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Gene Review

HSD17B6  -  hydroxysteroid (17-beta) dehydrogenase 6

Homo sapiens

Synonyms: 17-beta-HSD 6, 17-beta-HSD6, 17-beta-hydroxysteroid dehydrogenase type 6, 3-alpha->beta-HSE, 3-alpha->beta-hydroxysteroid epimerase, ...
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Disease relevance of HSD17B6


Psychiatry related information on HSD17B6

  • First, an ATP-independent, heat-induced alteration of HSF allows it to bind the HSE; the temperature at which activation occurs in vitro implies that a human factor directly senses temperature [5].
  • DESIGN: Cross-sectional study on adults from Western India. SETTING: Rural, semi urban, urban higher/middle/lower socioeconomic regions (HSE/MSE/LSE) having diverse dietary habits and environmental conditions [6].
  • 4. The experience of the author and colleagues in the HSE supports the evidence for the occurrence of volatile substance abuse (particularly of organic solvents) in industry but the extent of the practice is not known [7].

High impact information on HSD17B6

  • Here we report in situ laser-ablation analyses of sulphides in mantle-derived rocks which show that these sulphides do not have chondritic HSE patterns, but that different generations of sulphide within single samples show extreme variability in the relative abundances of HSEs [8].
  • As evident from EMSA analysis, in contrast to 1,25(OH)(2)D(3) SAKA-T cells treated with b-FGF demonstrated increased levels of HSF-2 binding to the HSE present in the RANKL gene promoter region [9].
  • Gel mobility and supershift assays showed that LEDGF in the nuclear extracts of TGF-beta1-treated human lens epithelial cells did not bind to stress-response elements and HSE [10].
  • HSE cells were treated with cytokines, metabolic inhibitors, and steroids under various conditions, and prostaglandin biosynthesis was determined by radioimmunoassay [11].
  • To characterize the effects of interleukin-1 alpha (IL-1) on prostanoid biosynthesis by human rheumatoid synovium microvessel endothelium (HSE) [11].

Chemical compound and disease context of HSD17B6

  • HSE-binding was not induced by several stresses known to induce the synthesis of hsps in other cell types in different organisms including zinc, copper, cobalt, manganese, recovery from anoxia, UV-irradiation, and increased pH [12].

Biological context of HSD17B6


Anatomical context of HSD17B6

  • To examine the regulation of intercellular adhesion molecule 1 (ICAM-1) in human synovial microvascular endothelial cells (HSE) and human umbilical vein endothelial cells (HUVE) upon exposure to a variety of agents [15].
  • HSE also engrafted onto hu-PBL-SCID mice that were exposed to alloantigen by prior injection with interferon-gamma-treated keratinocytes identical to those used to generate the HSE [1].
  • This antigen was detected in the HSE of both skeletal muscle and heart, and was unaffected by treatment with Triton X-100 [16].
  • 4. We show here that this promoter is inducible in cultured cells by interleukin-1 (IL-1) in a transient assay system and that the HSE and AP-1 binding site are required for this inducibility [17].
  • In contrast to conclusions based on simple stimuli, the directions of turns are represented by an interneuron, the HSE cell, quite independent of the spatial layout of the environment and its textural properties when the cell is stimulated with behaviourally generated optic flow [18].

Associations of HSD17B6 with chemical compounds

  • Human short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity (RODH-like enzymes) are thought to contribute to the oxidation of retinol for retinoic acid biosynthesis and to the metabolism of androgenic and neuroactive 3alpha-hydroxysteroids [19].
  • To test the feasibility of this hypothesis, thirteen different inducers were selected, and it was shown that all chemical inducers as well as heat shock cause drastic oxidation of glutathione under conditions under which they induce HSE DNA-binding activity [20].
  • While Vira-A therapy as the treatment for diagnosed HSE is significant, it may be associated with difficulties in fluid overload [21].
  • Data from the HSE 1999 were employed to study ethnic differences in blood glucose and glycosylated haemoglobin [22].
  • The relaxant effect of HSE was partly dependent on the presence of a functional endothelium as the action was significantly reduced in endothelium-denuded aortic rings [23].

Other interactions of HSD17B6


Analytical, diagnostic and therapeutic context of HSD17B6

  • Following our previous characterization of the first human 3(alpha-->beta)hydroxysteroid epimerase (hHSE), we determined the genomic structure and chromosomal localization of the hHSE gene using fluorescent in situ hybridization (FISH) in this study [24].
  • In the present study, the responses of the equatorial horizontal cell HSE of Calliphora and the yaw torque responses of Calliphora and Musca were recorded under identical visual stimulation with moving periodic gratings [25].
  • These observations led to the conclusions that the spatial extent of the activation-induced DeltaS/S was much broader in the GE data, and that the physiological processes that give rise to the temporal fluctuations lost coherence over millimeter distances in HSE compared to GE fMRI data [26].
  • Newly synthesized cyclooxygenase (COX) was quantitated by immunoprecipitation of metabolically labeled HSE cell lysates [11].
  • IL-1 treatment of HSE cells induces COX II, as demonstrated by both Northern blotting and immunoprecipitation [11].


