Disease relevance of NSC266155

• Thiobarbiturate-reactive substances were decreased in the lung extracts of mice bearing hypersensitivity granulomas injected with rh-SOD [1].
• Primary open-angle glaucoma alters retinal recovery from a thiobarbiturate: spatial frequency dependence [2].
• With thiobarbiturate anesthesia, Greyhounds had long periods of respiratory depression, struggled, and relapsed into sleep, whereas in the other dogs, the recovery was quiet [3].
• Blood gas analysis, clearance and micropuncture studies were therefore performed in rats anaesthetised with TB or the related thiobarbiturate thiopentone (TP) (both 100 mg/kg body weight) to establish whether the latter meets this requirement [4].
• Blood was sampled for the determination of serum malondialdehyde (MDA) by the thiobarbiturate assay, total antioxidant status (TAS) by a chromogenic assay, tumor necrosis factor alpha by a bioassay on fibrosarcoma L929 cell line, and endotoxins (LPS) by the QCL-1000 LAL assay [5].

Psychiatry related information on NSC266155

• Similar excitatory or depressant response rate dependent effects on monkeys responding on a variable interval reinforcement schedule were observed following intravenous administration of either thyrotropin releasing hormone (TRH) or thiobarbiturate [6].

High impact information on NSC266155

• Rats were anesthetized with thiobarbiturate, a 12-mm segment of duodenum with intact blood supply was cannulated in situ and bicarbonate secretion titrated by pH-stat [7].
• Rats were anesthetized with thiobarbiturate, a 12-mm segment of proximal duodenum with intact blood supply was cannulated in situ, and the alkaline secretion was titrated by pH stat [8].
• The authors evaluated thiopental (a thiobarbiturate) and methohexital (an oxybarbiturate), two compounds with similar physicochemical properties but different structures, to determine whether they have distinct effects on the major ionic currents that determine action potential duration (APD) in ventricular myocytes [9].
• Levels of thiobarbiturate reactive substances and carbon-centered radicals were increased in the cerebral cortex, while superoxide dismutase activity was also increased in the mitochondrial and cytosolic fraction of cerebrocortical homogenates [10].
• RESULTS: Both asthmatic and nonasthmatic patients who received a thiobarbiturate for induction had a greater incidence of wheezing than did patients receiving propofol [11].

Chemical compound and disease context of NSC266155

• SELECTION CRITERIA: Randomised or quasi randomised trials of any one or more of the barbiturate class of drugs (amobarbital, barbital, hexobarbital, mephobarbital, methohexital, murexide, pentobarbital, phenobarbital, secobarbital, thiobarbiturate) where study participants had a clinically diagnosed acute traumatic brain injury of any severity [12].

Biological context of NSC266155

• Lipid peroxidation was measured in these three systems as thiobarbiturate-reacting material [13].
• These results suggest that thiobarbiturates and oxybarbiturates affect vascular smooth muscle differently and that the affected site in thiobarbiturate-induced vasodilatation is distal to regulation of [Ca2+]i [14].
• Thiobarbiturate-induced dysrhythmias: the role of heart rate and autonomic imbalance [15].
• The carbohydrate moiety of these proteins is thought to interfere with the thiobarbiturate (TBA) and nitroblue tetrazolium colorimetric tests which are used for assaying non-enzymatic glycosylation (NEG) of serum proteins [16].
• Five indices of cell damage were used to quantitate cytotoxicity: dye (trypan blue) uptake, loss of cell respiration, the extracellular release of lysosomal enzymes, the formation of thiobarbiturate (TBA)-reacting substances, and the oxidation of cellular NADH and NADPH [17].

Anatomical context of NSC266155

• A marked depletion of total and free -SH content was found in aorta, epicardium and endocardium, with a striking increase in the formation of thiobarbiturate-reactive substance by aortic mitochondria at all time points [18].
• Application of the thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes [19].
• Thiobarbiturate-induced contractions were greater in mesenteric than in cerebral arteries previously contracted with PGF2 alpha [20].
• One-month administration of beta-catechin solution increased SOD activity in the mitochondria fraction of striatum and midbrain and decreased thiobarbiturate reactive substance formation in the cortex and cerebellum of aged rats [21].
• Malondialdehyde (MDA), a product of polyunsaturated fat peroxidation, was measured as the thiobarbiturate derivative in the supernatant following incubation of erythrocytes in hydrogen peroxide [22].

Associations of NSC266155 with other chemical compounds

• The hydroxyl radical generating system also initiated a rapid onset of membrane lipid peroxidation, as measured by accumulation of thiobarbiturate reactive material [23].
• The latter is more convenient because a quick, simple IV injection will preclude the necessity for physical restraint required to administer a large volume of guaifenesin/thiobarbiturate combination [24].
• Salicylate and Fe alone caused a small increase in lipid peroxidation (LPO) measured as malondialdehyde formation in the liver by means of the thiobarbiturate method [25].
• The levels of sialic acid in sera, with or without treatment of neuraminidase, were measured by the thiobarbiturate method [26].
• On the other hand, inhibition of AR during the post-ischemic reperfusion phase did not affect cardiac performance and ATP content, but it significantly attenuated creatine kinase release and the level of thiobarbiturate-reactive substances in transgenic mouse hearts [27].

Gene context of NSC266155

• This increase was accompanied by a decrease in the activities of the selenoenzyme, glutathione peroxidase, and the copper-containing enzyme superoxide dismutase, together with a rise in thiobarbiturate-reactive substances in the heart [28].
• Phosphorylated KDO present in Vibrio cholerae and B. pertussis LPS respond poorly in the thiobarbiturate assay (specific for KDO) [29].
• LPS species that induced high levels of IL 1 release from human monocytes exhibited a high thiobarbiturate-reactive 2-keto-3-deoxy-octonic acid (KDO) content [30].
• Suppression of neutrophil migration and chemiluminescence is due to the sulphur atom in the thiobarbiturate molecule [31].
• LPS was measured by the QCL-1000 LAL assay, TNFalpha and IFNgamma by ELISA, NO by a colorimetric assay and MDA by the thiobarbiturate assay [32].

Analytical, diagnostic and therapeutic context of NSC266155

• Endotoxin was measured by a colorimetric Limulus amebocyte lysate assay and malondialdehyde (MDA) was measured by the thiobarbiturate assay and passage through a high-performance liquid chromatography (HPLC) system as a marker of the oxidative status [33].
• In an attempt to investigate the significance of lipid peroxidation in the pathogenesis of gastritis associated with or without Helicobacter pylori infection, malonodialdehyde (MDA) levels were measured by the thiobarbiturate assay in the gastric juice of 101 patients undergoing upper GI endoscopy and correlated with histopathological findings [34].
• These results suggest that the increase in thiobarbiturate-reacting substance content during reperfusion is independent of the postischemic contractile failure [35].
• The dilemma posed by cesarean section of a young woman with posterior fossa brain tumor led us to revive use of Kosaka's higher doses of thiobarbiturate [36].

References