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Gene Review

Ilk  -  integrin linked kinase

Mus musculus

Synonyms: AA511515, ESTM24, Integrin-linked protein kinase
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Disease relevance of Ilk


Psychiatry related information on Ilk


High impact information on Ilk

  • ILK, PINCH and parvin: the tIPP of integrin signalling [8].
  • Furthermore, expression of a mutant ILK lacking kinase activity and/or paxillin binding in ILK-deficient fibroblasts can rescue cell spreading, F-actin organization, FA formation, and proliferation [9].
  • Altogether these data show that mammalian ILK modulates actin rearrangements at integrin-adhesion sites [9].
  • Finally, ILK-deficient fibroblasts have diminished proliferation rates [9].
  • Likewise, ILK-deficient fibroblasts showed abnormal F-actin aggregates associated with impaired cell spreading and delayed formation of stress fibers and FAs [9].

Chemical compound and disease context of Ilk


Biological context of Ilk


Anatomical context of Ilk


Associations of Ilk with chemical compounds


Physical interactions of Ilk


Regulatory relationships of Ilk


Other interactions of Ilk


Analytical, diagnostic and therapeutic context of Ilk

  • Here, we demonstrate a novel role for integrin-linked kinase (ILK) in mediating renal epithelial cell morphogenesis in embryonic kidney explants and identify p38(MAPK) as a target of ILK signaling in a cell culture model of renal epithelial morphogenesis [14].
  • Analysis of peripheral T cells by quantitative PCR and by breeding Lck-Cre(+)/ILK(flox/flox) mice to a YFP-transgenic reporter strain demonstrated an approximate 20-fold enrichment of ILK-competent cells, suggesting these cells have a competitive advantage in trafficking to and/or survival in peripheral lymphatic organs [5].
  • To investigate beta1-integrin activity, integrin-linked kinase (ILK) expression was measured by immunoblotting [23].
  • Electron microscopy revealed an early foot process effacement, as well as morphologic abnormality, in ILK-deficient podocytes [24].


  1. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Yau, C.Y., Wheeler, J.J., Sutton, K.L., Hedley, D.W. Cancer Res. (2005) [Pubmed]
  2. Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells. Ishii, T., Furuoka, H., Muroi, Y., Nishimura, M. J. Biol. Chem. (2003) [Pubmed]
  3. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Troussard, A.A., Costello, P., Yoganathan, T.N., Kumagai, S., Roskelley, C.D., Dedhar, S. Oncogene (2000) [Pubmed]
  4. Integrin-linked kinase regulates endothelial cell survival and vascular development. Friedrich, E.B., Liu, E., Sinha, S., Cook, S., Milstone, D.S., MacRae, C.A., Mariotti, M., Kuhlencordt, P.J., Force, T., Rosenzweig, A., St-Arnaud, R., Dedhar, S., Gerszten, R.E. Mol. Cell. Biol. (2004) [Pubmed]
  5. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Liu, E., Sinha, S., Williams, C., Cyrille, M., Heller, E., Snapper, S.B., Georgopoulos, K., St-Arnaud, R., Force, T., Dedhar, S., Gerszten, R.E. Mol. Cell. Biol. (2005) [Pubmed]
  6. Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase. Mo, J.S., Kim, M.Y., Han, S.O., Kim, I.S., Ann, E.J., Lee, K.S., Seo, M.S., Kim, J.Y., Lee, S.C., Park, J.W., Choi, E.J., Seong, J.Y., Joe, C.O., Faessler, R., Park, H.S. Mol. Cell. Biol. (2007) [Pubmed]
  7. The roles of integrin-linked kinase in the regulation of myogenic differentiation. Huang, Y., Li, J., Zhang, Y., Wu, C. J. Cell Biol. (2000) [Pubmed]
  8. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate, K.R., Montañez, E., Kudlacek, O., Fässler, R. Nat. Rev. Mol. Cell Biol. (2006) [Pubmed]
  9. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchenco, P.D., Fässler, R. Genes Dev. (2003) [Pubmed]
  10. High glucose and angiotensin II increase beta1 integrin and integrin-linked kinase synthesis in cultured mouse podocytes. Han, S.Y., Kang, Y.S., Jee, Y.H., Han, K.H., Cha, D.R., Kang, S.W., Han, D.S. Cell Tissue Res. (2006) [Pubmed]
  11. Functional consequences of integrin-linked kinase activation in podocyte damage. Teixeira, V.d.e. .P., Blattner, S.M., Li, M., Anders, H.J., Cohen, C.D., Edenhofer, I., Calvaresi, N., Merkle, M., Rastaldi, M.P., Kretzler, M. Kidney Int. (2005) [Pubmed]
  12. Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Lu, H., Fedak, P.W., Dai, X., Du, C., Zhou, Y.Q., Henkelman, M., Mongroo, P.S., Lau, A., Yamabi, H., Hinek, A., Husain, M., Hannigan, G., Coles, J.G. Circulation (2006) [Pubmed]
  13. Integrin-linked kinase regulates chondrocyte shape and proliferation. Grashoff, C., Aszódi, A., Sakai, T., Hunziker, E.B., Fässler, R. EMBO Rep. (2003) [Pubmed]
  14. Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Leung-Hagesteijn, C., Hu, M.C., Mahendra, A.S., Hartwig, S., Klamut, H.J., Rosenblum, N.D., Hannigan, G.E. Mol. Cell. Biol. (2005) [Pubmed]
  15. PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage. Li, S., Bordoy, R., Stanchi, F., Moser, M., Braun, A., Kudlacek, O., Wewer, U.M., Yurchenco, P.D., Fässler, R. J. Cell. Sci. (2005) [Pubmed]
  16. Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. Yang, Y., Guo, L., Blattner, S.M., Mundel, P., Kretzler, M., Wu, C. J. Am. Soc. Nephrol. (2005) [Pubmed]
  17. Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly. Niewmierzycka, A., Mills, J., St-Arnaud, R., Dedhar, S., Reichardt, L.F. J. Neurosci. (2005) [Pubmed]
  18. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. Terpstra, L., Prud'homme, J., Arabian, A., Takeda, S., Karsenty, G., Dedhar, S., St-Arnaud, R. J. Cell Biol. (2003) [Pubmed]
  19. Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. Lorenz, K., Grashoff, C., Torka, R., Sakai, T., Langbein, L., Bloch, W., Aumailley, M., Fässler, R. J. Cell Biol. (2007) [Pubmed]
  20. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. Barker, T.H., Baneyx, G., Cardó-Vila, M., Workman, G.A., Weaver, M., Menon, P.M., Dedhar, S., Rempel, S.A., Arap, W., Pasqualini, R., Vogel, V., Sage, E.H. J. Biol. Chem. (2005) [Pubmed]
  21. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Makino, K., Day, C.P., Wang, S.C., Li, Y.M., Hung, M.C. Oncogene (2004) [Pubmed]
  22. gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response. Chu, H., Thievessen, I., Sixt, M., Lämmermann, T., Waisman, A., Braun, A., Noegel, A.A., Fässler, R. Mol. Cell. Biol. (2006) [Pubmed]
  23. Interstitial remodeling in beta1-adrenergic receptor transgenic mice. Seeland, U., Selejan, S., Engelhardt, S., Müller, P., Lohse, M.J., Böhm, M. Basic Res. Cardiol. (2007) [Pubmed]
  24. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. Dai, C., Stolz, D.B., Bastacky, S.I., St-Arnaud, R., Wu, C., Dedhar, S., Liu, Y. J. Am. Soc. Nephrol. (2006) [Pubmed]
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