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Gene Review

Ddb1  -  damage specific DNA binding protein 1

Mus musculus

Synonyms: 127kDa, AA408517, DDB p127 subunit, DNA damage-binding protein 1, DNA repair protein, ...
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Disease relevance of Ddb1


High impact information on Ddb1


Chemical compound and disease context of Ddb1


Biological context of Ddb1


Anatomical context of Ddb1


Associations of Ddb1 with chemical compounds


Other interactions of Ddb1


Analytical, diagnostic and therapeutic context of Ddb1


  1. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Difilippantonio, M.J., Zhu, J., Chen, H.T., Meffre, E., Nussenzweig, M.C., Max, E.E., Ried, T., Nussenzweig, A. Nature (2000) [Pubmed]
  2. A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. Weeda, G., Eveno, E., Donker, I., Vermeulen, W., Chevallier-Lagente, O., Taïeb, A., Stary, A., Hoeijmakers, J.H., Mezzina, M., Sarasin, A. Am. J. Hum. Genet. (1997) [Pubmed]
  3. DNA repair proteins affect the lifecycle of herpes simplex virus 1. Lilley, C.E., Carson, C.T., Muotri, A.R., Gage, F.H., Weitzman, M.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice. Beecham, E.J., Mushinski, J.F., Shacter, E., Potter, M., Bohr, V.A. Mol. Cell. Biol. (1991) [Pubmed]
  5. DNA repair and repair fidelity in metastatic variants of the B16 murine melanoma. Usmani, B.A., Lunec, J., Sherbet, G.V. J. Cell. Biochem. (1993) [Pubmed]
  6. DNA repair, genome stability, and aging. Lombard, D.B., Chua, K.F., Mostoslavsky, R., Franco, S., Gostissa, M., Alt, F.W. Cell (2005) [Pubmed]
  7. Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Madhani, H.D., Bohr, V.A., Hanawalt, P.C. Cell (1986) [Pubmed]
  8. Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells. Kültz, D., Chakravarty, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice. Cressman, V.L., Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., Godfrey, V., Koller, B.H. Mol. Cell. Biol. (2006) [Pubmed]
  10. DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53. Beneke, R., Geisen, C., Zevnik, B., Bauch, T., Müller, W.U., Küpper, J.H., Möröy, T. Mol. Cell. Biol. (2000) [Pubmed]
  11. The Effect of 3-Methyladenine DNA Glycosylase-Mediated DNA Repair on the Induction of Toxicity and Diabetes by the {beta}-Cell Toxicant Streptozotocin. Burns, N., Gold, B. Toxicol. Sci. (2007) [Pubmed]
  12. Peplomycin-induced DNA repair synthesis in permeable mouse ascites sarcoma cells. Zhang, B., Watanabe, S., Akiyama, K., Li, T., Fukushima, K., Tsutsui, K., Seki, S. Acta Med. Okayama (1991) [Pubmed]
  13. cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells. Seki, N., Hayashi, A., Hattori, A., Kozuma, S., Sasaki, M., Suzuki, Y., Sugano, S., Muramatsu, M., Saito, T. DNA Res. (1999) [Pubmed]
  14. DNA repair defects associated with chromosomal translocation breaksite regions. Beecham, E.J., Jones, G.M., Link, C., Huppi, K., Potter, M., Mushinski, J.F., Bohr, V.A. Mol. Cell. Biol. (1994) [Pubmed]
  15. DNA repair is activated in early stages of p53-induced apoptosis. Geske, F.J., Nelson, A.C., Lieberman, R., Strange, R., Sun, T., Gerschenson, L.E. Cell Death Differ. (2000) [Pubmed]
  16. Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cells. Li, J., Sejas, D.P., Rani, R., Koretsky, T., Bagby, G.C., Pang, Q. J. Biol. Chem. (2006) [Pubmed]
  17. DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Hsia, K.T., Millar, M.R., King, S., Selfridge, J., Redhead, N.J., Melton, D.W., Saunders, P.T. Development (2003) [Pubmed]
