The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN97719     6-hydroxy-2-sulfanylidene-1H- pyrimidin-4-one

Synonyms: AG-E-06905, AG-H-93188, CHEMBL1650611, ANW-30988, NSC-266155, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC266155


Psychiatry related information on NSC266155


High impact information on NSC266155

  • Rats were anesthetized with thiobarbiturate, a 12-mm segment of duodenum with intact blood supply was cannulated in situ and bicarbonate secretion titrated by pH-stat [7].
  • Rats were anesthetized with thiobarbiturate, a 12-mm segment of proximal duodenum with intact blood supply was cannulated in situ, and the alkaline secretion was titrated by pH stat [8].
  • The authors evaluated thiopental (a thiobarbiturate) and methohexital (an oxybarbiturate), two compounds with similar physicochemical properties but different structures, to determine whether they have distinct effects on the major ionic currents that determine action potential duration (APD) in ventricular myocytes [9].
  • Levels of thiobarbiturate reactive substances and carbon-centered radicals were increased in the cerebral cortex, while superoxide dismutase activity was also increased in the mitochondrial and cytosolic fraction of cerebrocortical homogenates [10].
  • RESULTS: Both asthmatic and nonasthmatic patients who received a thiobarbiturate for induction had a greater incidence of wheezing than did patients receiving propofol [11].

