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Chemical Compound Review

Blue vitriol     copper sulfate pentahydrate

Synonyms: Triangle, Vencedor, Bluestone, Calcanthite, Kupfervitriol, ...
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Disease relevance of CUPRIC SULFATE

  • Both studies used BCG (Tice, Chicago, IL) 3 x 10(8) live organisms per treatment by Tine technique and C parvum (Burroughs-Wellcome, Triangle Park, NC) subcutaneous at a dose of 4 mg/m2 (SECSG) or 5 micrograms/m2 (Hershey) per treatment [1].
  • In sheep given copper (Cu) at the level of 10 ml of a 0.2% solution of CuSO4.5H2O/kg body weight, the volume density of nuclei and cytoplasm of hepatocytes increased and the volume density of the sinusoids and the space of Disse decreased [2].
  • One of the new agents intensively studied in the last decade for the treatment of metastatic breast cancer is vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) [3].
  • Eighteen patients with metastatic non-small cell lung cancer were treated with a combination of intravenous vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Medicament, Paris, France) 25 mg/m2 on days 1 and 8 and intravenous paclitaxel 175 mg/m2 on day 2 every 3 weeks [4].
  • The plant-pathogenic bacterium Ralstonia solanacearum was first shown to enter into the VBNC state both in response to cupric sulfate when in a saline solution and when placed in autoclaved soil [5].

Psychiatry related information on CUPRIC SULFATE

  • Accurate and precise quantification of mercury requires that the pH be between 9.3 and 9.5, the reaction temperature above 25 degrees C, the reaction time longer than 1 min, and, for urine samples only, the cupric sulfate concentration 10 mumol/L [6].
  • Using a modification of the classic Drama Triangle to enhance pastoral care [7].
  • Harm reduction and alternative development in the Golden Triangle [8].
  • Asian countries adjacent to the Golden Triangle and their neighbors have witnessed an evolution in "drug abuse" from traditional opium smoking to heroin eating, smoking, and finally heroin injection [9].
  • A recent study of 630 heroin users was conducted in China's Yunnan Province, located close to the Golden Triangle. Data collected between August 1997 and February 1998 indicate injecting heroin users, in comparison to noninjectors, were more likely to have used drugs for a longer period of time, and to use drugs more frequently everyday [9].

High impact information on CUPRIC SULFATE

  • The "Golden Triangle" of suppressed CMI, angiogenesis, and reduced apoptosis would provide the ideal environment for the serial mutations to occur that are required for the development of malignant disease [10].
  • These tissue resident antigen presenting cells have been shown to upregulate expression of MHC class II (Sakai et al. 1986, Traugott & Lebon 1988), certain adhesion molecules (Cannella et al. 1990), and B7 costimulatory molecules (K. M. Nikcevich, J. A. Bluestone, and S. D. Miller, in preparation) in response to pro-inflammatory cytokines [11].
  • Health-related quality of life measured by the disease-specific instrument MSQ (Migraine-Specific Quality of Life Questionnaire-Version 1.0, 1992 Glaxo Wellcome Inc, Research Triangle Park, NC) showed significant improvement at 3 and at 6 months compared with baseline scores (P<.05) [12].
  • 1843U89 (Glaxo-Wellcome, Research Triangle Park, NC), currently in Phase I trial, does not require the RFC; polyglutamation of this potent TS inhibitor leads to its higher cellular retention without augmenting its TS inhibitory activity [13].
  • Efforts to conserve biodiversity in the Coral Triangle should work to preserve both existing biodiversity as well as the processes creating the biodiversity [14].

Chemical compound and disease context of CUPRIC SULFATE


Biological context of CUPRIC SULFATE

  • Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Concluding remarks [20].
  • Results indicate that the biodiversity in this well-studied group in the Coral Triangle and Red Sea may be underestimated by a minimum of 50% to more than 150%, suggesting a much greater challenge in lesser-studied groups [21].
  • This analysis was conducted in 107 French EGEA families with at least two asthmatic siblings, considering 157 markers that were part of our previous genome screen, using the TTS (the Triangle Test Statistic) which has been developed to detect both linkage and intra-sibpair genetic heterogeneity [22].
  • Generally, the new method also outperformed all the other competing approaches including Triangle and Fitch which is the most popular least-squares method for reconstructing phylogenies [23].
  • Cupric sulfate induced mRNA specific to the copper resistance gene cluster previously cloned from Pseudomonas syringae pv. tomato PT23. mRNA from each of the four genes of this cluster responded in a similar manner to induction over time and with different concentrations of cupric sulfate [24].

