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Gene Review

SYPL1  -  synaptophysin-like 1

Homo sapiens

Synonyms: H-SP1, Pantophysin, SYPL, Synaptophysin-like protein 1
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Disease relevance of SYPL1

  • The synthesis of four proteins we designated as heat stress proteins (HSPs) was increased by shifts to higher temperatures (HSP-1, 75 kilodaltons [kDa]; HSP-2, 42 kDa; HSP-3, 39 kDa; and HSP-4, 27 kDa); and the amount of one protein we designated as heat-labile protein 1 (29.5 kDa) was decreased at higher temperatures [1].
  • It is apparent from the above discussion that acute stress, such as ischemia and reperfusion, hypoxia and reoxygenation, hyperthermia and oxidative stress, can rapidly potentiate the induction of genes for certain members of the HSP families and for antioxidants/antioxidant enzymes [2].
  • In addition to the capsid proteins derived from native virions, antisera to both bacterial HSP proteins recognised expression protein VP1 of coxsackievirus A9 [3].
  • These results show that the 35-kD antigen and HSP1 from Af downregulate IgE in vitro but are capable of inducing eosinophilia in ABPA [4].
  • BACKGROUND/AIMS: Chronic infections such as those caused by Chlamydia pneumoniae and periodontopathic bacteria such as Porphyromonas gingivalis have been associated with atherosclerosis, possibly due to cross-reactivity of the immune response to bacterial GroEL with human heat shock protein (hHSP) 60 [5].

Psychiatry related information on SYPL1


High impact information on SYPL1


Chemical compound and disease context of SYPL1

  • To study reactivity of chlamydial HSP 60 in sarcoidosis sera, sarkosyl-soluble (contains the 60 kDa HSP) and sarkosyl-insoluble (contains the 60 kDa structural protein) fractions of C. pneumoniae elementary bodies were prepared [10].

Biological context of SYPL1

  • We have previously shown that phagocytosis, while activating NADPH oxidase, induced in PBM the synthesis of heat shock (HS) proteins (HSP) [11].
  • The present study was undertaken to establish whether this increase in HSP expression was related to O2-. and/or to classical second messengers such as protein kinase C (PKC) [11].
  • These results suggest that O2-. is not involved in the PMA-mediated induction of hsp70 and hsp90 and that, in contrast to HS, PMA increases the expression of HSP as a result of PKC-induced mRNA stabilization rather than of transcriptional activation of HS genes [11].
  • Taken together, these results demonstrate that in plants some HSP genes are inducible by oxidative stresses, as in micro-organisms and other eukaryotic cells [12].
  • These studies establish that AEG3482 inhibits JNK activation and apoptosis by a mechanism involving induced expression of HSP proteins [13].

Anatomical context of SYPL1

  • In addition, pantophysin may provide a marker for the analysis of other vesicles in adipocytes [9].
  • Addition of HSP mRNA to the control cell-free system stimulated protein synthesis at 42 degrees C, but not at 30 degrees C. These findings suggest that translation of HSP 70 mRNA is specifically promoted at high temperature and repressed during recovery from heat shock by regulatory mechanisms active at the level of initiation [14].
  • METHODS: Cells from an immortalized, neuronally committed, human embryonic spinal cord-derived cell line (HSP1) that expresses motor neuronal properties in vitro were transplanted into adult rat spinal cord [15].
  • The present work focuses on the equine protein SP-1/2 (also named HSP-1/2) with particular emphasis on its interaction with lipid membranes by employing the intrinsic protein fluorescence and a number of spin-labeled and fluorescent lipid analogues [16].
  • HS did not increase heterologous T cell responses nor T cell proliferation induced by the non-processed superantigens such as staphylococcal enterotoxin B. The effect of HS was inhibited by actinomycin B and thus appeared dependent upon HSP synthesis [17].

Associations of SYPL1 with chemical compounds


Other interactions of SYPL1


Analytical, diagnostic and therapeutic context of SYPL1

  • Thus, the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) were compared with those of heat shock on the expression, in PBM, of the major HSP, hsp70 and hsp90, using biometabolic labeling, Western and Northern blotting, and gel mobility shift assays [11].
  • To confirm this finding, we performed an enzyme-linked immunoassay (ELISA) with a monoclonal antibody (EP10) to a synaptophysin-like protein in brain samples from 45 prospectively studied elderly subjects with an average age of 83.3 +/- 10.1 years [23].
  • We conclude that with certain precautions this method can be used to measure relative amounts of synaptophysin-like immunoreactivity and to infer the density of presynaptic boutons in human situations and in animal models [24].
  • In this study, the HSP response in early stages of human liver transplantation was investigated [25].
  • The expressed HSP 70s mRNA was then isolated and detected using the RT-PCR method [26].


