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Gene Review

ENPP3  -  ectonucleotide pyrophosphatase/phosphodies...

Homo sapiens

Synonyms: B10, CD203c, E-NPP 3, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, NPP3, ...
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Disease relevance of ENPP3

  • Our results suggested that E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma [1].
  • Human PDNP3 is expressed in glioma cells, prostate, and uterus, but not in the alimentary tract [2].
  • Differential expression of PC-1 and B10 could modulate cartilage mineralization in degenerative joint diseases [3].
  • PNAE represents the main biologically active antitumor component of the cACPL biopreparation and exhibits a significant antitumor effect in vivo in B10/An mice bearing Mc11 fibrosarcoma [4].
  • Among the phages selected was clone lambda B10 containing two complete lectin genes in the same orientation approximately 4 kb apart [5].

High impact information on ENPP3

  • T cells able to suppress either anti-lysozyme plaque-forming cells (PFC) response are induced in B10 mice after immunization with HEL-complete Freund's adjuvant (CFA) or HUL-CFA [6].
  • However, anti-HEL or anti-HUL primary antibody responses in vivo or in vitro can be obtained in B10 mice by immunization with the appropriate lysozyme coupled to erythrocytes [6].
  • Lipopolysaccharide-stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative [7].
  • In contrast to B10, HEL-CFA priming in B10.Q micr induces helper cells whereas HUL-CFA priming induces suppressor cells [6].
  • Glutamine B10 and histidine E7 (the distal histidine) swing towards each other and, between them, stabilize a water molecule in the normally hydrophobic heme pocket [8].

Chemical compound and disease context of ENPP3


Biological context of ENPP3


Anatomical context of ENPP3


Associations of ENPP3 with chemical compounds

  • Transcytosis of two apical membrane proteins-the alkaline phosphodiesterase B10 and dipeptidyl peptidase IV-was affected to the same extent by 201-F and nocodazole [16].
  • In addition, it contains a tyrosine at position 10 of B helix (B10) in place of the leucine generally found there in vertebrate myoglobins and hemoglobins [17].
  • Immunoblotting of these fragments with the monoclonal antibody (MoAb) B10 directed to factor V and the thrombin-generated C1 fragment yields results demonstrating a common epitope in these calpain-generated components of 200, 160, 140 and 120 kd [18].
  • The C conformer is stabilized by a strong polar interaction of the CO with the distal B10 tyrosine residue [19].
  • The corresponding cell surface antigen was identified as a membrane glycoprotein (gp130RB13-6) and purified by immunoaffinity chromatography from the tumorigenic neuroectodermal rat cell line BT4Ca [20].

