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MeSH Review

Twins, Dizygotic

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Disease relevance of Twins, Dizygotic

  • Recent studies have established that disease concordance in dizygotic twins is the same as that in siblings generally, for both T1D and the MHC-associated autoimmune disease gluten-sensitive enteropathy, leaving little room for a differential environmental trigger [1].
  • PKD1 manifests as typical adult onset disease in the father, but is seen as severe disease, detected as enlarged polycystic kidneys in utero, in one of a pair of dizygotic twins; the other twin has the mutation but no evidence of cysts, consistent with an adult onset disease course [2].
  • The concordance rates for glucose intolerance, overall obesity and low HDL-cholesterol were significantly higher among monozygotic than dizygotic twins indicating a genetic influence on the development of these phenotypes [3].
  • Intrapair birth weight difference correlated positively with the intrapair difference in creatinine clearance equally in monozygotic and dizygotic twins (r = 0.35, P < 0.0001; r = 0.43, P < 0.0001, respectively) [4].
  • Antibodies to acetylcholine receptors (AChR-ab) were detected in a patient with myasthenia gravis (MG) and at much lower levels in her asymptomatic fraternal twin and one other asymptomatic sibling [5].

Psychiatry related information on Twins, Dizygotic


High impact information on Twins, Dizygotic

  • IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers [7].
  • The correlations for IGFBP-3 concentration were r = 0.65 (P < 0.0001) and r = 0.23 (P < 0.06) for monozygotic and dizygotic twins, respectively [8].
  • For the IGF-II concentration the intrapair correlations were r = 0.66 (P < 0.0001) for the monozygotic and r = 0.34 (P < 0.01) for the dizygotic twins [8].
  • Among the dizygotic twins (n = 8), no set was found to be concordant for PBC [9].
  • Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment [10].

Chemical compound and disease context of Twins, Dizygotic


Biological context of Twins, Dizygotic


Anatomical context of Twins, Dizygotic


Associations of Twins, Dizygotic with chemical compounds

  • Intraclass correlations for identical and fraternal twin detection thresholds to pyridine were small and not significantly different [22].
  • We report the occurrence of neonatal LE, manifested by photosensitivity and discoid LE skin lesions, in one fraternal twin [23].
  • RESULTS: The resemblance in twin pairs for total caffeine consumption, heavy caffeine use, caffeine intoxication, caffeine tolerance, and caffeine withdrawal was substantially greater in monozygotic than in dizygotic twin pairs [24].
  • BACKGROUND: Studies of monozygotic and dizygotic twins indicate an important genetic influence on the variability of responsiveness to norepinephrine in superficial human vein [25].
  • The intrapair differences in angiotensin converting enzyme levels for monozygotic, concordant dizygotic, and discordant dizygotic twins were 1.36 +/- 1.6, 1.86 +/- 1.6, and 17.25 +/- 4.3 U/L, respectively [26].

Gene context of Twins, Dizygotic

  • Finally, the degree of allele sharing at ADRB1 (1165) also predicted variability in SBP and DBP at rest among dizygotic twin pairs (P < 0.04) [27].
  • Genome-scans were performed in 701 dizygotic twin pairs from four samples with data on plasma levels of HDL- and LDL-cholesterol and their major protein constituents, apolipoprotein AI (ApoAI) and Apolipoprotein B (ApoB) [28].
  • Novel compound heterozygous nonsense mutations R518X/Q530X in the C-terminus of KCNQ1 were identified in both affected dizygotic twins; both the parents and a sibling each carried only one of the mutant alleles and were asymptomatic with modestly prolonged QTc intervals (0.46, 0.50, and 0.45 seconds, respectively) [29].
  • In the present study, a panel of 93 dizygotic twin pairs discordant for rheumatoid arthritis were typed for HLA-A, -B, -Cw, and -DR antigens [30].
  • In a sample of 282 female Caucasian dizygotic twins aged 21-80 years, we aimed to investigate the associations between blood pressure and five single nucleotide polymorphisms (SNPs) including the 825C>T and haplotypes of the GNB3 gene [31].

