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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Joint Capsule

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Disease relevance of Joint Capsule


High impact information on Joint Capsule


Biological context of Joint Capsule


Anatomical context of Joint Capsule


Associations of Joint Capsule with chemical compounds


Gene context of Joint Capsule

  • Changes in joint blood flow, measured by laser Doppler perfusion imaging, were produced by topical applications of selective tachykinin receptor agonists to the joint capsule [11].
  • Using progressively deleted and mutant promoter constructs of MMP-9, we show that serum amyloid A-activating factor (SAF)-1, a novel transcription factor, and the AP-1 family of proteins cooperatively regulate cytokine-mediated induction of MMP-9 in the resident cells of the joint capsule [7].
  • RESULTS: The power Doppler mode identified increased synovial microvascular blood flow inside the joint capsule in 17 of 21 RA patients (81%) vs one of the healthy controls [24].
  • The mRNA levels for lumican and decorin were increased in the joint capsules of the contracture knees in all groups when compared to normal capsules [2].
  • In the joint capsules of the patients with elbow contractures, relative mRNA levels were increased for: collagen Types I, III, and V (1.5-2.5 times); biglycan (1.5 times); and matrix metalloproteinases-1, -2, -9, -13, and -15 (1.6-3.9 times) [25].

Analytical, diagnostic and therapeutic context of Joint Capsule


  1. Calcium oxalate microcrystalline-associated arthritis in end-stage renal disease. Hoffman, G.S., Schumacher, H.R., Paul, H., Cherian, V., Reed, R., Ramsay, A.G., Franck, W.A. Ann. Intern. Med. (1982) [Pubmed]
  2. Joint capsule matrix turnover in a rabbit model of chronic joint contractures: Correlation with human contractures. Hildebrand, K.A., Zhang, M., Hart, D.A. J. Orthop. Res. (2006) [Pubmed]
  3. The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyarthritis. Guilbaud, G., Iggo, A. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1985) [Pubmed]
  4. Comparison of extracapsular changes by magnetic resonance imaging in patients with rheumatoid arthritis and polymyalgia rheumatica. McGonagle, D., Pease, C., Marzo-Ortega, H., O'Connor, P., Gibbon, W., Emery, P. J. Rheumatol. (2001) [Pubmed]
  5. Spinal position sense in ankylosing spondylitis. Swinkels, A., Dolan, P. Spine. (2004) [Pubmed]
  6. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Ernfors, P., Lee, K.F., Kucera, J., Jaenisch, R. Cell (1994) [Pubmed]
  7. Transcriptional induction of matrix metalloproteinase-9 in the chondrocyte and synoviocyte cells is regulated via a novel mechanism: evidence for functional cooperation between serum amyloid A-activating factor-1 and AP-1. Ray, A., Bal, B.S., Ray, B.K. J. Immunol. (2005) [Pubmed]
  8. Calcium pentosan polysulfate inhibits the catabolism of aggrecan in articular cartilage explant cultures. Munteanu, S.E., Ilic, M.Z., Handley, C.J. Arthritis Rheum. (2000) [Pubmed]
  9. Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice. van de Loo, F.A., Kuiper, S., van Enckevort, F.H., Arntz, O.J., van den Berg, W.B. Am. J. Pathol. (1997) [Pubmed]
  10. Neural changes in acute arthritis in monkeys. IV. Time-course of amino acid release into the lumbar dorsal horn. Sorkin, L.S., Westlund, K.N., Sluka, K.A., Dougherty, P.M., Willis, W.D. Brain Res. Brain Res. Rev. (1992) [Pubmed]
  11. Characterization of tachykinin receptors mediating plasma extravasation and vasodilatation in normal and acutely inflamed knee joints of the rat. Lam, F.Y., Wong, M.C. Br. J. Pharmacol. (1996) [Pubmed]
  12. Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse. Ohtsuki, T., Furuya, S., Yamada, T., Nomura, S., Hata, J., Yabe, Y., Hosoda, Y. Calcif. Tissue Int. (1998) [Pubmed]
  13. Meniscus-like synovial fold in the atlantoaxial (C1-C2) joint. Chang, H., Found, E.M., Clark, C.R., Goel, V.K., Gang, C.S. Journal of spinal disorders. (1992) [Pubmed]
  14. Sodium urate arthritis: effects on the sensory properties of articular afferents in the chicken. Gentle, M.J. Pain (1997) [Pubmed]
  15. Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity. Ilic, M.Z., Vankemmelbeke, M.N., Holen, I., Buttle, D.J., Clem Robinson, H., Handley, C.J. Matrix Biol. (2000) [Pubmed]
  16. Cephaloridine penetration into bone and synovial capsule of patients undergoing hip joint replacement. Hughes, S.P., Benson, M.K., Dash, C.H., Field, C.A. J. Antimicrob. Chemother. (1975) [Pubmed]
  17. A lethal, Larsen-like multiple joint dislocation syndrome. Chen, H., Chang, C.H., Perrin, E., Perrin, J. Am. J. Med. Genet. (1982) [Pubmed]
  18. Imaging skeletal pathology in mutant mice by microcomputed tomography. Ford-Hutchinson, A.F., Cooper, D.M., Hallgrímsson, B., Jirik, F.R. J. Rheumatol. (2003) [Pubmed]
  19. Amyloid in osteoarthritic hip joints: deposits in relation to chondromatosis, pyrophosphate, and inflammatory cell infiltrate in the synovial membrane and fibrous capsule. Ladefoged, C. Ann. Rheum. Dis. (1983) [Pubmed]
  20. Effects of paracetamol and aspirin on neural activity of joint mechanonociceptors in adjuvant arthritis. McQueen, D.S., Iggo, A., Birrell, G.J., Grubb, B.D. Br. J. Pharmacol. (1991) [Pubmed]
  21. Spatial heterogeneity of the effects of calcitonin gene-related peptide (CGRP) on the microvasculature of ligaments in the rabbit knee joint. Ferrell, W.R., McDougall, J.J., Bray, R.C. Br. J. Pharmacol. (1997) [Pubmed]
  22. Concentration of flucloxacillin in femoral head and joint capsule in total hip replacement. Pollard, J.P., Hughes, S.P., Evans, M.J., Scott, J.E., Benson, M.K. J. Antimicrob. Chemother. (1979) [Pubmed]
  23. Role of sympathetic postganglionic neurons in synovial plasma extravasation induced by bradykinin. Miao, F.J., Jänig, W., Levine, J. J. Neurophysiol. (1996) [Pubmed]
  24. A new approach to studying angiogenesis in rheumatoid arthritis by means of power Doppler ultrasonography and measurement of serum vascular endothelial growth factor. Strunk, J., Heinemann, E., Neeck, G., Schmidt, K.L., Lange, U. Rheumatology (Oxford, England) (2004) [Pubmed]
  25. High rate of joint capsule matrix turnover in chronic human elbow contractures. Hildebrand, K.A., Zhang, M., Hart, D.A. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  26. A study of the biological behavior of the meniscus as a transplant in the medial compartment of a dog's knee. Canham, W., Stanish, W. The American journal of sports medicine. (1986) [Pubmed]
  27. Highly sulphated glycosaminoglycans in articular cartilage and other tissues containing beta 2 microglobulin dialysis amyloid deposits. Athanasou, N.A., Puddle, B., Sallie, B. Nephrol. Dial. Transplant. (1995) [Pubmed]
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