Anatomical context of CUPRIC SULFATE

  • After renal pedicle dissection the renal artery was secured with Hem-o-lok (Weck Closure Systems, Research Triangle Park, North Carolina) clips [25].
  • Two Hem-o-lok clips (Weck Closure Systems, Research Triangle Park, NC) were easily placed on the renal vein, which was then transacted safely [26].
  • We hypothesized that a rat model of human bronchitis would be more susceptible to the pulmonary effects of concentrated ambient particles (CAPs) from Research Triangle Park, NC [27].
  • A preliminary test of the genotoxic effect of BaP (0.05, 0.5, 1 and 500 micrograms.l-1), cupric sulfate (10, 25, 50 and 100 micrograms.l-1) and a paper mill effluent (1, 3, 10 and 30 mg.l-1) was performed in C. gigas heart cells cultured for 6 days [28].
  • The nature as well as the extent of the peroxidative response of microsomes to cupric sulfate were dependent on glutathione levels in addition to those of iron [29].

Associations of CUPRIC SULFATE with other chemical compounds

  • One effort involves combining IFN alfa with zidovudine (AZT; Retrovir; Burroughs Wellcome, Research Triangle Park, NC) [30].
  • TS inhibitory antifolates developed to date that are in various stages of clinical evaluation are ZD 1694 and ZD9331 (Astra-Zeneca, London, UK), (Eli Lilly, Indianapolis, IN), LY231514 (BW1843U89 (Glaxo-Wellcome, Research Triangle Park, NC), and AG337 and AG331 (Agouron, La Jolla, CA) [31].
  • Previously, we demonstrated that complex formation between unesterified cholesterol, phosphatidylcholine liposomes and cupric sulfate-oxidized LDL dramatically enhances the ability of the liposomes to augment cellular cholesterol accretion (Greenspan P, Yu H, Mao F, Gutman RL. J Lipid Res 1997;38:101-109) [32].
  • Molecular hydrogen yields are reported for cupric sulfate solutions irradiated with high-energy heavy ions [33].
  • Newer dry powder inhalers such as Turbuhaler (budesonide, Astra USA, Westborough, MA) and Diskus (salmeterol, GlaxoSmithKline, Research Triangle Park, NC) have some advantages over conventional metereddose inhalers (MDIs) including easier technique of usage [34].

Gene context of CUPRIC SULFATE

  • Regulation of hsp70 synthesis induced by cupric sulfate and zinc sulfate in thermotolerant HeLa cells [35].
  • The novel dual EGFR/ErbB-2 tyrosine kinase inhibitor lapatinib (GlaxoSmithKline; Research Triangle Park, NC) has been shown to inhibit tumor cell growth in vitro and in xenograft models for a variety of human tumors [36].
  • Cases in the PEA-BP and ADHD groups were outpatients obtained by consecutive new case ascertainment, and CC subjects were from a survey conducted by the Research Triangle Institute. To fit the study phenotype, PEA-BP subjects needed to have current DSM-IV mania or hypomania with elation and/or grandiosity as one criterion [37].
  • A symposium on Human Tissue Monitoring and Specimen Banking: Opportunities for Exposure Assessment, Risk Assessment, and Epidemiologic Research was held from 30 March to 1 April 1993 in Research Triangle Park, North Carolina. There were 117 registered participants from 18 states and 5 foreign countries [38].
  • The five blood substitutes in this study were obtained from Apex Bioscience (Research Triangle Park, NC), Baxter Healthcare Corp. (Deerfield, IL), Biopure Corp. (Cambridge, MA), Hemoglobin Therapeutics, and Hemosol, Inc. (Etobicoke, Ontario, Canada) [39].

