The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CEACAM3  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: CD66D, CD66d, CEA, CGM1, Carcinoembryonic antigen CGM1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CEACAM3


Psychiatry related information on CEACAM3


High impact information on CEACAM3

  • Using a statewide cancer registry system, the analysis suggested that the preoperative level of serum CEA was an indicator of survival in patients with colorectal cancer, independent of the stage of disease at diagnosis [10].
  • CEA, AFP and other potential tumor markers [11].
  • We demonstrate here that CEA mediates Ca2+-independent, homotypic aggregation of cultured human colon adenocarcinoma cells (LS-180) and rodent cells transfected with functional CEA cDNA [12].
  • Carcinoembryonic antigen (CEA) is a member of a family of cell surface glycoproteins that are produced in excess in essentially all human colon carcinomas and in a high proportion of carcinomas at many other sites [12].
  • We also show that, whereas CEA is localized mainly to epithelial cell membranes facing the lumen in normal adult intestine, it is found on adjacent cell membranes in both embryonic intestine and colonic tumors [12].

Chemical compound and disease context of CEACAM3


Biological context of CEACAM3

  • The granulocyte-specific CEACAM3 receptor has properties of a single chain phagocytic receptor and may thus contribute to innate immunity by the elimination of Neisseria and other CEACAM-binding pathogens that colonize human mucosal surfaces [18].
  • This correlation of overproduction of an adhesion molecule with neoplastic transformation provoked a test of the effect of CEA on cell differentiation [3].
  • The blocking of the upregulation of myogenin, a transcriptional regulator responsible for the execution of the entire myogenic differentiation program, indicates that CEA expression intercepts the process at a very early stage [3].
  • As in humans, immune responsiveness to CEA, as reflected by antibody formation, was not detectable in transgenic mice bearing CEA-positive tumors [19].
  • A 32.6-kb fragment containing the complete human CEA gene and flanking sequences was isolated from a genomic cosmid clone and used to produce transgenic C57BL/6 mice [19].

Anatomical context of CEACAM3

  • Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens [1].
  • We examined the role of phosphatidylinositol 3-kinases (PI3Ks) in gonococcal invasion of epithelial cell lines expressing either CEACAM1 or CEACAM3 [20].
  • Of these, CEACAM3 is restricted to neutrophils and contains an immunoreceptor tyrosine-based activation motif (ITAM) reminiscent of that found within certain phagocytic Fc receptors [13].
  • In addition, although CEACAM3 is not recognized as a receptor by the subfamily of Afa/Dr adhesins, it is recruited around bacteria in HeLa cells [21].
  • CEA was not found by immunohistochemistry in other tissues of the digestive tract, nor was it found in a wide range of other tissues or organs [19].

Associations of CEACAM3 with chemical compounds

  • Internalization and Rac stimulation are also inhibited by compromising the integrity of an immunoreceptor tyrosine-based activation motif (ITAM)-like sequence in the cytoplasmic tail of CEACAM3 or by interference with Src family protein tyrosine kinases that phosphorylate CEACAM3 [1].
  • CEACAM3-mediated internalization, but not that mediated by CEACAM1, was accompanied by localized and transient accumulation of the class I PI3K product phosphatidylinositol 3,4,5-trisphosphate at sites of bacterial engulfment [20].
  • These interactions were inhibited by anti-CEA antibody, but could not be inhibited by addition of heparin [2].
  • Incorporation of fucose and galactose into purified carcinoembryonic antigen (CEA), used as an exogenous acceptor by colon glycosyltransferases, was demonstrated by immunoprecipitation with rabbit antiserum to human CEA [22].
  • The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin superfamily and can be subdivided into the CEA and pregnancy-specific glycoprotein subgroups [23].

Physical interactions of CEACAM3

  • Moreover, CEACAM3 engagement triggers membrane recruitment and increased GTP loading of Rac that are not observed upon bacterial binding to CEACAM6 [1].

Regulatory relationships of CEACAM3

  • CEACAM3 was tyrosine phosphorylated by a Src family kinase-dependent process upon infection by gonococci expressing CEACAM-specific Opa proteins [13].

