The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TSPAN31  -  tetraspanin 31

Homo sapiens

Synonyms: SAS, Sarcoma-amplified sequence, Tetraspanin-31, Tspan-31
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TSPAN31

 

Psychiatry related information on TSPAN31

  • The Brief Psychiatric Rating Scale (BPRS; Total, Positive, and Negative subscale scores) and the Simpson-Angus Scale for Extrapyramidal Symptoms (SAS) were also completed on the two occasions [6].
  • Correlations between comparable ratings on the Social Adjustment Scale II (SAS II) ranged from 0.78 to 0.86 [7].
  • To describe all sleep episodes and the recovery process across 4 days, and to relate adjustment to individual differences, 49 Scandinavian Airlines System (SAS) air crew were monitored for 9 days with activity monitors and sleep/wake diary before-during-after flight [8].
  • Associations between the physical activity phenotypes and the polymorphisms were analyzed using the MIXED model (SAS) [9].
  • The methods are illustrated on an example in Alzheimer's disease in a classical framework using SAS PROC MIXED and MLwiN, and in a Bayesian framework using BUGS [10].
 

High impact information on TSPAN31

  • All amplicons were discontinuous between CDK4/SAS and MDM2 [2].
  • These studies revealed two centers of amplification, one at CDK4/SAS and the other at MDM2 [2].
  • Superoxide dismutase in SAS human tongue carcinoma cell line is a factor defining invasiveness and cell motility [11].
  • This article describes an apparent inverse relationship between cell motility and intracellular Cu-Zn superoxide dismutase (SOD) activity of two human squamous carcinoma-derived clones, SAS-H1 with high invasiveness and SAS-L1 with low invasiveness [11].
  • The amplified sequences are derived from chromosome 12q13-14 and encode a gene designated SAS (sarcoma amplified sequence) [12].
 

Chemical compound and disease context of TSPAN31

 

Biological context of TSPAN31

  • This cosmid, previously known to contain three genes (CDK4, SAS, and OS9), was sequenced, and that information was used for computer-assisted analysis [18].
  • Notably, more than 40% of all amplicons in both soft tissue and bone tumors were mapped to chromosome 12, and at least one of the previously reported recurrent amplifications in 12q13.3-14.1 and 12q15.1, including SAS and CDK4, and MDM2, respectively, were present in 85% of the soft tissue tumors and in all of the bone tumors [19].
  • Four high grade intramedullary tumors had elevated mRNA expression of SAS, but did not exhibit gene amplification [3].
  • One of the amplified oncogenes (SAS/CDK4) was found in a chromosomal region that was undetected by CGH [20].
  • We investigated 529 subjects from 175 sibships who were originally part of the Honolulu Heart Program. Analyses included nonparametric linkage and association using SAGE (Statistical Analysis for Genetic Epidemiology) and FBAT (family-based test of association) programs and Monte Carlo simulation of Fisher's exact test in SAS [21].
 

Anatomical context of TSPAN31

  • The activation of proMMP-2 by co-culture was also observed in other carcinoma cell lines, HSC-4 and SAS, but not in normal human keratinocytes [22].
  • MATERIALS AND METHODS: Using the departmental SAS data-base we identified all patients with cervix cancer treated between 1974 and 1988 and investigated the 647 patients who received 20 fractions of external beam radiotherapy plus intracavitary therapy with a total dose to point A of at least 60Gy [23].
  • METHODS: The National Hospital Discharge database for 1998 to 2001 was acquired from the Centers for Disease Control. All gallbladder disease related admissions were extracted, and the cholecystectomies (ICD-9-CM codes 51.2X) were analyzed using the SAS package [24].
  • RESULTS: A procedure based on generalized estimating equations (PROC GENMOD; SAS Institute; Cary, NC) was used to fit marginal models to determine risk factors influencing the prevalence of chronic respiratory symptoms (wheeze, dyspnea, sputum, and cough) [25].
  • Based on PROC CORR analysis (SAS), this correlated negatively with blood neutrophil count (r=-0.634; P=0.0009) and serum cortisol concentration (r=-0.659; P<0.0001), but showed no relationship with serum progesterone or estradiol concentrations (P > or =0.09) [26].
 