Analytical, diagnostic and therapeutic context of Twins, Dizygotic


  1. The genetics of HLA-associated disease. Larsen, C.E., Alper, C.A. Curr. Opin. Immunol. (2004) [Pubmed]
  2. A stable, nonsense mutation associated with a case of infantile onset polycystic kidney disease 1 (PKD1). Peral, B., Ong, A.C., San Millán, J.L., Gamble, V., Rees, L., Harris, P.C. Hum. Mol. Genet. (1996) [Pubmed]
  3. Genetic versus environmental aetiology of the metabolic syndrome among male and female twins. Poulsen, P., Vaag, A., Kyvik, K., Beck-Nielsen, H. Diabetologia (2001) [Pubmed]
  4. Birth weight and creatinine clearance in young adult twins: influence of genetic, prenatal, and maternal factors. Gielen, M., Pinto-Sietsma, S.J., Zeegers, M.P., Loos, R.J., Fagard, R., de Leeuw, P.W., Beunen, G., Derom, C., Vlietinck, R. J. Am. Soc. Nephrol. (2005) [Pubmed]
  5. Antiacetylcholine receptor antibody and its relationship to HLA type in asymptomatic siblings of a patient with myasthenia gravis. Seybold, M.E., Lindstrom, J.M. Neurology (1981) [Pubmed]
  6. CO2-induced panic attacks: a twin study. Bellodi, L., Perna, G., Caldirola, D., Arancio, C., Bertani, A., Di Bella, D. The American journal of psychiatry. (1998) [Pubmed]
  7. IBD sharing around the PPARG locus is not increased in dizygotic twins or their mothers. Duffy, D., Montgomery, G., Treloar, S., Birley, A., Kirk, K., Boomsma, D., Beem, L., de Geus, E., Slagboom, E., Knighton, J., Reed, P., Martin, N. Nat. Genet. (2001) [Pubmed]
  8. Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. Harrela, M., Koistinen, H., Kaprio, J., Lehtovirta, M., Tuomilehto, J., Eriksson, J., Toivanen, L., Koskenvuo, M., Leinonen, P., Koistinen, R., Seppälä, M. J. Clin. Invest. (1996) [Pubmed]
  9. Primary biliary cirrhosis in monozygotic and dizygotic twins: genetics, epigenetics, and environment. Selmi, C., Mayo, M.J., Bach, N., Ishibashi, H., Invernizzi, P., Gish, R.G., Gordon, S.C., Wright, H.I., Zweiban, B., Podda, M., Gershwin, M.E. Gastroenterology (2004) [Pubmed]
  10. Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning. Al-Hendy, A., Moshynska, O., Saxena, A., Feyles, V. Lancet (2000) [Pubmed]
  11. beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins. Connors, S.L., Crowell, D.E., Eberhart, C.G., Copeland, J., Newschaffer, C.J., Spence, S.J., Zimmerman, A.W. J. Child Neurol. (2005) [Pubmed]
  12. Variable response to the diepoxybutane test in two dizygotic twins with Fanconi's anemia and flow cytometry for diagnosis confirmation. Toraldo, R., Canino, G., Tolone, C., D'Avanzo, M., Porfirio, B., Hoehn, H., Schroeder-Kurth, T., Pistoia, V. Pediatric hematology and oncology. (1998) [Pubmed]
  13. Bacterial agglutinin activity in the saliva of human identical and fraternal twins. Malamud, D., Christensen, C.M., Navazesh, M., Davis, C. Arch. Oral Biol. (1988) [Pubmed]
  14. Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Box, N.F., Wyeth, J.R., O'Gorman, L.E., Martin, N.G., Sturm, R.A. Hum. Mol. Genet. (1997) [Pubmed]
  15. N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. Chen, B., Nelson, D.M., Sadovsky, Y. J. Biol. Chem. (2006) [Pubmed]
  16. The influence of zygosity status on blood pressure and on lipid profiles in male and female twins. Poulsen, P., Vaag, A., Beck-Nielsen, H. J. Hypertens. (2002) [Pubmed]
  17. Elevation of follicular phase inhibin and luteinizing hormone levels in mothers of dizygotic twins suggests nonovarian control of human multiple ovulation. Martin, N.G., Robertson, D.M., Chenevix-Trench, G., de Kretser, D.M., Osborne, J., Burger, H.G. Fertil. Steril. (1991) [Pubmed]
