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Gene Review

Adrb3  -  adrenergic receptor, beta 3

Mus musculus

Synonyms: Adrb-3, Adrb3r, B3bar, Beta-3 AR, Beta-3 adrenergic receptor, ...
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Chemical compound and disease context of Adrb3


Biological context of Adrb3


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Regulatory relationships of Adrb3


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Analytical, diagnostic and therapeutic context of Adrb3


  1. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Mantzoros, C.S., Qu, D., Frederich, R.C., Susulic, V.S., Lowell, B.B., Maratos-Flier, E., Flier, J.S. Diabetes (1996) [Pubmed]
  2. Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. Rohlfs, E.M., Daniel, K.W., Premont, R.T., Kozak, L.P., Collins, S. J. Biol. Chem. (1995) [Pubmed]
  3. Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Boivin, B., Lavoie, C., Vaniotis, G., Baragli, A., Villeneuve, L.R., Ethier, N., Trieu, P., Allen, B.G., Hébert, T.E. Cardiovasc. Res. (2006) [Pubmed]
  4. Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition. Revelli, J.P., Preitner, F., Samec, S., Muniesa, P., Kuehne, F., Boss, O., Vassalli, J.D., Dulloo, A., Seydoux, J., Giacobino, J.P., Huarte, J., Ody, C. J. Clin. Invest. (1997) [Pubmed]
  5. Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice. Cohen, M.L., Bloomquist, W., Ito, M., Lowell, B.B. Recept. Channels (2000) [Pubmed]
  6. Phenotypic linkage between single-nucleotide polymorphisms of beta3-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior. Aoyama, M., Shidoji, Y., Saimei, M., Tsunawake, N., Ichinose, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Enerbäck, S., Jacobsson, A., Simpson, E.M., Guerra, C., Yamashita, H., Harper, M.E., Kozak, L.P. Nature (1997) [Pubmed]
  8. Structure and function of the beta 3-adrenergic receptor. Strosberg, A.D. Annu. Rev. Pharmacol. Toxicol. (1997) [Pubmed]
  9. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist. Nagase, I., Yoshida, T., Kumamoto, K., Umekawa, T., Sakane, N., Nikami, H., Kawada, T., Saito, M. J. Clin. Invest. (1996) [Pubmed]
  10. The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64. Walston, J., Lowe, A., Silver, K., Yang, Y., Bodkin, N.L., Hansen, B.C., Shuldiner, A.R. Gene (1997) [Pubmed]
  11. Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1- and putative beta4-adrenoceptors in mouse left atria: no evidence for beta2- and beta3-adrenoreceptor function. Oostendorp, J., Kaumann, A.J. Naunyn Schmiedebergs Arch. Pharmacol. (2000) [Pubmed]
  12. Insulin resistance and type 2 diabetes mellitus: its relationship with the beta 3-adrenergic receptor. García-Rubi, E., Calles-Escandón, J. Arch. Med. Res. (1999) [Pubmed]
  13. Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. Surwit, R.S., Dixon, T.M., Petro, A.E., Daniel, K.W., Collins, S. Endocrinology (2000) [Pubmed]
  14. Transcriptional down-regulation by insulin of the beta 3-adrenergic receptor expression in 3T3-F442A adipocytes: a mechanism for repressing the cAMP signaling pathway. Fève, B., Elhadri, K., Quignard-Boulangé, A., Pairault, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. Targeted disruption of the beta 3-adrenergic receptor gene. Susulic, V.S., Frederich, R.C., Lawitts, J., Tozzo, E., Kahn, B.B., Harper, M.E., Himms-Hagen, J., Flier, J.S., Lowell, B.B. J. Biol. Chem. (1995) [Pubmed]
  16. Mechanism of amelioration of insulin resistance by beta3-adrenoceptor agonist AJ-9677 in the KK-Ay/Ta diabetic obese mouse model. Kato, H., Ohue, M., Kato, K., Nomura, A., Toyosawa, K., Furutani, Y., Kimura, S., Kadowaki, T. Diabetes (2001) [Pubmed]
  17. Brown adipose tissue response to cafeteria diet-feeding involves induction of the UCP2 gene and is impaired in female rats as compared to males. Roca, P., Rodriguez, A.M., Oliver, P., Bonet, M.L., Quevedo, S., Picó, C., Palou, A. Pflugers Arch. (1999) [Pubmed]
  18. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Collins, S., Daniel, K.W., Rohlfs, E.M., Ramkumar, V., Taylor, I.L., Gettys, T.W. Mol. Endocrinol. (1994) [Pubmed]
  19. Transcriptional modulation by n-butyric acid of beta 1-, beta 2-, and beta 3-adrenergic receptor balance in 3T3-F442A adipocytes. Krief, S., Fève, B., Baude, B., Zilberfarb, V., Strosberg, A.D., Pairault, J., Emorine, L.J. J. Biol. Chem. (1994) [Pubmed]
  20. Anti-obesity and anti-diabetic activities of a new beta3 adrenergic receptor agonist, (S)-(Z)-[4-[[1-[2-[(2-hydroxy-3-phenoxypropyl)]amino]ethyl]-1-propenyl] phenoxy] acetic acid ethanedioic acid (SWR-0342SA), in KK-Ay mice. Kiso, T., Namikawa, T., Tokunaga, T., Sawada, K., Kakita, T., Shogaki, T., Ohtsubo, Y. Biol. Pharm. Bull. (1999) [Pubmed]
  21. Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. Thomas, R.F., Holt, B.D., Schwinn, D.A., Liggett, S.B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. Hadri, K.E., Courtalon, A., Gauthereau, X., Chambaut-Guérin, A.M., Pairault, J., Fève, B. J. Biol. Chem. (1997) [Pubmed]
  23. Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice. Nonogaki, K., Memon, R.A., Grunfeld, C., Feingold, K.R., Tecott, L.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  24. Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level. Bakopanos, E., Silva, J.E. Diabetes (2000) [Pubmed]
  25. Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist. Oana, F., Takeda, H., Matsuzawa, A., Akahane, S., Isaji, M., Akahane, M. Eur. J. Pharmacol. (2005) [Pubmed]
  26. Effect of CL 316,243, a novel beta 3-adrenoceptor agonist, on insulin secretion in perfused mouse pancreas. Yoshida, T., Yoshioka, K., Hiraoka, N., Umekawa, T., Sakane, N., Kondo, M. Endocr. J. (1994) [Pubmed]
  27. Beta-3 adrenoceptor (beta-3AR) expression in leptin treated OB/OB mice. Breslow, M.J., An, Y., Berkowitz, D.E. Life Sci. (1997) [Pubmed]
  28. Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse. Nakamura, Y., Nagase, I., Asano, A., Sasaki, N., Yoshida, T., Umekawa, T., Sakane, N., Saito, M. J. Vet. Med. Sci. (2001) [Pubmed]
  29. Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes. Nahmias, C., Blin, N., Elalouf, J.M., Mattei, M.G., Strosberg, A.D., Emorine, L.J. EMBO J. (1991) [Pubmed]
  30. Down-regulation of beta3 adrenoreceptor gene expression in brown fat cells is transient and recovery is dependent upon a short-lived protein factor. Bengtsson, T., Redegren, K., Strosberg, A.D., Nedergaard, J., Cannon, B. J. Biol. Chem. (1996) [Pubmed]
  31. White adipose tissue contributes to UCP1-independent thermogenesis. Granneman, J.G., Burnazi, M., Zhu, Z., Schwamb, L.A. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
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