The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ORM1  -  orosomucoid 1

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AGP


High impact information on AGP


Biological context of AGP


Anatomical context of AGP

  • Alpha1-acid glycoprotein (AGP) is an immunomodulatory protein expressed by hepatocytes in response to the systemic reaction that follows tissue damage caused by inflammation, infection or trauma [13].
  • Blood serum values for cortisol and alpha1-acid glycoprotein (AGP) exhibited few treatment differences [14].
  • Bovine AGP was detected by Western blotting in all the samples analysed, and could be quantified in colostrum at 162 (+/- 63.7) microg/mL and 114.5 (+/- 67.8) microg/mL during the first 12 h and 24 h respectively [13].
  • In order to investigate the origin of AGP in bovine milk, a search for mRNA was carried out in somatic cells and mammary gland tissue: mRNA expression of the boAGP gene was detected in mammary gland tissue, but not in somatic cells [13].
  • The effects of human AGP on the oxidative changes in erythrocytes exposed to oxygen radicals were investigated [1].

Associations of AGP with chemical compounds


Regulatory relationships of AGP


Other interactions of AGP


Analytical, diagnostic and therapeutic context of AGP


  1. Effects of alpha 1-acid glycoprotein on erythrocyte deformability and membrane stabilization. Matsumoto, K., Nishi, K., Tokutomi, Y., Irie, T., Suenaga, A., Otagiri, M. Biol. Pharm. Bull. (2003) [Pubmed]
  2. Serum antibodies to cow's milk proteins in ulcerative colitis and Crohn's disease. Knoflach, P., Park, B.H., Cunningham, R., Weiser, M.M., Albini, B. Gastroenterology (1987) [Pubmed]
  3. Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice. Van Molle, W., Libert, C., Fiers, W., Brouckaert, P. J. Immunol. (1997) [Pubmed]
  4. Effects of localized Pasteurella haemolytica infection on erythromycin-binding properties of bovine alpha-1-acid glycoprotein, albumin, serum, and tissue chamber fluids. Walker, J.L., Clarke, C.R., Hague, C.M., Bourne, D.W., Lessley, B.A. Antimicrob. Agents Chemother. (1994) [Pubmed]
  5. Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein. Bilello, J.A., Bilello, P.A., Prichard, M., Robins, T., Drusano, G.L. J. Infect. Dis. (1995) [Pubmed]
  6. Simultaneous enantiomeric determination of dansyl-D,L-phenylalanine by fluorescence spectroscopy in the presence of alpha-acid glycoprotein. Yan, Y., Myrick, M.L. Anal. Chem. (1999) [Pubmed]
  7. Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins. Kageyama, S., Anderson, B.D., Hoesterey, B.L., Hayashi, H., Kiso, Y., Flora, K.P., Mitsuya, H. Antimicrob. Agents Chemother. (1994) [Pubmed]
  8. Tools to analyze protein farnesylation in cells. Troutman, J.M., Roberts, M.J., Andres, D.A., Spielmann, H.P. Bioconjug. Chem. (2005) [Pubmed]
  9. Decreased elimination of drug in the presence of alpha-1-acid glycoprotein is related to a reduced hepatocyte uptake. Qin, M., Nilsson, M., Oie, S. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  10. alpha(1)-Acid glycoprotein modulates apoptosis in bovine monocytes. Ceciliani, F., Pocacqua, V., Miranda-Ribera, A., Bronzo, V., Lecchi, C., Sartorelli, P. Vet. Immunol. Immunopathol. (2007) [Pubmed]
  11. Characterization of ligand binding sites on the alpha1-acid glycoprotein in humans, bovines and dogs. Matsumoto, K., Sukimoto, K., Nishi, K., Maruyama, T., Suenaga, A., Otagiri, M. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  12. Contribution of alpha 1-acid glycoprotein to species difference in lincosamides-plasma protein binding kinetics. Son, D.S., Osabe, M., Shimoda, M., Kokue, E. J. Vet. Pharmacol. Ther. (1998) [Pubmed]
  13. Identification of the bovine alpha1-acid glycoprotein in colostrum and milk. Ceciliani, F., Pocacqua, V., Provasi, E., Comunian, C., Bertolini, A., Bronzo, V., Moroni, P., Sartorelli, P. Vet. Res. (2005) [Pubmed]
  14. Effects of individual housing design and size on behavior and stress indicators of special-fed Holstein veal calves. Wilson, L.L., Terosky, T.L., Stull, C.L., Stricklin, W.R. J. Anim. Sci. (1999) [Pubmed]
  15. Separation of alpha-acid glycoprotein glycoforms using affinity-based reversed micellar extraction and separation. Choe, J., Zhang, F., Wolff, M.W., Murhammer, D.W., Linhardt, R.J., Dordick, J.S. Biotechnol. Bioeng. (2000) [Pubmed]
  16. Structures of intact glycoproteins from vibrational circular dichroism. Shanmugam, G., Polavarapu, P.L. Proteins (2006) [Pubmed]
  17. Measurement of neutral sugars in glycoproteins as dansyl derivatives by automated high-performance liquid chromatography. Eggert, F.M., Jones, M. J. Chromatogr. (1985) [Pubmed]
  18. Lectin affinity chromatography of proteins bearing O-linked oligosaccharides: application of jacalin-agarose. Hortin, G.L., Trimpe, B.L. Anal. Biochem. (1990) [Pubmed]
  19. Possible involvement of protein kinase C with induction of haptoglobin in cows by treatment with dexamethasone and by starvation. Yoshino, K., Katoh, N., Takahashi, K., Yuasa, A. Am. J. Vet. Res. (1993) [Pubmed]
  20. Serum albumin decreases transendothelial permeability to macromolecules. Lum, H., Siflinger-Birnboim, A., Blumenstock, F., Malik, A.B. Microvasc. Res. (1991) [Pubmed]
  21. A specific detection of GlcNAc{beta}1-6Man{alpha}1 branches in N-linked glycoproteins based on the specificity of N-acetylglucosaminyltransferase VI. Watanabe, T., Ihara, H., Miyoshi, E., Honke, K., Taniguchi, N., Taguchi, T. Glycobiology (2006) [Pubmed]
  22. Development of a liquid chromatography/electrospray tandem mass spectrometry method for confirmation of chloramphenicol residues in milk after alfa-1-acid glycoprotein affinity chromatography. Gallo, P., Nasi, A., Vinci, F., Guadagnuolo, G., Brambilla, G., Fiori, M., Serpe, L. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  23. Specific protein interacting with a tumor promoter, debromoaplysiatoxin, in bovine serum is alpha 1-acid glycoprotein. Ueyama, H., Sasaki, I., Shimomura, K., Suganuma, M. J. Cancer Res. Clin. Oncol. (1995) [Pubmed]
  24. Correlation of serum concentration of alpha 1-acid glycoprotein with lymphocyte blastogenesis and development of experimentally induced or naturally acquired hepatic abscesses in cattle. Motoi, Y., Itoh, H., Tamura, K., Miyamoto, T., Oohashi, T., Nagasawa, S. Am. J. Vet. Res. (1992) [Pubmed]
WikiGenes - Universities