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Gene Review

SH3PXD2A  -  SH3 and PX domains 2A

Homo sapiens

Synonyms: Adapter protein TKS5, FISH, Five SH3 domain-containing protein, KIAA0418, SH3 and PX domain-containing protein 2A, ...
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Disease relevance of SH3PXD2A


Psychiatry related information on SH3PXD2A

  • RESULTS: Fish oil took several weeks to lower TG level, and patient compliance during 3 months of therapy was inadequate [6].
  • RESULTS: Fish consumption was significantly associated with higher self-reported mental health status, even after adjustment for possible confounders [7].
  • In this study rating scales and assessment instruments for children aged < 15, such as CPRS with General Scoring Sheet (Fish, 1985), were used to assess the broad spectrum of psychopathology in this age group [8].

High impact information on SH3PXD2A

  • Classic (complete) lecithin:cholesterol acyltransferase (LCAT) deficiency and Fish-eye disease (partial LCAT deficiency) are genetic syndromes associated with markedly decreased plasma levels of high density lipoprotein (HDL) cholesterol but not with an increased risk of atherosclerotic cardiovascular disease [9].
  • Furthermore, development of an in situ Rho[GTP] affinity assay allowed us to detect endogenous Rho[GTP] at podosomes, where it colocalized with F-actin, cortactin, and Fish. Therefore, Rho is not globally inactivated in Src-transformed fibroblasts, but is necessary for the assembly and function of structures implicated in tumor cell invasion [10].
  • CONCLUSION: Fish oil, in doses that reduce blood pressure and lipid levels in hypertensive persons, does not adversely affect glucose metabolism [11].
  • RESULTS: Fish oil supplementation resulted in a significant decrease in rectal dialysate levels of leukotriene B4 from 71.0 to 27.7 pg/mL (average change, -43.3 pg/mL; 95% CI, -83 to -3.6) [12].
  • CONCLUSIONS: Fish oil concentrate at high doses followed by low-dose maintenance therapy cannot sustain the initial large plasma triglyceride reductions [13].

Chemical compound and disease context of SH3PXD2A

  • [Bettany JA, Fish DR, Mendel FC: Influence of high voltage pulsed direct current on edema formation following impact injury [14].
  • PROCEDURE--Gentamicin was administered at dosages of 2.5, 5, 15, and 50 mg/kg of body weight, i.p., and 3.5 mg/kg, i.m. Fish were euthanatized at various periods (2, 3, 7, 14, and 28 days) after gentamicin administration [15].
  • The liver alpha-tocopherol concentrations were increased by supplemental vitamin C in vitamin E-deficient dietary groups which indicates a sparing or regenerating effect of vitamin C on vitamin E. Fish fed vitamin C-deficient diets (-C-E and -C+E) exhibited severe deficiency symptoms, such as scoliosis, lens cataracts, anorexia, and haemorrhages [16].
  • In addition, the Diseases of Fish (Control) Regulations have since been passed so that new European Union rules for the control of infectious salmon anaemia, viral haemorrhagic septicaemia and infectious haematopoietic necrosis may be enforced nationally [17].
  • Tungsten-iron and tungsten-polymer shot were given conditional approval for waterfowl hunting by the U.S. Fish and Wildlife Service based partly on the results of a 30-day acute toxicity trial utilizing mallards (Anas platyrhynchos) [18].

