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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Calphosan     calcium 2-hydroxypropanoate

Synonyms: HSDB 976, CCRIS 3669, AG-E-10925, CHEMBL2106111, LS-2396, ...
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Disease relevance of lactic acid


Psychiatry related information on lactic acid

  • SCT also decreased quantified motor activity, frequency and severity of periodic agitated episodes, serum CPK and prolactin, and nocturnal sleep, while DHT or calcium lactate had opposite effects on the same parameters [6].

High impact information on lactic acid


Chemical compound and disease context of lactic acid


Biological context of lactic acid


Anatomical context of lactic acid


Associations of lactic acid with other chemical compounds


Gene context of lactic acid

  • Calcium lactate crystals were observed in cheeses made from SM2 at and below pH 5.1, whereas CLC were observed in cheeses from CSM2 and CSM3 at and below pH 5 [29].
  • Some rats were pretreated with calcium lactate to inhibit the calcitonin-induced hypocalcaemia [30].
  • Calcium caseinate (CC) and whey protein isolate (WPI) films were prepared to contain 5 or 10% Gluconal Cal (GC), a mixture of calcium lactate and gluconate, or 0.1 or 0.2% alpha-tocopheryl acetate (VE), respectively [31].
  • After calcium lactate loading tests, the hypokinetic volunteers displayed a faster excretion of calcium and a decreased blood PTH content as compared to the control and hyperhydrated groups of volunteers [32].
  • The first group (HEBP) received 200 mg of HEBP per day for 2 weeks, followed by 2 g calcium lactate and 0.5 microg alphacalcidol per day for the next 10 weeks [33].