  1. Thermoregulation of protein synthesis in Borrelia burgdorferi. Cluss, R.G., Boothby, J.T. Infect. Immun. (1990) [Pubmed]
  2. Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress. Das, D.K., Maulik, N., Moraru, I.I. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  3. Picornavirus proteins share antigenic determinants with heat shock proteins 60/65. Härkönen, T., Puolakkainen, M., Sarvas, M., Airaksinen, U., Hovi, T., Roivainen, M. J. Med. Virol. (2000) [Pubmed]
  4. IgE down regulation and cytokine induction by Aspergillus antigens in human allergic bronchopulmonary aspergillosis. Murali, P.S., Kurup, V.P., Bansal, N.K., Fink, J.N., Greenberger, P.A. J. Lab. Clin. Med. (1998) [Pubmed]
  5. Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. Ford, P.J., Gemmell, E., Hamlet, S.M., Hasan, A., Walker, P.J., West, M.J., Cullinan, M.P., Seymour, G.J. Oral Microbiol. Immunol. (2005) [Pubmed]
  6. Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease. Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Paljärvi, L., Koivisto, E., Riekkinen, P.J. Neuroscience (1995) [Pubmed]
  7. The threshold induction temperature of the 90-kDa heat shock protein is subject to acclimatization in eurythermal goby fishes (genus Gillichthys). Dietz, T.J., Somero, G.N. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Lower heat shock factor activation and binding and faster rate of HSP-70A messenger RNA turnover in heat sensitive human leukemias. Mivechi, N.F., Ouyang, H., Hahn, G.M. Cancer Res. (1992) [Pubmed]
  9. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles. Brooks, C.C., Scherer, P.E., Cleveland, K., Whittemore, J.L., Lodish, H.F., Cheatham, B. J. Biol. Chem. (2000) [Pubmed]
  10. Serological response to Chlamydia pneumoniae in patients with sarcoidosis. Puolakkainen, M., Campbell, L.A., Kuo, C.C., Leinonen, M., Grönhagen-Riska, C., Saikku, P. J. Infect. (1996) [Pubmed]
  11. Differential expression and regulation of hsp70 and hsp90 by phorbol esters and heat shock. Jacquier-Sarlin, M.R., Jornot, L., Polla, B.S. J. Biol. Chem. (1995) [Pubmed]
  12. Accumulation of small heat shock proteins, including mitochondrial HSP22, induced by oxidative stress and adaptive response in tomato cells. Banzet, N., Richaud, C., Deveaux, Y., Kazmaier, M., Gagnon, J., Triantaphylidès, C. Plant J. (1998) [Pubmed]
  13. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Salehi, A.H., Morris, S.J., Ho, W.C., Dickson, K.M., Doucet, G., Milutinovic, S., Durkin, J., Gillard, J.W., Barker, P.A. Chem. Biol. (2006) [Pubmed]
  14. Translational regulation of the synthesis of a major heat shock protein in HeLa cells. de Benedetti, A., Baglioni, C. J. Biol. Chem. (1986) [Pubmed]
  15. Fate of immortalized human neuronal progenitor cells transplanted in rat spinal cord. Li, P., Tessler, A., Han, S.S., Fischer, I., Rao, M.S., Selzer, M.E. Arch. Neurol. (2005) [Pubmed]
  16. Interaction of fibronectin type II proteins with membranes: the stallion seminal plasma protein SP-1/2. Greube, A., Müller, K., Töpfer-Petersen, E., Herrmann, A., Müller, P. Biochemistry (2004) [Pubmed]
  17. Exposure of monocytes to heat shock does not increase class II expression but modulates antigen-dependent T cell responses. Mariéthoz, E., Tacchini-Cottier, F., Jacquier-Sarlin, M., Sinclair, F., Polla, B.S. Int. Immunol. (1994) [Pubmed]
  18. Ubiquitin mRNA is a major stress-induced transcript in mammalian cells. Fornace, A.J., Alamo, I., Hollander, M.C., Lamoreaux, E. Nucleic Acids Res. (1989) [Pubmed]
  19. Positive Darwinian selection at the pantophysin (Pan I) locus in marine gadid fishes. Pogson, G.H., Mesa, K.A. Mol. Biol. Evol. (2004) [Pubmed]
  20. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. Leube, R.E. Differentiation (1994) [Pubmed]
  21. Regional synaptic pathology in Alzheimer's disease. Honer, W.G., Dickson, D.W., Gleeson, J., Davies, P. Neurobiol. Aging (1992) [Pubmed]
  22. Skin responses to fractional photothermolysis. Laubach, H.J., Tannous, Z., Anderson, R.R., Manstein, D. Lasers in surgery and medicine. (2006) [Pubmed]
  23. Correlations of synaptic and pathological markers with cognition of the elderly. Dickson, D.W., Crystal, H.A., Bevona, C., Honer, W., Vincent, I., Davies, P. Neurobiol. Aging (1995) [Pubmed]
  24. Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. Masliah, E., Terry, R.D., Alford, M., DeTeresa, R. J. Histochem. Cytochem. (1990) [Pubmed]
  25. Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation. Flohé, S., Speidel, N., Flach, R., Lange, R., Erhard, J., Schade, F.U. Transpl. Int. (1998) [Pubmed]
  26. Evaluation of biological responses to polymeric biomaterials by RT-PCR analysis. II: Study of HSP 70 mRNA expression. Kato, S., Akagi, T., Kishida, A., Sugimura, K., Akashi, M. Journal of biomaterials science. Polymer edition. (1997) [Pubmed]
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