Other interactions of CEACAM3

  • CEACAM3- but not CEACAM6-mediated uptake is blocked by dominant-negative versions of the small GTPase Rac [1].
  • Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family [24].
  • In vitro exposure of acute promyelocytic leukemia cells to arsenic trioxide (As2O3) induces the solitary expression of CD66c (NCA-50/90), a member of the CEA family [25].
  • On the basis of previous work with various monoclonal antibodies (Mab) raised against carcino-embryonic antigen (CEA), the anti-CEA Mab 47 was identified which selectively reacted with a surface glycoprotein (95 kDa; NCA 95) of normal human granulocytes [26].
  • Many polyps and dysplastic lesions in ulcerative colitis have phenotypic changes (blood group antigen, cytokeratins, CEA, TAG-72.3 antigen expression) and genetic changes (c-K-ras mutation, enhanced c-myc expression and pp60c-src activity) which are characteristic of invasive cancers [27].

Analytical, diagnostic and therapeutic context of CEACAM3


  1. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. Schmitter, T., Agerer, F., Peterson, L., Munzner, P., Hauck, C.R. J. Exp. Med. (2004) [Pubmed]
  2. Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. Chen, T., Grunert, F., Medina-Marino, A., Gotschlich, E.C. J. Exp. Med. (1997) [Pubmed]
  3. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts. Eidelman, F.J., Fuks, A., DeMarte, L., Taheri, M., Stanners, C.P. J. Cell Biol. (1993) [Pubmed]
  4. Transduction and expression of the human carcinoembryonic antigen gene in a murine colon carcinoma cell line. Robbins, P.F., Kantor, J.A., Salgaller, M., Hand, P.H., Fernsten, P.D., Schlom, J. Cancer Res. (1991) [Pubmed]
  5. CEA (carcinoembryonic antigen): its role as a marker in the management of cancer. Goldenberg, D.M., Neville, A.M., Carter, A.C., Go, V.L., Holyoke, E.D., Isselbacher, K.J., Schein, P.S., Schwartz, M. J. Cancer Res. Clin. Oncol. (1981) [Pubmed]
  6. Are carcinoembryonic antigen levels of value in the curative management of colorectal cancer? Wanebo, H.J. Surgery (1981) [Pubmed]
  7. Immunostimulatory CpG oligonucleotides enhance the immune response of anti-idiotype vaccine that mimics carcinoembryonic antigen. Baral, R.N., Saha, A., Chatterjee, S.K., Foon, K.A., Krieg, A.M., Weiner, G.J., Bhattacharya-Chatterjee, M. Cancer Immunol. Immunother. (2003) [Pubmed]
  8. Comparative evaluation of serum CA 195 and carcinoembryonic antigen in metastatic carcinoma. Verdi, C.J., Ahmann, F.R., Schifman, R.B., Elvick, A.L., Ahmann, M.E., Marx, P.C. Cancer (1993) [Pubmed]
  9. Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trial. Manesis, E.K., Giannoulis, G., Zoumboulis, P., Vafiadou, I., Hadziyannis, S.J. Hepatology (1995) [Pubmed]
  10. The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer. Sener, S.F., Imperato, J.P., Chmiel, J., Fremgen, A., Sylvester, J. CA: a cancer journal for clinicians. (1989) [Pubmed]
  11. CEA, AFP and other potential tumor markers. Zamcheck, N., Pusztaszeri, G. CA: a cancer journal for clinicians. (1975) [Pubmed]
  12. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Benchimol, S., Fuks, A., Jothy, S., Beauchemin, N., Shirota, K., Stanners, C.P. Cell (1989) [Pubmed]
  13. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. McCaw, S.E., Schneider, J., Liao, E.H., Zimmermann, W., Gray-Owen, S.D. Mol. Microbiol. (2003) [Pubmed]
  14. Monoclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and nonneoplastic duct lesions as well as nonduct type neoplasias. Bätge, B., Bosslet, K., Sedlacek, H.H., Kern, H.F., Klöppel, G. Virchows Archiv. A, Pathological anatomy and histopathology. (1986) [Pubmed]
