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Il13  -  interleukin 13

Rattus norvegicus

Synonyms: IL-13, Il-13, Interleukin-13, T-cell activation protein P600
 
 
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Disease relevance of Il13

  • The CNS transcription of the HIV-1 replication factor IL-1beta in the context of limited transcription of the IL-1 replication inhibitors IL-1ra, IL-10, and IL-13 might help explain the negative impact of systemic inflammation on the clinical course of AIDS [1].
  • Our data strongly suggest that IL-13 may control brain inflammation by inducing the death of activated microglia in vivo, resulting in an enhancement of neuronal survival [2].
  • Using a reverse transcriptase-polymerase chain reaction method, a cDNA for the complete coding region and part of the 5'-untranslated region of rat IL-13 was cloned from rat renal cortex RNA following the induction of anti-glomerular basement membrane antibody-induced glomerulonephritis [3].
  • Furthermore, LPS- and OX8-stimulated AM from Brown Norway rats produce more Th2 type cytokines (IL-10 and IL-13) than AM from Sprague Dawley rats, suggesting that these cells may play an important role in creating a cytokine milieu that may favour the development of allergic reactions [4].
  • This represents a potential mechanism by which IL-4/IL-13 could play a role in the pathogenesis of lung fibrosis [5].
 

High impact information on Il13

 

Chemical compound and disease context of Il13

  • Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6 [5].
  • Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to pseudomonas exotoxin [9].
 

Biological context of Il13

  • In conclusion, cytoprotection rendered by virally induced IL-13 against hepatic I/R injury in this clinically relevant rat hepatic cold I/R injury model was accomplished via decreased apoptosis and induction of antiapoptotic/antioxidant molecules [10].
  • Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo [2].
  • The deduced amino acid sequence of rat IL-13 reveals 63% and 79% homology with the human and mouse proteins, respectively [3].
  • These data indicate that endogenous IL-10, IL-13 and SLPI are important regulators of the inflammatory response by reducing gene activation with resultant generation of peptide mediators/cytokines and chemokines [11].
  • IL-10 was able to inhibit KC production of both SO and TNF- in vitro, and this was achieved more effectively than IL-4 or IL-13; no such effects were seen on KC phagocytosis [8].
 

Anatomical context of Il13

  • We previously reported that IL-13, an anti-inflammatory cytokine, induced the death of activated microglia [12].
  • Both CD4+ and CD8+ T cells are activated in response to allergen challenge in the sensitized rat and express Thelper2 cytokines (IL-4, IL-5 and IL-13) [13].
  • Electrophoretic mobility shift analysis of nuclear extracts from alveolar macrophages and whole lung tissues demonstrated that both IL-10 and IL-13 suppressed nuclear localization of NF-kappa B after in vivo deposition of IgG immune complexes [7].
  • The present study underlines the importance of IL-10 and IL-13, cytokines with potent antiinflammatory properties, in inhibiting the proinflammatory cytokine (TNF-alpha and IL-1beta)-mediated degradation of SM to ceramide in rat primary astrocytes [14].
  • To identify the active component involved, we examined the expression of known macrophage deactivators IL-10, IL-13, and TGF-beta 1 in mesangial cells [15].
 

Associations of Il13 with chemical compounds

 

Regulatory relationships of Il13

 

Other interactions of Il13

  • In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13 [7].
  • However, inhibition of HO-1 with tin protoporphyrin reversed cytoprotective/antiapoptotic effects of IL-13 [10].
  • Treatment of rat primary astrocytes with TNF-alpha or IL-1beta led to rapid degradation of SM to ceramide, whereas IL-10 and IL-13 by themselves were unable to induce the degradation of SM to ceramide [14].
  • Under the basal culture conditions, strong expression of TGF-beta 1 mRNA was observed, whereas expression of neither IL-10 nor IL-13 was detected [15].
  • There was no marked change in IL-5, IL-13 or transforming growth factor-beta (TGF-beta) in either strain [19].
 