Analytical, diagnostic and therapeutic context of CUPRIC SULFATE


  1. Corynebacterium parvum versus bacille Calmette-Guérin adjuvant immunotherapy of stage II malignant melanoma. Lipton, A., Harvey, H.A., Balch, C.M., Antle, C.E., Heckard, R., Bartolucci, A.A. J. Clin. Oncol. (1991) [Pubmed]
  2. An ultrastructural and morphometric study of the liver of normal and copper-poisoned sheep. Gooneratne, S.R., Howell, J.M., Cook, R.D. Am. J. Pathol. (1980) [Pubmed]
  3. Vinorelbine (Navelbine) in the treatment of breast cancer: a summary. Abeloff, M.D. Semin. Oncol. (1995) [Pubmed]
  4. Pilot study of vinorelbine (navelbine) and paclitaxel in patients with refractory non-small cell lung cancer. Chang, A.Y., DeVore, R., Johnson, D. Semin. Oncol. (1996) [Pubmed]
  5. The viable but nonculturable state of Ralstonia solanacearum may be involved in long-term survival and plant infection. Grey, B.E., Steck, T.R. Appl. Environ. Microbiol. (2001) [Pubmed]
  6. Reduction of organic mercury in water, urine, and blood by sodium borohydride for direct determination of total mercury content. Margel, S., Hirsh, J. Clin. Chem. (1984) [Pubmed]
  7. Using a modification of the classic Drama Triangle to enhance pastoral care. Hasty, C. Journal of pastoral care. (2001) [Pubmed]
  8. Harm reduction and alternative development in the Golden Triangle. Lyttleton, C., Cohen, P.T. Drug and alcohol review. (2003) [Pubmed]
  9. Reawakening the dragon: changing patterns of opiate use in Asia, with particular emphasis on China's Yunnan province. McCoy, C.B., McCoy, H.V., Lai, S., Yu, Z., Wang, X., Meng, J. Substance use & misuse. (2001) [Pubmed]
  10. Chronic immune activation and inflammation in the pathogenesis of AIDS and cancer. Dalgleish, A.G., O'Byrne, K.J. Adv. Cancer Res. (2002) [Pubmed]
  11. Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Miller, S.D., McRae, B.L., Vanderlugt, C.L., Nikcevich, K.M., Pope, J.G., Pope, L., Karpus, W.J. Immunol. Rev. (1995) [Pubmed]
  12. Changes in resource use and outcomes for patients with migraine treated with sumatriptan: a managed care perspective. Lofland, J.H., Johnson, N.E., Batenhorst, A.S., Nash, D.B. Arch. Intern. Med. (1999) [Pubmed]
  13. Thymidylate synthase inhibitors. Touroutoglou, N., Pazdur, R. Clin. Cancer Res. (1996) [Pubmed]
  14. Comparative phylogeography of three codistributed stomatopods: origins and timing of regional lineage diversification in the Coral Triangle. Barber, P.H., Erdmann, M.V., Palumbi, S.R. Evolution (2006) [Pubmed]
  15. Iodine-131 tositumomab (Bexxar) in a radiation oncology environment. Macklis, R.M. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  16. Severe low back pain secondary to acute interstitial nephritis following administration of ranitidine. Karras, D.J. The American journal of emergency medicine. (1994) [Pubmed]
  17. Utilization of copper in copper proteinate, copper lysine, and cupric sulfate using the rat as an experimental model. Du, Z., Hemken, R.W., Jackson, J.A., Trammell, D.S. J. Anim. Sci. (1996) [Pubmed]
  18. Therapeutic aerosols and airway secretions. Rubin, B.K. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine. (1996) [Pubmed]
  19. Heparin and other rapidly acting anticoagulants. Hyers, T.M. Seminars in vascular surgery. (2005) [Pubmed]
  20. Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Concluding remarks. Vouk, V.B. Environ. Health Perspect. (1976) [Pubmed]
  21. Estimating diversity of Indo-Pacific coral reef stomatopods through DNA barcoding of stomatopod larvae. Barber, P., Boyce, S.L. Proc. Biol. Sci. (2006) [Pubmed]
  22. Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families. Dizier, M.H., Besse-Schmittler, C., Guilloud-Bataille, M., Selinger-Leneman, H., Kauffmann, F., Clerget-Darpoux, F., Demenais, F. Eur. J. Hum. Genet. (2001) [Pubmed]
  23. A weighted least-squares approach for inferring phylogenies from incomplete distance matrices. Makarenkov, V., Lapointe, F.J. Bioinformatics (2004) [Pubmed]