Associations of TSPAN31 with chemical compounds

  • Oxybuprocaine induces a false-positive response in immunochromatographic SAS Adeno Test [13].
  • Apoptosis in the SAS/m p53 cells was induced by X-rays with glycerol pre-treatment, but not without glycerol pre-treatment, whereas apoptosis in the SAS/ neo cells was induced in both cases [14].
  • Unique pairs of dyads were used to create networks using SAS Interactive Matrix Language. PAJEK and UCINET were used to analyze the largest component from all years (1996-2000), during the epidemic (1997-1998), and after the epidemic (1999-2000) [27].
  • Both the carcinogenicity and the mutagenicity of quinolone and quinoline derivatives, as determined by SAS, can be attributed to their genotoxicity potential [28].
  • OBJECTIVE: To investigate whether a solution of oxybuprocaine hydrochloride, 0.4%, results in a false-positive response in an immunochromatographic SAS Adeno Test. DESIGN: Experimental study [13].
 

Analytical, diagnostic and therapeutic context of TSPAN31

  • Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes [1].
  • Southern and Northern blot analysis confirmed the coamplification of MDM2, CDK4, SAS, and CHOP [29].
  • Outcome measures included the GAS, PSE, SAS, patient and relatives' satisfaction, number of admissions, and length of stay [30].
  • Differential gene expression between PA and AD was analyzed in 6 female patients using human cDNA microarray slides and data analyzed using the Stanford Microarray Database. Statistical analysis for the gene expression was performed using the SAS mixed models [31].
  • Beta-endorphin-like activity, measured by radioimmunoassay, was somewhat lower in patients with SAS (14.0 +/- 2.8 pmol/ml) than in control subjects (21.8 +/- 7.6 pmol/ml) (p less than 0.05) [32].

