The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RPL22  -  ribosomal protein L22

Homo sapiens

Synonyms: 60S ribosomal protein L22, EAP, EBER-associated protein, Epstein-Barr virus small RNA-associated protein, HBP15, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RPL22

  • EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs) [1].
  • An AML1/EAP fusion transcript, different from the one described in a therapy-related myelodysplasia, was detected in both CML-BC cases [2].
  • Our findings demonstrate that this EAP regimen is modestly active but is associated with substantial toxicity [3].
  • Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein [4].
  • EAP in advanced gastric cancer [5].

Psychiatry related information on RPL22

  • Plasma concentrations of endothelium-associated proteins (EAP) (plasma fibronectin (PFN), angiotensin-converting enzyme, factor VIII-related antigen (F VIII-R:Ag)) and tissue plasminogen activator and serum thyroid hormone concentrations were studied in nine patients with anorexia nervosa (AN), before and after weight gain [6].
  • Psychological characteristics of adolescents with risk factors of cardiovascular disease (elevated arterial pressure - EAP - and smoking) were examined in Moscow secondary school pupils aged 12-14 years, using an abridged variant of the psychodiagnostic MMPI questionnaire [7].

High impact information on RPL22


Chemical compound and disease context of RPL22


Biological context of RPL22


Anatomical context of RPL22


Associations of RPL22 with chemical compounds


Physical interactions of RPL22

  • This transcript is expected to result in a predicted protein containing the AML1 nuclear binding domain with an attached stretch of 17 amino acids unrelated to the EAP small ribosomal protein [2].

Other interactions of RPL22

  • The two genes are EAP, which codes for the abundant ribosomal protein L22, and MDS1, which encodes a small polypeptide of unknown function [24].
  • Therefore, JLB is located within the intergenic sequence between rps19 and rpl22 [25].

Analytical, diagnostic and therapeutic context of RPL22

  • EAP also resulted in significantly longer hospitalizations per study month (8 v 5 days) [26].
  • Combination therapy consisting of arterial infusion chemotherapy (EPF, EAP) and transcatheter arterial embolization (TAE) [27].
  • CONCLUSIONS: The close approximation of the measured data to the model data indicates the feasibility of the clinical use of an EAP-based cochlear implant fitting protocol [28].
  • Nonequilibrium isoelectric focusing with 4-6.5 PhastGel produced readily interpretable phenotypes in the EAP typing system [29].
  • The subjects consisted of 16 patients with VSA, 18 patients with effort angina (EAP) and 15 healthy individuals, who were used as the control group [30].


