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Gene Review

Bsg  -  basigin

Mus musculus

Synonyms: 5A11/Basigin, AI115436, AI325119, Basic immunoglobulin superfamily, Basigin, ...
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Disease relevance of Bsg


Psychiatry related information on Bsg


High impact information on Bsg


Biological context of Bsg


Anatomical context of Bsg


Associations of Bsg with chemical compounds

  • There was no change in expression or distribution of the glucose transporter (GLUT)-1 in the RPE and retina of the Bsg(-/-) mouse [12].
  • Basigin and embigin, two related members of the immunoglobulin superfamily, a sialomucin MGC-24 and other glycoproteins were discovered as carriers of developmentally regulated carbohydrate markers [15].
  • In contrast, the fundus and the fluorescein fundus angiography and morphology of the retina at the light microscopic level appeared to be normal until 8 weeks of age in Bsg knockout mice [16].
  • Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily [2].
  • Finally, Bsg (-1-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it [17].

Regulatory relationships of Bsg


Other interactions of Bsg


Analytical, diagnostic and therapeutic context of Bsg


  1. Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Fan, Q.W., Kadomatsu, K., Uchimura, K., Muramatsu, T. Dev. Growth Differ. (1998) [Pubmed]
  2. Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Kuno, N., Kadomatsu, K., Fan, Q.W., Hagihara, M., Senda, T., Mizutani, S., Muramatsu, T. FEBS Lett. (1998) [Pubmed]
  3. Extracellular cyclophilins contribute to the regulation of inflammatory responses. Arora, K., Gwinn, W.M., Bower, M.A., Watson, A., Okwumabua, I., MacDonald, H.R., Bukrinsky, M.I., Constant, S.L. J. Immunol. (2005) [Pubmed]
  4. Increased basigin in bleomycin-induced lung injury. Betsuyaku, T., Kadomatsu, K., Griffin, G.L., Muramatsu, T., Senior, R.M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  5. A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, T., Taguchi, O., Yamamura, K., Arimura, K., Muramatsu, T. Dev. Biol. (1998) [Pubmed]
  6. Neurothelin: an inducible cell surface glycoprotein of blood-brain barrier-specific endothelial cells and distinct neurons. Schlosshauer, B., Herzog, K.H. J. Cell Biol. (1990) [Pubmed]
  7. Brain induces the expression of an early cell surface marker for blood-brain barrier-specific endothelium. Risau, W., Hallmann, R., Albrecht, U., Henke-Fahle, S. EMBO J. (1986) [Pubmed]
  8. Unavailability of CD147 leads to selective erythrocyte trapping in the spleen. Coste, I., Gauchat, J.F., Wilson, A., Izui, S., Jeannin, P., Delneste, Y., MacDonald, H.R., Bonnefoy, J.Y., Renno, T. Blood (2001) [Pubmed]
  9. Developmental analyses of 5A11/Basigin, 5A11/Basigin-2 and their putative binding partner MCT1 in the mouse eye. Clamp, M.F., Ochrietor, J.D., Moroz, T.P., Linser, P.J. Exp. Eye Res. (2004) [Pubmed]
  10. Tissue distribution of basigin and monocarboxylate transporter 1 in the adult male mouse: A study using the wild-type and basigin gene knockout mice. Nakai, M., Chen, L., Nowak, R.A. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2006) [Pubmed]
  11. Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Yoshida, S., Shibata, M., Yamamoto, S., Hagihara, M., Asai, N., Takahashi, M., Mizutani, S., Muramatsu, T., Kadomatsu, K. Eur. J. Biochem. (2000) [Pubmed]
  12. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Philp, N.J., Ochrietor, J.D., Rudoy, C., Muramatsu, T., Linser, P.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  13. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Muramatsu, T., Miyauchi, T. Histol. Histopathol. (2003) [Pubmed]
  14. Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Hérubel, F., El Mouatassim, S., Guérin, P., Frydman, R., Ménézo, Y. Zygote (2002) [Pubmed]
  15. Protein-bound carbohydrates on cell-surface as targets of recognition: an odyssey in understanding them. Muramatsu, T. Glycoconj. J. (2000) [Pubmed]
  16. Retinal dysfunction in basigin deficiency. Hori, K., Katayama, N., Kachi, S., Kondo, M., Kadomatsu, K., Usukura, J., Muramatsu, T., Mori, S., Miyake, Y. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  17. Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier. Igakura, T., Kadomatsu, K., Taguchi, O., Muramatsu, H., Kaname, T., Miyauchi, T., Yamamura, K., Arimura, K., Muramatsu, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  18. Caveolin-1 up-regulates CD147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines. Jia, L., Wang, S., Zhou, H., Cao, J., Hu, Y., Zhang, J. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  19. Deglycosylation of CD147 down-regulates Matrix Metalloproteinase-11 expression and the adhesive capability of murine hepatocarcinoma cell HcaF in vitro. Jia, L., Zhou, H., Wang, S., Cao, J., Wei, W., Zhang, J. IUBMB Life (2006) [Pubmed]
  20. The immunoglobulin-superfamily molecule basigin is a binding protein for oligomannosidic carbohydrates: an anti-idiotypic approach. Heller, M., von der Ohe, M., Kleene, R., Mohajeri, M.H., Schachner, M. J. Neurochem. (2003) [Pubmed]
  21. Retinal degeneration following failed photoreceptor maturation in 5A11/basigin null mice. Ochrietor, J.D., Moroz, T.M., Kadomatsu, K., Muramatsu, T., Linser, P.J. Exp. Eye Res. (2001) [Pubmed]
  22. Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Fan, Q.W., Yuasa, S., Kuno, N., Senda, T., Kobayashi, M., Muramatsu, T., Kadomatsu, K. Neurosci. Res. (1998) [Pubmed]
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