Biological context of SH3PXD2A

  • CONCLUSION: Fish oil did not significantly influence appetite, tiredness, nausea, well-being, caloric intake, nutritional status, or function after 2 weeks compared with placebo in patients with advanced cancer and loss of both weight and appetite [19].
  • ORs constitute 17 gene families, 4 of which contain more than 100 members each. "Fish-like" Class I ORs, previously considered a relic in higher tetrapods, constitute as much as 10% of the human repertoire, all in one large cluster on chromosome 11 [20].
  • Identification of the clones was based on the amino acid sequence identity between the cDNA-deduced amino acid sequence and the reported amino acid sequence obtained from a fragment of the alpha 4(IV) collagen polypeptide M28+ (Butkowski, R. J., Shen, G.-Q., Wieslander, J., Michael, A. F., and Fish, A. J. (1990) J. Lab. Clin. Med. 115, 365-373) [21].
  • A commonly utilized IEP86 cDNA expression clone (herein called the original cDNA) (E. Baracchini, E. Glezer, K. Fish, R. M. Stenberg, J. A. Nelson, and P. Ghazal, Virology 188:518-529, 1992) shows the Towne R68 and seven serines but contains the AD169 E455 and A541 plus two amino acid mutations, M242I and A463T [22].
  • Microsatellites, which have rapidly become the preferred markers in population genetics, reliably assign individual chinook salmon to the winter, fall, late-fall, or spring chinook runs in the Sacramento River in California's Central Valley (Banks et al. 2000. Can. J. Fish. Aquat. Sci. 57:915-927) [23].

Anatomical context of SH3PXD2A

  • Finally, coexpression of Tks5/Fish and Src in epithelial cells resulted in the appearance of podosomes [1].
  • Recent studies show that bony fishes harbor a similar system of specialized nonmacrophagic scavenger endothelial cells in either kidney [Smedsrød, B., Gjøen, T., Sveinbjørnsson, B. & Berg, T. (1993) J. Fish Biol. 42, 279-291] or heart [Sørensen, K. K., Melkko, J. & Smedsrød, B. (1998) J. Exp. Biol. 201, 1707-1718], but not in liver [24].
  • Moreover, it stimulates the E-cadherin regulator Hakai, interacts with and phosphorylates the novel podosome-linked adaptor protein Fish, and progressively phosphorylates the gap junction component connexion 43 [25].
  • RESULTS: Fish oil supplementation induced n-3 fatty acid incorporation in normotriglyceridemic and hypertriglyceridemic erythrocyte membranes without decreasing their resistance to AAPH. n-3 Fatty acids significantly protected normotriglyceridemic but not hypertriglyceridemic erythrocytes against hemolysis [26].
  • RESULTS: Fish-oil supplementation decreased PGE(2) production and increased IFN-gamma production and lymphocyte proliferation from baseline values [27].

Associations of SH3PXD2A with chemical compounds

  • Compared with the previous strain (Kitamikado, M., and Ueno, R. (1970) Bull. Jpn. Soc. Sci. Fish. 36, 1175-1180), this strain releases comparable levels of endo-beta-galactosidase with lower levels of exoglycosidases in the culture medium containing 0.3% of keratan sulfate [28].
  • RESULTS: Fish-oil plus antioxidant dietary supplementation was associated with higher EPA and DHA incorporation into PBMCs (P < 0.001) and lower arachidonic acid (P = 0.006) and lower production of IFN-gamma by mitogen-stimulated PBMCs (P = 0.012) and of PGE(2) by lipopolysaccharide-stimulated PBMCs (P = 0.047) [29].
  • RESULTS: Fish oils and atorvastatin significantly decreased plasma triacylglycerols and increased HDL cholesterol and HDL2 cholesterol (P < 0.05 for main effects) [30].
  • Arginyl residues of human antithrombin III have been implicated to involve in the heparin binding site [Jorgensen, A. M., Borders, C. L., & Fish, W. W. (1985) Biochem, J. 231, 59-63] [31].
  • This results in irreversible formation of enzyme-bound NADH and of adenine (Ade) and inactivation [Abeles, R. H., TAshjian, A. H., Jr., & Fish, S (1980) Biochem. Biophys. Res. Commun. 95, 612-617] [32].