  1. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). Toczyski, D.P., Steitz, J.A. EMBO J. (1991) [Pubmed]
  2. AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts. Sacchi, N., Nisson, P.E., Watkins, P.C., Faustinella, F., Wijsman, J., Hagemeijer, A. Genes Chromosomes Cancer (1994) [Pubmed]
  3. Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma. Ajani, J.A., Mayer, R.J., Ota, D.M., Steele, G.D., Evans, D., Roh, M., Sugarbaker, D.J., Dumas, P., Gray, C., Vena, D.A. J. Natl. Cancer Inst. (1993) [Pubmed]
  4. Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein. Leopardi, R., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. EAP in advanced gastric cancer. Taal, B.G., ten Bokkel Huinink, W.W., Franklin, H., Rodenhuis, S. J. Clin. Oncol. (1990) [Pubmed]
  6. Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa. Komaki, G., Tamai, H., Mukuta, T., Kobayashi, N., Mori, K., Nakagawa, T., Kumagai, L.F. Br. J. Nutr. (1992) [Pubmed]
  7. Psychological correlates of elevated arterial pressure and smoking in adolescents. Suslova, E.A., Aleksandrova VYu, n.u.l.l. Cor et vasa. (1988) [Pubmed]
  8. The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Toczyski, D.P., Matera, A.G., Ward, D.C., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Preoperative chemotherapy in locally advanced and nonresectable gastric cancer: a phase II study with etoposide, doxorubicin, and cisplatin. Wilke, H., Preusser, P., Fink, U., Gunzer, U., Meyer, H.J., Meyer, J., Siewert, J.R., Achterrath, W., Lenaz, L., Knipp, H. J. Clin. Oncol. (1989) [Pubmed]
  10. Cisplatin, doxorubicin and etoposide (PAV) in advanced gastric carcinoma: the SAKK experience. Swiss Group for Clinical Cancer Research (SAKK). Roth, A.D., Herrmann, R., Morant, R., Borner, M.M., Honegger, H.P., Obrist, R., Bacchi, M., Lange, J., Alberto, P., Castiglione, M. Eur. J. Cancer (1998) [Pubmed]
  11. New developments in the treatment of gastric carcinoma. Wilke, H., Preusser, P., Fink, U., Achterrath, W., Meyer, H.J., Stahl, M., Lenaz, L., Meyer, J., Siewert, J.R., Geerlings, H. Semin. Oncol. (1990) [Pubmed]
  12. FEP regimen (epidoxorubicin, etoposide and cisplatin) in advanced gastric cancer, with or without low-dose GM-CSF: an Italian Trial in Medical Oncology (ITMO) study. Bajetta, E., Di Bartolomeo, M., Carnaghi, C., Buzzoni, R., Mariani, L., Gebbia, V., Comella, G., Pinotti, G., Ianniello, G., Schieppati, G., Bochicchio, A.M., Maiorino, L. Br. J. Cancer (1998) [Pubmed]
  13. Epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF) in locally advanced or metastatic gastric cancer: a single institution experience. Aitini, E., Rabbi, C., Mambrini, A., Cavazzini, G., Pari, F., Zamagni, D., Cantore, M., Pagani, M., Sorio, M., Lusenti, A., Adami, F., Smerieri, F. Tumori. (2001) [Pubmed]
  14. The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Nucifora, G., Begy, C.R., Erickson, P., Drabkin, H.A., Rowley, J.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. Shu-Nu, C., Lin, C.H., Lin, A. FEBS Lett. (2000) [Pubmed]
  16. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. Kamura, T., Burian, D., Khalili, H., Schmidt, S.L., Sato, S., Liu, W.J., Conrad, M.N., Conaway, R.C., Conaway, J.W., Shilatifard, A. J. Biol. Chem. (2001) [Pubmed]
  17. The soybean chloroplast genome: complete sequence of the rps19 gene, including flanking parts containing exon 2 of rpl2 (upstream), but rpl22 (downstream). Spielmann, A., Roux, E., von Allmen, J.M., Stutz, E. Nucleic Acids Res. (1988) [Pubmed]
  18. Regulation of the synthesis of the third component of complement and factor B in cord blood monocytes by lipopolysaccharide. Sutton, M.B., Strunk, R.C., Cole, F.S. J. Immunol. (1986) [Pubmed]
  19. Endotoxin-associated protein: a potent stimulus for human granulocytopoietic activity which may be accessory cell independent. Bjornson, B.H., Agura, E., Harvey, J.M., Johns, M., Andrews, R.G., McCabe, W.R. Infect. Immun. (1988) [Pubmed]
  20. Effects of endotoxin-associated protein on hematopoiesis. Porat, R., Yanoov, M., Johns, M.A., Shibolet, S., Michalevicz, R. Infect. Immun. (1992) [Pubmed]
  21. Phase II study with the combination etoposide, doxorubicin, and cisplatin in advanced measurable gastric cancer. Preusser, P., Wilke, H., Achterrath, W., Fink, U., Lenaz, L., Heinicke, A., Meyer, J., Meyer, H.J., Buente, H. J. Clin. Oncol. (1989) [Pubmed]
  22. Endotoxin-associated protein: interleukin-1-like activity on serum amyloid A synthesis and T-lymphocyte activation. Johns, M.A., Sipe, J.D., Melton, L.B., Strom, T.B., McCabe, W.R. Infect. Immun. (1988) [Pubmed]
  23. Adjuvant chemotherapy in gastric cancer: 5-year results of a randomised study by the Italian Trials in Medical Oncology (ITMO) Group. Bajetta, E., Buzzoni, R., Mariani, L., Beretta, E., Bozzetti, F., Bordogna, G., Aitini, E., Fava, S., Schieppati, G., Pinotti, G., Visini, M., Ianniello, G., Di, B.M. Ann. Oncol. (2002) [Pubmed]
  24. Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties. Zent, C., Kim, N., Hiebert, S., Zhang, D.E., Tenen, D.G., Rowley, J.D., Nucifora, G. Curr. Top. Microbiol. Immunol. (1996) [Pubmed]
  25. Organization and nucleotide sequence of genes at both junctions between the two inverted repeats and the large single-copy region in the rice chloroplast genome. Moon, E., Wu, R. Gene (1988) [Pubmed]
  26. FAMTX versus etoposide, doxorubicin, and cisplatin: a random assignment trial in gastric cancer. Kelsen, D., Atiq, O.T., Saltz, L., Niedzwiecki, D., Ginn, D., Chapman, D., Heelan, R., Lightdale, C., Vinciguerra, V., Brennan, M. J. Clin. Oncol. (1992) [Pubmed]
  27. Combination therapy consisting of arterial infusion chemotherapy (EPF, EAP) and transcatheter arterial embolization (TAE). Yodono, H., Takekawa, S.D., Tarusawa, K., Ikami, I., Kanehira, J., Saito, Y., Takahashi, S., Sasaki, T., Nishi, N., Kimura, T. Cancer Chemother. Pharmacol. (1994) [Pubmed]
  28. A model of a nucleus 24 cochlear implant fitting protocol based on the electrically evoked whole nerve action potential. Franck, K.H. Ear and hearing. (2002) [Pubmed]
  29. Bloodstain characterization in the EAP, Hp, Hb, AK and Glo I typing systems using minigels and the PhastSystem. Shutler, G.G., Tompkins, D.C. Forensic Sci. Int. (1988) [Pubmed]
  30. Circadian variation of basal total vascular tone and chronotherapy in patients with vasospastic angina pectoris. Mori, H., Nakamura, N., Tamura, N., Sawai, M., Tanno, T., Narita, T., Singh, R.B., Otsuka, K. Biomed. Pharmacother. (2002) [Pubmed]
WikiGenes - Universities