Disease relevance of CASP14

• METHODS AND RESULTS: Mice lacking TNF-Rp55 expression after targeted disruption of the TNF-Rp55 gene were backcrossed into a genetic background susceptible to the induction of myocarditis with cardiac myosin [1].
• 2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells [2].
• Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients [3].
• Light emitted from s.c. and i.p. IGROV1 ovarian carcinoma xenografts was measured following treatment with dlCR2 Ren. Mice bearing s.c. IGROV1 xenografts were injected with 2.96 to 3.7 MBq of [(18)F]FLT 48 and 168 hours following i.t. injection of dl922-947 or control virus Ad LM-X [4].
• Human C-Reactive Protein Protects Mice from Streptococcus pneumoniae Infection without Binding to Pneumococcal C-Polysaccharide [5].

Psychiatry related information on CASP14

• MATERIALS AND METHODS: Mice with targeted deletion of the gene coding for the alpha7 subunit of nicotinic receptors and wild-type controls were trained on a five-choice serial reaction time task with food reinforcers presented under varying parametric conditions [6].
• The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-beta Peptide Levels in Cell Culture and Mice [7].

High impact information on CASP14

• Hyperekplexia Phenotype of Glycine Receptor alpha1 Subunit Mutant Mice Identifies Zn(2+) as an Essential Endogenous Modulator of Glycinergic Neurotransmission [8].
• Phenotypic and Functional Analysis of Immune CD8+ T Cell Responses Induced by a Single Injection of a HIV DNA Vaccine in Mice [9].
• Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice [10].
• Colonic Anion Secretory Defects and Metabolic Acidosis in Mice Lacking the NBC1 Formula Cotransporter [11].
• Therapeutic Targeting of CC Ligand 21 or CC Chemokine Receptor 7 Abrogates Pulmonary Fibrosis Induced by the Adoptive Transfer of Human Pulmonary Fibroblasts to Immunodeficient Mice [12].

Chemical compound and disease context of CASP14

• Cag Pathogenicity Island-independent Up-regulation of Matrix Metalloproteinases-9 and -2 Secretion and Expression in Mice by Helicobacter pylori Infection [13].
• Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice [14].
• MARCO Mediates Silica Uptake and Toxicity in Alveolar Macrophages from C57BL/6 Mice [15].
• EXPERIMENTAL DESIGN: Mice implanted with human breast cancer (MX-1) were treated with cyclophosphamide and evaluated using diffusion MRI and growth kinetics [16].
• Tauopathy-like Abnormalities and Neurologic Deficits in Mice Immunized With Neuronal Tau Protein [17].

Biological context of CASP14

• slc26a3 (dra)-deficient Mice Display Chloride-losing Diarrhea, Enhanced Colonic Proliferation, and Distinct Up-regulation of Ion Transporters in the Colon [18].
• AIMS/HYPOTHESIS: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake [19].
• METHODS: Mice were intradermally prevaccinated with plasmid DNA, followed by sensitization and intranasal allergen provocation with recombinant Phl p 5 [20].
• Measles Virus Infection of SLAM (CD150) Knockin Mice Reproduces Tropism and Immunosuppression in Human Infection [21].
• 1. Mice fed with CBZ were assessed for brain structure size, seizure behavior and expression of markers for neuronal plasticity and rescue in brain [22].

Anatomical context of CASP14

• Tumor Signaling to the Bone Marrow Changes the Phenotype of Monocytes and Pulmonary Macrophages during Urethane-Induced Primary Lung Tumorigenesis in A/J Mice [23].
• RESULTS: Mice treated with the PDGF inhibitor AG 1296 showed an inhibition of corneal neovascularization of 21.1% and a reduction of pericytes of 52% in the newly formed vessels compared with untreated animals [24].
• Spatial and Temporal Expression of Lactobacillus plantarum Genes in the Gastrointestinal Tracts of Mice [25].
• In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium [26].
• Chemoprotection Effect of Multidrug Resistance 1 (MDR1) Gene Transfer to Hematopoietic Progenitor Cells and Engrafted in Mice with Cancer Allows Intensified Chemotherapy [27].

Associations of CASP14 with chemical compounds

• Plasminogen Activator Inhibitor Type-1-Deficient Mice Have an Enhanced IFN-{gamma} Response to Lipopolysaccharide and Staphylococcal Enterotoxin B [28].
• Glycated Fibroblast Growth Factor-2 Is Quickly Produced in Vitro upon Low-Millimolar Glucose Treatment and Detected in Vivo in Diabetic Mice [29].
• Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-{alpha}-deficient Mice [30].
• RESULTS: Mice in the sham-treated group consumed significantly more sucrose solution than water, whereas MCAO-treated mice consumed similar amounts of each, suggesting anhedonia among MCAO-treated mice [31].
• Differential Contributions of Dopamine D(1), D(2), and D(3) Receptors to MDMA-Induced Effects on Locomotor Behavior Patterns in Mice [32].

Analytical, diagnostic and therapeutic context of CASP14

• Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma [33].
• METHODS: Mice received intranasal ovalbumin (OVA) vaccinations on a weekly basis [34].
• METHODS.: Mice made deficient for full-length CD80 but which retain expression of the shorter IgV-CD80 (CD80 mice) were used as donor or recipient of a heart allograft [35].
• METHODS: Mice received an intraperitoneal injection of the agonistic anti-Fas antibody 72 h after an intravenous injection of either adenoviral vector (1x10(11) particles) expressing human HB-EGF (Ad.HB-EGF), human HGF (Ad.HGF) or no gene (Ad.dE1.3), and were sacrificed 24 or 36 h later to assess liver injury and regeneration [36].
• To address the role of one integrin, beta(3), in the pathogenesis of cardiac hypertrophy, beta(3)(-/-) mice were examined. beta(3)(-/-) Mice developed moderate spontaneous cardiac hypertrophy associated with systolic and diastolic dysfunction, and these abnormalities were exacerbated by transverse aortic constriction [37].

References