  18. The P300 component of the auditory event-related potential in monozygotic and dizygotic twins. Rogers, T.D., Deary, I. Acta psychiatrica Scandinavica. (1991) [Pubmed]
  19. Human lymphocyte telomerase is genetically regulated. Kosciolek, B.A., Rowley, P.T. Genes Chromosomes Cancer (1998) [Pubmed]
  20. Aggregation of thyroid autoantibodies in first-degree relatives of patients with autoimmune thyroid disease is mainly due to genes: a twin study. Brix, T.H., Hansen, P.S., Kyvik, K.O., Hegedüs, L. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
  21. Synthesis of prolactin by human decidua in vitro. Golander, A., Hurley, T., Barrett, J., Handwerger, S. J. Endocrinol. (1979) [Pubmed]
  22. Ability to smell androstenone is genetically determined. Wysocki, C.J., Beauchamp, G.K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  23. Neonatal lupus erythematosus occurring in one fraternal twin. Serologic and immunogenetic studies. Callen, J.P., Fowler, J.F., Kulick, K.B., Stelzer, G., Smith, S.Z. Arthritis Rheum. (1985) [Pubmed]
  24. Caffeine intake, tolerance, and withdrawal in women: a population-based twin study. Kendler, K.S., Prescott, C.A. The American journal of psychiatry. (1999) [Pubmed]
  25. Familial studies of heritability of alpha1-adrenergic receptor responsiveness in superficial veins. Gupta, A., Carruthers, S.G. Clin. Pharmacol. Ther. (1997) [Pubmed]
  26. Angiotensin-converting enzyme and angiotensinogen gene polymorphisms, plasma levels, cardiac dimensions. A twin study. Busjahn, A., Knoblauch, H., Knoblauch, M., Bohlender, J., Menz, M., Faulhaber, H.D., Becker, A., Schuster, H., Luft, F.C. Hypertension (1997) [Pubmed]
  27. Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. McCaffery, J.M., Pogue-Geile, M.F., Ferrell, R.E., Petro, N., Manuck, S.B. J. Hypertens. (2002) [Pubmed]
  28. Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Heijmans, B.T., Beekman, M., Putter, H., Lakenberg, N., van der Wijk, H.J., Whitfield, J.B., Posthuma, D., Pedersen, N.L., Martin, N.G., Boomsma, D.I., Slagboom, P.E. Eur. J. Hum. Genet. (2005) [Pubmed]
  29. Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome). Ning, L., Moss, A.J., Zareba, W., Robinson, J., Rosero, S., Ryan, D., Qi, M. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. (2003) [Pubmed]
  30. Unexpected HLA haplotype sharing in dizygotic twin pairs discordant for rheumatoid arthritis. Jawaheer, D., MacGregor, A.J., Gregersen, P.K., Silman, A.J., Ollier, W.E. J. Med. Genet. (1996) [Pubmed]
  31. Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twins. Dong, Y., Zhu, H., Wang, X., Dalageorgou, C., Carter, N., Spector, T.D., Snieder, H. Pharmacogenetics (2004) [Pubmed]
  32. Genetic analysis of febrile convulsions: twin and family studies. Tsuboi, T. Hum. Genet. (1987) [Pubmed]
  33. The Trp64Arg mutation of the adrenergic beta-3 receptor gene impairs insulin secretion: a twin study. Christiansen, C., Poulsen, P., Beck-Nielsen, H. Diabet. Med. (1999) [Pubmed]
  34. Successful paternity of twins following bone marrow transplantation with busulfan, melphalan and cyclophosphamide conditioning. Shepherd, J.D., Hoar, D.I., Keown, P.A., Phillips, G.L. Bone Marrow Transplant. (1996) [Pubmed]
  35. Merthiolate testing in twins. Holst, R., Möller, H. Contact Derm. (1975) [Pubmed]
  36. Genetic and environmental influences on serum levels of immunoglobulins and complement components in monozygotic and dizygotic twins. Di Franco, P., Brai, M., Misiano, G., Piazza, A.M., Giorgi, G., Cossarizza, A., Franceschi, C. Journal of clinical & laboratory immunology. (1988) [Pubmed]
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