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Gene Review

DDX41  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

Homo sapiens

Synonyms: ABS, DEAD box protein 41, DEAD box protein abstrakt homolog, MGC8828
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Disease relevance of DDX41

  • ABS was nontoxic for thymocytes but lysed the majority of chronic lymphocytic leukemia (CLL) cells [1].
  • Telithromycin 800 mg once daily has been US FDA approved for the treatment of acute bacterial sinusitis (ABS; treatment duration 5 days), acute bacterial exacerbations of chronic bronchitis (AECB; 5 days) and mild-to-moderate community-acquired pneumonia (CAP; 7-10 days) [2].
  • Growth of Alcaligenes sp. strain O-1 with 2-aminobenzenesulfonate (ABS; orthanilate) as sole source of carbon and energy requires expression of the soluble, multicomponent 2-aminobenzenesulfonate 2,3-dioxygenase system (deaminating) (ABSDOS) which is plasmid-encoded [3].
  • An improved method of coupling a soluble complex, ABS, isolated from B, abortus to sheep red blood cells by chromic chloride in the presence of barbital buffer resulted in a highly specific and reliable passive hemagglutination test for the diagnosis of human and animal brucellosis [4].
  • This study aimed to develop, test, and explore the underlying dimensions of a new questionnaire, the Attitudes to Back Pain Scale (ABS), in a specific group of clinicians, practitioners who specialize in musculoskeletal therapy [5].

Psychiatry related information on DDX41

  • MATERIALS AND METHODS: The case volume from the Residency Review Committee (RRC) operative logs, ABSITE scores, ABS performance, fellowship training, and subsequent career choices were examined for all graduating chief residents in general surgery from our program over the past 17 years [6].
  • As predicted by theory, high scores on the ABS were associated with body-image distortion [7].
  • Measures of life satisfaction (LSI-A), psychological well being (ABS), self-esteem (SES), and depression (BDI) were given pre- and postintervention to determine the most therapeutic treatment modalities [8].
  • With 1996 data as the base, using total population data from the ABS and mental health population data derived by amending 'the list' to remove duplications, pre1996 deaths and post1996 additions, mortality rates for the period 1996-2000 were compared [9].
  • Reiss Screen subscale scores correlated with Irritability, Lethargy, and Hyperactivity on the Aberrant Behavior Checklist (ABC) and with Social Behavior and Disturbing Interpersonal Behavior on the ABS Part II [10].

High impact information on DDX41

  • Leukocyte adhesion: High-speed cells with ABS [11].
  • Chronic lymphocytic leukemia cells rosetted with either sheep erythrocytes or erythrocyte-antibody-complement complexes were lysed by ATS and ABS, respectively [12].
  • Mitogenic responses of blood lymphocytes to phytohemagglutinin (PHA) and concanavalin-A (Con A) were abrogated by treating them with ATS and C, whereas ABS suppressed only their response to Con A [12].
  • ATS also reacted with T cells purified by nylon fiber column filtration but ABS did not [12].
  • ABS, on the other hand, did not stain thymocytes but reacted selectively with the cells located in the lymphoid follicles of lymph node [12].

Chemical compound and disease context of DDX41


Biological context of DDX41

  • Recent studies suggest that an 'automatic braking system' (ABS), involving selectin cell-adhesion molecules, enables leukocytes to roll at a fairly constant velocity despite large variations in blood flow rate [11].
  • Bioinformatic analysis demonstrated the presence of 3 potential sterol regulatory elements (SRE) and 3 ADD-1 binding sequences (ABS), also known as E-box motifs [14].
  • Improved fits were obtained by incorporating the following expression in the model to adjust oral bioavailability as a function of postoperative day (POD): F = 0.2 + 10 x ABS (POD - 7)/([POD + 10] x 60) [15].
  • The sequence of 32b on the left arm of yeast chromosome XII reveals six known genes, a new member of the seripauperins family and a new ABS transporter homologous to the human multidrug resistance protein [16].
  • The highest number of phylogenetically inferred changes attributed to balancing selection was found at beta-chain residues located in the ABS and at those residues implicated in disease susceptibility [17].