Chemical compound and disease context of NSC266155


Biological context of NSC266155


Anatomical context of NSC266155


Associations of NSC266155 with other chemical compounds


Gene context of NSC266155


Analytical, diagnostic and therapeutic context of NSC266155


  1. Suppression of pulmonary hypersensitivity granulomas in mice by superoxide dismutase. Kasama, T., Kobayashi, K., Yamagata, N., Matsuda, T., Kasahara, K., Takahashi, T. Immunopharmacology (1992) [Pubmed]
  2. Primary open-angle glaucoma alters retinal recovery from a thiobarbiturate: spatial frequency dependence. Ofri, R., Dawson, W.W., Foli, K., Gelatt, K.N. Exp. Eye Res. (1993) [Pubmed]
  3. Barbiturate anesthesia in greyhound and mixed-breed dogs: comparative cardiopulmonary effects, anesthetic effects, and recovery rates. Robinson, E.P., Sams, R.A., Muir, W.W. Am. J. Vet. Res. (1986) [Pubmed]
  4. Renal and single-nephron function is comparable in thiobutabarbitone- and thiopentone-anaesthetised rats. Häberle, D.A., Davis, J.M., Kawabata, M., Metz, C., Wapler, P., Stachl, M. Pflugers Arch. (1993) [Pubmed]
  5. The significance of oxidant/antioxidant balance for the pathogenesis of experimental sepsis by multidrug-resistant Pseudomonas aeruginosa. Koussoulas, V., Giamarellos-Bourboulis, E.J., Adamis, T., Mouktaroudi, M., Sabracos, L., Perrea, D., Giamarellou, H., Dionyssiou-Asteriou, A. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  6. Mutual antagonism of behavioral effects of TRH and thiobarbiturate on an operant task in rhesus monkeys. Kraemer, G.W., Klopf, F.H., McKinney, W.T. Psychopharmacology (Berl.) (1979) [Pubmed]
  7. Central nervous alpha1-adrenoceptor stimulation induces duodenal luminal release of melatonin. Sjöblom, M., Flemström, G. J. Pineal Res. (2004) [Pubmed]
  8. Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin. Flemström, G., Sjöblom, M., Jedstedt, G., Akerman, K.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  9. Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes. Martynyuk, A.E., Morey, T.E., Raatikainen, M.J., Seubert, C.N., Dennis, D.M. Anesthesiology (1999) [Pubmed]
  10. Oxidative stress alters arginine metabolism in rat brain: effect of sub-convulsive hyperbaric oxygen exposure. Ito, T., Yufu, K., Mori, A., Packer, L. Neurochem. Int. (1996) [Pubmed]
  11. Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blinded trial. Pizov, R., Brown, R.H., Weiss, Y.S., Baranov, D., Hennes, H., Baker, S., Hirshman, C.A. Anesthesiology (1995) [Pubmed]
  12. Barbiturates for acute traumatic brain injury. Roberts, I. Cochrane database of systematic reviews (Online) (2000) [Pubmed]
  13. Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol. Shertzer, H.G., Berger, M.L., Tabor, M.W. Biochem. Pharmacol. (1988) [Pubmed]
  14. Thiobarbiturates suppress depolarization-induced contraction of vascular smooth muscle without suppression of calcium influx. Kitamura, R., Kakuyama, M., Nakamura, K., Miyawaki, I., Mori, K. British journal of anaesthesia. (1996) [Pubmed]
  15. Thiobarbiturate-induced dysrhythmias: the role of heart rate and autonomic imbalance. Muir, W.W. Am. J. Vet. Res. (1977) [Pubmed]
  16. Thiobarbiturate and fructosamine assays: significance and interest of the borohydride blank. Vanhaeverbeek, M., Brohee, D., Lefevre, A., Piro, P., Kennes, B., Neve, P. Acta diabetologica. (1994) [Pubmed]
  17. Bipyridylium herbicide toxicity: effects of paraquat and diquat on isolated rat hepatocytes. Suleiman, S.A., Stevens, J.B. J. Environ. Pathol. Toxicol. Oncol. (1987) [Pubmed]
  18. Lipid peroxidation and oxidative stress during acute allylamine-induced cardiovascular toxicity. Awasthi, S., Boor, P.J. J. Vasc. Res. (1994) [Pubmed]
  19. Application of the thiobarbiturate assay to the measurement of lipid peroxidation products in microsomes. Albro, P.W., Corbett, J.T., Schroeder, J.L. J. Biochem. Biophys. Methods (1986) [Pubmed]
  20. Responses to barbiturates of isolated dog cerebral and mesenteric arteries contracted with KCl and prostaglandin F2 alpha. Moriyama, S., Nakamura, K., Hatano, Y., Harioka, T., Mori, K. Acta anaesthesiologica Scandinavica. (1990) [Pubmed]
  21. The efficacy of an antioxidant cocktail on lipid peroxide level and superoxide dismutase activity in aged rat brain and DNA damage in iron-induced epileptogenic foci. Komatsu, M., Hiramatsu, M. Toxicology (2000) [Pubmed]
  22. Erythrocyte malondialdehyde release in vitro: a functional measure of vitamin E status. Cynamon, H.A., Isenberg, J.N., Nguyen, C.H. Clin. Chim. Acta (1985) [Pubmed]
  23. Free radical-induced injury to C6 glioma cells. Goldberg, W.J., Dickens, B.F., Tadvalkar, G., Bernstein, J.J., Laws, E.R., Weglicki, W.B. Neurosurgery (1991) [Pubmed]
  24. Immobilization and anesthesia of two hand-reared zebras. Lin, H.C., Thurmon, J.C., Benson, G.J., Tranquilli, W.J. J. Am. Vet. Med. Assoc. (1993) [Pubmed]
  25. Effects of Fe, salicylate and Zn on metallothionein and lipid peroxidation in vivo. Günther, T., Grossrau, R., Höllriegl, V., Vormann, J. Journal of trace elements and electrolytes in health and disease. (1991) [Pubmed]
  26. Measurement of sialic acid and acute phase reactant proteins in sera of patients with diabetic nephropathy. Tomino, Y., Inoue, W., Yagame, M., Nomoto, Y., Sakai, H., Ito, K., Nagaoka, K., Ikeda, N. The Journal of diabetic complications. (1988) [Pubmed]
  27. Aldose reductase inhibitors improve myocardial reperfusion injury in mice by a dual mechanism. Iwata, K., Matsuno, K., Nishinaka, T., Persson, C., Yabe-Nishimura, C. J. Pharmacol. Sci. (2006) [Pubmed]
  28. Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: a possible mechanism of cadmium cardiotoxicity. Jamall, I.S., Smith, J.C. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  29. Interleukin-1 induction by lipopolysaccharides: structural requirements of the 3-deoxy-D-manno-2-octulosonic acid (KDO). Haeffner-Cavaillon, N., Caroff, M., Cavaillon, J.M. Mol. Immunol. (1989) [Pubmed]
  30. Dissociation between the interleukin 1-inducing capacity and Limulus reactivity of lipopolysaccharides from gram-negative bacteria. Laude-Sharp, M., Haeffner-Cavaillon, N., Caroff, M., Lantreibecq, F., Pusineri, C., Kazatchkine, M.D. Cytokine (1990) [Pubmed]
  31. Suppression of neutrophil migration and chemiluminescence is due to the sulphur atom in the thiobarbiturate molecule. Kress, H.G., Eberlein, T., Hörber, B., Weis, K.H. Acta anaesthesiologica Scandinavica. (1989) [Pubmed]
  32. Immunomodulatory intervention in sepsis by multidrug-resistant Pseudomonas aeruginosa with thalidomide: an experimental study. Giamarellos-Bourboulis, E.J., Bolanos, N., Laoutaris, G., Papadakis, V., Koussoulas, V., Perrea, D., Karayannacos, P.E., Giamarellou, H. BMC Infect. Dis. (2005) [Pubmed]
  33. Portal and systemic endotoxemia in abdominal operations: the significance of acute abdomen. Plachouras, D., Stamatakos, M., Baziaka, F., Giamarellos-Bourboulis, E., Tsaganos, T., Giamarellou, H., Safioleas, M. J. Surg. Res. (2006) [Pubmed]
  34. Lipid peroxidation in chronic gastritis; any influence of Helicobacter pylori? Giamarellos-Bourboulis, E.J., Tzivras, M., Kourtesas, D., Arnaoutis, T.P., Delladatsima, I., Dionyssiou-Asteriou, A., Davaris, P., Vafiadis-Zouboulis, I., Archimandritis, A. Prostaglandins Leukot. Essent. Fatty Acids (2003) [Pubmed]
  35. Effects of N-(2-mercaptopropionyl)-glycine on postischemic contractile function in ischemic/reperfused hearts. Dissociation of thiobarbiturate-reacting substance formation and contractile dysfunction. Tanonaka, K., Yoneda, M., Kamiyama, T., Liu, J., Takeo, S. Archives internationales de pharmacodynamie et de thérapie. (1995) [Pubmed]
  36. Cesarean section in a patient with brain tumor: a clinical report. Cook, H.E. Military medicine. (1989) [Pubmed]
WikiGenes - Universities