Analytical, diagnostic and therapeutic context of SH3PXD2A


  1. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Seals, D.F., Azucena, E.F., Pass, I., Tesfay, L., Gordon, R., Woodrow, M., Resau, J.H., Courtneidge, S.A. Cancer Cell (2005) [Pubmed]
  2. Images in clinical medicine. Fish-tank granuloma. Wolfe, S.F., Gurevitch, A.W. N. Engl. J. Med. (1997) [Pubmed]
  3. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Anti, M., Armelao, F., Marra, G., Percesepe, A., Bartoli, G.M., Palozza, P., Parrella, P., Canetta, C., Gentiloni, N., De Vitis, I. Gastroenterology (1994) [Pubmed]
  4. Fish oil supplementation does not lower plasma cholesterol in men with hypercholesterolemia. Results of a randomized, placebo-controlled crossover study. Wilt, T.J., Lofgren, R.P., Nichol, K.L., Schorer, A.E., Crespin, L., Downes, D., Eckfeldt, J. Ann. Intern. Med. (1989) [Pubmed]
  5. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. Zampelas, A., Panagiotakos, D.B., Pitsavos, C., Das, U.N., Chrysohoou, C., Skoumas, Y., Stefanadis, C. J. Am. Coll. Cardiol. (2005) [Pubmed]
  6. Insulin therapy for a non-diabetic patient with severe hypertriglyceridemia. Jabbar, M.A., Zuhri-Yafi, M.I., Larrea, J. Journal of the American College of Nutrition. (1998) [Pubmed]
  7. Fish consumption and self-reported physical and mental health status. Silvers, K.M., Scott, K.M. Public health nutrition. (2002) [Pubmed]
  8. Psychopathological differences among three groups of school children affected by the war in Croatia. Sikić, N., Javornik, N., Stracenski, M., Bunjevac, T., Buljan-Flander, G. Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti. (1997) [Pubmed]
  9. Markedly accelerated catabolism of apolipoprotein A-II (ApoA-II) and high density lipoproteins containing ApoA-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease. Rader, D.J., Ikewaki, K., Duverger, N., Schmidt, H., Pritchard, H., Frohlich, J., Clerc, M., Dumon, M.F., Fairwell, T., Zech, L. J. Clin. Invest. (1994) [Pubmed]
  10. Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. Berdeaux, R.L., Díaz, B., Kim, L., Martin, G.S. J. Cell Biol. (2004) [Pubmed]
  11. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Toft, I., Bønaa, K.H., Ingebretsen, O.C., Nordøy, A., Jenssen, T. Ann. Intern. Med. (1995) [Pubmed]
  12. Dietary supplementation with fish oil in ulcerative colitis. Stenson, W.F., Cort, D., Rodgers, J., Burakoff, R., DeSchryver-Kecskemeti, K., Gramlich, T.L., Beeken, W. Ann. Intern. Med. (1992) [Pubmed]
  13. Can the hypotriglyceridemic effect of fish oil concentrate be sustained? Schectman, G., Kaul, S., Cherayil, G.D., Lee, M., Kissebah, A. Ann. Intern. Med. (1989) [Pubmed]
  14. Influence of high voltage pulsed direct current on edema formation following impact injury. Bettany, J.A., Fish, D.R., Mendel, F.C. Physical therapy. (1990) [Pubmed]
  15. Evaluation of gentamicin-induced nephrotoxicosis in toadfish. Reimschuessel, R., Chamie, S.J., Kinnel, M. J. Am. Vet. Med. Assoc. (1996) [Pubmed]
  16. Interaction between vitamins C and E affects their tissue concentrations, growth, lipid oxidation, and deficiency symptoms in yellow perch (Perca flavescens). Lee, K.J., Dabrowski, K. Br. J. Nutr. (2003) [Pubmed]
  17. National legislation in Great Britain for the control of fish diseases. Hill, B.J. Rev. - Off. Int. Epizoot. (1996) [Pubmed]
  18. Reproductive effects and duckling survivability following chronic dosing with tungsten-iron and tungsten-polymer shot in adult game-farm mallards. Mitchell, R.R., Fitzgerald, S.D., Aulerich, R.J., Balander, R.J., Powell, D.C., Tempelmen, R.J., Stevens, W., Bursia, S.J. J. Wildl. Dis. (2001) [Pubmed]
  19. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. Bruera, E., Strasser, F., Palmer, J.L., Willey, J., Calder, K., Amyotte, G., Baracos, V. J. Clin. Oncol. (2003) [Pubmed]