  15. Serial plasma carcinoembryonic antigen measurements during treatment of metastatic breast cancer. Mughal, A.W., Hortobagyi, G.N., Fritsche, H.A., Buzdar, A.U., Yap, H.Y., Blumenschein, G.R. JAMA (1983) [Pubmed]
  16. Antitumor activity and immune responses induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine. Kantor, J., Irvine, K., Abrams, S., Kaufman, H., DiPietro, J., Schlom, J. J. Natl. Cancer Inst. (1992) [Pubmed]
  17. Serum protein-bound carbohydrates for following the course of disease in patients with metastatic breast carcinoma. Waalkes, T.P., Mrochek, J.E., Dinsmore, S.R., Tormey, D.C. J. Natl. Cancer Inst. (1978) [Pubmed]
  18. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. Billker, O., Popp, A., Brinkmann, V., Wenig, G., Schneider, J., Caron, E., Meyer, T.F. EMBO J. (2002) [Pubmed]
  19. Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy. Clarke, P., Mann, J., Simpson, J.F., Rickard-Dickson, K., Primus, F.J. Cancer Res. (1998) [Pubmed]
  20. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. Booth, J.W., Telio, D., Liao, E.H., McCaw, S.E., Matsuo, T., Grinstein, S., Gray-Owen, S.D. J. Biol. Chem. (2003) [Pubmed]
  21. Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Berger, C.N., Billker, O., Meyer, T.F., Servin, A.L., Kansau, I. Mol. Microbiol. (2004) [Pubmed]
  22. Alterations in glycosyltransferase activity in human colon cancer. LaMont, J.T., Isselbacher, K.J. J. Natl. Cancer Inst. (1975) [Pubmed]
  23. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Berling, B., Kolbinger, F., Grunert, F., Thompson, J.A., Brombacher, F., Buchegger, F., von Kleist, S., Zimmermann, W. Cancer Res. (1990) [Pubmed]
  24. Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family. Nagel, G., Grunert, F., Kuijpers, T.W., Watt, S.M., Thompson, J., Zimmermann, W. Eur. J. Biochem. (1993) [Pubmed]
  25. In vitro exposure of acute promyelocytic leukemia cells to arsenic trioxide (As2O3) induces the solitary expression of CD66c (NCA-50/90), a member of the CEA family. Di Noto, R., Boccuni, P., Costantini, S., Dello Russo, A., Lo Pardo, C., Copia, C., Annunziata, M., Cimino, R., Ferrara, F., Del Vecchio, L. Tissue Antigens (1999) [Pubmed]
  26. In vivo labelling of granulocytes using 123I-tagged anti-granulocyte antibodies. Seybold, K. Nuclear medicine communications. (1988) [Pubmed]
  27. Phenotypic and genetic alterations in pre-cancerous cells in the colon. Lundy, J., Chen, J., Wang, P., Fromowitz, F., Schuss, A., Lynch, S., Brugge, J., Viola, M.V. Anticancer Res. (1988) [Pubmed]
  28. Differential expression of tumor-associated antigens in human colon carcinomas xenografted into nude mice. Gold, D.V., Shochat, D., Primus, F.J., Dexter, D.L., Calabresi, P., Goldenberg, D.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  29. Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments. Buchegger, F., Pfister, C., Fournier, K., Prevel, F., Schreyer, M., Carrel, S., Mach, J.P. J. Clin. Invest. (1989) [Pubmed]
  30. Therapy of established tumors in a novel murine model transgenic for human carcinoembryonic antigen and HLA-A2 with a combination of anti-idiotype vaccine and CTL peptides of carcinoembryonic antigen. Saha, A., Chatterjee, S.K., Foon, K.A., Celis, E., Bhattacharya-Chatterjee, M. Cancer Res. (2007) [Pubmed]
  31. Monoclonal antibody recognizing a carcinoembryonic antigen epitope differentially expressed in human colonic carcinoma versus normal adult colon tissues. Zhang, H.Z., Ordonez, N.G., Batsakis, J.G., Chan, J.C. Cancer Res. (1989) [Pubmed]
WikiGenes - Universities