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Chemical Compound Review

Fosdrine     methyl(E)-3- dimethoxyphosphoryloxybut- 2...

Synonyms: Duraphos, Meniphos, Mevinfos, Phosdrin, Phosfene, ...
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Disease relevance of Phosdrin


High impact information on Phosdrin


Chemical compound and disease context of Phosdrin


Biological context of Phosdrin

  • We investigated possible changes in bioenergetics at the rostral ventrolateral medulla (RVLM), a medullary site where sympathetic vasomotor tone originates and where the organophosphate poison mevinphos (Mev) acts to elicit cardiovascular intoxication [13].
  • MOSs for mean acute occupational exposure of mixer/loader/applicators associated with ground application and of harvesters working in fruit trees were less than the value conventionally recommended to protect people from the toxic effects of mevinphos [14].
  • We evaluated the functional changes in the mitochondrial respiratory chain at the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic vasomotor tone, in an experimental model of fatal organophosphate poisoning using the insecticide mevinphos (Mev) [15].
  • They increased the 24h LD50 values of mevinphos about three times in comparison with non-treated intoxicated animals [16].
  • Biological monitoring of workers exposed to mevinphos in greenhouses [17].

Anatomical context of Phosdrin


Associations of Phosdrin with other chemical compounds

  • By far, the highest esterase inhibiting potency was found in a sample collected in an area with intense horticultural activities in June, and was attributed to high concentrations of dichlorvos, mevinphos, pirimiphos-methyl and methiocarb [23].
  • Atropine, scopolamine, mevinphos, and eserine selectively block directional sensitivity of visual integrative neurones in the thalamus [24].
  • Red blood cell and plasma cholinesterase activities were equally sensitive for all but mevinphos and diazinon [25].
  • In addition, it was noted that increasing the initial pH of mevinphos rinsate to a basic level was required to reach higher COD removal efficiency and positive microtoxicity reduction efficiency while it was not necessary for the treatment of carbofuran rinsate [26].
  • On the other hand, both monopyridinium oximes were significantly more efficacious than HI-6 and as efficacious as obidoxime when they were administered 30 sec. after mevinphos poisoning [27].

Gene context of Phosdrin

  • We evaluated the relationship between the toxicity induced by the organophosphate mevinphos (Mev) and inducible nitric oxide synthase (iNOS) in the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic neurogenic vasomotor tone [28].
  • No cases of acute pancreatitis following mevinphos (CAS 7786-34-71) poisoning have been reported to date [4].
  • 3. On the other hand, there were significant differences in their therapeutic efficacy when they were administered 30 sec following mevinphos challenge [16].
  • Toxicity, acetylcholinesterase inhibition and metabolism of enolic phosphate esters resembling the insecticide, phosdrin [29].

