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Gene Review

umpG  -  broad specificity 5'(3')-nucleotidase and...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2739, JW2714, surE, ygbC
 
 
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Disease relevance of surE

 

High impact information on surE

 

Chemical compound and disease context of surE

 

Biological context of surE

  • These cells were found to survive poorly in stationary phase, at elevated temperatures, and in high-salt media compared with parent cells containing the intact gene, and we thus designate this gene surE (survival). surE appears to be the first gene of a bicistronic operon also containing the pcm gene [14].
  • Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes [15].
  • Analysis of the nucleotide sequence and of the origins of transcription have confirmed that the P2-appC-appB- (ORFX)-P1-appA region is organized on the chromosome as an operon transcribed clockwise from P2 and that P1 is a minor promoter for appA alone [16].
  • Analyses of the sequences, phylogenetic distribution, and genomic organization of the SurE family reveal examples of genomes encoding multiple surE genes, and suggest that SurE homologs constitute a broad family of enzymes with phosphatase-like activities [17].
  • The product of the previously identified appY gene, which when present on a high-copy-number plasmid stimulates synthesis of acid phosphatase, was shown to activate the cyx promoter [18].
 

Anatomical context of surE

 

Associations of surE with chemical compounds

 

Regulatory relationships of surE

  • A null mutation in surE also suppressed stress-survival defects previously observed in a pcm mutant strain, providing further evidence for an interaction between the two gene products [15].
 

Other interactions of surE

 

