Stasko, S.E., Wagner, G.F. Dev. Dyn. (2001) [Pubmed]
  18. Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation. Hasilo, C.P., McCudden, C.R., Gillespie, J.R., James, K.A., Hirvi, E.R., Zaidi, D., Wagner, G.F. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  19. Dynamic changes in stanniocalcin gene expression in the mouse uterus during early implantation. Stasko, S.E., DiMattia, G.E., Wagner, G.F. Mol. Cell. Endocrinol. (2001) [Pubmed]
  20. Stanniocalcin 1 (STC1) protein and mRNA are developmentally regulated during embryonic mouse osteogenesis: the potential of stc1 as an autocrine/paracrine factor for osteoblast development and bone formation. Yoshiko, Y., Aubin, J.E., Maeda, N. J. Histochem. Cytochem. (2002) [Pubmed]
  21. The distribution of stanniocalcin 1 protein in fetal mouse tissues suggests a role in bone and muscle development. Jiang, W.Q., Chang, A.C., Satoh, M., Furuichi, Y., Tam, P.P., Reddel, R.R. J. Endocrinol. (2000) [Pubmed]
  22. Molecular cloning and characterization of mouse stanniocalcin cDNA. Chang, A.C., Dunham, M.A., Jeffrey, K.J., Reddel, R.R. Mol. Cell. Endocrinol. (1996) [Pubmed]
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