References

  1. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Jankowski, S.A., Mitchell, D.S., Smith, S.H., Trent, J.M., Meltzer, P.S. Oncogene (1994) [Pubmed]
  2. Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Reifenberger, G., Ichimura, K., Reifenberger, J., Elkahloun, A.G., Meltzer, P.S., Collins, V.P. Cancer Res. (1996) [Pubmed]
  3. Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. Wunder, J.S., Eppert, K., Burrow, S.R., Gokgoz, N., Bell, R.S., Andrulis, I.L., Gogkoz, N. Oncogene (1999) [Pubmed]
  4. Gene amplification in human gliomas. Collins, V.P. Glia (1995) [Pubmed]
  5. Molecular cytogenetic characterization and physical mapping of 12q13-15 amplification in human cancers. Elkahloun, A.G., Bittner, M., Hoskins, K., Gemmill, R., Meltzer, P.S. Genes Chromosomes Cancer (1996) [Pubmed]
  6. The effect of tandospirone, a serotonin(1A) agonist, on memory function in schizophrenia. Sumiyoshi, T., Matsui, M., Yamashita, I., Nohara, S., Kurachi, M., Uehara, T., Sumiyoshi, S., Sumiyoshi, C., Meltzer, H.Y. Biol. Psychiatry (2001) [Pubmed]
  7. The multidimensional scale of independent functioning: a new instrument for measuring functional disability in psychiatric populations. Jaeger, J., Berns, S.M., Czobor, P. Schizophrenia bulletin. (2003) [Pubmed]
  8. Eastward long distance flights, sleep and wake patterns in air crews in connection with a two-day layover. Lowden, A., Akerstedt, T. Journal of sleep research. (1999) [Pubmed]
  9. Melanocortin-4 receptor gene and physical activity in the Québec Family Study. Loos, R.J., Rankinen, T., Tremblay, A., Pérusse, L., Chagnon, Y., Bouchard, C. International journal of obesity (2005) (2005) [Pubmed]
  10. Meta-analysis of continuous outcome data from individual patients. Higgins, J.P., Whitehead, A., Turner, R.M., Omar, R.Z., Thompson, S.G. Statistics in medicine. (2001) [Pubmed]
  11. Superoxide dismutase in SAS human tongue carcinoma cell line is a factor defining invasiveness and cell motility. Muramatsu, H., Kogawa, K., Tanaka, M., Okumura, K., Nishihori, Y., Koike, K., Kuga, T., Niitsu, Y. Cancer Res. (1995) [Pubmed]
  12. SAS amplification in soft tissue sarcomas. Smith, S.H., Weiss, S.W., Jankowski, S.A., Coccia, M.A., Meltzer, P.S. Cancer Res. (1992) [Pubmed]
  13. Oxybuprocaine induces a false-positive response in immunochromatographic SAS Adeno Test. Hoshino, T., Takanashi, T., Okada, M., Uchida, S. Ophthalmology (2002) [Pubmed]
  14. Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53. Ohnishi, K., Ota, I., Takahashi, A., Ohnishi, T. Br. J. Cancer (2000) [Pubmed]
  15. Heritability of the ankle-brachial index: the framingham offspring study. Murabito, J.M., Guo, C.Y., Fox, C.S., D'Agostino, R.B. Am. J. Epidemiol. (2006) [Pubmed]
  16. Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status. Ohnishi, K., Takahashi, A., Yokota, S., Ohnishi, T. Int. J. Radiat. Biol. (2004) [Pubmed]
  17. Changes of sympatho-adrenal and hypothalamo-pituitary-adrenocortical system in patients with head injury. Kôiv, L., Merisalu, E., Zilmer, K., Tomberg, T., Kaasik, A.E. Acta neurologica Scandinavica. (1997) [Pubmed]
  18. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. Elkahloun, A.G., Krizman, D.B., Wang, Z., Hofmann, T.A., Roe, B., Meltzer, P.S. Genomics (1997) [Pubmed]
  19. Genomic profiling of bone and soft tissue tumors with supernumerary ring chromosomes using tiling resolution bacterial artificial chromosome microarrays. Heidenblad, M., Hallor, K.H., Staaf, J., J??nsson, G., Borg, A., H??glund, M., Mertens, F., Mandahl, N. Oncogene (2006) [Pubmed]
  20. Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis. Takeo, S., Arai, H., Kusano, N., Harada, T., Furuya, T., Kawauchi, S., Oga, A., Hirano, T., Yoshida, T., Okita, K., Sasaki, K. Cancer Genet. Cytogenet. (2001) [Pubmed]
  21. Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese americans from hawaii. Kovac, I.P., Havlik, R.J., Foley, D., Peila, R., Hernandez, D., Wavrant-De Vrièze, F., Singleton, A., Egan, J., Taub, D., Rodriguez, B., Masaki, K., Curb, J.D., Fujimoto, W.Y., Wilson, A.F. Diabetes (2007) [Pubmed]
  22. Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts. Sato, T., Iwai, M., Sakai, T., Sato, H., Seiki, M., Mori, Y., Ito, A. Br. J. Cancer (1999) [Pubmed]
  23. The effect of overall treatment time on the survival and toxicity of radical radiotherapy for cervical carcinoma. Erridge, S.C., Kerr, G.R., Downing, D., Duncan, W., Price, A. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2002) [Pubmed]
  24. A nationwide study of conversion from laparoscopic to open cholecystectomy. Livingston, E.H., Rege, R.V. Am. J. Surg. (2004) [Pubmed]
  25. Longitudinal changes in prevalence of respiratory symptoms among Canadian grain elevator workers. Pahwa, P., McDuffie, H.H., Dosman, J.A. Chest (2006) [Pubmed]
  26. Effects of glucocorticoids on Fas gene expression in bovine blood neutrophils. Chang, L.C., Madsen, S.A., Toelboell, T., Weber, P.S., Burton, J.L. J. Endocrinol. (2004) [Pubmed]
  27. Phase-specific network differences associated with the syphilis epidemic in Baltimore city, 1996-2000. Cunningham, S.D., Michaud, J.M., Johnson, S.M., Rompalo, A., Ellen, J.M. Sexually transmitted diseases. (2004) [Pubmed]
  28. Probabilistic neural network multiple classifier system for predicting the genotoxicity of quinolone and quinoline derivatives. He, L., Jurs, P.C., Kreatsoulas, C., Custer, L.L., Durham, S.K., Pearl, G.M. Chem. Res. Toxicol. (2005) [Pubmed]
  29. Cytogenetic and molecular genetic analysis of a pediatric pleomorphic sarcoma reveals similarities to adult malignant fibrous histiocytoma. Palmer, J.L., Masui, S., Pritchard, S., Kalousek, D.K., Sorensen, P.H. Cancer Genet. Cytogenet. (1997) [Pubmed]
  30. Community psychiatric nurse teams: intensive support versus generic care. Muijen, M., Cooney, M., Strathdee, G., Bell, R., Hudson, A. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  31. Gene expression profiling in human preadipocytes and adipocytes by microarray analysis. Urs, S., Smith, C., Campbell, B., Saxton, A.M., Taylor, J., Zhang, B., Snoddy, J., Jones Voy, B., Moustaid-Moussa, N. J. Nutr. (2004) [Pubmed]
  32. Increased CSF opioid activity in sleep apnea syndrome. Regression after successful treatment. Gislason, T., Almqvist, M., Boman, G., Lindholm, C.E., Terenius, L. Chest (1989) [Pubmed]
 
WikiGenes - Universities