  24. Induction of the copper resistance operon from Pseudomonas syringae. Mellano, M.A., Cooksey, D.A. J. Bacteriol. (1988) [Pubmed]
  25. Ligation of the renal vein during laparoscopic nephrectomy: an effective and reliable method to replace vascular staplers. Janetschek, G., Bagheri, F., Abdelmaksoud, A., Biyani, C.S., Leeb, K., Jeschke, S. J. Urol. (2003) [Pubmed]
  26. The Use of Polymer (Hem-o-lok) Clips for Management of the Renal Hilum During Laparoscopic Nephrectomy. Baumert, H., Ballaro, A., Arroyo, C., Kaisary, A.V., Mulders, P.F., Knipscheer, B.C. Eur. Urol. (2006) [Pubmed]
  27. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Kodavanti, U.P., Mebane, R., Ledbetter, A., Krantz, T., McGee, J., Jackson, M.C., Walsh, L., Hilliard, H., Chen, B.Y., Richards, J., Costa, D.L. Toxicol. Sci. (2000) [Pubmed]
  28. The micronucleus assay in Crassostrea gigas for the detection of seawater genotoxicity. Burgeot, T., His, E., Galgani, F. Mutat. Res. (1995) [Pubmed]
  29. Promotion of iron-induced rat liver microsomal lipid peroxidation by copper. Beckman, J.K., Borowitz, S.M., Greene, H.L., Burr, I.M. Lipids (1988) [Pubmed]
  30. Approaches to interferon combination therapy in the treatment of AIDS. Krown, S.E. Semin. Oncol. (1990) [Pubmed]
  31. Thymidylate synthase inhibitors. Danenberg, P.V., Malli, H., Swenson, S. Semin. Oncol. (1999) [Pubmed]
  32. Cholesteryl esterase-treated LDL augments oxidized LDL-mediated cholesteryl ester deposition in mouse peritoneal macrophages. Yu, H., Gutman, R.L., Ryu, B.H., Greenspan, P. Atherosclerosis (1998) [Pubmed]
  33. Radiation chemistry of high-energy carbon, neon, and argon ions: molecular hydrogen yields. Appleby, A., Christman, E.A., Jayko, M. Radiat. Res. (1989) [Pubmed]
  34. Does introduction of new "easy to use" inhalational devices improve medical personnel's knowledge of their proper use? Chopra, N., Oprescu, N., Fask, A., Oppenheimer, J. Ann. Allergy Asthma Immunol. (2002) [Pubmed]
  35. Regulation of hsp70 synthesis induced by cupric sulfate and zinc sulfate in thermotolerant HeLa cells. Hatayama, T., Asai, Y., Wakatsuki, T., Kitamura, T., Imahara, H. J. Biochem. (1993) [Pubmed]
  36. Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Burris, H.A. Oncologist (2004) [Pubmed]
  37. Psychosocial functioning in a prepubertal and early adolescent bipolar disorder phenotype. Geller, B., Bolhofner, K., Craney, J.L., Williams, M., DelBello, M.P., Gundersen, K. Journal of the American Academy of Child and Adolescent Psychiatry. (2000) [Pubmed]
  38. Human tissue monitoring and specimen banking: opportunities for exposure assessment, risk assessment, and epidemiologic research. Lee, L.W., Griffith, J., Zenick, H., Hulka, B.S. Environ. Health Perspect. (1995) [Pubmed]
  39. Co-oximetry interference by hemoglobin-based blood substitutes. Ali, A.A., Ali, G.S., Steinke, J.M., Shepherd, A.P. Anesth. Analg. (2001) [Pubmed]
  40. Leukemia-associated changes identified by quantitative flow cytometry. IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21). Porwit-MacDonald, A., Janossy, G., Ivory, K., Swirsky, D., Peters, R., Wheatley, K., Walker, H., Turker, A., Goldstone, A.H., Burnett, A. Blood (1996) [Pubmed]
  41. A comparison of bone mineral densities among female athletes in impact loading and active loading sports. Fehling, P.C., Alekel, L., Clasey, J., Rector, A., Stillman, R.J. Bone (1995) [Pubmed]
  42. Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey. Hnizdo, E., Sullivan, P.A., Bang, K.M., Wagner, G. Am. J. Epidemiol. (2002) [Pubmed]
  43. Quality of life analyses from vinorelbine (Navelbine) clinical trials of women with metastatic breast cancer. Bertsch, L.A., Donaldson, G. Semin. Oncol. (1995) [Pubmed]
  44. Anti-emetic principles of Magnolia obovata bark and Zingiber officinale rhizome. Kawai, T., Kinoshita, K., Koyama, K., Takahashi, K. Planta Med. (1994) [Pubmed]
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