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Gene Review

SERPINA1  -  serpin peptidase inhibitor, clade A (alpha...

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Disease relevance of SERPINA1


High impact information on SERPINA1


Biological context of SERPINA1


Anatomical context of SERPINA1


Associations of SERPINA1 with chemical compounds


Other interactions of SERPINA1


Analytical, diagnostic and therapeutic context of SERPINA1


  1. High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice. Archibald, A.L., McClenaghan, M., Hornsey, V., Simons, J.P., Clark, A.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Characterization of a 54 kDa, alpha 1-antitrypsin-like protein isolated from ascitic fluid of an endometrial cancer patient. Tanaka, N., Sekiya, S., Takamizawa, H., Kato, N., Moriyama, Y., Fujimura, S. Jpn. J. Cancer Res. (1991) [Pubmed]
  3. Milk trypsin-inhibitor capacity as an indicator of bovine mastitis--a novel principle which can be automated. Sandholm, M., Honkanen-Buzalski, T., Kangasniemi, R. J. Dairy Res. (1984) [Pubmed]
  4. Acute phase response in heifers with experimentally induced mastitis. Hirvonen, J., Pyörälä, S., Jousimies-Somer, H. J. Dairy Res. (1996) [Pubmed]
  5. Release of fibronectin, sulfated glycosaminoglycans and beta-hexosaminidase from injured smooth muscle cells and fibroblasts in culture--possible transferable effects on new cultures. Stavenow, L., Hultberg, B. Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology. (1985) [Pubmed]
  6. Tissue-specific gene expression in mouse hepatocytes cultured in growth-restricting medium. Spiegelberg, T., Bishop, J.O. Mol. Cell. Biol. (1988) [Pubmed]
  7. Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice. Van Molle, W., Libert, C., Fiers, W., Brouckaert, P. J. Immunol. (1997) [Pubmed]
  8. Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes. Olson, S.T., Bock, P.E., Kvassman, J., Shore, J.D., Lawrence, D.A., Ginsburg, D., Björk, I. J. Biol. Chem. (1995) [Pubmed]
  9. Preparation and characterization of latent alpha 1-antitrypsin. Lomas, D.A., Elliott, P.R., Chang, W.S., Wardell, M.R., Carrell, R.W. J. Biol. Chem. (1995) [Pubmed]
  10. Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol. Kuznetsov, G., Brostrom, M.A., Brostrom, C.O. J. Biol. Chem. (1992) [Pubmed]
  11. Complete cDNA sequence of bovine alpha 1-antitrypsin. Sinha, D., Bakhshi, M.R., Kirby, E.P. Biochim. Biophys. Acta (1992) [Pubmed]
  12. The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes. Ramji, D.P., Tadros, M.H., Hardon, E.M., Cortese, R. Nucleic Acids Res. (1991) [Pubmed]
  13. Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution. Mourey, L., Samama, J.P., Delarue, M., Petitou, M., Choay, J., Moras, D. J. Mol. Biol. (1993) [Pubmed]
  14. Weaning to hypoallergenic formula improves gut barrier function in breast-fed infants with atopic eczema. Arvola, T., Moilanen, E., Vuento, R., Isolauri, E. J. Pediatr. Gastroenterol. Nutr. (2004) [Pubmed]
  15. Hexa- and pentapeptide extension of proalbumin: feedback inhibition of albumin synthesis by its propeptide in isolated hepatocytes and in the cell-free system. Weigand, K., Schmid, M., Villringer, A., Birr, C., Heinrich, P.C. Biochemistry (1982) [Pubmed]
  16. Anti-pneumolysin activity of commercially available alpha 1-antitrypsin is due to cholesterol impurities. Rubins, J.B., Freiberg, M.R. Microb. Pathog. (1994) [Pubmed]
  17. Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system. Forney, J.R., Yang, S., Du, C., Healey, M.C. J. Parasitol. (1996) [Pubmed]
  18. Interference of cartilage surface with interaction of granulocyte elastase with alpha 1-proteinase inhibitor. An in vitro model of enzyme inhibition in the joint space. Burkhardt, H., Kasten, M., Rauls, S., Rehkopf, E. Rheumatol. Int. (1987) [Pubmed]
  19. Role of a membrane-associated serine esterase in the oxidant activation of phospholipase A2 by t-butyl hydroperoxide. Chakraborti, S., Michael, J.R., Gurtner, G.H., Ghosh, S.S., Dutta, G., Merker, A. Biochem. J. (1993) [Pubmed]
  20. Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin. Forney, J.R., Yang, S., Healey, M.C. Antimicrob. Agents Chemother. (1997) [Pubmed]
  21. Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates. Ohta, K., Makinen, K.K., Loesche, W.J. Infect. Immun. (1986) [Pubmed]
  22. Cleavage of proteins of reproductive secretions by extracellular proteinases of Tritrichomonas foetus. Talbot, J.A., Nielsen, K., Corbeil, L.B. Can. J. Microbiol. (1991) [Pubmed]
  23. On the influence of the substrate (elastin) in elastase-alpha 1 antitrypsin interactions. Hornebeck, W., Soleilhac, J.M., Velebny, V., Robert, L. Pathol. Biol. (1985) [Pubmed]
  24. Cloning of fibrinogen, prothrombin, and alpha 1-antitrypsin. Davie, E.W. Harvey Lect. (1981) [Pubmed]
  25. Kinetic dissection of alpha 1-antitrypsin inhibition mechanism. Shin, J.S., Yu, M.H. J. Biol. Chem. (2002) [Pubmed]
  26. Isolation, chemical, and physical properties of alpha-1-antitrypsin. Musiani, P., Tomasi, T.B. Biochemistry (1976) [Pubmed]
  27. Differences between the binding of trypsin and chymotrypsin by alpha 1-proteinase inhibitor. Hercz, A. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  28. Effective cryopreservation and long-term storage of primary human hepatocytes with recovery of viability, differentiation, and replicative potential. Adams, R.M., Wang, M., Crane, A.M., Brown, B., Darlington, G.J., Ledley, F.D. Cell transplantation. (1995) [Pubmed]
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