  1. The allogeneic response to cultured human skin equivalent in the hu-PBL-SCID mouse model of skin rejection. Briscoe, D.M., Dharnidharka, V.R., Isaacs, C., Downing, G., Prosky, S., Shaw, P., Parenteau, N.L., Hardin-Young, J. Transplantation (1999) [Pubmed]
  2. The kinetics of HIV-1 long terminal repeat transcriptional activation resemble those of hsp70 promoter in heat-shock treated HeLa cells. Kretz-Remy, C., Arrigo, A.P. FEBS Lett. (1994) [Pubmed]
  3. Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation. Wang, J., Yao, M., Zhang, Z., Gu, J., Zhang, Y., Li, B., Sun, L., Liu, X. FEBS Lett. (2003) [Pubmed]
  4. Hyperfixation of 99mTc-HMPAO and hypofixation of 123I-iomazenil in acute herpes encephalitis. Launes, J., Hokkanen, L., Nikkinen, P., Liewendahl, K., Salonen, O., Sirén, J., Iivanainen, M. Neuroreport (1995) [Pubmed]
  5. Activation in vitro of sequence-specific DNA binding by a human regulatory factor. Larson, J.S., Schuetz, T.J., Kingston, R.E. Nature (1988) [Pubmed]
  6. Are lifestyle factors good predictors of retinol and vitamin C deficiency in apparently healthy adults? Chiplonkar, S.A., Agte, V.V., Mengale, S.S., Tarwadi, K.V. European journal of clinical nutrition. (2002) [Pubmed]
  7. Use and abuse of volatile substances in industry. Parker, S.E. Human toxicology. (1989) [Pubmed]
  8. Non-chondritic distribution of the highly siderophile elements in mantle sulphides. Alard, O., Griffin, W.L., Lorand, J.P., Jackson, S.E., O'Reilly, S.Y. Nature (2000) [Pubmed]
  9. Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. Roccisana, J.L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G.D., Reddy, S.V. J. Biol. Chem. (2004) [Pubmed]
  10. Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells. Sharma, P., Fatma, N., Kubo, E., Shinohara, T., Chylack, L.T., Singh, D.P. J. Biol. Chem. (2003) [Pubmed]
  11. Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1. Inhibition by glucocorticoids. Szczepanski, A., Moatter, T., Carley, W.W., Gerritsen, M.E. Arthritis Rheum. (1994) [Pubmed]
  12. Induction of the DNA-binding and transcriptional activities of heat shock factor 1 is uncoupled in Xenopus oocytes. Bharadwaj, S., Hnatov, A., Ali, A., Ovsenek, N. Biochim. Biophys. Acta (1998) [Pubmed]
  13. Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome. Jones, M.R., Italiano, L., Wilson, S.G., Mullin, B.H., Mead, R., Dudbridge, F., Watts, G.F., Stuckey, B.G. Fertil. Steril. (2006) [Pubmed]
  14. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Bauman, D.R., Steckelbroeck, S., Williams, M.V., Peehl, D.M., Penning, T.M. Mol. Endocrinol. (2006) [Pubmed]
  15. Regulation of the expression of intercellular adhesion molecule 1 in cultured human endothelial cells derived from rheumatoid synovium. Gerritsen, M.E., Kelley, K.A., Ligon, G., Perry, C.A., Shen, C.P., Szczepanski, A., Carley, W.W. Arthritis Rheum. (1993) [Pubmed]
  16. Myasthenia gravis. Identification of skeletal and heart muscle antigens not related to the acetylcholine receptor. Mehl, V.S., Lang, R.W. J. Neuroimmunol. (1984) [Pubmed]
  17. Interleukin-1 stimulates the beta-amyloid precursor protein promoter. Donnelly, R.J., Friedhoff, A.J., Beer, B., Blume, A.J., Vitek, M.P. Cell. Mol. Neurobiol. (1990) [Pubmed]
  18. Neuronal processing of behaviourally generated optic flow: experiments and model simulations. Kern, R., Lutterklas, M., Petereit, C., Lindemann, J.P., Egelhaaf, M. Network (Bristol, England) (2001) [Pubmed]
  19. Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity. Belyaeva, O.V., Kedishvili, N.Y. Genomics (2006) [Pubmed]
  20. Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response. Zou, J., Salminen, W.F., Roberts, S.M., Voellmy, R. Cell Stress Chaperones (1998) [Pubmed]
  21. A great nursing challenge--recognition and effective management of the patient with herpes simplex encephalitis. Wahlquist, G.I. Journal of neurosurgical nursing. (1981) [Pubmed]
  22. Coronary risk in South Asians: role of ethnicity and blood sugar. Aarabi, M., Jackson, P.R. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. (2004) [Pubmed]
  23. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. Ajay, M., Chai, H.J., Mustafa, A.M., Gilani, A.H., Mustafa, M.R. Journal of ethnopharmacology (2007) [Pubmed]
  24. Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha-->beta)-hydroxysteroid epimerase. Huang, X.F., Luu-The, V. Biochim. Biophys. Acta (2001) [Pubmed]
  25. Neural circuits mediating visual flight control in flies. I. Quantitative comparison of neural and behavioral response characteristics. Hausen, K., Wehrhahn, C. J. Neurosci. (1989) [Pubmed]
  26. Signal and noise characteristics of Hahn SE and GE BOLD fMRI at 7 T in humans. Yacoub, E., Van De Moortele, P.F., Shmuel, A., Uğurbil, K. Neuroimage (2005) [Pubmed]
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