Disease relevance of lactic acid

• The patient had a 13-year history of hypocalcemia resulting from surgically induced hypoparathyroidism, which he controlled with calcium lactate [1].
• Three patients with clinically different severities of vitamin D-dependent rickets, type II, with alopecia, which is 1,25-dihydroxyvitamin D-receptor-defect rickets and is particularly resistant to treatment with calciferol analogues, were treated with large doses of 1 alpha-hydroxyvitamin D3 (1 alpha-(OH)D3) and 2 g of calcium lactate [2].
• Enhanced calcium and phosphorus retention was achieved in 16 very low birth weight infants (birth weight 1117 +/- 42 g, gestation 29 +/- 0.2 weeks) fed a preparation of fortified human milk augmented with calcium lactate and monobasic and dibasic phosphate salts [3].
• Effect of a mouthrinse containing calcium lactate on the formation and mineralization of dental plaque [4].
• The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats [5].

Psychiatry related information on lactic acid

• SCT also decreased quantified motor activity, frequency and severity of periodic agitated episodes, serum CPK and prolactin, and nocturnal sleep, while DHT or calcium lactate had opposite effects on the same parameters [6].

High impact information on lactic acid

• One group, not receiving added calcium, was the MNNG control group; while the second group also received added calcium lactate, and the third group received calcium carbonate [7].
• Effect of histamine H2-receptor antagonist on the phosphorus-binding abilities of calcium carbonate and calcium lactate in hemodialysis patients [8].
• The inhibitory effect of magnesium hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate [9].
• Despite a significant increase in total plasma calcium (P less than 0.01) and in 24-h urinary excretion of calcium (P less than 0.025) while taking calcium lactate gluconate, there was no fall in blood pressure with calcium supplementation compared to treatment with placebo [10].
• Blood was sampled at successive stages of the operation for measurement of ionized and total calcium, lactate, blood gases, pH, hematocrit, and other constituents [11].

Chemical compound and disease context of lactic acid

• The median deoxypyridinoline (Dpd) level was significantly lower after 1 year of treatment (5.8 mmol/mmol creatinine [Cr]) than the baseline value (10.2 mmol/mmol Cr) in the IP, but not in the CL group, suggesting that IP treatment suppresses bone resorption [12].
• Fluoride concentrations in dental plaque and saliva after the use of a fluoride dentifrice preceded by a calcium lactate rinse [13].
• Three grams of calcium lactate and 3 g of sodium potassium citrate were administered to 46 urolithiasis patients, whose stones were mainly composed of calcium oxalate [14].
• Bronchodilator effect and toxicity of theophylline 300 mg twice a day (R1), salbutamol 4 mg tid (R2), their combination in higher (200/4mg, R3), and lower doses (100/2mg R4), and placebo (calcium lactate 300 mg) tid (R5) were compared in 25 patients with bronchial asthma in a randomized crossover trial [15].
• 1. Hypertension was produced in rabbits by unilateral renal encapsulation combined with contralateral nephrectomy or by the administration of calciferol and calcium lactate [16].

Biological context of lactic acid

• In contrast mice receiving multiple oral supplements of calcium lactate showed minimal tissue necrosis due to DCA administration and the frequency of mitotic events and cellular proliferation activity remained similar to levels seen in untreated controls [17].
• Daily water intake was reduced by calcium lactate in all cases [18].
• Calcium lactate is one of the most important calcium sources and has, in comparison with other organic calcium salts, a good solubility and bioavailability [19].
• In conclusion, YP, with the advantage of being clearer than EY, is capable of sustaining embryo development to the blastocyst stage in a simple salt solution of NaCl, KCl and NaHCO3 supplemented with hemicalcium L-lactate [20].
• In Experiment 1, two groups of lactating rats, one having a litter size adjusted to four pups (n = 10) on the day after parturition and the other a litter size adjusted to 16 pups (n = 9), were given ad lib access to a 2.4% solution of calcium lactate, demineralised water, and a calcium deficient diet [21].

Anatomical context of lactic acid

• However, increasing the concentration of hemicalcium L-lactate from 5 mM to 10 mM decreased (p < 0.001) the percentage of embryos reaching the morula or blastocyst stage (experiment 3) [22].
• Increasing hemicalcium L-lactate level from 5 to 10, 20 or 25 mM resulted in a significant decrease (P<0.05) in percent development into blastocysts (36.5% vs. 24.8%, 11.6% and 6.7%, respectively) [20].
• Oocytes were fertilised in DMH medium with 7.75 mM calcium lactate [23].
• Hepatocyte viability was 25% higher (p < 0.05) in CaCl2 than in calcium lactate (CaLa) when the cells were gelled by contact with these calcium solutions at room temperature (RT) [24].

Associations of lactic acid with other chemical compounds

• The effect of histamine H2-receptor antagonist (famotidine) on the phosphorus-binding abilities of calcium carbonate and calcium lactate were examined in 13 chronic hemodialysis patients [8].
• Calcium phosphate supplementation results in lower rat fecal bile acid concentrations and a more quiescent colonic cell proliferation pattern than does calcium lactate [25].
• The group of SHR ingesting calcium chloride had a lower mean systolic blood pressure, and that ingesting calcium lactate had a higher mean systolic blood pressure than the control group receiving no exposure to calcium in preference tests [26].
• AIMS: To evaluate the responses of Baker's yeast (Saccharomyces cerevisiae) activity to the natural antimicrobials acetic acid, calcium lactate, a lactate-containing cocktail and lactic acid compared to calcium propionate [27].
• Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels [28].

Gene context of lactic acid

• Calcium lactate crystals were observed in cheeses made from SM2 at and below pH 5.1, whereas CLC were observed in cheeses from CSM2 and CSM3 at and below pH 5 [29].
• Some rats were pretreated with calcium lactate to inhibit the calcitonin-induced hypocalcaemia [30].
• Calcium caseinate (CC) and whey protein isolate (WPI) films were prepared to contain 5 or 10% Gluconal Cal (GC), a mixture of calcium lactate and gluconate, or 0.1 or 0.2% alpha-tocopheryl acetate (VE), respectively [31].
• After calcium lactate loading tests, the hypokinetic volunteers displayed a faster excretion of calcium and a decreased blood PTH content as compared to the control and hyperhydrated groups of volunteers [32].
• The first group (HEBP) received 200 mg of HEBP per day for 2 weeks, followed by 2 g calcium lactate and 0.5 microg alphacalcidol per day for the next 10 weeks [33].

Analytical, diagnostic and therapeutic context of lactic acid

• Calcium lactate may be useful as a phosphorus binder in such hemodialysis patients [8].
• Crossed immunoelectrophoresis of prothrombin in the presence of calcium lactate revealed a population of des-carboxyprothrombin [34].
• Human volunteers rinsed four times per day with a calcium lactate (165 mmol/l) solution for 1 week [4].
• In the iprifravone-treated (IP) group, L2-4 BMD was similar before and after treatment (0.78 and 0.77 g/cm(2), respectively), but in the calcium lactate-treated (CL) group, L2-4 BMD decreased significantly from 0.81 to 0.79 g/cm(2) after 1 year of treatment (p < 0.0001) [12].
• The effects of parathyroidectomy (P) via wide thyroidectomy in 22 dogs treated with calphosan (20 ml/d) and L-thyroxin (0.02 mg/kg) preceding shock was also studied as above: Ca-S/P, No-Ca/P, and Ca-B/P; four sham dogs had anesthesia but no shock (Anes/P) [35].

References