Regulatory relationships of ENPP3


Other interactions of ENPP3


Analytical, diagnostic and therapeutic context of ENPP3


  1. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma. Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H., Yoon, S., Kasuga, M. Int. J. Mol. Med. (2003) [Pubmed]
  2. Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells. Andoh, K., Piao, J.H., Terashima, K., Nakamura, H., Sano, K. Biochim. Biophys. Acta (1999) [Pubmed]
  3. Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes. Johnson, K., Vaingankar, S., Chen, Y., Moffa, A., Goldring, M.B., Sano, K., Jin-Hua, P., Sali, A., Goding, J., Terkeltaub, R. Arthritis Rheum. (1999) [Pubmed]
  4. A novel nontoxic alkyl-phospholipid with selective antitumor activity, plasmanyl-(N-acyl)-ethanolamine (PNAE), isolated from degenerating chick embryonal tissues and from an anticancer biopreparation cACPL. Kára, J., Borovicka, M., Liebl, V., Smolíková, J., Ubik, K. Neoplasma (1986) [Pubmed]
  5. Characterization of two Phaseolus vulgaris phytohemagglutinin genes closely linked on the chromosome. Hoffman, L.M., Donaldson, D.D. EMBO J. (1985) [Pubmed]
  6. Differential major histocompatibility complex-related activation of idiotypic suppressor T cells. Suppressor T cells cross-reactive to two distantly related lysozymes are not induced by one of them. Adorini, L., Harvey, M.A., Rozycka-Jackson, D., Miller, A., Sercarz, E.E. J. Exp. Med. (1980) [Pubmed]
  7. Serological and biochemical identification of hybrid Ia antigens. Lafuse, W.P., McCormick, J.F., David, C.S. J. Exp. Med. (1980) [Pubmed]
  8. Hemoglobin St. Louis [beta 28 (B10) Leu replaced by Gln]: crystal structure of the fully reduced (deoxy) form. Anderson, N.L. J. Clin. Invest. (1976) [Pubmed]
  9. Comparative activity and distribution studies of five platinum analogues in nude mice bearing human ovarian carcinoma xenografts. Boven, E., van der Vijgh, W.J., Nauta, M.M., Schlüper, H.M., Pinedo, H.M. Cancer Res. (1985) [Pubmed]
  10. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Schmidt, A., Endo, N., Rutledge, S.J., Vogel, R., Shinar, D., Rodan, G.A. Mol. Endocrinol. (1992) [Pubmed]
  11. Chronic urticaria sera increase basophil CD203c expression. Yasnowsky, K.M., Dreskin, S.C., Efaw, B., Schoen, D., Vedanthan, P.K., Alam, R., Harbeck, R.J. J. Allergy Clin. Immunol. (2006) [Pubmed]
  12. Contributions of nuclear medicine to the therapy of malignant tumors. Feinendegen, L.E. J. Cancer Res. Clin. Oncol. (1993) [Pubmed]
  13. A dose-ranging study to evaluate the beta 1-adrenoceptor selectivity of bisoprolol. Lipworth, B.J., Irvine, N.A., McDevitt, D.G. Eur. J. Clin. Pharmacol. (1991) [Pubmed]
  14. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Jin-Hua, P., Goding, J.W., Nakamura, H., Sano, K. Genomics (1997) [Pubmed]
  15. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. Bühring, H.J., Seiffert, M., Giesert, C., Marxer, A., Kanz, L., Valent, P., Sano, K. Blood (2001) [Pubmed]
  16. Functional specialization of stable and dynamic microtubules in protein traffic in WIF-B cells. Poüs, C., Chabin, K., Drechou, A., Barbot, L., Phung-Koskas, T., Settegrana, C., Bourguet-Kondracki, M.L., Maurice, M., Cassio, D., Guyot, M., Durand, G. J. Cell Biol. (1998) [Pubmed]
  17. Formation of two hydrogen bonds from the globin to the heme-linked oxygen molecule in Ascaris hemoglobin. De Baere, I., Perutz, M.F., Kiger, L., Marden, M.C., Poyart, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Factor V is activated and cleaved by platelet calpain: comparison with thrombin proteolysis. Bradford, H.N., Annamalai, A., Doshi, K., Colman, R.W. Blood (1988) [Pubmed]
  19. Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins. Das, T.K., Dewilde, S., Friedman, J.M., Moens, L., Rousseau, D.L. J. Biol. Chem. (2006) [Pubmed]
  20. Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. Deissler, H., Lottspeich, F., Rajewsky, M.F. J. Biol. Chem. (1995) [Pubmed]
  21. Basophil Interleukin 4 and Interleukin 13 Production Is Suppressed during the Early Phase of Rush Immunotherapy. Plewako, H., Wosi??ska, K., Arvidsson, M., Bjorkander, J., Skov, P.S., H??kansson, L., Rak, S. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  22. Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. Monneret, G., Boumiza, R., Gravel, S., Cossette, C., Bienvenu, J., Rokach, J., Powell, W.S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  23. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases. Yano, Y., Hayashi, Y., Sano, K., Nagano, H., Nakaji, M., Seo, Y., Ninomiya, T., Yoon, S., Yokozaki, H., Kasuga, M. Cancer Lett. (2004) [Pubmed]
  24. Ecto-phosphodiesterase/pyrophosphatase of lymphocytes and non-lymphoid cells: structure and function of the PC-1 family. Goding, J.W., Terkeltaub, R., Maurice, M., Deterre, P., Sali, A., Belli, S.I. Immunol. Rev. (1998) [Pubmed]
  25. Evidence of in vivo basophil activation in chronic idiopathic urticaria. Vasagar, K., Vonakis, B.M., Gober, L.M., Viksman, A., Gibbons, S.P., Saini, S.S. Clin. Exp. Allergy (2006) [Pubmed]
  26. Epitope mapping of functional domains of human factor Va with human and murine monoclonal antibodies. Evidence for the interaction of heavy chain with factor Xa and calcium. Annamalai, A.E., Rao, A.K., Chiu, H.C., Wang, D., Duttá-Roy, A.K., Walsh, P.N., Colman, R.W. Blood (1987) [Pubmed]
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