Anatomical context of DDX41

  • In further studies, it was shown that phytohemagglutin-responsibility of peripheral blood lymphocytes was not affected by treating them with ABS and complement [1].
  • Anti-human B cell serum (ABS) was developed by sequentially absorbing a rabbit anti-human tonsil serum (AHTS) with human red cells, liver, serum, and thymocytes [1].
  • Indirect immunofluorescence was carried out on tissue sections of human tonsils and lymph nodes, which indicated that ABS-reactive cells were concentrated in lymphoid follicles including germinal centers, while plasma cells and cells located in the thymus-dependent area were essentially devoid of immunofluorescence [1].
  • RESULTS: Cellular outputs were significantly higher with fetal calf serum (FCS) than with cord blood serum (CBS) or adult group AB serum (ABS) in the presence of 6SMF, however, CBS was as effective as FCS [18].
  • ABS production in heat - treated microsomes (3 min at 45 degrees C) correlated significantly with testosterone 6beta-hydroxylation (CYP3A4; P < 0.05) and band intensities on Western blots probed with an antibody selective for 3A4 (P < 0.05) [19].

Associations of DDX41 with chemical compounds

  • In patients with ABS, telithromycin was as effective as a 10-day course of amoxicillin/clavulanic acid 500/125 mg three times daily or cefuroxime axetil 250 mg twice daily [2].
  • Furthermore, endurance training resulted in a decrease in glucose flux at both ABS and REL exercise intensities after endurance exercise training [20].
  • A Linear Solvation Energy Relationship (LSER) developed by Abraham has been applied to the partition of organic solutes in an Aqueous Biphasic System (ABS) and to published values of their 1-octanol/water partition coefficients [21].
  • Glycerol R(a) was not different at either the ABS or REL posttraining exercise intensities compared with pretraining [20].
  • With 10% ABS, this non-specific binding occurred on the solid phase with and without cardiolipin and could be accurately evaluated by subtracting the absorbance of control wells [22].

Analytical, diagnostic and therapeutic context of DDX41

  • Absence of detectable BTX ABS may occur in patients with poor response to BTX injections because of inadequate dosage, injections of inappropriate muscles, or poor sensitivity of the BTX ABS bioassay [23].
  • The interview consisted of disease-specific questions (RSCL), general questionnaires (NHP I and II, ABS), the Visual Analogue Scale, a specific questionnaire (Anxiety), and evaluative questions about social support and transplantation [24].
  • CONCLUSIONS: This report represents the first detailed postimplant day 0 dosimetric evaluation comparing ABS recommended quality parameters used to evaluate prostate brachytherapy [25].
  • There were no cases of iris aspiration into the working end of the phacoemulsification needle; however, the iris was aspirated into the ABS opening of the flared tip in 1 case [26].
  • In addition, delta ABS values in ELISA were highly correlated to titers obtained in immunofluorescence (r = 0.80, P less than 0.001) [27].