Analytical, diagnostic and therapeutic context of surE

References

  1. Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Zhang, R.G., Skarina, T., Katz, J.E., Beasley, S., Khachatryan, A., Vyas, S., Arrowsmith, C.H., Clarke, S., Edwards, A., Joachimiak, A., Savchenko, A. Structure (Camb.) (2001) [Pubmed]
  2. Crystallization and preliminary X-ray crystallographic analysis of the surE protein from Thermotoga maritima. Kwak, J.E., Ha, K.S., Lee, J.Y., Im, Y.J., Park, S.H., Eom, S.H., Suh, S.W. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  3. Bacterial acid phosphatase gene fusions useful as targets for cloning-dependent insertional inactivation. Thaller, M.C., Berlutti, F., Schippa, S., Selan, L., Rossolini, G.M. Biotechnol. Prog. (1998) [Pubmed]
  4. Expression of hepatitis B surface antigen gene in yeast. Miyanohara, A., Toh-e, A., Nozaki, C., Hamada, F., Ohtomo, N., Matsubara, K. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Chiang, C.Y., Kyritsis, G., Graves, D.T., Amar, S. Infect. Immun. (1999) [Pubmed]
  6. The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes. Horwitz, M.A. J. Exp. Med. (1983) [Pubmed]
  7. Membrane insertion of uracil permease, a polytopic yeast plasma membrane protein. Silve, S., Volland, C., Garnier, C., Jund, R., Chevallier, M.R., Haguenauer-Tsapis, R. Mol. Cell. Biol. (1991) [Pubmed]
  8. A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. Zhou, H., Kartsogiannis, V., Hu, Y.S., Elliott, J., Quinn, J.M., McKinstry, W.J., Gillespie, M.T., Ng, K.W. J. Biol. Chem. (2001) [Pubmed]
  9. The structure of the promoter and amino terminal region of the pH 2.5 acid phosphatase structural gene (appA) of E. coli: a negative control of transcription mediated by cyclic AMP. Touati, E., Danchin, A. Biochimie (1987) [Pubmed]
  10. Phosphorylation of nucleosides by the mutated acid phosphatase from Morganella morganii. Mihara, Y., Utagawa, T., Yamada, H., Asano, Y. Appl. Environ. Microbiol. (2000) [Pubmed]
  11. Pleiotropic mutations in appR reduce pH 2.5 acid phosphatase expression and restore succinate utilisation in CRP-deficient strains of Escherichia coli. Touati, E., Dassa, E., Boquet, P.L. Mol. Gen. Genet. (1986) [Pubmed]
  12. Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome: a potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli. Thaller, M.C., Schippa, S., Bonci, A., Berlutti, F., Selan, L., Rossolini, G.M. FEMS Microbiol. Lett. (1999) [Pubmed]
  13. Acid phosphatase/phosphotransferases from enteric bacteria. Mihara, Y., Utagawa, T., Yamada, H., Asano, Y. J. Biosci. Bioeng. (2001) [Pubmed]
  14. A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome. Li, C., Ichikawa, J.K., Ravetto, J.J., Kuo, H.C., Fu, J.C., Clarke, S. J. Bacteriol. (1994) [Pubmed]
  15. Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. Visick, J.E., Ichikawa, J.K., Clarke, S. FEMS Microbiol. Lett. (1998) [Pubmed]
  16. A new oxygen-regulated operon in Escherichia coli comprises the genes for a putative third cytochrome oxidase and for pH 2.5 acid phosphatase (appA). Dassa, J., Fsihi, H., Marck, C., Dion, M., Kieffer-Bontemps, M., Boquet, P.L. Mol. Gen. Genet. (1991) [Pubmed]
  17. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. Mura, C., Katz, J.E., Clarke, S.G., Eisenberg, D. J. Mol. Biol. (2003) [Pubmed]
  18. Role of the transcriptional activator AppY in regulation of the cyx appA operon of Escherichia coli by anaerobiosis, phosphate starvation, and growth phase. Atlung, T., Brøndsted, L. J. Bacteriol. (1994) [Pubmed]
  19. Effects of endotoxin treatment on the differentiation of guinea pig megakaryocytes to blood platelets. Raha, S., Wesemann, W. J. Cell. Sci. (1983) [Pubmed]
  20. Incorporation of bacterial lipopolysaccharide by human Leu-11a+ natural killer cells. Ultrastructural and functional correlations. Kang, Y.H., Carl, M., Maheshwari, R.K., Watson, L.P., Yaffe, L., Grimley, P.M. Lab. Invest. (1988) [Pubmed]
  21. Phagocytosis and leukocyte enzymes in ascorbic acid deficient guinea pigs. Shilotri, P.G. J. Nutr. (1977) [Pubmed]
  22. Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. Shekels, L.L., Smith, A.J., Van Etten, R.L., Bernlohr, D.A. Protein Sci. (1992) [Pubmed]
  23. Toxic effects of methyl methanesulfonate (MMS) on activated macrophages from chickens. Qureshi, M.A., Bloom, S.E., Hamilton, J.W., Dietert, R.R. Environ. Mol. Mutagen. (1989) [Pubmed]
  24. Biochemical characterization of the class B acid phosphatase (AphA) of Escherichia coli MG1655. Passariello, C., Forleo, C., Micheli, V., Schippa, S., Leone, R., Mangani, S., Thaller, M.C., Rossolini, G.M. Biochim. Biophys. Acta (2006) [Pubmed]
  25. Isolation and characterization of a thiamin pyrophosphokinase gene, THI80, from Saccharomyces cerevisiae. Nosaka, K., Kaneko, Y., Nishimura, H., Iwashima, A. J. Biol. Chem. (1993) [Pubmed]
  26. Plasma acid phosphatase levels in endotoxaemia: modification by drugs and chemically detoxified endotoxins. Godin, D.V., Tuchek, J.M. Br. J. Pharmacol. (1983) [Pubmed]
  27. Asp304 of Escherichia coli acid phosphatase is involved in leaving group protonation. Ostanin, K., Van Etten, R.L. J. Biol. Chem. (1993) [Pubmed]
  28. Evidence of histidine phosphorylation in isocitrate lyase from Escherichia coli. Robertson, E.F., Hoyt, J.C., Reeves, H.C. J. Biol. Chem. (1988) [Pubmed]
  29. Overexpression, site-directed mutagenesis, and mechanism of Escherichia coli acid phosphatase. Ostanin, K., Harms, E.H., Stevis, P.E., Kuciel, R., Zhou, M.M., Van Etten, R.L. J. Biol. Chem. (1992) [Pubmed]
  30. Intracellular processing and toxicity of the truncated androgen receptor: nuclear congophilia-associated cell death. Feng, B., Chen, L., Drmanovic, Z., Kakabadze, I., Mendell, J.R., Marzluf, G.A., Sahenk, Z. J. Neuropathol. Exp. Neurol. (2000) [Pubmed]
  31. Cytogenetic aspects of B-cell chronic lymphocytic leukemia: their correlation with clinical stage and different polyclonal mitogens. Castoldi, G.L., Lanza, F., Cuneo, A. Cancer Genet. Cytogenet. (1987) [Pubmed]
  32. Bacterial antigen and acid phosphatase in macrophages in experimental pyelonephritis. Thomsen, O.F. Acta pathologica et microbiologica Scandinavica. Section A, Pathology. (1975) [Pubmed]
 
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