Analytical, diagnostic and therapeutic context of Phosdrin


  1. Cholinergic receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos. Chan, J.Y., Chan, S.H., Dai, K.Y., Cheng, H.L., Chou, J.L., Chang, A.Y. Neuropharmacology (2006) [Pubmed]
  2. The minimal oral toxicity level for mevinphos in man. Rider, J.A., Puletti, E.J., Swader, J.I. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  3. Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat. Yen, D.H., Chan, J.Y., Huang, C.I., Lee, C.H., Chan, S.H., Chang, A.Y. Shock (2005) [Pubmed]
  4. Acute pancreatitis following organophosphate intoxication. Hsiao, C.T., Yang, C.C., Deng, J.F., Bullard, M.J., Liaw, S.J. J. Toxicol. Clin. Toxicol. (1996) [Pubmed]
  5. Neurological effects and cholinesterase inhibition in man by subacute administration of mevinphos. Verberk, M.M., Sallé, H.J. Activitas nervosa superior. (1977) [Pubmed]
  6. De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme l1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication. Chang, C., Chang, A.Y., Chan, S.H. Shock (2004) [Pubmed]
  7. Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates. Sobti, R.C., Krishan, A., Pfaffenberger, C.D. Mutat. Res. (1982) [Pubmed]
  8. Insecticide dissipation after repeated field application to a northern Thailand ultisol. Ciglasch, H., Busche, J., Amelung, W., Totrakool, S., Kaupenjohann, M. J. Agric. Food Chem. (2006) [Pubmed]
  9. Piperonyl butoxide as a tool in aquatic toxicological research with organophosphate insecticides. Ankley, G.T., Dierkes, J.R., Jensen, D.A., Peterson, G.S. Ecotoxicol. Environ. Saf. (1991) [Pubmed]
  10. Cholinesterase activity depression among California agricultural pesticide applicators. Ames, R.G., Brown, S.K., Mengle, D.C., Kahn, E., Stratton, J.W., Jackson, R.J. Am. J. Ind. Med. (1989) [Pubmed]
  11. p-Nitrophenylacetate hydrolysis by honey bee esterases: kinetics and inhibition. Spoonamore, J.E., Frohlich, D.R., Wells, M.A. Xenobiotica (1993) [Pubmed]
  12. Toxicity detection from EILATox-Oregon Workshop samples by using kinetic photobacteria measurement: the Flash method. Hakkila, K., Lappalainen, J., Virta, M. Journal of applied toxicology : JAT. (2004) [Pubmed]
  13. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Yen, D.H., Chan, J.Y., Tseng, H.P., Huang, C.I., Lee, C.H., Chan, S.H., Chang, A.Y. Shock (2004) [Pubmed]
  14. Risks from occupational and dietary exposure to mevinphos. Cochran, R.C., Formoli, T.A., Silva, M.H., Kellner, T.P., Lewis, C.M., Pfeifer, K.F. Reviews of environmental contamination and toxicology. (1996) [Pubmed]
  15. Neuroprotective Role of Coenzyme Q10 against Dysfunction of Mitochondrial Respiratory Chain at Rostral Ventrolateral Medulla during Fatal Mevinphos Intoxication in the Rat. Li, F.C., Tseng, H.P., Chang, A.Y. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  16. A comparison of the efficacy of new monopyridinium oximes with the oxime HI-6 against mevinphos in mice. Kassa, J., Bielavský, J. Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové. (1999) [Pubmed]
  17. Biological monitoring of workers exposed to mevinphos in greenhouses. Jauhiainen, A., Kangas, J., Laitinen, S., Savolainen, K. Bulletin of environmental contamination and toxicology. (1992) [Pubmed]
  18. Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Worek, F., Kirchner, T., Bäcker, M., Szinicz, L. Arch. Toxicol. (1996) [Pubmed]
  19. Contrast optimization of Macaca mulatta basal ganglia in magnetic resonance images at 4.7 Tesla. Bonny, J., Durif, F., Bazin, J.E., Touraille, E., Yelnik, J., Renou, J.P. J. Neurosci. Methods (2001) [Pubmed]
  20. Observations on the accidental poisoning of birds by organophosphate insecticides and other toxic substances. Reece, R.L., Handson, P. Vet. Rec. (1982) [Pubmed]
  21. Effect of commercial formulation of four organophosphorus insecticides on the LH-induced germinal vesicle breakdown in the oocytes of a freshwater teleost, Mystus vittatus (Bloch)--a preliminary in vitro study. Haider, S., Upadhyaya, N. Ecotoxicol. Environ. Saf. (1986) [Pubmed]
  22. Cytological and cytochemical changes in reactive connective tissue cells following exposure to phosdrin. Dimova, P., Boyadjiev, S. Folia medica. (1982) [Pubmed]
  23. Biological and chemical analysis of the toxic potency of pesticides in rainwater. Hamers, T., Smit, M.G., Murk, A.J., Koeman, J.H. Chemosphere (2001) [Pubmed]
  24. Effects of organophosphate pesticides and other drugs on subcortical mechanisms of visual integration. Revzin, A.M. Aviation, space, and environmental medicine. (1976) [Pubmed]
  25. Acute dermal toxicities of various organophosphate insecticides in mice. Skinner, C.S., Kilgore, W.W. Journal of toxicology and environmental health. (1982) [Pubmed]
  26. Photocatalytic oxidation of pesticide rinsate. Kuo, W.S. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (2002) [Pubmed]
  27. The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice. Kassa, J., Bielavský, J. Pharmacol. Toxicol. (1997) [Pubmed]
  28. Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat. Chang, A.Y., Chan, J.Y., Kao, F.J., Huang, C.M., Chan, S.H. J. Biomed. Sci. (2001) [Pubmed]
  29. Toxicity, acetylcholinesterase inhibition and metabolism of enolic phosphate esters resembling the insecticide, phosdrin. Woods, A.E., Morgan, P.E., Coates, J.T. Bulletin of environmental contamination and toxicology. (1975) [Pubmed]
  30. Aphicide persistence on spinach and mustard greens. Sweeden, M.B., McLeod, P.J. J. Econ. Entomol. (1997) [Pubmed]
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