Analytical, diagnostic and therapeutic context of lactic acid


  1. Spontaneous return of normocalcemia. Association with long-term hypoparathyroidism. Licata, A.A., Guccion, J.G., Glowitz, R.J. JAMA (1978) [Pubmed]
  2. 1 alpha-hydroxyvitamin D3 treatment of three patients with 1,25-dihydroxyvitamin D-receptor-defect rickets and alopecia. Takeda, E., Kuroda, Y., Saijo, T., Naito, E., Kobashi, H., Yokota, I., Miyao, M. Pediatrics (1987) [Pubmed]
  3. Improved mineral balance in very low birth weight infants fed fortified human milk. Schanler, R.J., Garza, C. J. Pediatr. (1988) [Pubmed]
  4. Effect of a mouthrinse containing calcium lactate on the formation and mineralization of dental plaque. van der Hoeven, J.S., Schaeken, M.J., Creugers, T.J. Caries Res. (1989) [Pubmed]
  5. Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats. Maekawa, A., Matsushima, Y., Onodera, H., Shibutani, M., Yoshida, J., Kodama, Y., Kurokawa, Y., Hayashi, Y. Food Chem. Toxicol. (1991) [Pubmed]
  6. Calcium: bivalent cation in the bivalent psychoses. Carman, J.S., Wyatt, R.J. Biol. Psychiatry (1979) [Pubmed]
  7. Effect of a calcium-enriched diet on the colonic epithelial hyperproliferation induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats on a low calcium and fat diet. Reshef, R., Rozen, P., Fireman, Z., Fine, N., Barzilai, M., Shasha, S.M., Shkolnik, T. Cancer Res. (1990) [Pubmed]
  8. Effect of histamine H2-receptor antagonist on the phosphorus-binding abilities of calcium carbonate and calcium lactate in hemodialysis patients. Takahashi, N., Shoji, T., Matsubara, K., Hitomi, H., Hashimoto, M., Kiyomoto, H., Uchida, K., Miki, S., Hirohata, M., Ishizu, T., Akiyama, K., Mizushige, K., Matsuo, H., Yuasa, S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  9. The inhibitory effect of magnesium hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate. Wang, A., Yoshimi, N., Tanaka, T., Mori, H. Carcinogenesis (1994) [Pubmed]
  10. Does oral calcium supplementation lower high blood pressure? A double blind study. Cappuccio, F.P., Markandu, N.D., Singer, D.R., Smith, S.J., Shore, A.C., MacGregor, G.A. J. Hypertens. (1987) [Pubmed]
  11. Relationship between serum lactate and ionized calcium in open-heart surgery. Toffaletti, J., Christenson, R.H., Mullins, S., Harris, R.E. Clin. Chem. (1986) [Pubmed]
  12. Effects of 1-year ipriflavone treatment on lumbar bone mineral density and bone metabolic markers in postmenopausal women with low bone mass. Ohta, H., Komukai, S., Makita, K., Masuzawa, T., Nozawa, S. Horm. Res. (1999) [Pubmed]
  13. Fluoride concentrations in dental plaque and saliva after the use of a fluoride dentifrice preceded by a calcium lactate rinse. Pessan, J.P., Sicca, C.M., de Souza, T.S., da Silva, S.M., Whitford, G.M., Buzalaf, M.A. Eur. J. Oral Sci. (2006) [Pubmed]
  14. Reduction of urinary oxalate by combined calcium and citrate administration without increase in urinary calcium oxalate stone formers. Ito, H., Suzuki, F., Yamaguchi, K., Nishikawa, Y., Kotake, T. Clin. Nephrol. (1992) [Pubmed]
  15. Is combined therapy of sympathomimetics and theophylline indicated? Jain, N.K., Sharma, S.D., Garg, V.K., Sharma, T.N., Devpura, K. The Journal of asthma : official journal of the Association for the Care of Asthma. (1993) [Pubmed]
  16. Adrenal weight and catecholamine content in renal and calciferol-induced hypertension in rabbits. Angell-James, J.E., Powis, D.A. Clinical science and molecular medicine. (1975) [Pubmed]
  17. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Wargovich, M.J., Eng, V.W., Newmark, H.L., Bruce, W.R. Carcinogenesis (1983) [Pubmed]
  18. Calcium supplementation of hen drinking water. Damron, B.L., Flunker, L.K. Poult. Sci. (1995) [Pubmed]
  19. DC calcium lactate, a new filler-binder for direct compaction of tablets. Bolhuis, G.K., Eissens, A.C., Zoestbergen, E. International journal of pharmaceutics. (2001) [Pubmed]
  20. A simple salt solution medium supplemented with yolk plasma and lactate (YPLM) supports development of preimplantation bovine embryos in vitro. Elhassan, Y.M., Kraemer, D.C., Westhusin, M.E. Anim. Reprod. Sci. (1999) [Pubmed]
  21. Factors influencing the self-selection of calcium in lactating rats. Millelire, L., Woodside, B. Physiol. Behav. (1989) [Pubmed]
  22. Development of bovine embryos in vitro as affected by energy substrates. Rosenkrans, C.F., Zeng, G.Q., MCNamara, G.T., Schoff, P.K., First, N.L. Biol. Reprod. (1993) [Pubmed]
  23. Effect of Hoechst 33342 staining on developmental competence of prepubertal goat oocytes. Velilla, E., López-Béjar, M., Rodríguez-González, E., Vidal, F., Paramio, M.T. Zygote (2002) [Pubmed]
  24. Factors affecting hepatocyte viability and CYPIA1 activity during encapsulation. Wang, L., Sun, J., Li, L., Harbour, C., Mears, D., Koutalistras, N., Sheil, A.G. Artificial cells, blood substitutes, and immobilization biotechnology. (2000) [Pubmed]
  25. Calcium phosphate supplementation results in lower rat fecal bile acid concentrations and a more quiescent colonic cell proliferation pattern than does calcium lactate. Lupton, J.R., Chen, X.Q., Frølich, W. Nutrition and cancer. (1995) [Pubmed]
  26. Calcium appetite, blood pressure and electrolytes in spontaneously hypertensive rats. Ferrell, F., Dreith, A.Z. Physiol. Behav. (1986) [Pubmed]
  27. Effect of selected natural antimicrobials on Baker's yeast activity. Pattison, T.L., von Holy, A. Lett. Appl. Microbiol. (2001) [Pubmed]
  28. Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels. Wargovich, M.J., Allnutt, D., Palmer, C., Anaya, P., Stephens, L.C. Cancer Lett. (1990) [Pubmed]
  29. Cheese pH, protein concentration, and formation of calcium lactate crystals. Agarwal, S., Powers, J.R., Swanson, B.G., Chen, S., Clark, S. J. Dairy Sci. (2006) [Pubmed]
  30. Relationships between the effects of peripherally administered salmon calcitonin on calcaemia and brain biogenic amines. Gaggi, R., De Iasio, R., Gianni, A.M. Jpn. J. Pharmacol. (1989) [Pubmed]
  31. Barrier and mechanical properties of milk protein-based edible films containing nutraceuticals. Mei, Y., Zhao, Y. J. Agric. Food Chem. (2003) [Pubmed]
  32. Calcium loading and renal function in trained subjects during restriction of muscular activity and chronic hyperhydration. Zorbas, Y.G., Federenko, Y.F., Naexu, K.A. Biological trace element research. (1994) [Pubmed]
  33. Effect of intermittent cyclical treatment with etidronate disodium (HEBP) and calcium plus alphacalcidol in postmenopausal osteoporosis. Shiota, E., Tsuchiya, K., Yamaoka, K., Kawano, O. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. (2001) [Pubmed]
  34. Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants. Brenner, B., Tavori, S., Zivelin, A., Keller, C.B., Suttie, J.W., Tatarsky, I., Seligsohn, U. Br. J. Haematol. (1990) [Pubmed]
  35. The beneficial role of calcium supplementation during resuscitation from shock. Denis, R., Lucas, C.E., Ledgerwood, A.M., Wallace, J.R., Grabow, D.E., Harrigan, C., Dawe, E.J. The Journal of trauma. (1985) [Pubmed]
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