Analytical, diagnostic and therapeutic context of Il13

References

  1. Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications. Wong, M.L., Bongiorno, P.B., Rettori, V., McCann, S.M., Licinio, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo. Shin, W.H., Lee, D.Y., Park, K.W., Kim, S.U., Yang, M.S., Joe, E.H., Jin, B.K. Glia (2004) [Pubmed]
  3. Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis. Lakkis, F.G., Cruet, E.N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  4. Alveolar macrophages of allergic resistant and susceptible strains of rats show distinct cytokine profiles. Sirois, J., Bissonnette, E.Y. Clin. Exp. Immunol. (2001) [Pubmed]
  5. Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. Liu, T., Jin, H., Ullenbruch, M., Hu, B., Hashimoto, N., Moore, B., McKenzie, A., Lukacs, N.W., Phan, S.H. J. Immunol. (2004) [Pubmed]
  6. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Monney, L., Sabatos, C.A., Gaglia, J.L., Ryu, A., Waldner, H., Chernova, T., Manning, S., Greenfield, E.A., Coyle, A.J., Sobel, R.A., Freeman, G.J., Kuchroo, V.K. Nature (2002) [Pubmed]
  7. In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13. Lentsch, A.B., Shanley, T.P., Sarma, V., Ward, P.A. J. Clin. Invest. (1997) [Pubmed]
  8. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Thompson, K., Maltby, J., Fallowfield, J., McAulay, M., Millward-Sadler, H., Sheron, N. Hepatology (1998) [Pubmed]
  9. Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to pseudomonas exotoxin. Murad, G.J., Walbridge, S., Morrison, P.F., Garmestani, K., Degen, J.W., Brechbiel, M.W., Oldfield, E.H., Lonser, R.R. Clin. Cancer Res. (2006) [Pubmed]
  10. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Ke, B., Shen, X.D., Lassman, C.R., Gao, F., Busuttil, R.W., Kupiec-Weglinski, J.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2003) [Pubmed]
  11. Endogenous regulation of the acute inflammatory response. Ward, P.A., Lentsch, A.B. Mol. Cell. Biochem. (2002) [Pubmed]
  12. Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. Yang, M.S., Ji, K.A., Jeon, S.B., Jin, B.K., Kim, S.U., Jou, I., Joe, E. J. Immunol. (2006) [Pubmed]
  13. Rat models of asthma and chronic obstructive lung disease. Martin, J.G., Tamaoka, M. Pulmonary pharmacology & therapeutics. (2006) [Pubmed]
  14. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase. Pahan, K., Khan, M., Singh, I. J. Neurochem. (2000) [Pubmed]
  15. Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells . Kitamura, M., Sütö, T., Yokoo, T., Shimizu, F., Fine, L.G. J. Immunol. (1996) [Pubmed]
  16. Secretion of inflammatory mediators by isolated rat Kupffer cells: the effect of octreotide. Valatas, V., Kolios, G., Manousou, P., Xidakis, C., Notas, G., Ljumovic, D., Kouroumalis, E.A. Regul. Pept. (2004) [Pubmed]
  17. IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Kim, S., Shim, J.J., Burgel, P.R., Ueki, I.F., Dao-Pick, T., Tam, D.C., Nadel, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  18. IL-4 and IL-13 upregulate arginase I expression by cAMP and JAK/STAT6 pathways in vascular smooth muscle cells. Wei, L.H., Jacobs, A.T., Morris, S.M., Ignarro, L.J. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  19. Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Gillespie, K.M., Saoudi, A., Kuhn, J., Whittle, C.J., Druet, P., Bellon, B., Mathieson, P.W. Eur. J. Immunol. (1996) [Pubmed]
  20. Comparison of Th1/Th2 cytokine profiles of initial wound healing of rats induced by PDCM and e-PTFE. Lu, H.K., Ko, M.T., Wu, M.F. Journal of biomedical materials research. Part B, Applied biomaterials. (2004) [Pubmed]
  21. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Ke, B., Shen, X.D., Zhai, Y., Gao, F., Busuttil, R.W., Volk, H.D., Kupiec-Weglinski, J.W. Hum. Gene Ther. (2002) [Pubmed]
 
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