  18. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Trucco, C., Oliver, F.J., de Murcia, G., Ménissier-de Murcia, J. Nucleic Acids Res. (1998) [Pubmed]
  19. Kinetics of DNA adduct formation and removal in mouse hepatocytes following in vivo exposure to 5,9-dimethyldibenzo[c,g]carbazole. Renault, D., Brault, D., Lossouarn, Y., Périn-Roussel, O., Taras-Valéro, D., Périn, F., Thybaud, V. Carcinogenesis (2000) [Pubmed]
  20. Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. Wei, Q., Cheng, L., Xie, K., Bucana, C.D., Dong, Z. J. Invest. Dermatol. (1997) [Pubmed]
  21. In vitro comparisons of SENCAR and BALB/c primary epidermal cells. Strickland, J.E., Allen, P.T., Sauder, D.N., Kawamura, H., Fong, M.C., Yuspa, S.H. Environ. Health Perspect. (1986) [Pubmed]
  22. Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes. Mori, H., Sugie, S., Yoshimi, N., Asada, Y., Furuya, T., Williams, G.M. Cancer Res. (1985) [Pubmed]
  23. Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes. Mori, H., Kawai, K., Ohbayashi, F., Kuniyasu, T., Yamazaki, M., Hamasaki, T., Williams, G.M. Cancer Res. (1984) [Pubmed]
  24. Cyclin-Dependent Kinase 2 Functions in Normal DNA Repair and Is a Therapeutic Target in BRCA1-Deficient Cancers. Deans, A.J., Khanna, K.K., McNees, C.J., Mercurio, C., Heierhorst, J., McArthur, G.A. Cancer Res. (2006) [Pubmed]
  25. DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors. Becker, K., Gregel, C., Fricke, C., Komitowski, D., Dosch, J., Kaina, B. Carcinogenesis (2003) [Pubmed]
  26. Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA. Jaruga, P., Birincioglu, M., Rosenquist, T.A., Dizdaroglu, M. Biochemistry (2004) [Pubmed]
  27. Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Moynahan, M.E., Cui, T.Y., Jasin, M. Cancer Res. (2001) [Pubmed]
  28. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Glassner, B.J., Weeda, G., Allan, J.M., Broekhof, J.L., Carls, N.H., Donker, I., Engelward, B.P., Hampson, R.J., Hersmus, R., Hickman, M.J., Roth, R.B., Warren, H.B., Wu, M.M., Hoeijmakers, J.H., Samson, L.D. Mutagenesis (1999) [Pubmed]
  29. Expanded simple tandem repeat (ESTR) mutation induction in the male germline: lessons learned from lab mice. Somers, C.M. Mutat. Res. (2006) [Pubmed]
  30. Early decrease in dna repair proteins, Ku70 and Ku86, and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Kim, G.W., Noshita, N., Sugawara, T., Chan, P.H. Stroke (2001) [Pubmed]
  31. Characterization of gene expression profile associated with energy restriction-induced cold tolerance of heart. Wada, Y., Kayo, T., Koizumi, A. Microsc. Res. Tech. (2002) [Pubmed]
  32. Spontaneous neurinoma in an African lungfish, Protopterus annectens, and DNA repair studies on normal and neoplastic tissues. Ishikawa, T., Masahito, P., Nemoto, N., Matsumoto, J., Shima, A. J. Natl. Cancer Inst. (1986) [Pubmed]
  33. Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents. Allan, J.M., Engelward, B.P., Dreslin, A.J., Wyatt, M.D., Tomasz, M., Samson, L.D. Cancer Res. (1998) [Pubmed]
  34. Split-dose exposure to N-methyl-N'-nitro-N-nitrosoguanidine in BALB/3T3 C1 a31-1-1 cells: evidence of DNA repair by alkaline elution without changes in cell survival, mutation and transformation rates. Bignami, M., Dogliotti, E., Benigni, R., Kaighn, M.E., Saffiotti, U. Mutat. Res. (1985) [Pubmed]
  35. ADP effects on bleomycin-induced DNA repair synthesis and adenylate kinase activity in permeable mouse sarcoma cells. Seki, S., Mori, S., Oda, T. Biochem. Int. (1989) [Pubmed]
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