  20. The complete human olfactory subgenome. Glusman, G., Yanai, I., Rubin, I., Lancet, D. Genome Res. (2001) [Pubmed]
  21. Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2. Kamagata, Y., Mattei, M.G., Ninomiya, Y. J. Biol. Chem. (1992) [Pubmed]
  22. Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation. Barrasa, M.I., Harel, N., Yu, Y., Alwine, J.C. J. Virol. (2003) [Pubmed]
  23. Evolution of a perfect simple sequence repeat locus in the context of its flanking sequence. Blankenship, S.M., May, B., Hedgecock, D. Mol. Biol. Evol. (2002) [Pubmed]
  24. Scavenger endothelial cells of vertebrates: a nonperipheral leukocyte system for high-capacity elimination of waste macromolecules. Seternes, T., Sørensen, K., Smedsrød, B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Newest findings on the oldest oncogene; how activated src does it. Frame, M.C. J. Cell. Sci. (2004) [Pubmed]
  26. Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects. Mabile, L., Piolot, A., Boulet, L., Fortin, L.J., Doyle, N., Rodriguez, C., Davignon, J., Blache, D., Lussier-Cacan, S. Am. J. Clin. Nutr. (2001) [Pubmed]
  27. Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. Trebble, T.M., Wootton, S.A., Miles, E.A., Mullee, M., Arden, N.K., Ballinger, A.B., Stroud, M.A., Burdge, G.C., Calder, P.C. Am. J. Clin. Nutr. (2003) [Pubmed]
  28. Isolation and characterization of an endo-beta-galactosidase from a new strain of Escherichia freundii. Nakagawa, H., Yamada, T., Chien, J.L., Gardas, A., Kitamikado, M., Li, S.C., Li, Y.T. J. Biol. Chem. (1980) [Pubmed]
  29. Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease. Trebble, T.M., Arden, N.K., Wootton, S.A., Calder, P.C., Mullee, M.A., Fine, D.R., Stroud, M.A. Am. J. Clin. Nutr. (2004) [Pubmed]
  30. Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity. Chan, D.C., Watts, G.F., Nguyen, M.N., Barrett, P.H. Am. J. Clin. Nutr. (2006) [Pubmed]
  31. Evidence that arginine-129 and arginine-145 are located within the heparin binding site of human antithrombin III. Sun, X.J., Chang, J.Y. Biochemistry (1990) [Pubmed]
  32. S-Adenosylhomocysteinase: mechanism of inactivation by 2'-deoxyadenosine and interaction with other nucleosides. Abeles, R.H., Fish, S., Lapinskas, B. Biochemistry (1982) [Pubmed]
  33. Early enteral feeding in postsurgical cancer patients. Fish oil structured lipid-based polymeric formula versus a standard polymeric formula. Kenler, A.S., Swails, W.S., Driscoll, D.F., DeMichele, S.J., Daley, B., Babineau, T.J., Peterson, M.B., Bistrian, B.R. Ann. Surg. (1996) [Pubmed]
  34. N-3 fatty acids do not lead to an increased diabetic risk in patients with hyperlipidemia and abnormal glucose tolerance. Italian Fish Oil Multicenter Study. Sirtori, C.R., Paoletti, R., Mancini, M., Crepaldi, G., Manzato, E., Rivellese, A., Pamparana, F., Stragliotto, E. Am. J. Clin. Nutr. (1997) [Pubmed]
  35. Fatty acids in human platelets and plasma. Fish oils decrease sensitivity toward N2 microbubbles. Bakken, A.M., Farstad, M., Holmsen, H. J. Appl. Physiol. (1991) [Pubmed]
  36. A pooled analysis of case-control studies of thyroid cancer. VI. Fish and shellfish consumption. Bosetti, C., Kolonel, L., Negri, E., Ron, E., Franceschi, S., Dal Maso, L., Galanti, M.R., Mark, S.D., Preston-Martin, S., McTiernan, A., Land, C., Jin, F., Wingren, G., Hallquist, A., Glattre, E., Lund, E., Levi, F., Linos, D., La Vecchia, C. Cancer Causes Control (2001) [Pubmed]
  37. The complete amino acid sequence of growth hormone of an elasmobranch, the blue shark (Prionace glauca). Yamaguchi, K., Yasuda, A., Lewis, U.J., Yokoo, Y., Kawauchi, H. Gen. Comp. Endocrinol. (1989) [Pubmed]
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