  1. Characterization of human B lymphocyte specific antigens. Ishii, Y., Koshiba, H., Ueno, H., Maeyama, I., Takami, T. J. Immunol. (1975) [Pubmed]
  2. Telithromycin. Wellington, K., Noble, S. Drugs (2004) [Pubmed]
  3. The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1. Mampel, J., Ruff, J., Junker, F., Cook, A.M. Microbiology (Reading, Engl.) (1999) [Pubmed]
  4. A passive hemagglutination test for the detection of Brucella infection. Renoux, M. J. Immunol. Methods (1980) [Pubmed]
  5. The attitudes to back pain scale in musculoskeletal practitioners (ABS-mp): the development and testing of a new questionnaire. Pincus, T., Vogel, S., Santos, R., Breen, A., Foster, N., Underwood, M. The Clinical journal of pain. (2006) [Pubmed]
  6. Broad-based general surgery training is a model of continued utility for the future. Cheadle, W.G., Franklin, G.A., Richardson, J.D., Polk, H.C. Ann. Surg. (2004) [Pubmed]
  7. The attention to body shape scale: a new measure of body focus. Beebe, D.W. Journal of personality assessment. (1995) [Pubmed]
  8. Examining key variables in selected reminiscing modalities. Haight, B.K., Dias, J.K. International psychogeriatrics / IPA. (1992) [Pubmed]
  9. Mortality and mental illness. Drew, L.R. The Australian and New Zealand journal of psychiatry. (2005) [Pubmed]
  10. Correlations among the Reiss Screen, the Adaptive Behavior Scale Part II, and the Aberrant Behavior Checklist. Walsh, K.K., Shenouda, N. American journal of mental retardation : AJMR. (1999) [Pubmed]
  11. Leukocyte adhesion: High-speed cells with ABS. van der Merwe, P.A. Curr. Biol. (1999) [Pubmed]
  12. Identification of human peripheral T cell antigens. Koshiba, H., Ishii, Y., Yamanaka, N., Kikuchi, K. J. Immunol. (1977) [Pubmed]
  13. Specificities and some properties of human T and B lymphocyte antisera. Morita, T., Morita, R., Takagi, S., Shimoyama, N., Nagai, K. Tohoku J. Exp. Med. (1981) [Pubmed]
  14. Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes. Schoonjans, K., Gelman, L., Haby, C., Briggs, M., Auwerx, J. J. Mol. Biol. (2000) [Pubmed]
  15. NONMEM population pharmacokinetic modeling of orally administered cyclosporine from routine drug monitoring data after heart transplantation. Parke, J., Charles, B.G. Therapeutic drug monitoring. (1998) [Pubmed]
  16. The sequence of 32b on the left arm of yeast chromosome XII reveals six known genes, a new member of the seripauperins family and a new ABS transporter homologous to the human multidrug resistance protein. Purnelle, B., Goffeau, A. Yeast (1997) [Pubmed]
  17. The evolution of allelic diversity at the primate major histocompatibility complex class II loci. Erlich, H.A., Gyllensten, U.B. Hum. Immunol. (1991) [Pubmed]
  18. Serum supplement, inoculum cell density, and accessory cell effects are dependent on the cytokine combination selected to expand human HPCs ex vivo. Xu, R., Medchill, M., Reems, J.A. Transfusion (2000) [Pubmed]
  19. Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. Rawden, H.C., Kokwaro, G.O., Ward, S.A., Edwards, G. British journal of clinical pharmacology. (2000) [Pubmed]
  20. Substrate utilization during endurance exercise in men and women after endurance training. Carter, S.L., Rennie, C., Tarnopolsky, M.A. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  21. Comparison of an empirical and a theoretical linear solvation energy relationship applied to the characterization of solute distribution in a poly(ethylene) glycol-salt aqueous biphasic system. Huddleston, J.G., Willauer, H.D., Burney, M.T., Tate, L.J., Carruth, A.D., Rogers, R.D. Journal of chemical information and computer sciences. (2004) [Pubmed]
  22. ELISA for the detection of anticardiolipin antibodies. High specificity based on the use of adult bovine serum as buffer and systematic subtraction of non-specific binding. Rupin, A., Gruel, Y., Watier, H., Girard, A.C., Leroy, J., Bardos, P. J. Immunol. Methods (1991) [Pubmed]
  23. Response and immunoresistance to botulinum toxin injections. Jankovic, J., Schwartz, K. Neurology (1995) [Pubmed]
  24. Comparison before and after transplantation of pancreas-kidney and pancreas-kidney with loss of pancreas--a prospective controlled quality of life study. Adang, E.M., Engel, G.L., van Hooff, J.P., Kootstra, G. Transplantation (1996) [Pubmed]
  25. Potential role of various dosimetric quality indicators in prostate brachytherapy. Merrick, G.S., Butler, W.M., Dorsey, A.T., Lief, J.H. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  26. Performance comparison of the Alcon Legacy 20000 straight and flared 0.9 mm Aspiration Bypass System tips. Davison, J.A. Journal of cataract and refractive surgery. (2002) [Pubmed]
  27. Simultaneous use of Plasmodium falciparum crude antigen and red blood cell control antigen in the enzyme-linked immunosorbent assay for malaria. Demedts, P., Vermeulen-Van Overmeir, C., Wery, M. Am. J. Trop. Med. Hyg. (1987) [Pubmed]
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